Detailed information for compound 1508863

Basic information

Technical information
  • TDR Targets ID: 1508863
  • Name: 2-[(2-chlorophenyl)methylsulfanyl]-5-[(2S)-py rrolidin-2-yl]-1,3,4-oxadiazole
  • MW: 295.788 | Formula: C13H14ClN3OS
  • H donors: 1 H acceptors: 2 LogP: 2.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1CSc1nnc(o1)[C@@H]1CCCN1
  • InChi: 1S/C13H14ClN3OS/c14-10-5-2-1-4-9(10)8-19-13-17-16-12(18-13)11-6-3-7-15-11/h1-2,4-5,11,15H,3,6-8H2/t11-/m0/s1
  • InChiKey: OHZPWJQFNQRAMR-NSHDSACASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(2-chlorophenyl)methylthio]-5-[(2S)-2-pyrrolidinyl]-1,3,4-oxadiazole
  • 2-[(2-chlorobenzyl)thio]-5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide receptor 0.0061 0.1136 0.1136
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0631 0.0533
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0631 0.0533
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0163 0.342 0.4439
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus multilocularis neuropeptide FF receptor 2 0.0061 0.1136 0.1136
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0061 0.1136 0.2016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.096 0.096
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0015 0.0104 0.0104
Brugia malayi Muscleblind-like protein 0.0167 0.3511 0.6543
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni amine GPCR 0.0061 0.1136 0.1043
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0061 0.1136 0.1136
Onchocerca volvulus 0.0061 0.1136 0.1915
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0167 0.3511 0.4556
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.017 0.017
Brugia malayi Pip kinase protein 1 0.0015 0.0104 0.0048
Schistosoma mansoni hypothetical protein 0.0061 0.1136 0.1043
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0061 0.1136 0.1043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni histamine h1 receptor 0.0061 0.1136 0.1043
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.1115 0.1447
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0038 0.0631 0.0819
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0163 0.342 0.6353
Echinococcus granulosus allatostatin A receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0187 0.016
Echinococcus granulosus neuroligin 0.0038 0.0631 0.0631
Echinococcus granulosus neuropeptide FF receptor 2 0.0061 0.1136 0.1136
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0187 0.0252
Onchocerca volvulus 0.0061 0.1136 0.1915
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0061 0.1136 0.1474
Brugia malayi neuropeptide F receptor 0.0061 0.1136 0.2016
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0061 0.1136 0.1136
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.2474 0.8837
Brugia malayi sulfakinin receptor protein 0.0061 0.1136 0.2016
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.1289 0.1289
Schistosoma mansoni neuropeptide receptor 0.0061 0.1136 0.1043
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0187 0.016
Brugia malayi G-protein coupled receptor 0.0061 0.1136 0.2016
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0061 0.1136 0.1043
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0227 0.4828 0.4773
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0061 0.1136 0.1043
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.1136 0.1136
Schistosoma mansoni neuroligin 3 (S09 family) 0.0038 0.0631 0.0533
Echinococcus multilocularis muscleblind protein 0.0167 0.3511 0.3511
Echinococcus granulosus neuropeptide receptor A26 0.0061 0.1136 0.1136
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.1136 0.1474
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1138 0.198
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.2774 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Entamoeba histolytica protein kinase domain containing protein 0.0163 0.342 1
Plasmodium falciparum glutathione reductase 0.0053 0.096 0.1639
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0211 0.0211
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.1136 0.1043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.1136 0.1043
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0038 0.0631 0.0533
Onchocerca volvulus 0.0061 0.1136 0.1915
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0187 0.0252
Leishmania major hypothetical protein, conserved 0.0249 0.5325 1
Loa Loa (eye worm) hypothetical protein 0.0227 0.4828 0.6265
Brugia malayi Carboxylesterase family protein 0.0227 0.4828 0.9053
Loa Loa (eye worm) hypothetical protein 0.0167 0.3511 0.4556
Echinococcus granulosus hypothetical protein 0.0061 0.1136 0.1136
Echinococcus multilocularis G protein coupled receptor 139 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.017 0.017
