Detailed information for compound 150896

Basic information

Technical information
  • TDR Targets ID: 150896
  • Name: 1-(6-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-pi peridin-1-ylpropan-1-ol
  • MW: 311.461 | Formula: C21H29NO
  • H donors: 1 H acceptors: 1 LogP: 3.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1
  • InChi: 1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2
  • InChiKey: YSXKPIUOCJLQIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • Beperiden
  • Biperiden
  • Biperiden Hydrochloride
  • Biperiden [Usan:Ban:Inn:Jan]
  • Biperidene Hydrochloride
  • Biperidene [Inn-French]
  • Biperideno [Inn-Spanish]
  • Biperidenum [Inn-Latin]
  • Biperidine
  • Biperidine Hydrochloride
  • 1-(6-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol
  • 1-(6-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)-1-propanol
  • 1-(6-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-yl-propan-1-ol
  • 1-(6-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidino-propan-1-ol
  • 514-65-8
  • Akineton
  • BRN 0290038
  • EINECS 208-184-6
  • KL 373
  • alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol
  • alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol
  • Prestwick0_000502
  • SPBio_002344
  • Prestwick1_000502
  • PDSP2_000808
  • NCIOpen2_009564
  • C07941
  • PDSP1_000821
  • Prestwick2_000502
  • 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl-
  • Akineton (TN)
  • Biperiden (JAN/USP/INN)
  • D00779
  • 1-(Bicyclo(2.2.1)hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol
  • 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1
  • 1-PIPERIDINEPROPANOL, alpha-5-NORBORNEN-2-YL-alpha-PHENYL-
  • 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-
  • 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) [German]
  • 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol
  • 5-20-02-00242 (Beilstein Handbook Reference)
  • 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type I, alpha subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase 0.0231 0.0811 0.1891
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Brugia malayi NADH-dependent xylose reductase 0.0067 0.0176 0.0171
Loa Loa (eye worm) hypothetical protein 0.0383 0.1403 0.1403
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.004 0.0074 0.0151
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0163 0.0362
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0163 0.0362
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0478 0.1856
Schistosoma mansoni lamin 0.0033 0.0043 0.0079
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0029 0.0024
Onchocerca volvulus 0.0029 0.0029 0.0004
Echinococcus granulosus g protein coupled receptor 0.0029 0.0029 0.0044
Toxoplasma gondii phospholipase/carboxylesterase 0.004 0.0074 0.0453
Schistosoma mansoni amine GPCR 0.0029 0.0029 0.0044
Echinococcus granulosus serotonin receptor 0.0029 0.0029 0.0044
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0134 0.0438 0.1606
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Schistosoma mansoni sodium/chloride dependent transporter 0.006 0.015 0.0333
Mycobacterium ulcerans hypothetical protein 0.0029 0.0028 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0231 0.0811 0.0811
Loa Loa (eye worm) amidase 0.0134 0.0438 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Brugia malayi hypothetical protein 0.0197 0.0681 0.0677
Schistosoma mansoni hypothetical protein 0.0049 0.0108 0.0232
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0086 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0028 0.0109
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0029 0.0044
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0029 0.0044
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0028 0.0109
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0028 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Brugia malayi Flap endonuclease-1 0.0031 0.0039 0.0034
Leishmania major aldo-keto reductase-like protein 0.0231 0.0811 0.0807
Loa Loa (eye worm) hypothetical protein 0.0529 0.1967 0.1967
Onchocerca volvulus 0.0029 0.0029 0.0004
Leishmania major C-8 sterol isomerase-like protein 0.26 1 1
Brugia malayi Serotonin receptor 0.0029 0.0029 0.0024
Onchocerca volvulus 0.0043 0.0086 0.0455
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0091 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0355 0.1292 0.1292
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0231 0.0811 0.304
Trypanosoma cruzi C-8 sterol isomerase, putative 0.26 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0478 0.1856
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0231 0.0811 0.0807
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.0074 0.0069
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0091 0.0271 0.0617
Brugia malayi neuropeptide F receptor 0.0029 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni aldo-keto reductase 0.0231 0.0811 0.1897
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.006 0.015 0.015
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0029 0.0044
Trichomonas vaginalis aldo/keto reductase, putative 0.0231 0.0811 0.304
Echinococcus granulosus aldo keto reductase 0.0231 0.0811 0.1891
Echinococcus granulosus uncharacterized sodium dependent transporter 0.006 0.015 0.0332
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.004 0.0074 0.0069
Brugia malayi G-protein coupled receptor 0.0029 0.0029 0.0024
Onchocerca volvulus 0.0067 0.0176 0.117
Schistosoma mansoni biogenic amine receptor 0.0029 0.0029 0.0044
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0686 0.2579 1
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.006 0.015 0.015
Plasmodium vivax hypothetical protein, conserved 0.004 0.0074 0.0287
