|Plasmodium falciparum||bifunctional dihydrofolate reductase-thymidylate synthase||0.0157||0.3083||0.5|
|Trypanosoma cruzi||dihydrofolate reductase-thymidylate synthase||0.0157||0.3083||0|
|Toxoplasma gondii||bifunctional dihydrofolate reductase-thymidylate synthase||0.0157||0.3083||0.5|
|Leishmania major||dihydrofolate reductase-thymidylate synthase||0.0157||0.3083||0|
|Trypanosoma brucei||dihydrofolate reductase-thymidylate synthase||0.0157||0.3083||0|
|Plasmodium vivax||bifunctional dihydrofolate reductase-thymidylate synthase, putative||0.0157||0.3083||0.5|
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.