Detailed information for compound 1509075

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 507.535 | Formula: C22H26FN5O6S
  • H donors: 1 H acceptors: 6 LogP: 2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N1CCC(CC1)Oc1ncnc2c1[nH]c(=O)n2c1ccc(cc1F)S(=O)(=O)C)OC(C)(C)C
  • InChi: 1S/C22H26FN5O6S/c1-22(2,3)34-21(30)27-9-7-13(8-10-27)33-19-17-18(24-12-25-19)28(20(29)26-17)16-6-5-14(11-15(16)23)35(4,31)32/h5-6,11-13H,7-10H2,1-4H3,(H,26,29)
  • InChiKey: AXLNAZYMBNKFJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens G protein-coupled receptor 119 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor G protein-coupled receptor 119 335 aa 274 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major trypanothione reductase 0.0049 0.0286 0.0736
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0018 0.005 0.0019
Trichomonas vaginalis reverse transcriptases, putative 0.0018 0.005 0.0128
Echinococcus granulosus thymidylate kinase 0.0075 0.0483 0.0813
Echinococcus multilocularis frizzled 0.0035 0.0175 0.0279
Schistosoma mansoni thymidylate kinase 0.0075 0.0483 0.0454
Schistosoma mansoni hypothetical protein 0.0019 0.0053 0.0022
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0143 0.0964
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Plasmodium vivax thymidylate kinase, putative 0.0075 0.0483 1
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0776 0.1995
Schistosoma mansoni intermediate filament proteins 0.0028 0.0124 0.0094
Brugia malayi phosphofructokinase 0.0114 0.0776 0.4317
Schistosoma mansoni frizzled-like receptor 0.0035 0.0175 0.0144
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0769 0.8837
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.004 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.005 0.0128
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0865 1
Giardia lamblia Thymidine kinase 0.0521 0.3891 1
Mycobacterium tuberculosis Probable reductase 0.0113 0.0769 0.8837
Entamoeba histolytica Thymidylate kinase, putative 0.0075 0.0483 0.1242
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0776 0.1995
Leishmania major ribonuclease H1, putative 0.0179 0.1273 0.3272
Brugia malayi Zinc knuckle family protein 0.0018 0.005 0.0251
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0059 0.0152
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0039
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.004 0.0009
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.004 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0059 0.0152
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0143 0.0368
Entamoeba histolytica thymidine kinase, putative 0.0521 0.3891 1
Trypanosoma cruzi thymidylate kinase, putative 0.0075 0.0483 0.1242
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0143 0.2596
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0143 0.0368
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0059 0.008
Echinococcus granulosus secreted frizzled protein 0.0016 0.0031 0.0031
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0018 0.005 0.0064
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0143 0.2596
Schistosoma mansoni protein kinase 0.0018 0.005 0.0019
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0077
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.004 0.0102
Echinococcus multilocularis RNA directed DNA polymerase 0.0018 0.005 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0197 0.1414 0.2308
Trypanosoma cruzi ribonuclease H1, putative 0.0179 0.1273 0.3272
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0776 0.0748
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.004 0.0046
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.004 0.034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.004 0.0102
Schistosoma mansoni frizzled 0.0035 0.0175 0.0144
Trypanosoma brucei ingi protein (ORF1) 0.0197 0.1414 0.2308
Plasmodium vivax glutathione reductase, putative 0.0049 0.0286 0.5709
Echinococcus multilocularis frizzled 10 0.0035 0.0175 0.0279
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3891 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0059 0.0234
Trypanosoma brucei RNA helicase, putative 0.0814 0.6125 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0776 0.1995
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0077
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0075 0.0483 0.5371
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Schistosoma mansoni hypothetical protein 0.0342 0.2517 0.2494
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.004 0.0102
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0769 0.8837
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0776 0.1995
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0865 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0143 0.0269
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0059 0.0096
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0059 0.0262
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Echinococcus multilocularis secreted frizzled protein 0.0016 0.0031 0.0031
