Detailed information for compound 1508056

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 219.237 | Formula: C12H13NO3
  • H donors: 1 H acceptors: 3 LogP: 1.71 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C1C(=O)N(O)C(=O)c2c1cccc2)C
  • InChi: 1S/C12H13NO3/c1-7(2)10-8-5-3-4-6-9(8)11(14)13(16)12(10)15/h3-7,10,16H,1-2H3
  • InChiKey: GZCBOPVTDAJEOV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 245 aa 25.7 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 226 aa 24.3 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Trypanosoma congolense Retroviral aspartyl protease/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative Reverse transcriptase   259 aa 237 aa 29.1 %
Candida albicans ReverseTranscriptase similar to fruit fly Tom element Reverse transcriptase   259 aa 244 aa 27.9 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 208 aa 26.4 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Candida albicans polyprotein of retrotransposon Tca8 Reverse transcriptase   259 aa 238 aa 26.5 %
Candida albicans hypothetical protein Reverse transcriptase   259 aa 223 aa 29.1 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 222 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi acetyl-Coenzyme A synthetase 2 0.002 0.0035 0.026
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.002 0.0033 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0243 0.0602
Schistosoma mansoni hypothetical protein 0.0028 0.0069 0.0081
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0393 0.1002
Onchocerca volvulus 0.0061 0.0208 0.1715
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0061 0.0208 0.0526
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0212 0.966
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0159 0.7197
Loa Loa (eye worm) cysteine protease 0.0016 0.0018 0.0055
Mycobacterium ulcerans hypothetical protein 0.0069 0.0243 0.0602
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0069 0.0243 0.0602
Echinococcus granulosus Niemann Pick C1 protein 0.0192 0.0764 0.0883
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0144 0.0559
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0247
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0061 0.0208 0.051
Schistosoma mansoni hypothetical protein 0.008 0.0286 0.0336
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0069 0.0243 0.0602
Echinococcus multilocularis expressed conserved protein 0.0181 0.0714 0.0701
Schistosoma mansoni aldehyde dehydrogenase 0.0178 0.0702 0.0825
Trypanosoma brucei glucosidase, putative 0.0035 0.0098 0.079
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0159 0.0145
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.1229
Echinococcus multilocularis protein dispatched 1 0.0094 0.0348 0.0335
Plasmodium falciparum acyl-CoA synthetase 0.0052 0.0169 0.0421
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0219 1
Brugia malayi hypothetical protein 0.0035 0.0097 0.0779
Schistosoma mansoni hypothetical protein 0.008 0.0286 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0326 0.0383
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0159 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.002 0.0035 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0016 0.0103
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.002 0.0035 0.005
Plasmodium falciparum glutathione reductase 0.0046 0.0144 0.0355
Schistosoma mansoni protein phosphatase 2C 0.0024 0.0052 0.0061
Leishmania major trypanothione reductase 0.0046 0.0144 0.1999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0061 0.0208 0.0229
Trichomonas vaginalis rotamase, putative 0.0065 0.0226 0.0586
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0061 0.0208 0.2924
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0052 0.0192
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0037 0.0028
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0061 0.0208 0.0526
Leishmania major cathepsin L-like protease 0.0016 0.0018 0.0195
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0564
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0192 0.0764 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0069 0.014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0016 0.0564
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0188 0.1552
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0016 0.0174
Echinococcus granulosus snurportin 1 0.0601 0.2496 0.2924
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0243 0.342
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.002 0.0035 0.0262
Brugia malayi CHE-14 protein 0.0083 0.0299 0.2475
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0033 0.0243
Toxoplasma gondii propionate-CoA ligase 0.002 0.0035 0.005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0159 0.7197
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0018 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0243 0.342
Loa Loa (eye worm) AMP-binding enzyme family protein 0.002 0.0035 0.0124
Toxoplasma gondii cathepsin CPL 0.0016 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0294 0.1193 0.477
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Leishmania major cathepsin L-like protease 0.0016 0.0018 0.0195
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0174
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0037 0.1534
Brugia malayi AMP-binding enzyme family protein 0.002 0.0035 0.026
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0035 0.005