Chlamydia trachomatis acyltransferase family protein 0.004 0.0074 0.1689
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Toxoplasma gondii protein c14orf29, putative 0.004 0.0074 0.0453
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0029 0.0044
Echinococcus granulosus abhydrolase domain containing 3 0.004 0.0074 0.0151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.052 0.052
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Echinococcus granulosus aldo keto reductase 0.0231 0.0811 0.1891
Echinococcus granulosus allatostatin A receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0197 0.0681 0.0681
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0029 0.0044
Mycobacterium ulcerans amidase 0.0134 0.0438 0.1697
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Echinococcus granulosus fatty acid amide hydrolase 1 0.1113 0.4233 0.9966
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0029 0.0044
Schistosoma mansoni sodium/chloride dependent transporter 0.006 0.015 0.0333
Trypanosoma brucei aldo/keto reductase, putative 0.0067 0.0176 0.0171
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.006 0.015 0.0333
Schistosoma mansoni peptidase 0.004 0.0074 0.0152
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0074
Brugia malayi hypothetical protein 0.0147 0.0487 0.0482
Brugia malayi hypoxia-induced factor 1 0.0182 0.0622 0.0617
Brugia malayi hypothetical protein 0.0034 0.0051 0.0046
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.006 0.015 0.0332
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0029 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0163 0.0633
Plasmodium falciparum lysophospholipase, putative 0.0686 0.2579 1
Plasmodium vivax PST-A protein 0.004 0.0074 0.0287
Plasmodium vivax hypothetical protein, conserved 0.004 0.0074 0.0287
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0028 0.0023
Brugia malayi ORL1-like opioid receptor 0.0029 0.0029 0.0024
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0231 0.0811 0.304
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0029 0.0024
Trypanosoma brucei prostaglandin f synthase 0.0231 0.0811 0.0807
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.006 0.015 0.0333
Mycobacterium tuberculosis Conserved protein 0.0067 0.0176 0.0683
Echinococcus granulosus orexin receptor type 2 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0029 0.0024
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0029 0.0029
Echinococcus granulosus microtubule associated protein 2 0.0698 0.2623 0.6167
Trypanosoma cruzi Emopamil binding protein, putative 0.027 0.0965 0.0961
Brugia malayi Amidase family protein 0.0134 0.0438 0.0433
Toxoplasma gondii phospholipase 0.004 0.0074 0.0453
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0044
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0039 0.0034
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.027 0.0965 0.0961
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0287 0.0282
Plasmodium vivax unspecified product 0.004 0.0074 0.0287
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0029 0.0044
Plasmodium vivax PST-A protein 0.004 0.0074 0.0287
Echinococcus granulosus sodium channel protein 0.0045 0.0093 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.0029 0.0004
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.0029 0.0004
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0029 0.0044
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0074 0.0138
Echinococcus multilocularis tumor protein p63 0.0362 0.1322 0.3096
Onchocerca volvulus 0.0231 0.0811 0.6194
Onchocerca volvulus 0.0029 0.0029 0.0004
Onchocerca volvulus 0.006 0.015 0.0968
Plasmodium vivax alpha/beta hydrolase, putative 0.004 0.0074 0.0287
Brugia malayi Dopamine receptor 0.0029 0.0029 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0287 0.0655
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0029 0.0044
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0163 0.0158
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.006 0.015 0.0333
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0039 0.0039
Echinococcus granulosus intermediate filament protein 0.0033 0.0043 0.0079
Schistosoma mansoni single-minded 0.0059 0.0145 0.032
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0231 0.0811 0.0807
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0029 0.0044
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Entamoeba histolytica aldose reductase, putative 0.0231 0.0811 0.307
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Onchocerca volvulus 0.0029 0.0029 0.0004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0422 0.1637
Mycobacterium ulcerans amidase 0.0134 0.0438 0.1697
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus granulosus fmrfamide receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0029 0.0044
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Toxoplasma gondii hypothetical protein 0.006 0.015 0.1444
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.006 0.015 0.015
Onchocerca volvulus 0.0231 0.0811 0.6194
Schistosoma mansoni neuropeptide receptor 0.0029 0.0029 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.0176 0.054
Loa Loa (eye worm) hypothetical protein 0.006 0.015 0.015
Entamoeba histolytica alcohol dehydrogenase, putative 0.0067 0.0176 0.058
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0074 0.0287
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0231 0.0811 0.0807
Toxoplasma gondii hypothetical protein 0.004 0.0074 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Loa Loa (eye worm) oxidoreductase 0.0231 0.0811 0.0811
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0029 0.0044
Brugia malayi Thioredoxin reductase 0.0057 0.0138 0.0134