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Onchocerca volvulus 0.0061 0.1136 0.1915
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Plasmodium falciparum glycogen synthase kinase 3 0.0163 0.342 0.6353
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.017 0.022
Echinococcus multilocularis neuropeptide receptor 0.0061 0.1136 0.1136
Schistosoma mansoni amine GPCR 0.0061 0.1136 0.1043
Schistosoma mansoni hypothetical protein 0.0061 0.1136 0.1043
Schistosoma mansoni neuropeptide f receptor 76f 0.0061 0.1136 0.1043
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.1136 0.1043
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0182 0.384 0.384
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0061 0.1136 0.1043
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0061 0.1136 0.1136
Echinococcus multilocularis g-protein coupled receptor 0.0061 0.1136 0.1136
Onchocerca volvulus 0.0061 0.1136 0.1915
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.1136 0.1043
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.1136 0.1136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Schistosoma mansoni hypothetical protein 0.019 0.4013 0.395
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0187 0.016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1308 1
Schistosoma mansoni biogenic amine receptor 0.0061 0.1136 0.1043
Onchocerca volvulus 0.0038 0.0631 0.0405
Brugia malayi ORL1-like opioid receptor 0.0061 0.1136 0.2016
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Entamoeba histolytica protein kinase domain containing protein 0.0163 0.342 1
Onchocerca volvulus 0.0061 0.1136 0.1915
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0061 0.1136 0.2016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0187 0.016
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0112 0.2266 0.2266
Brugia malayi Melatonin receptor type 1A 0.0061 0.1136 0.2016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0187 0.016
Giardia lamblia Kinase, CMGC GSK 0.0163 0.342 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0163 0.342 0.6353
Echinococcus multilocularis allatostatin A receptor 0.0061 0.1136 0.1136
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0187 0.5
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0187 0.0187
Onchocerca volvulus 0.0061 0.1136 0.1915
Schistosoma mansoni opsin-like receptor 0.0061 0.1136 0.1043
Onchocerca volvulus 0.0061 0.1136 0.1915
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0038 0.0631 0.0819
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0061 0.1136 0.1043
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0187 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1308 1
Brugia malayi Thioredoxin reductase 0.0053 0.096 0.1679
Onchocerca volvulus 0.0061 0.1136 0.1915
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.017 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Echinococcus granulosus 7tm_1 domain containing protein 0.0061 0.1136 0.1136
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.017 0.0126
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.017 0.0126
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.13 0.1209
Trypanosoma cruzi PAB1-binding protein , putative 0.0249 0.5325 1
Echinococcus granulosus g-protein coupled receptor 0.0061 0.1136 0.1136
Echinococcus granulosus G protein coupled receptor 139 0.0061 0.1136 0.1136
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Echinococcus granulosus g protein coupled receptor 0.0061 0.1136 0.1136
Echinococcus granulosus g protein coupled receptor 0.0061 0.1136 0.1136
Onchocerca volvulus 0.0061 0.1136 0.1915
Brugia malayi larval opioid receptor 0.0061 0.1136 0.2016
Brugia malayi follicle stimulating hormone receptor 0.0061 0.1136 0.2016
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0061 0.1136 0.1136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0187 0.016
Brugia malayi CXXC zinc finger family protein 0.0032 0.0496 0.0795
Brugia malayi G protein-coupled receptor 0.0061 0.1136 0.2016
Schistosoma mansoni biogenic amine receptor 0.0061 0.1136 0.1043
Echinococcus multilocularis neuropeptide receptor A26 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0631 0.0819
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.1248 0.1248
Mycobacterium tuberculosis Probable reductase 0.0121 0.2474 0.8837
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.2774 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0163 0.342 0.4439
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.096 0.096
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.096 0.2985
Brugia malayi hypothetical protein 0.0249 0.5325 1
Echinococcus granulosus protein kinase shaggy 0.0163 0.342 0.342
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0038 0.0631 0.1715