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0024 0.0108
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0018 0.005 0.0153
Toxoplasma gondii ribonuclease HI protein 0.0179 0.1273 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0079 0.0415
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.003 0.0134 0.0345
Echinococcus multilocularis frizzled 0.0035 0.0175 0.0279
Brugia malayi Fz domain containing protein 0.0016 0.0031 0.0144
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0018 0.005 0.0064
Treponema pallidum ribonuclease H (rnhA) 0.0179 0.1273 1
Brugia malayi Zinc knuckle family protein 0.0018 0.005 0.0251
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0865 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0286 0.2985
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0286 0.0489
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.004 0.0102
Trichomonas vaginalis thymidylate kinase, putative 0.0075 0.0483 0.1242
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0776 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0039
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Chlamydia trachomatis thymidylate kinase 0.0075 0.0483 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.004 0.0065
Echinococcus granulosus frizzled 0.0035 0.0175 0.0279
Brugia malayi reverse transcriptase 0.0018 0.005 0.0251
Echinococcus granulosus frizzled 0.0035 0.0175 0.0279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0077
Brugia malayi 6-phosphofructokinase 0.0114 0.0776 0.4317
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0024 0.0027
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0059 0.0152
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0143 0.2335
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0286 0.0736
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0776 0.0748
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0018 0.005 0.0026
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0143 0.0964
Echinococcus multilocularis frizzled 4 0.0035 0.0175 0.0279
Onchocerca volvulus 0.0028 0.0124 0.0752
Trypanosoma cruzi thymidine kinase, putative 0.0521 0.3891 1
Echinococcus multilocularis ribonuclease H1 0.0179 0.1273 0.2178
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0059 0.0425
Loa Loa (eye worm) hypothetical protein 0.0755 0.5677 1
Echinococcus granulosus geminin 0.0342 0.2517 0.4328
Schistosoma mansoni hypothetical protein 0.0019 0.0053 0.0022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.004 0.0102
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0018 0.005 0.0081
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0776 0.1995
Giardia lamblia CDC8 0.0075 0.0483 0.1151
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.004 0.0136
Brugia malayi hypothetical protein 0.0018 0.005 0.0251
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.003 0.0134 0.0345
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0776 0.1995
Brugia malayi RNase H family protein 0.0179 0.1273 0.71
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.004 0.0102
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0124 0.0203
Brugia malayi reverse transcriptase 0.0018 0.005 0.0251
Echinococcus multilocularis geminin 0.0342 0.2517 0.4328
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0143 0.0368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.004 0.0102
Toxoplasma gondii thymidylate kinase 0.0075 0.0483 0.3682
Giardia lamblia Reverse transcriptase/endonuclease 0.0018 0.005 0.0026
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0776 0.1353
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0063
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0059 0.0088
Trypanosoma brucei unspecified product 0.0197 0.1414 0.2308
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0286 0.0472
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0059 0.0761
Toxoplasma gondii exonuclease III APE 0.002 0.0059 0.029
Echinococcus granulosus ribonuclease H1 0.0179 0.1273 0.2178
Trichomonas vaginalis reverse transcriptases, putative 0.0018 0.005 0.0128
Echinococcus multilocularis lamin dm0 0.0028 0.0124 0.0192
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Schistosoma mansoni hypothetical protein 0.0018 0.005 0.0019
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.004 0.0102
Loa Loa (eye worm) hypothetical protein 0.0028 0.0124 0.0203
Schistosoma mansoni hypothetical protein 0.0018 0.005 0.0019
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0776 0.1319
Echinococcus multilocularis lamin 0.0028 0.0124 0.0192
Echinococcus granulosus lamin dm0 0.0028 0.0124 0.0192
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0143 0.2335
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0769 0.8837
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0143 0.0368
Trypanosoma brucei thymidylate kinase, putative 0.0075 0.0483 0.0789
Trichomonas vaginalis thymidylate kinase, putative 0.0075 0.0483 0.1242
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0018 0.005 0.0081
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0059 0.0436