Echinococcus multilocularis phd:f box containing protein 0.0024 0.0052 0.0038
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0018 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0067
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0443 0.1134
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0154 0.1262
Schistosoma mansoni acetyl-CoA synthetase 0.002 0.0035 0.0041
Plasmodium vivax importin-beta 2, putative 0.0056 0.0188 0.0472
Entamoeba histolytica hypothetical protein 0.0046 0.0142 0.1819
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0212 0.966
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0033 0.1338
Toxoplasma gondii thioredoxin reductase 0.0046 0.0144 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.002 0.0035 0.005
Entamoeba histolytica Ran family GTPase 0.0021 0.0037 0.0434
Schistosoma mansoni alpha-glucosidase 0.0136 0.0526 0.0618
Trichomonas vaginalis hypothetical protein 0.0903 0.3777 1
Plasmodium falciparum importin beta, putative 0.0056 0.0188 0.0472
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.002 0.0035 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0052 0.0192
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0018 0.0055
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.026
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0619 0.2467
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0097 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Brugia malayi Cathepsin L-like precursor 0.0016 0.0018 0.0114
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0016 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0089 0.0715
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.041
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0212 0.966
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0024 0.0052 0.0095
Plasmodium falciparum thioredoxin reductase 0.0016 0.0016 0.0017
Trichomonas vaginalis helicase, putative 0.0019 0.003 0.0067
Brugia malayi Cathepsin L-like precursor 0.0016 0.0018 0.0114
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0061 0.0208 0.9496
Echinococcus granulosus peregrin 0.0028 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0064 0.0219 0.0863
Leishmania major cathepsin L-like protease 0.0016 0.0018 0.0195
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0016 0.0103
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Entamoeba histolytica hypothetical protein 0.0035 0.0097 0.1219
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.002 0.0035 0.005
Loa Loa (eye worm) oxidoreductase 0.002 0.0035 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0619 0.0713
Plasmodium falciparum JmjC domain-containing protein, putative 0.0024 0.0052 0.0112
Plasmodium vivax vivapain-2 0.0016 0.0018 0.0021
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.002 0.0035 0.005
Brugia malayi hypothetical protein 0.0294 0.1193 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0299 0.1181
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0097 0.0114
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.0132
Trichomonas vaginalis antibiotic synthetase, putative 0.002 0.0035 0.0082
Loa Loa (eye worm) hypothetical protein 0.0056 0.0188 0.0735
Leishmania major acetyl-CoA synthetase, putative 0.002 0.0035 0.0443
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0069 0.014
Schistosoma mansoni rotamase 0.0065 0.0226 0.0265
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0178 0.0702 1
Schistosoma mansoni importin beta-1 0.0056 0.0188 0.0221
Schistosoma mansoni aldehyde dehydrogenase 0.0178 0.0702 0.0825
Echinococcus granulosus importin subunit beta 1 0.0056 0.0188 0.0205
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0035 0.005
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0061 0.0208 0.051
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.002 0.0035 0.005
Trypanosoma brucei acetyl-CoA synthetase, putative 0.002 0.0035 0.0262
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0067
Echinococcus granulosus expressed protein 0.0065 0.0226 0.0249
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0018 0.0195
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.0192 0.0764 0.3047
Echinococcus granulosus jumonji domain containing 1A 0.0024 0.0052 0.0045
Brugia malayi RNA, U transporter 1 0.016 0.0627 0.5243
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0035 0.005
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0159 0.062
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0018 0.0179
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0059 0.0053
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0016 0.0019
Schistosoma mansoni hypothetical protein 0.1196 0.5019 0.5903
Treponema pallidum NADH oxidase 0.0016 0.0016 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0067
Plasmodium falciparum phd finger protein, putative 0.0028 0.0069 0.0157
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0619 0.5172
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0142 0.6432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0564
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0564
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.041
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0018 0.0004
Onchocerca volvulus 0.0016 0.0018 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0159 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0052 0.0169 0.0659
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.015 0.0584 0.0672