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Schistosoma mansoni neuropeptide receptor 0.0061 0.1136 0.1043
Loa Loa (eye worm) acetylcholinesterase 1 0.0227 0.4828 0.6265
Echinococcus multilocularis neuropeptide s receptor 0.0061 0.1136 0.1136
Schistosoma mansoni cpg binding protein 0.0032 0.0496 0.0396
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0187 0.016
Loa Loa (eye worm) hypothetical protein 0.0227 0.4828 0.6265
Loa Loa (eye worm) hypothetical protein 0.0018 0.017 0.022
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Brugia malayi Dopamine receptor protein 1 0.0061 0.1136 0.2016
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0631 0.0819
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.1136 0.1043
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.017 0.0067
Echinococcus multilocularis muscleblind protein 1 0.0167 0.3511 0.3511
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.2774 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Echinococcus multilocularis BC026374 protein (S09 family) 0.0038 0.0631 0.0631
Echinococcus granulosus acetylcholinesterase 0.0227 0.4828 0.4828
Loa Loa (eye worm) FYVE zinc finger family protein 0.0015 0.0104 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Brugia malayi Carboxylesterase family protein 0.0038 0.0631 0.1053
Loa Loa (eye worm) TYRA-2 protein 0.0061 0.1136 0.1474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Schistosoma mansoni hypothetical protein 0.0061 0.1136 0.1043
Loa Loa (eye worm) carboxylesterase 0.0038 0.0631 0.0819
Schistosoma mansoni biogenic amine receptor 0.0061 0.1136 0.1043
Echinococcus granulosus alpha 1A adrenergic receptor 0.0061 0.1136 0.1136
Echinococcus multilocularis neuropeptide receptor 0.0061 0.1136 0.1136
Echinococcus granulosus 7TM GPCR rhodopsin 0.0061 0.1136 0.1136
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0038 0.0631 0.0631
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0163 0.342 0.3351
Onchocerca volvulus 0.0038 0.0631 0.0405
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0038 0.0631 0.1715
Brugia malayi hypothetical protein 0.0136 0.282 0.5226
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0187 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0061 0.1136 0.1136
Echinococcus multilocularis fmrfamide receptor 0.0061 0.1136 0.1136
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Schistosoma mansoni adenoreceptor 0.0061 0.1136 0.1043
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0112 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Plasmodium vivax glutathione reductase, putative 0.0053 0.096 0.1639
Brugia malayi Carboxylesterase family protein 0.0227 0.4828 0.9053
Plasmodium falciparum glutathione reductase 0.0018 0.0187 0.016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0187 0.016
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0187 0.016
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.096 0.1639
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0187 0.016
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0038 0.0631 0.0631
Loa Loa (eye worm) glutathione reductase 0.0053 0.096 0.1245
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.1289 0.1672
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Plasmodium falciparum ataxin-2 like protein, putative 0.0249 0.5325 1
Echinococcus multilocularis protein kinase shaggy 0.0163 0.342 0.342
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.1136 0.1136
Brugia malayi jmjC domain containing protein 0.0018 0.017 0.0174
Brugia malayi GnHR receptor homolog 0.0061 0.1136 0.2016
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.1136 0.1043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0187 0.016
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0061 0.1136 0.2016
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus multilocularis serotonin receptor 0.0061 0.1136 0.1136
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0187 0.016
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Echinococcus granulosus neuropeptide receptor 0.0061 0.1136 0.1136
Echinococcus multilocularis carboxylesterase 5A 0.0227 0.4828 0.4828
Schistosoma mansoni neuropeptide receptor 0.0061 0.1136 0.1043
Echinococcus granulosus tachykinin peptides receptor 99D 0.0061 0.1136 0.1136
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.1136 0.1474
Echinococcus granulosus sex peptide receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) melatonin receptor type 1A 0.0061 0.1136 0.1474
Schistosoma mansoni myosin xvIII 0.0061 0.1136 0.1043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0356 0.7706 1
Brugia malayi glutathione reductase 0.0053 0.096 0.1679
Schistosoma mansoni gliotactin 0.0038 0.0631 0.0533
Loa Loa (eye worm) hypothetical protein 0.0038 0.0631 0.0819