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.006 0.015 0.0146
Loa Loa (eye worm) oxidoreductase 0.0231 0.0811 0.0811
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0074
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0029 0.0044
Toxoplasma gondii peptidase S15, putative 0.004 0.0074 0.0453
Brugia malayi hypothetical protein 0.006 0.015 0.0146
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0028 0.0109
Loa Loa (eye worm) glutathione reductase 0.0057 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.006 0.015 0.015
Echinococcus granulosus lamin dm0 0.0033 0.0043 0.0079
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0067 0.0176 0.0392
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0124 0.1101
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0478 0.1766
Plasmodium vivax hypothetical protein, conserved 0.004 0.0074 0.0287
Plasmodium vivax unspecified product 0.004 0.0074 0.0287
Loa Loa (eye worm) serotonin transporter b 0.0355 0.1292 0.1292
Plasmodium falciparum lysophospholipase, putative 0.0686 0.2579 1
Entamoeba histolytica aldose reductase, putative 0.0231 0.0811 0.307
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.006 0.015 0.0332
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0067 0.0176 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0287 0.0653
Mycobacterium ulcerans hypothetical protein 0.0067 0.0176 0.0683
Echinococcus multilocularis sodium channel protein 0.0045 0.0093 0.0196
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0401 0.0401
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0163 0.0633
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0086 0.0332
Loa Loa (eye worm) oxidoreductase 0.0231 0.0811 0.0811
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0029 0.0044
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Schistosoma mansoni flap endonuclease-1 0.0028 0.0027 0.0041
Mycobacterium tuberculosis Probable oxidoreductase 0.0231 0.0811 0.3145
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.0074 0.0152
Loa Loa (eye worm) hypothetical protein 0.26 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Leishmania major hypothetical protein, conserved 0.027 0.0965 0.0961
Plasmodium vivax lysophospholipase, putative 0.004 0.0074 0.0287
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0029 0.0044
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0029 0.0024
Echinococcus multilocularis aldo keto reductase 0.0231 0.0811 0.1891
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0145 0.032
Onchocerca volvulus 0.0231 0.0811 0.6194
Entamoeba histolytica alcohol dehydrogenase, putative 0.0067 0.0176 0.058
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0028
Onchocerca volvulus 0.0029 0.0029 0.0004
Echinococcus granulosus g protein coupled receptor 0.0029 0.0029 0.0044
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0231 0.0811 0.0807
Echinococcus multilocularis voltage gated potassium channel subunit 0.0067 0.0176 0.0392
Loa Loa (eye worm) hypothetical protein 0.0032 0.0041 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0108 0.0103
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0231 0.0811 0.304
Loa Loa (eye worm) hypothetical protein 0.0355 0.1292 0.1292
Onchocerca volvulus 0.027 0.0965 0.7415
Loa Loa (eye worm) hypothetical protein 0.0355 0.1292 0.1292
Plasmodium falciparum thioredoxin reductase 0.0057 0.0138 0.0537
Toxoplasma gondii hypothetical protein 0.004 0.0074 0.0453
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0686 0.2579 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0138 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0028 0.0023
Brugia malayi Melatonin receptor type 1A 0.0029 0.0029 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0163 0.0363
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0067 0.0176 0.054
Echinococcus granulosus somatostatin receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Brugia malayi Protein C20orf22 0.004 0.0074 0.0069
Leishmania major hypothetical protein, conserved 0.004 0.0074 0.0069
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0134 0.0438 0.1697
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.006 0.015 0.015
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0043 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0091 0.0271 0.0617
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0134 0.0438 0.1697
Brugia malayi Sodium:neurotransmitter symporter family protein 0.006 0.015 0.0146
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Entamoeba histolytica aldose reductase, putative 0.0231 0.0811 0.307
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Onchocerca volvulus 0.0029 0.0029 0.0004
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0074 0.0138
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0422 0.1545
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.0074 0.0453
Trypanosoma brucei monoglyceride lipase, putative 0.0686 0.2579 0.2575
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0074 0.0069
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0067 0.0176 0.0171
Plasmodium falciparum transporter, putative 0.006 0.015 0.0584
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0029 0.0044
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0029 0.0044
Onchocerca volvulus 0.0231 0.0811 0.6194
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0124
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0074 0.0138
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Loa Loa (eye worm) oxidoreductase 0.0231 0.0811 0.0811
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.006 0.015 0.1444
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0028 0.0109
Plasmodium vivax aldehyde reductase, putative 0.0067 0.0176 0.0683
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0074 0.0138