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0069 0.0243 0.0602
Onchocerca volvulus 0.002 0.0035 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0067
Loa Loa (eye worm) oxidoreductase 0.0061 0.0208 0.0818
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Mycobacterium ulcerans aldehyde dehydrogenase 0.0178 0.0702 0.1822
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0016 0.0174
Echinococcus granulosus dnaJ subfamily B 0.1196 0.5019 0.5896
Loa Loa (eye worm) retinol dehydrogenase 12 0.0061 0.0208 0.0818
Brugia malayi jmjC domain containing protein 0.0024 0.0052 0.0403
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0018 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0144 0.6493
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0061 0.0208 0.051
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Schistosoma mansoni hypothetical protein 0.0015 0.0014 0.0016
Brugia malayi Niemann-Pick C1 protein precursor 0.0192 0.0764 0.6388
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0018 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0098 0.4346
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0159 0.7197
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0212 0.966
Mycobacterium ulcerans acetyl-CoA synthetase 0.002 0.0035 0.005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0219 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0619 0.0606
Onchocerca volvulus 0.0016 0.0018 0.0114
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0077 0.009
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.002 0.0035 0.005
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0208 0.2685
Echinococcus multilocularis Niemann Pick C1 protein 0.0275 0.1113 0.1101
Onchocerca volvulus 0.0016 0.0018 0.0114
Schistosoma mansoni hypothetical protein 0.0033 0.0089 0.0105
Schistosoma mansoni patched 1 0.0083 0.0299 0.0351
Loa Loa (eye worm) hypothetical protein 0.0069 0.0243 0.0957
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0016 0.0103
Trypanosoma brucei oxidoreductase-like protein 0.0061 0.0208 0.1727
Echinococcus multilocularis geminin 0.0165 0.0647 0.0634
Schistosoma mansoni hypothetical protein 0.008 0.0286 0.0336
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.0073
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0016 0.0017
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0159 0.0171
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0018 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0116 0.012
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0016 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0018 0.0179
Plasmodium falciparum acetyl-CoA synthetase, putative 0.002 0.0035 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0243 0.0602
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0243 0.0602
Echinococcus granulosus phd:f box containing protein 0.0024 0.0052 0.0045
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0073 0.0069
Plasmodium falciparum thioredoxin reductase 0.0046 0.0144 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0018 0.0036
Schistosoma mansoni alpha glucosidase 0.0035 0.0098 0.0115
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0144 0.0338
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0156 0.7041
Mycobacterium tuberculosis Possible oxidoreductase 0.0061 0.0208 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0299 0.078
Entamoeba histolytica hypothetical protein 0.0035 0.0097 0.1219
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0178 0.0704 0.0828
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0035 0.005
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0144 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0018 0.0036
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0299 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0157 0.0372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0564
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.002 0.0035 0.1439
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.002 0.0035 0.0443
Trichomonas vaginalis ran, putative 0.0021 0.0037 0.0087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0069 0.0243 0.0602
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0903 0.3777 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0098 0.0247
Loa Loa (eye worm) hypothetical protein 0.0052 0.0169 0.0659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0159 0.0171
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0208 0.0818
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0024 0.0052 0.223
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0098 0.0099
Plasmodium vivax acetyl-CoA synthetase, putative 0.002 0.0035 0.0067
Schistosoma mansoni hypothetical protein 0.0292 0.1185 0.1394
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0061 0.0208 0.1727
Trypanosoma brucei trypanothione reductase 0.0046 0.0144 0.1181
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0226 0.0586
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0061 0.0208 0.051
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.002 0.0035 0.1439
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0061 0.0208 0.051
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0018 0.0021
Brugia malayi jmjC domain containing protein 0.0024 0.0052 0.0403
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0061 0.0208 0.051
Brugia malayi jmjC domain containing protein 0.015 0.0584 0.4879