Trypanosoma brucei ribonuclease H1 0.0179 0.1273 0.2079
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0143 0.0368
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0018 0.005 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.004 0.0102
Loa Loa (eye worm) thymidylate kinase 0.0075 0.0483 0.0837
Brugia malayi hypothetical protein 0.0018 0.005 0.0251
Trichomonas vaginalis ribonuclease H1, putative 0.0179 0.1273 0.3272
Echinococcus granulosus smoothened 0.0771 0.5799 1
Mycobacterium tuberculosis Possible maturase 0.0018 0.005 0.0122
Echinococcus granulosus secreted frizzled protein 5 0.0016 0.0031 0.0031
Brugia malayi thymidylate kinase 0.0075 0.0483 0.2677
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Schistosoma mansoni thymidylate kinase 0.0075 0.0483 0.0454
Echinococcus granulosus KRAB A domain containing protein 0.0018 0.005 0.0064
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0018 0.005 0.0026
Schistosoma mansoni hypothetical protein 0.0075 0.0483 0.0454
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0776 0.597
Schistosoma mansoni phosphoglucomutase 0.0179 0.1273 0.1246
Echinococcus granulosus RNA directed DNA polymerase 0.0018 0.005 0.0064
Trypanosoma cruzi ribonuclease H1, putative 0.0179 0.1273 0.3272
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0035 0.0175 0.0292
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.004 0.0102
Brugia malayi 6-phosphofructokinase 0.0114 0.0776 0.4317
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0776 0.1995
Brugia malayi reverse transcriptase 0.0018 0.005 0.0251
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0865 1
Brugia malayi Thioredoxin reductase 0.0049 0.0286 0.1574
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0018 0.005 0.0064
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0019 0.0053 0.0077
Schistosoma mansoni lamin 0.0028 0.0124 0.0094
Brugia malayi hypothetical protein 0.0018 0.005 0.0251
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0197 0.1414 0.2308
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0776 0.1995
Schistosoma mansoni frizzled-like receptor 0.0019 0.0053 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0059 0.0152
Trypanosoma cruzi thymidine kinase, putative 0.0521 0.3891 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0769 0.8837
Onchocerca volvulus Putative thymidylate kinase 0.0075 0.0483 0.3642
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0018 0.005 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0143 0.0368
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0019 0.0053 0.0267
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0143 0.0964
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0776 0.1353
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.004 0.0065
Onchocerca volvulus 0.0028 0.0124 0.0752
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0776 0.1353
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3891 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.024 0.1744 0.1718
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0124 0.0203
Schistosoma mansoni hypothetical protein 0.0019 0.0053 0.0022
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0018 0.005 0.0128
Mycobacterium ulcerans thymidylate kinase 0.0075 0.0483 0.6022
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0143 0.0368
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Echinococcus granulosus bloom syndrome protein 0.0022 0.0079 0.0115
Leishmania major thymidylate kinase-like protein 0.0075 0.0483 0.1242
Schistosoma mansoni hypothetical protein 0.0342 0.2517 0.2494
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0143 0.2335
Schistosoma mansoni frizzled-like receptor 0.0019 0.0053 0.0022
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.004 0.0065
Toxoplasma gondii thioredoxin reductase 0.0049 0.0286 0.2107
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0286 0.0472
Echinococcus multilocularis frizzled 5 0.0035 0.0175 0.0279
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0179 0.1273 1
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.004 0.0136
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.1791 0.3144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0059 0.008
Schistosoma mansoni hypothetical protein 0.0814 0.6125 0.6113
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0059 0.0152
Trypanosoma brucei trypanothione reductase 0.0049 0.0286 0.0467
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0043 0.0013
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Brugia malayi follicle stimulating hormone receptor 0.0246 0.1791 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0007
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0059 0.0157
Echinococcus multilocularis secreted frizzled protein 0.0016 0.0031 0.0031
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0286 0.5709
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0035 0.0175 0.0949
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.004 0.0065
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0143 0.0368