Echinococcus granulosus sodium and chloride dependent glycine 0.006 0.015 0.0332
Echinococcus granulosus tm gpcr rhodopsin 0.1117 0.4247 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0287 0.0655
Echinococcus multilocularis lamin dm0 0.0033 0.0043 0.0079
Schistosoma mansoni fatty-acid amide hydrolase 0.1113 0.4233 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0043 0.0043
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0029 0.0044
Mycobacterium ulcerans amidase 0.0134 0.0438 0.1697
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.052 0.0515
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0029 0.0044
Plasmodium falciparum lysophospholipase, putative 0.0686 0.2579 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0091 0.0271 0.0617
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0108 0.0231
Trypanosoma cruzi amidase, putative 0.0134 0.0438 0.0433
Echinococcus granulosus GPCR family 2 0.0049 0.0108 0.0231
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.027 0.0965 0.0961
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0091 0.0271 0.0617
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0134 0.0438 0.1009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0108 0.0231
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0686 0.2579 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0108 0.0231
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0091 0.0271 0.0267
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0074 0.0138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0029 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0138 0.0134
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Plasmodium vivax PST-A protein 0.004 0.0074 0.0287
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0045 0.0093 0.0196
Plasmodium vivax lysophospholipase, putative 0.004 0.0074 0.0287
Schistosoma mansoni adenoreceptor 0.0029 0.0029 0.0044
Schistosoma mansoni hypothetical protein 0.0106 0.0329 0.0755
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Loa Loa (eye worm) oxidoreductase 0.0231 0.0811 0.0811
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0686 0.2579 1
Loa Loa (eye worm) hypothetical protein 0.006 0.015 0.015
Echinococcus granulosus sodium and chloride dependent glycine 0.006 0.015 0.0332
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0074 0.0287
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0074 0.0138
Trichomonas vaginalis aldo/keto reductase, putative 0.0231 0.0811 0.304
Plasmodium falciparum amino acid transporter, putative 0.006 0.015 0.0584
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0029 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0028 0.0023
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Plasmodium vivax PST-A protein 0.004 0.0074 0.0287
Giardia lamblia Aldose reductase 0.0231 0.0811 1
Entamoeba histolytica hypothetical protein 0.004 0.0074 0.018
Trypanosoma cruzi aldo-keto reductase 0.0231 0.0811 0.0807
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0005 0.0005
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Schistosoma mansoni amine GPCR 0.0029 0.0029 0.0044
Entamoeba histolytica hypothetical protein 0.004 0.0074 0.018
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0039 0.0043
Brugia malayi Amidase family protein 0.0134 0.0438 0.0433
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0134 0.0438 0.1697
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0029 0.0044
Mycobacterium ulcerans hypothetical protein 0.004 0.0074 0.0287
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0329 0.0324
Brugia malayi putative amidase 0.0134 0.0438 0.0433
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.006 0.015 0.0333
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0029 0.0029
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0029 0.0029
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0091 0.0271 0.0617
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni intermediate filament proteins 0.0033 0.0043 0.0079
Plasmodium vivax PST-A protein 0.0686 0.2579 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0038 0.0038
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0029 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0124 0.0119
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Plasmodium vivax lysophospholipase, putative 0.004 0.0074 0.0287
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0287 0.0653
Echinococcus multilocularis abhydrolase domain containing 3 0.004 0.0074 0.0151
Loa Loa (eye worm) amidase 0.0134 0.0438 0.0438
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0049 0.0108 0.0232
Plasmodium falciparum exported lipase 2 0.004 0.0074 0.0287
Brugia malayi Sodium:neurotransmitter symporter family protein 0.006 0.015 0.0146
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0029 0.0044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0029 0.0044
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0134 0.0438 0.0433
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0134 0.0438 0.1009
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.006 0.015 0.015
Giardia lamblia Aldose reductase 0.0231 0.0811 1
Echinococcus multilocularis lamin 0.0033 0.0043 0.0079
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0029 0.0044
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0134 0.0438 0.1013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0005 0.0019
Onchocerca volvulus Putative nachr subunit 0.0091 0.0271 0.1925
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0134 0.0438 0.1697
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.004 0.0074 0.0069
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0029 0.0044