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0069 0.0065
Leishmania major acetyl-CoA synthetase, putative 0.002 0.0035 0.0443
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.002 0.0035 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Plasmodium vivax vivapain-2 0.0016 0.0018 0.0021
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.1462
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.015 0.0584 0.0571
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0037 0.0028
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.0277
Echinococcus multilocularis importin subunit beta 1 0.0056 0.0188 0.0174
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0016 0.0564
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0069 0.0157
Plasmodium vivax JmjC domain containing protein 0.0024 0.0052 0.0112
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0016 0.0032
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0299 0.0285
Schistosoma mansoni hypothetical protein 0.0035 0.0097 0.0114
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0065 0.0226 0.1861
Schistosoma mansoni hypothetical protein 0.0015 0.0014 0.0016
Schistosoma mansoni ran 0.0021 0.0037 0.0044
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Brugia malayi glutathione reductase 0.0046 0.0144 0.1173
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0065 0.0226 0.0888
Entamoeba histolytica hypothetical protein 0.0035 0.0097 0.1219
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0064 0.0219 0.2828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0903 0.3777 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.0216
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0016 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0326 0.1289
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.005
Brugia malayi Thioredoxin reductase 0.0046 0.0144 0.1173
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0159 0.0379
Trypanosoma brucei protein kinase, putative 0.005 0.0159 0.1309
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0178 0.0702 0.081
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0069 0.0081
Toxoplasma gondii aldehyde dehydrogenase 0.0178 0.0702 0.1822
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.0208 0.1715
Brugia malayi jmjC domain containing protein 0.0096 0.0357 0.2963
Onchocerca volvulus 0.0084 0.0305 0.2529
Leishmania major pteridine reductase 1 0.0061 0.0208 0.2924
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0189 0.8598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0326 0.0383
Schistosoma mansoni phosphatidylserine receptor 0.0024 0.0052 0.0061
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0016 0.0103
Schistosoma mansoni microtubule-associated protein tau 0.2019 0.8502 1
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0061 0.0208 0.0245
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0098 0.4346
Onchocerca volvulus 0.002 0.0035 0.026
Trichomonas vaginalis antibiotic synthetase, putative 0.002 0.0035 0.0082
Leishmania major cathepsin L-like protease 0.0062 0.0212 0.2975
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0124
Echinococcus multilocularis lysine specific demethylase 6a 0.0024 0.0052 0.0038
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0018 0.0114
Onchocerca volvulus 0.0061 0.0208 0.1715
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0157 0.0372
Echinococcus multilocularis lysine specific demethylase 5A 0.0091 0.0336 0.0323
Schistosoma mansoni jumonji domain containing protein 0.0131 0.0503 0.0592
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0159 0.1309
Onchocerca volvulus 0.0091 0.0337 0.2795
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0243 0.0602
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0037 0.0279
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0061 0.0208 0.2924
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0018 0.0114
Leishmania major cathepsin L-like protease 0.0016 0.0018 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.002 0.0035 0.0407
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0014 0.0081
Brugia malayi CXXC zinc finger family protein 0.0084 0.0305 0.2529
Loa Loa (eye worm) AMP-binding enzyme family protein 0.002 0.0035 0.0124
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0061 0.0208 0.051
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0903 0.3777 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0159 0.0623 0.1614
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0061 0.0208 0.051
Echinococcus multilocularis dnaJ subfamily B 0.1196 0.5019 0.5012
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0393 0.1002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.002 0.0035 0.005
Trypanosoma brucei RNA helicase, putative 0.0292 0.1185 1
Onchocerca volvulus 0.002 0.0035 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0903 0.3777 1
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0035 0.005
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.0357 0.0404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Echinococcus multilocularis jumonji domain containing 1A 0.0024 0.0052 0.0038
Entamoeba histolytica acyl-coA synthetase, putative 0.0069 0.0243 0.3141
Echinococcus multilocularis microtubule associated protein 2 0.2019 0.8502 0.85
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Echinococcus multilocularis cysteine protease 0.0016 0.0018 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0098 0.0247