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0187 0.0252
Mycobacterium ulcerans carboxylesterase, LipT 0.0038 0.0631 0.396
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.017 0.0126
Brugia malayi Tachykinin-like peptides receptor 99D 0.0061 0.1136 0.2016
Echinococcus multilocularis acetylcholinesterase 0.0227 0.4828 0.4828
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0015 0.0104 0.0048
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.1136 0.1136
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0182 0.384 0.3775
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0187 0.016
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0187 0.0207
Brugia malayi Serotonin receptor 0.0061 0.1136 0.2016
Echinococcus granulosus orexin receptor type 2 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Treponema pallidum NADH oxidase 0.0018 0.0187 0.5
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.017 0.017
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0061 0.1136 0.1136
Schistosoma mansoni growth hormone secretagogue receptor 0.0061 0.1136 0.1043
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Brugia malayi neuropeptide F receptor 0.0061 0.1136 0.2016
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.017 0.017
Brugia malayi Dopamine receptor 0.0061 0.1136 0.2016
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0163 0.342 0.6353
Trypanosoma brucei trypanothione reductase 0.0053 0.096 0.1639
Echinococcus multilocularis para nitrobenzyl esterase 0.0038 0.0631 0.0631
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.2474 0.8837
Echinococcus granulosus somatostatin receptor 0.0061 0.1136 0.1136
Schistosoma mansoni jumonji domain containing protein 0.0018 0.017 0.0067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0018 0.017 0.022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0187 0.016
Onchocerca volvulus 0.0038 0.0631 0.0405
Schistosoma mansoni amine GPCR 0.0061 0.1136 0.1043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.1136 0.1136
Echinococcus granulosus geminin 0.019 0.4013 0.4013
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0061 0.1136 0.2016
Onchocerca volvulus 0.0061 0.1136 0.1915
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Loa Loa (eye worm) hypothetical protein 0.0182 0.384 0.4983
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.017 0.0126
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Brugia malayi AKH receptor 0.0061 0.1136 0.2016
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0061 0.1136 0.1136
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.1136 0.1136
Echinococcus multilocularis fmrfamide receptor 0.0061 0.1136 0.1136
Brugia malayi Carboxylesterase family protein 0.0038 0.0631 0.1053
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.017 0.022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.1136 0.1136
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.2774 1
Echinococcus multilocularis g protein coupled receptor 0.0061 0.1136 0.1136
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.017 0.0067
Leishmania major trypanothione reductase 0.0053 0.096 0.1639
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.1136 0.1136
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.017 0.022
Echinococcus multilocularis orexin receptor type 2 0.0061 0.1136 0.1136
Trypanosoma brucei PAB1-binding protein , putative 0.0249 0.5325 1
Onchocerca volvulus 0.0061 0.1136 0.1915
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0187 0.016
Brugia malayi Carboxylesterase family protein 0.0038 0.0631 0.1053
Schistosoma mansoni jumonji domain containing protein 0.0066 0.1248 0.1156
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0187 0.016
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.1136 0.1136
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.1308 0.1308
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0061 0.1136 0.2016
Schistosoma mansoni amine GPCR 0.0061 0.1136 0.1043
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0182 0.384 0.3775
Brugia malayi Pip kinase protein 2 0.0182 0.384 0.717
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni cpg binding protein 0.0034 0.0537 0.0437
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Brugia malayi G-protein coupled receptor 0.0061 0.1136 0.2016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Onchocerca volvulus 0.0182 0.384 1
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0061 0.1136 0.1136
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.1308 0.1308
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0061 0.1136 0.1043
Trypanosoma brucei protein kinase, putative 0.0163 0.342 0.6353
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.1308 0.1217
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.017 0.0126