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0018 0.005 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.004 0.0102
Loa Loa (eye worm) glutathione reductase 0.0049 0.0286 0.0489
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0124 0.0667
Schistosoma mansoni phosphoglucomutase 0.0179 0.1273 0.1246
Echinococcus multilocularis secreted frizzled protein 5 0.0016 0.0031 0.0031
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0079 0.0115
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0059 0.0302
Giardia lamblia Ribonuclease H 0.0179 0.1273 0.3203
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0018 0.005 0.0064
Echinococcus granulosus frizzled 0.0035 0.0175 0.0279
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0776 0.1319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.004 0.0102
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0776 0.1267
Brugia malayi glutathione reductase 0.0049 0.0286 0.1574
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0018 0.005 0.0128
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.004 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0196
Brugia malayi hypothetical protein 0.0018 0.005 0.0251
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0035 0.0175 0.0292
Treponema pallidum thymidylate kinase (tmk) 0.0075 0.0483 0.3595
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0776 0.1995
Plasmodium falciparum thymidylate kinase 0.0075 0.0483 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.004 0.0102
Schistosoma mansoni phosphoglucomutase 0.0179 0.1273 0.1246
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0035 0.0175 0.0949
Echinococcus granulosus frizzled 4 0.0035 0.0175 0.0279
Schistosoma mansoni frizzled-like receptor 0.0035 0.0175 0.0144
Brugia malayi RNase H family protein 0.0179 0.1273 0.71
Onchocerca volvulus Ribonuclease H1 homolog 0.0179 0.1273 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0018 0.005 0.0064
Onchocerca volvulus 0.0018 0.005 0.0153
Plasmodium falciparum glutathione reductase 0.0049 0.0286 0.5558
Trypanosoma brucei thymidylate kinase, putative 0.0075 0.0483 0.0789
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0018 0.005 0.0081
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0075 0.0483 0.3595
Schistosoma mansoni lamin 0.0028 0.0124 0.0094
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0776 0.8918
Loa Loa (eye worm) RecQ helicase 0.0022 0.0079 0.0124
Echinococcus multilocularis musashi 0.0028 0.0124 0.0192
Echinococcus granulosus frizzled 5 0.0035 0.0175 0.0279
Echinococcus multilocularis smoothened 0.0771 0.5799 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0059 0.005
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0079 0.0204
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.004 0.0102
Brugia malayi intermediate filament protein 0.0028 0.0124 0.0667
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0079 0.0204
Trypanosoma brucei thymidine kinase 0.0521 0.3891 0.6352
Loa Loa (eye worm) sfrp2 0.0016 0.0031 0.0039
Brugia malayi Fz domain containing protein 0.0016 0.0031 0.0144
Schistosoma mansoni ap endonuclease 0.002 0.0059 0.0028
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0143 0.0839
Schistosoma mansoni ap endonuclease 0.002 0.0059 0.0028
Leishmania major thymidine kinase, putative 0.0521 0.3891 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0769 0.8837
Brugia malayi Pao retrotransposon peptidase family protein 0.0018 0.005 0.0251
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0059 0.0157
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0776 0.7663
Leishmania major hypothetical protein, conserved 0.003 0.0134 0.0345
Trypanosoma brucei ingi protein (ORF1) 0.0197 0.1414 0.2308
Onchocerca volvulus 0.0018 0.005 0.0153
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0769 0.7488
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0059 0.0152
Echinococcus granulosus lamin 0.0028 0.0124 0.0192
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3891 1
Brugia malayi RNase H family protein 0.0179 0.1273 0.71
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.005 0.0019
Echinococcus granulosus intermediate filament protein 0.0028 0.0124 0.0192
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0143 0.2335
Plasmodium falciparum thioredoxin reductase 0.0049 0.0286 0.5558
Echinococcus multilocularis thymidylate kinase 0.0075 0.0483 0.0813
Trypanosoma cruzi thymidylate kinase, putative 0.0075 0.0483 0.1242
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.004 0.0102

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) Agonist activity at rat GPR119 by melanophore assay ChEMBL. 21444206
EC50 (functional) = 0.6 nM Agonist activity at human GPR119 by melanophore assay ChEMBL. 21444206
Emax (functional) = 64 % Agonist activity at human GPR119 by melanophore assay relative to AR231453 ChEMBL. 21444206
Ratio EC50 (binding) = 3 Selectivity ratio of EC50 for rat GPR119 to EC50 for human GPR119 ChEMBL. 21444206

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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