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0061 0.0208 0.0462
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0197 0.0773
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0116 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0157 0.0372
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0144 0.0355
Brugia malayi Importin beta-1 subunit 0.0056 0.0188 0.1542
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0154 0.1262
Echinococcus multilocularis expressed protein 0.0065 0.0226 0.0212
Trypanosoma brucei pteridine reductase 1 0.0061 0.0208 0.1727
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0014 0.0081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0097 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0035 0.005
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0033 0.0412
Echinococcus multilocularis Niemann Pick C1 protein 0.0192 0.0764 0.0751
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0014 0.0039
Loa Loa (eye worm) hypothetical protein 0.0083 0.0299 0.1181
Entamoeba histolytica acyl-CoA synthetase, putative 0.0069 0.0243 0.3141
Brugia malayi PHD-finger family protein 0.0014 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0154 0.0602
Loa Loa (eye worm) hypothetical protein 0.0069 0.0243 0.0957
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0393 0.1002
Echinococcus granulosus lysine specific demethylase 6a 0.0024 0.0052 0.0045
Echinococcus multilocularis peregrin 0.0028 0.0069 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Schistosoma mansoni hypothetical protein 0.008 0.0286 0.0336
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0069 0.0243 0.0555
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0018 0.0114
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0061 0.0208 0.051
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.002 0.0035 0.005
Echinococcus granulosus expressed conserved protein 0.0181 0.0714 0.0825
Loa Loa (eye worm) hypothetical protein 0.0052 0.0169 0.0659
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0061 0.0208 0.051
Loa Loa (eye worm) hypothetical protein 0.0052 0.0169 0.0659
Brugia malayi jmjC domain containing protein 0.0024 0.0052 0.0403
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0195 0.0776 0.0913
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.002 0.0035 0.1439
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0033 0.1338
Mycobacterium ulcerans oxidoreductase 0.0061 0.0208 0.051
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Brugia malayi Cathepsin L-like precursor 0.0016 0.0018 0.0114
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0024 0.0052 0.0095
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0018 0.0114
Loa Loa (eye worm) hypothetical protein 0.0101 0.0377 0.1496
Onchocerca volvulus 0.0016 0.0018 0.0114
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Entamoeba histolytica hypothetical protein 0.0035 0.0097 0.1219
Schistosoma mansoni hypothetical protein 0.0015 0.0014 0.0016
Echinococcus granulosus cpg binding protein 0.0089 0.0325 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0055
Mycobacterium tuberculosis Possible oxidoreductase 0.0061 0.0208 0.051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0564
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0035 0.005
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0243 0.2006
Schistosoma mansoni hypothetical protein 0.0165 0.0647 0.0761
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0052 0.0169 0.0404
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0098 0.0247
Echinococcus granulosus Niemann Pick C1 protein 0.0275 0.1113 0.1295
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0035 0.026
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0159 0.0145
Leishmania major GTP-binding protein, putative 0.0021 0.0037 0.0473
Schistosoma mansoni cpg binding protein 0.0089 0.0325 0.0382
Onchocerca volvulus 0.002 0.0035 0.026
Brugia malayi Bromodomain containing protein 0.0028 0.0069 0.0544
Loa Loa (eye worm) hypothetical protein 0.0069 0.0243 0.0957
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0039
Entamoeba histolytica cysteine protease, putative 0.0016 0.0018 0.0179
Loa Loa (eye worm) CXXC zinc finger family protein 0.0084 0.0305 0.1206
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.002 0.0035 0.0025
Plasmodium falciparum enoyl-acyl carrier reductase 0.0903 0.3777 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0061 0.0208 0.051
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0159 0.2216
Leishmania major cathepsin L-like protease 0.0062 0.0212 0.2975
Trichomonas vaginalis rotamase, putative 0.0064 0.0219 0.0569
Echinococcus granulosus geminin 0.0165 0.0647 0.0746
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0016 0.0564
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0018 0.0633
Brugia malayi MAP kinase sur-1 0.005 0.0159 0.13
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0903 0.3777 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.002 0.0035 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0326 0.0383
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0064 0.0219 0.1819
Loa Loa (eye worm) hypothetical protein 0.0061 0.0208 0.0818
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Leishmania major oxidoreductase-like protein 0.0061 0.0208 0.2924
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0037 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0154 0.0602