Mycobacterium ulcerans lysophospholipase 0.0686 0.2579 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0029 0.0044
Schistosoma mansoni hypothetical protein 0.0049 0.0108 0.0232
Leishmania major hypothetical protein, conserved 0.0053 0.0124 0.0119
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.004 0.0074 0.0287
Plasmodium falciparum aldehyde reductase, putative 0.0067 0.0176 0.0683
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Echinococcus granulosus single minded 2 0.0043 0.0086 0.0179
Schistosoma mansoni neuropeptide receptor 0.0029 0.0029 0.0044
Toxoplasma gondii aldose reductase, putative 0.0231 0.0811 1
Plasmodium vivax alpha/beta hydrolase, putative 0.004 0.0074 0.0287
Plasmodium falciparum lysophospholipase, putative 0.004 0.0074 0.0287
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0029 0.0044
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0028 0.0109
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0029 0.0044
Onchocerca volvulus 0.0355 0.1292 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0287 0.0653
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0074 0.0138
Echinococcus multilocularis sodium and chloride dependent glycine 0.006 0.015 0.0332
Mycobacterium leprae Conserved hypothetical protein 0.0164 0.0552 0.2055
Plasmodium falciparum glutathione reductase 0.0057 0.0138 0.0537
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni biogenic amine receptor 0.0029 0.0029 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.0176 0.054
Trypanosoma brucei C-8 sterol isomerase, putative 0.26 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0029 0.0044
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.004 0.0074 0.018
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.006 0.015 0.0332
Plasmodium falciparum esterase, putative 0.004 0.0074 0.0287
Plasmodium vivax PST-A protein 0.004 0.0074 0.0287
Trypanosoma cruzi serine peptidase, putative 0.004 0.0074 0.0069
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0134 0.0438 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0163 0.0633
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0029 0.0029
Plasmodium falciparum exported lipase 1 0.004 0.0074 0.0287
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0074 0.0138
Onchocerca volvulus 0.0053 0.0123 0.0749
Loa Loa (eye worm) hypothetical protein 0.006 0.015 0.015
Onchocerca volvulus 0.0231 0.0811 0.6194
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0029 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0029 0.0044
Brugia malayi RE15519p 0.0029 0.0029 0.0024
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0029 0.0044
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.006 0.015 0.0332
Echinococcus multilocularis serotonin receptor 0.0029 0.0029 0.0044
Schistosoma mansoni biogenic amine receptor 0.0029 0.0029 0.0044
Schistosoma mansoni neuropeptide receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0287 0.0655
Brugia malayi Cytochrome P450 family protein 0.0031 0.0038 0.0033
Echinococcus granulosus lamin 0.0033 0.0043 0.0079
Echinococcus granulosus uncharacterized sodium dependent transporter 0.006 0.015 0.0332
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0067 0.0176 0.1775
Leishmania major hypothetical protein, conserved 0.0134 0.0438 0.0433
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0074 0.0138
Toxoplasma gondii aldo-keto reductase 0.0067 0.0176 0.1775
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0134 0.0438 0.1697
Onchocerca volvulus 0.0029 0.0029 0.0004
Brugia malayi neuropeptide F receptor 0.0029 0.0029 0.0024
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Echinococcus granulosus fatty acid amide hydrolase 1 0.0134 0.0438 0.1009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0287 0.0653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0134 0.0438 0.1697
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Chlamydia trachomatis hydrolase 0.004 0.0074 0.1689
Schistosoma mansoni sodium-dependent amino acid transporter 0.006 0.015 0.0333
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0029 0.0024
Leishmania major prostaglandin f synthase, putative 0.0231 0.0811 0.0807
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0029 0.0044
Echinococcus granulosus sex peptide receptor 0.0029 0.0029 0.0044
Brugia malayi Sodium:neurotransmitter symporter family protein 0.006 0.015 0.0146
Onchocerca volvulus 0.0029 0.0029 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0686 0.2579 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0108 0.0108
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Onchocerca volvulus 0.0029 0.0029 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0108 0.0231
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Treponema pallidum sodium- and chloride- dependent transporter 0.0355 0.1292 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Schistosoma mansoni amine GPCR 0.0029 0.0029 0.0044
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0086 0.0081
Mycobacterium leprae Possible oxidoreductase 0.0067 0.0176 0.058
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.0622 0.0622
Giardia lamblia Cgi67 serine protease precursor-like protein 0.004 0.0074 0.0453
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0401 0.0401
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0028 0.0109
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0108 0.0103
Brugia malayi G-protein coupled receptor 0.0029 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni fatty-acid amide hydrolase 0.0134 0.0438 0.1013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.006 0.015 0.0333
Loa Loa (eye worm) hypothetical protein 0.0155 0.052 0.052
Schistosoma mansoni opsin-like receptor 0.0029 0.0029 0.0044
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0039 0.0034