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0187 0.016
Brugia malayi putative neuropeptide receptor NPR1 0.0061 0.1136 0.2016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0187 0.016
Brugia malayi jmjC domain containing protein 0.0066 0.1248 0.2228
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.1289 0.1197
Onchocerca volvulus 0.0061 0.1136 0.1915
Schistosoma mansoni amine GPCR 0.0061 0.1136 0.1043
Plasmodium vivax JmjC domain containing protein 0.0018 0.017 0.0126
Echinococcus granulosus biogenic amine 5HT receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0061 0.1136 0.1043
Echinococcus multilocularis sex peptide receptor 0.0061 0.1136 0.1136
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.2474 0.8837
Echinococcus multilocularis g protein coupled receptor 0.0061 0.1136 0.1136
Schistosoma mansoni hypothetical protein 0.019 0.4013 0.395
Plasmodium falciparum ataxin-2 like protein, putative 0.0249 0.5325 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0187 0.016
Loa Loa (eye worm) pip kinase 1 0.0015 0.0104 0.0135
Echinococcus granulosus carboxylesterase 5A 0.0227 0.4828 0.4828
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0061 0.1136 0.1474
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0211 0.0211
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0187 0.0084
Loa Loa (eye worm) hypothetical protein 0.0038 0.0631 0.0819
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.2474 0.8837
Plasmodium vivax ataxin-2 like protein, putative 0.0249 0.5325 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus multilocularis G-protein coupled receptor, putative 0.0061 0.1136 0.1136
Schistosoma mansoni opsin-like receptor 0.0061 0.1136 0.1043
Trichomonas vaginalis CMGC family protein kinase 0.0163 0.342 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0061 0.1136 0.1136
Echinococcus granulosus acetylcholinesterase 0.0227 0.4828 0.4828
Echinococcus granulosus fmrfamide receptor 0.0061 0.1136 0.1136
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0061 0.1136 0.1136
Brugia malayi Dopamine receptor protein 2 0.0061 0.1136 0.2016
Echinococcus granulosus para nitrobenzyl esterase 0.0038 0.0631 0.0631
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0015 0.0104 0.0104
Echinococcus multilocularis lysine specific demethylase 5A 0.0066 0.1248 0.1248
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Loa Loa (eye worm) pip kinase 2 0.0182 0.384 0.4983
Onchocerca volvulus 0.0038 0.0631 0.0405
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.1136 0.1474
Echinococcus granulosus muscleblind protein 0.0167 0.3511 0.3511
Schistosoma mansoni opsin-like receptor 0.0061 0.1136 0.1043
Onchocerca volvulus Neuropeptide F receptor homolog 0.0061 0.1136 0.1915
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.096 0.1245
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Plasmodium falciparum thioredoxin reductase 0.0018 0.0187 0.016
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.017 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Schistosoma mansoni cpg binding protein 0.0034 0.0537 0.0437
Echinococcus granulosus neuropeptide s receptor 0.0061 0.1136 0.1136
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.1308 0.2344
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0015 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Trichomonas vaginalis spcc417.12 protein, putative 0.0038 0.0631 0.159
Schistosoma mansoni hypothetical protein 0.0112 0.2266 0.2184
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0015 0.0104 0.0135
Echinococcus multilocularis serotonin receptor 0.0061 0.1136 0.1136
Echinococcus granulosus serotonin receptor 0.0061 0.1136 0.1136
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0163 0.342 0.342
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0187 0.016
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0187 0.016
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0061 0.1136 0.1136
Brugia malayi Carboxylesterase family protein 0.0038 0.0631 0.1053
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Echinococcus multilocularis somatostatin receptor 0.0061 0.1136 0.1136
Brugia malayi jmjC domain containing protein 0.0018 0.017 0.0174
Schistosoma mansoni alpha-1 adrenergic receptor 0.0061 0.1136 0.1043
Brugia malayi Serotonin receptor 0.0061 0.1136 0.2016
Echinococcus granulosus BC026374 protein S09 family 0.0038 0.0631 0.0631
Brugia malayi jmjC domain containing protein 0.0018 0.017 0.0174
Brugia malayi intracellular kinase 0.0163 0.342 0.637
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.1136 0.1136
Echinococcus granulosus g protein coupled receptor 0.0061 0.1136 0.1136
Plasmodium falciparum thioredoxin reductase 0.0053 0.096 0.1639
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0061 0.1136 0.1474