Schistosoma mansoni cpg binding protein 0.0089 0.0325 0.0382
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0124
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0067
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0443 0.1134
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.1229
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.0357 0.1413
Schistosoma mansoni jumonji domain containing protein 0.0024 0.0052 0.0061
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0018 0.0021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0169 0.0404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0035 0.005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0067
Onchocerca volvulus 0.0069 0.0243 0.2006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0564
Loa Loa (eye worm) ctsf protein 0.0016 0.0018 0.0055
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0097 0.0779
Onchocerca volvulus Alhambra homolog 0.0028 0.0069 0.0544
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0247
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0024 0.0052 0.0406
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0037 0.1534
Schistosoma mansoni ran 0.0021 0.0037 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0326 0.0367
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0142 0.0366
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0174
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.0208 0.051
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0326 0.2702
Plasmodium vivax acyl-CoA synthetase, putative 0.0052 0.0169 0.0421
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0443 0.1089
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0178 0.0702 0.1822
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0059 0.022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0169 0.0659
Schistosoma mansoni cpg binding protein 0.0084 0.0305 0.0359
Leishmania major cathepsin L-like protease 0.0016 0.0018 0.0195
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0037 0.0055
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0299 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0393 0.1002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.0208 0.1715
Loa Loa (eye worm) fibroinase 0.0016 0.0018 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0212 0.1757
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0178 0.0702 0.0689
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Brugia malayi jmjC domain containing protein 0.0024 0.0052 0.0403
Leishmania major cathepsin L-like protease 0.0062 0.0212 0.2975
Schistosoma mansoni hypothetical protein 0.0601 0.2496 0.2936
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0017
Toxoplasma gondii peptidylprolyl isomerase 0.0064 0.0219 0.0539
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.005
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0061 0.0208 0.051
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0903 0.3777 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0016 0.0102
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0601 0.2496 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.002 0.0035 0.0021
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0098 0.0247
Onchocerca volvulus 0.0016 0.0018 0.0114
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0073 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.0188 0.0455
Echinococcus granulosus cathepsin l1 0.0016 0.0018 0.0005
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0052 0.0169 0.0404
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0142 0.0366
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0247
Schistosoma mansoni hypothetical protein 0.0015 0.0014 0.0016
Echinococcus multilocularis cpg binding protein 0.0089 0.0325 0.0312
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0188 0.1552
Schistosoma mansoni phd/f-box containing protein 0.0024 0.0052 0.0061
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0098 0.1338
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0061 0.0208 0.051
Plasmodium vivax glutathione reductase, putative 0.0046 0.0144 0.0355
Mycobacterium ulcerans aldehyde dehydrogenase 0.0178 0.0702 0.1822
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.002 0.0035 0.005
Brugia malayi PHD-finger family protein 0.0028 0.0069 0.0544
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0098 0.0374
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0243 0.2006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Echinococcus multilocularis JmjC domain containing protein 4 0.0024 0.0052 0.0038
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0247
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0144 0.013
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.002 0.0035 0.1439
Brugia malayi Cathepsin L-like precursor 0.0016 0.0018 0.0114
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.002 0.0035 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0178 0.0702 0.1822
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0061 0.0208 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0061 0.0208 0.9496
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.002 0.0035 0.005
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0061 0.0208 0.9496
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0052 0.0192
Schistosoma mansoni alpha-glucosidase 0.0136 0.0526 0.0618
Onchocerca volvulus 0.0016 0.0018 0.0114