Loa Loa (eye worm) hypothetical protein 0.0053 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Loa Loa (eye worm) hypothetical protein 0.0529 0.1967 0.1967
Trichomonas vaginalis aldo/keto reductase, putative 0.0231 0.0811 0.304
Schistosoma mansoni potassium channel beta 0.0067 0.0176 0.0393
Trypanosoma brucei trypanothione reductase 0.0057 0.0138 0.0134
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0029 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Plasmodium vivax amine transporter, putative 0.006 0.015 0.0584
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.2623 0.6167
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0067 0.0176 0.0176
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0686 0.2579 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0029 0.0044
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0163 0.1608
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0029 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0029 0.0029
Schistosoma mansoni aldo-keto reductase 0.0231 0.0811 0.1897
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0039 0.0034
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.006 0.015 0.0332
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0355 0.1292 0.3036
Plasmodium falciparum BEM46-like protein, putative 0.004 0.0074 0.0287
Loa Loa (eye worm) norepinephrine transporter 0.0355 0.1292 0.1292
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0124 0.0481
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Trypanosoma cruzi aldo/keto reductase, putative 0.0231 0.0811 0.0807
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0029 0.0029
Trypanosoma cruzi serine peptidase, putative 0.004 0.0074 0.0069
Brugia malayi glutathione reductase 0.0057 0.0138 0.0134
Onchocerca volvulus 0.006 0.015 0.0968
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0029 0.0044
Schistosoma mansoni opsin-like receptor 0.0029 0.0029 0.0044
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.004 0.0074 0.0453
Echinococcus multilocularis somatostatin receptor 0.0029 0.0029 0.0044
Brugia malayi MGC79044 protein 0.004 0.0074 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0176 0.054
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0039 0.0069
Echinococcus multilocularis aldehyde reductase 0.0164 0.0552 0.128
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Trichomonas vaginalis conserved hypothetical protein 0.0686 0.2579 1
Plasmodium falciparum aldo-keto reductase, putative 0.0067 0.0176 0.0683
Echinococcus granulosus serotonin transporter 0.0355 0.1292 0.3026
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0029 0.0029
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0355 0.1292 0.1288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0134 0.0438 0.1009
Toxoplasma gondii hypothetical protein 0.004 0.0074 0.0453
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Mycobacterium ulcerans amidase 0.0134 0.0438 0.1697
Echinococcus granulosus hypothetical protein 0.0231 0.0811 0.1891
Leishmania major trypanothione reductase 0.0057 0.0138 0.0134
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0039 0.0151
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0074 0.0287
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0686 0.2579 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0074 0.0069
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0029 0.0044
Plasmodium falciparum epoxide hydrolase 2 0.004 0.0074 0.0287
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0138 0.0303
Echinococcus multilocularis musashi 0.0033 0.0043 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0124 0.0481
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Echinococcus granulosus fatty acid amide hydrolase 1 0.1113 0.4233 0.9966
Mycobacterium tuberculosis Possible lysophospholipase 0.0686 0.2579 1
Onchocerca volvulus 0.0029 0.0029 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0029 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.006 0.015 0.3438
Brugia malayi GnHR receptor homolog 0.0029 0.0029 0.0024
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0123 0.0267
Plasmodium falciparum esterase, putative 0.0686 0.2579 1
Trypanosoma brucei aldo-keto reductase, putative 0.0231 0.0811 0.0807
Loa Loa (eye worm) hypothetical protein 0.1329 0.5071 0.5071
Plasmodium falciparum esterase, putative 0.004 0.0074 0.0287
Echinococcus granulosus flap endonuclease 1 0.0031 0.0039 0.0069
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.006 0.015 0.0333
Brugia malayi Dopamine receptor protein 1 0.0029 0.0029 0.0024
Echinococcus multilocularis sodium and chloride dependent glycine 0.006 0.015 0.0332
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0029 0.0044
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0029 0.0044
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0134 0.0438 1
Onchocerca volvulus 0.0029 0.0029 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0124 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.0138
Brugia malayi Serotonin receptor 0.0029 0.0029 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0124 0.0481
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0029 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Brugia malayi Dopamine receptor protein 2 0.0029 0.0029 0.0024
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0067 0.0176 0.0683
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1113 0.4233 0.9966
Toxoplasma gondii hypothetical protein 0.004 0.0074 0.0453
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0074 0.0287
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0029 0.0044
Onchocerca volvulus 0.0231 0.0811 0.6194
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.004 0.0074 0.0069