Loa Loa (eye worm) carboxylesterase 0.0038 0.0631 0.0819
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0182 0.384 0.384
Leishmania major hypothetical protein, conserved 0.0018 0.017 0.0126
Brugia malayi putative neuropeptide receptor 0.0061 0.1136 0.2016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.1248 0.1248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.1136 0.1043
Entamoeba histolytica protein kinase, putative 0.0163 0.342 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0038 0.0631 0.1715
Brugia malayi hypothetical protein 0.0161 0.3359 0.6253
Brugia malayi RE15519p 0.0061 0.1136 0.2016
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.1308 0.4332
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0249 0.5325 0.6909
Onchocerca volvulus 0.0061 0.1136 0.1915
Brugia malayi G protein-coupled receptor F59B2.13 0.0061 0.1136 0.2016
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0038 0.0631 0.159
Brugia malayi jmjC domain containing protein 0.0068 0.1289 0.2306
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0496 0.0643
Echinococcus multilocularis cpg binding protein 0.0034 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0038 0.0631 0.0819
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.1136 0.1136
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0015 0.0104 0.0104
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.1308 0.2307
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.1136 0.1043
Echinococcus multilocularis g protein coupled receptor 0.0061 0.1136 0.1136
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.2474 0.8837
Toxoplasma gondii LsmAD domain-containing protein 0.0249 0.5325 1
Onchocerca volvulus 0.0163 0.342 0.8745
Echinococcus multilocularis neuroligin 0.0038 0.0631 0.0631
Onchocerca volvulus 0.0061 0.1136 0.1915
Echinococcus granulosus cpg binding protein 0.0034 0.0537 0.0537
Echinococcus multilocularis geminin 0.019 0.4013 0.4013
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Echinococcus granulosus peptide allatostatin:somatostatin 0.0061 0.1136 0.1136
Schistosoma mansoni biogenic amine (5HT) receptor 0.0061 0.1136 0.1043
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.1136 0.1136
Schistosoma mansoni neuropeptide receptor 0.0061 0.1136 0.1043
Schistosoma mansoni hypothetical protein 0.0061 0.1136 0.1043
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0163 0.342 0.342
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus multilocularis phd:f box containing protein 0.0018 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Trichomonas vaginalis CMGC family protein kinase 0.0163 0.342 1
Toxoplasma gondii thioredoxin reductase 0.0053 0.096 0.1639
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0061 0.1136 0.1915
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0061 0.1136 0.1136
Echinococcus multilocularis acetylcholinesterase 0.0227 0.4828 0.4828
Brugia malayi jmjC domain containing protein 0.0018 0.017 0.0174
Echinococcus granulosus biogenic amine 5HT receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Schistosoma mansoni phd/f-box containing protein 0.0018 0.017 0.0067
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.096 0.1639
Onchocerca volvulus 0.0061 0.1136 0.1915
Onchocerca volvulus 0.0038 0.0631 0.0405
Brugia malayi hypothetical protein 0.0038 0.0631 0.1053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.1289 0.1197
Echinococcus granulosus phd:f box containing protein 0.0018 0.017 0.017
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0061 0.1136 0.1043
Schistosoma mansoni acetylcholinesterase 0.0038 0.0631 0.0533
Loa Loa (eye worm) hypothetical protein 0.0061 0.1136 0.1474
Echinococcus multilocularis dro:myosuppressin receptor 0.0061 0.1136 0.1136
Loa Loa (eye worm) carboxylesterase 0.0227 0.4828 0.6265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0187 0.016
Loa Loa (eye worm) hypothetical protein 0.0018 0.017 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0249 0.5325 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0038 0.0631 0.0533
Schistosoma mansoni biogenic amine (5HT) receptor 0.0061 0.1136 0.1043
Schistosoma mansoni protein phosphatase 2C 0.0018 0.017 0.0067
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0163 0.342 0.6353
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0187 0.016
Giardia lamblia Kinase, CMGC GSK 0.0163 0.342 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0061 0.1136 0.1474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.1136 0.1136
Brugia malayi hypothetical protein 0.0061 0.1136 0.2016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.1136 0.1136
Onchocerca volvulus 0.0061 0.1136 0.1915

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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