Schistosoma mansoni dihydropteridine reductase 0.0061 0.0208 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0067
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0064 0.0219 0.308
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0069 0.0243 0.0555
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0061 0.0208 0.051
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.002 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0341
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0142 0.0366
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0326 0.0312
Echinococcus multilocularis cysteine protease 0.0016 0.0018 0.0004
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0393 0.1002
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0098 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0067
Mycobacterium tuberculosis Probable reductase 0.0105 0.0393 0.1002
Loa Loa (eye worm) glutathione reductase 0.0046 0.0144 0.0559
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0037 0.0023
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0018 0.0021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0069 0.0243 0.3141
Onchocerca volvulus 0.0294 0.1193 1
Chlamydia trachomatis oxoacy-ACP reductase 0.0061 0.0208 0.051
Echinococcus granulosus JmjC domain containing protein 4 0.0024 0.0052 0.0045
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0018 0.0004
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0061 0.0208 0.0462
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0024 0.0052 0.0061
Leishmania major importin beta-1 subunit, putative 0.0046 0.0142 0.1981
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0018 0.0021
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0016 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Leishmania major hypothetical protein, conserved 0.0024 0.0052 0.0687
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0098 0.0785
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0069 0.0055
Echinococcus multilocularis snurportin 1 0.0601 0.2496 0.2486
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0357 0.0419
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0247
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0443 0.1134
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0059 0.0045
Schistosoma mansoni hypothetical protein 0.0165 0.0647 0.0761
Plasmodium falciparum glutathione reductase 0.0016 0.0016 0.0017
Echinococcus granulosus microtubule associated protein 2 0.2019 0.8502 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.002 0.0033 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0326 0.0367
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0061 0.0208 0.051
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0016 0.0003
Onchocerca volvulus 0.0016 0.0018 0.0114
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0024 0.0052 0.223
Brugia malayi Cathepsin L-like precursor 0.0016 0.0018 0.0114
Giardia lamblia PHD finger protein 15 0.0028 0.0069 0.3694
Brugia malayi AMP-binding enzyme family protein 0.002 0.0035 0.026
Brugia malayi AMP-binding enzyme family protein 0.002 0.0035 0.026
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0037 0.0073
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0061 0.0208 0.051
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0619 0.0606
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0357 0.0419
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0159 0.2216
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0067
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0023 0.0018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0069 0.0243 0.0602
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0243 0.2006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0326 0.0312
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0037 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Echinococcus multilocularis protein patched 0.0083 0.0299 0.0285
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.0208 0.051
Brugia malayi Cathepsin L-like precursor 0.0016 0.0018 0.0114
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0243 0.342
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0061 0.0208 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0018 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0157 0.0372
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.002 0.0035 0.005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0159 0.7197
Brugia malayi AMP-binding enzyme family protein 0.002 0.0035 0.026
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0208 0.051
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0037 0.0023
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0018 0.0021
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0903 0.3777 1
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0069 0.026
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0393 0.0957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0192

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 122.5 uM Cytotoxicity against human MT4 cells by MTT assay ChEMBL. 21185110
IC50 (binding) = 18.5 uM Inhibition of recombinant HIV-1 reverse transcriptase RNase H domain after 10 mins ChEMBL. 21185110
IC50 (binding) = 35.5 uM Inhibition of HIV-1 integrase after 1 hr by immunosorbent assay ChEMBL. 21185110

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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