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.006 0.015 0.0333
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0045 0.0093 0.0088
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Mycobacterium ulcerans amidase 0.0134 0.0438 0.1697
Brugia malayi amidase 0.1113 0.4233 0.423
Echinococcus granulosus monoacylglycerol lipase abhd12 0.004 0.0074 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0029 0.0044
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0074 0.0287
Schistosoma mansoni pol-related 0.0231 0.0811 0.1897
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0478 0.1856
Schistosoma mansoni neuropeptide receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1117 0.4247 1
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0029 0.0044
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.0074 0.0453
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni myosin xvIII 0.0029 0.0029 0.0044
Mycobacterium ulcerans peptide amidase, GatA 0.0134 0.0438 0.1697
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0163 0.0633
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0422 0.1637
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Echinococcus multilocularis serotonin receptor 0.0029 0.0029 0.0044
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0134 0.0438 0.1606
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0422 0.1637
Echinococcus granulosus aldehyde reductase 0.0164 0.0552 0.128
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0074 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0029 0.0044
Schistosoma mansoni opsin-like receptor 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0124 0.0119
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0029 0.0044
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0029 0.0044
Trypanosoma cruzi monoglyceride lipase, putative 0.0686 0.2579 0.2575
Echinococcus granulosus tumor protein p63 0.0362 0.1322 0.3096
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0067 0.0176 0.1775
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0231 0.0811 0.0807
Mycobacterium ulcerans hydrolase 0.004 0.0074 0.0287
Entamoeba histolytica ;Alias 0.004 0.0074 0.018
Brugia malayi intermediate filament protein 0.0033 0.0043 0.0038
Mycobacterium ulcerans oxidoreductase 0.0231 0.0811 0.3145
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.052 0.0515
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.006 0.015 0.1444
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0029 0.0024
Plasmodium falciparum flap endonuclease 1 0.0031 0.0039 0.0151
Leishmania major monoglyceride lipase, putative 0.0686 0.2579 0.2575
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0043 0.0043
Schistosoma mansoni sodium/chloride dependent transporter 0.0355 0.1292 0.3036
Trypanosoma brucei Emopamil binding protein, putative 0.027 0.0965 0.0961
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0138 0.0537
Schistosoma mansoni hypothetical protein 0.0049 0.0108 0.0232
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0029 0.0044
Brugia malayi hypothetical protein 0.0053 0.0124 0.0119
Brugia malayi G protein-coupled receptor 0.0029 0.0029 0.0024
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0029 0.0044
Trypanosoma brucei monoglyceride lipase, putative 0.0686 0.2579 0.2575
Mycobacterium ulcerans hypothetical protein 0.004 0.0074 0.0287
Onchocerca volvulus 0.0029 0.0029 0.0004
Brugia malayi AKH receptor 0.0029 0.0029 0.0024
Onchocerca volvulus 0.0029 0.0029 0.0004
Brugia malayi larval opioid receptor 0.0029 0.0029 0.0024
Echinococcus granulosus neuropeptide receptor 0.0029 0.0029 0.0044
Trypanosoma cruzi amidase, putative 0.0134 0.0438 0.0433
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.004 0.0074 0.0069
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1113 0.4233 0.9966
Plasmodium falciparum prodrug activation and resistance esterase 0.004 0.0074 0.0287
Schistosoma mansoni histamine h1 receptor 0.0029 0.0029 0.0044
Onchocerca volvulus 0.0029 0.0029 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0029 0.0044
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0231 0.0811 0.1891
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0029 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0028 0.0109
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0029 0.0044
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0029 0.0044
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0029 0.0044
Toxoplasma gondii hypothetical protein 0.006 0.015 0.1444
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0686 0.2579 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0029 0.0044
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0134 0.0438 0.1697
Schistosoma mansoni amine GPCR 0.0029 0.0029 0.0044
Echinococcus granulosus abhydrolase domain containing protein 13 0.004 0.0074 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Echinococcus multilocularis sex peptide receptor 0.0029 0.0029 0.0044
Mycobacterium ulcerans hypothetical protein 0.0686 0.2579 1
Trypanosoma cruzi Emopamil binding protein, putative 0.027 0.0965 0.0961
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0028 0.0023
Trichomonas vaginalis aldo-keto reductase, putative 0.0231 0.0811 0.304
Loa Loa (eye worm) hypothetical protein 0.1113 0.4233 0.4233
Onchocerca volvulus 0.0029 0.0029 0.0004
Brugia malayi hypothetical protein 0.0029 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Loa Loa (eye worm) solute carrier family 6 member 4 0.0355 0.1292 0.1292
Echinococcus multilocularis serotonin transporter 0.0355 0.1292 0.3026
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0134 0.0438 0.1697
Toxoplasma gondii thioredoxin reductase 0.0057 0.0138 0.1288
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0091 0.0271 0.0617
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.0074 0.0069
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0043
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.006 0.015 0.1444
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0029 0.0044
Echinococcus granulosus Phospholipase carboxylesterase 0.004 0.0074 0.0151
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0422 0.1637
Plasmodium vivax hypothetical protein, conserved 0.006 0.015 0.0584
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0028 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0028 0.0109
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis aldo keto reductase 0.0231 0.0811 0.1891
Loa Loa (eye worm) hypothetical protein 0.0091 0.0271 0.0271
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0029 0.0024
Trypanosoma cruzi aldo/keto reductase, putative 0.0067 0.0176 0.0171
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0074
Echinococcus granulosus g protein coupled receptor 0.0029 0.0029 0.0044
Brugia malayi PAS domain containing protein 0.0059 0.0145 0.014
Onchocerca volvulus 0.0033 0.0043 0.0121
Loa Loa (eye worm) hypothetical protein 0.0106 0.0329 0.0329
Leishmania major hypothetical protein, conserved 0.004 0.0074 0.0069
Brugia malayi putative neuropeptide receptor 0.0029 0.0029 0.0024
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.027 0.0965 0.0961
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0138 0.0537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0029 0.0044
Echinococcus granulosus voltage gated potassium channel subunit 0.0067 0.0176 0.0392
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0231 0.0811 0.0807
Echinococcus granulosus hypothetical protein 0.0029 0.0029 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.0176 0.054
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0163 0.0363
Plasmodium vivax glutathione reductase, putative 0.0057 0.0138 0.0537
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0686 0.2579 1
Echinococcus granulosus neuropeptide receptor 0.0029 0.0029 0.0044
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0029 0.0024
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0231 0.0811 0.1891
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0686 0.2579 1
Plasmodium falciparum lysophospholipase, putative 0.004 0.0074 0.0287
Plasmodium falciparum alpha/beta-hydrolase, putative 0.004 0.0074 0.0287
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Onchocerca volvulus 0.0033 0.0043 0.0121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.2623 0.6188
Brugia malayi sulfakinin receptor protein 0.0029 0.0029 0.0024
Brugia malayi MH2 domain containing protein 0.0125 0.0401 0.0396
Brugia malayi MGC83647 protein 0.004 0.0074 0.0069
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0422 0.1637
Onchocerca volvulus 0.006 0.015 0.0968
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis Phospholipase carboxylesterase 0.004 0.0074 0.0151
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0029 0.0044
Echinococcus granulosus aldo keto reductase 0.0231 0.0811 0.1891
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni amidase 0.1113 0.4233 1
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0029 0.0044
Mycobacterium tuberculosis Probable reductase 0.013 0.0422 0.1637
Loa Loa (eye worm) hypothetical protein 0.0049 0.0108 0.0108
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0029 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0287 0.0287
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0074
Onchocerca volvulus 0.0029 0.0029 0.0004
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0138 0.0138
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.0074 0.0152
Echinococcus multilocularis GPCR, family 2 0.0049 0.0108 0.0231
Schistosoma mansoni amine GPCR 0.0029 0.0029 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0005 0.0005
Onchocerca volvulus 0.0029 0.0029 0.0004
Schistosoma mansoni lamin 0.0033 0.0043 0.0079
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0231 0.0811 0.307
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.006 0.015 0.0333
Echinococcus multilocularis aldo keto reductase 0.0231 0.0811 0.1891
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0074 0.0287
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0029 0.0044

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing MDCKII cells ChEMBL. 12438524
Activity (functional) TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: ? uM, Biperiden: 100 uM) in MDR1-expressing MDCKII cells ChEMBL. 12438524
Anticonvulsant activity (functional) 0 Virtual screen for compounds with anticonvulsant activity ChEMBL. 12873507
CL (ADMET) = 12 ml/min.kg Total clearance in human ChEMBL. 20070106
CL (ADMET) = 12 ml/min.kg Hepatic clearance in human ChEMBL. 20070106
CL_renal (ADMET) = 0 ml/min.kg Renal clearance in human ChEMBL. 20070106
IC50 (binding) < 10 uM Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex ChEMBL. 2579237
IC50 (binding) < 10 uM Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex ChEMBL. 2579237
Inhibition (functional) Antagonist activity at histamine H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release at 100 uM by using fura-2AM-based fluorescence assay ChEMBL. 22793499
Inhibition (binding) = 62.9 % Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 microM ChEMBL. 2579237
Inhibition (binding) = 62.9 % Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 microM ChEMBL. 2579237
Retention_time (ADMET) = 5.78 min Drug level in Homo sapiens (human) whole blood assessed as retention time by UPLC-TOF-MS analysis ChEMBL. No reference
Vdss (ADMET) = 12 L/Kg Volume of distribution at steady state in human ChEMBL. 20070106

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.