Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor NHR-67 | 0.024 | 0.1165 | 0.1086 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0609 | 0.3355 | 0.2628 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0609 | 0.3355 | 0.7388 |
Echinococcus multilocularis | Nicastrin | 0.0116 | 0.0435 | 0.097 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0568 | 0.3109 | 0.6935 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0568 | 0.3109 | 0.3047 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.024 | 0.1165 | 0.2402 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.3355 | 0.3295 |
Toxoplasma gondii | hypothetical protein | 0.0083 | 0.0241 | 1 |
Echinococcus granulosus | Nicastrin | 0.0116 | 0.0435 | 0.0896 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0146 | 0.0611 | 0.1364 |
Brugia malayi | nuclear hormone receptor | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0609 | 0.3355 | 0.3295 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.1416 | 0.8129 | 1 |
Brugia malayi | hypothetical protein | 0.0083 | 0.0241 | 0.0153 |
Brugia malayi | ecdysone receptor | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | presenilin spe-4 | 0.0083 | 0.0241 | 0.0153 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.037 | 0.1937 | 0.4321 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0238 | 0.1157 | 0.23 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.3355 | 0.3295 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0221 | 0.1057 | 0.9136 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.0164 | 0.1936 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0609 | 0.3355 | 0.7388 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.024 | 0.1165 | 0.2318 |
Schistosoma mansoni | coup transcription factor | 0.0609 | 0.3355 | 0.7388 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0609 | 0.3355 | 0.3295 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.0164 | 0.0183 |
Onchocerca volvulus | 0.0609 | 0.3355 | 0.2628 | |
Schistosoma mansoni | nuclear receptor | 0.024 | 0.1165 | 0.2318 |
Schistosoma mansoni | nuclear hormone receptor | 0.024 | 0.1165 | 0.2318 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0067 | 0.0146 | 0.1259 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.037 | 0.1937 | 0.1864 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.024 | 0.1165 | 0.2599 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.024 | 0.1165 | 0.2402 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0238 | 0.1157 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0609 | 0.3355 | 0.7388 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0609 | 0.3355 | 0.7484 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0609 | 0.3355 | 0.7484 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.3355 | 0.3295 |
Onchocerca volvulus | 0.024 | 0.1165 | 0.0199 | |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1937 | 0.1864 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.024 | 0.1165 | 0.2402 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0609 | 0.3355 | 0.3295 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.024 | 0.1165 | 0.2318 |
Brugia malayi | nuclear receptor RXR | 0.037 | 0.1937 | 0.1864 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.024 | 0.1165 | 0.0199 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0609 | 0.3355 | 0.6914 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Brugia malayi | N-terminal motif family protein | 0.0209 | 0.0986 | 0.0905 |
Schistosoma mansoni | nuclear receptor | 0.024 | 0.1165 | 0.2318 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0224 | 0.1071 | 0.099 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.08 | 0.4483 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.024 | 0.1165 | 0.2599 |
Brugia malayi | nuclear receptor NHR-88 | 0.024 | 0.1165 | 0.1086 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0609 | 0.3355 | 0.7484 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0986 | 0.0905 |
Brugia malayi | hypothetical protein | 0.0083 | 0.0241 | 0.0153 |
Brugia malayi | Presenilin spe-4 | 0.0083 | 0.0241 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.0611 | 0.1036 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0238 | 0.1157 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0609 | 0.3355 | 0.6914 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Echinococcus multilocularis | Nicastrin | 0.0116 | 0.0435 | 0.097 |
Brugia malayi | hypothetical protein | 0.037 | 0.1937 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1937 | 0.1864 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0354 | 0.1842 | 0.4108 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.024 | 0.1165 | 0.0199 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.024 | 0.1165 | 0.1086 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0238 | 0.1157 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.024 | 0.1165 | 0.1086 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.1416 | 0.8129 | 1 |
Brugia malayi | Presenilin spe-4 | 0.0083 | 0.0241 | 0.0153 |
Onchocerca volvulus | 0.024 | 0.1165 | 0.0199 | |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0609 | 0.3355 | 0.3295 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.037 | 0.1937 | 0.1864 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.024 | 0.1165 | 0.1086 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0609 | 0.3355 | 0.6914 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0609 | 0.3355 | 0.3295 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.024 | 0.1165 | 0.2402 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0609 | 0.3355 | 0.3295 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | hypothetical protein | 0.0116 | 0.0435 | 0.0348 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0609 | 0.3355 | 0.3295 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0224 | 0.1071 | 0.099 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0609 | 0.3355 | 0.3295 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1937 | 0.1864 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0609 | 0.3355 | 0.6914 |
Echinococcus granulosus | presenilin | 0.0238 | 0.1157 | 0.2385 |
Brugia malayi | steroid hormone receptor | 0.1232 | 0.7042 | 0.7016 |
Schistosoma mansoni | thyroid hormone receptor | 0.0755 | 0.4219 | 0.9388 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0609 | 0.3355 | 0.2628 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0609 | 0.3355 | 0.6914 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.037 | 0.1937 | 0.1864 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0609 | 0.3355 | 0.6914 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | DR-78 | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | Nuclear hormone receptor E75 | 0.024 | 0.1165 | 0.1086 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0609 | 0.3355 | 0.3295 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0724 | 0.4032 | 0.8308 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0609 | 0.3355 | 0.7484 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0609 | 0.3355 | 0.7388 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0609 | 0.3355 | 0.7484 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0238 | 0.1157 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0862 | 0.4853 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0609 | 0.3355 | 0.7388 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0609 | 0.3355 | 0.3295 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.3355 | 0.3295 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.0164 | 0.0366 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0221 | 0.1057 | 0.9136 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.037 | 0.1937 | 0.4105 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0224 | 0.1071 | 0.2207 |
Brugia malayi | tailless protein | 0.024 | 0.1165 | 0.1086 |
Brugia malayi | Presenilin family protein | 0.0238 | 0.1157 | 0.1077 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0609 | 0.3355 | 0.6914 |
Schistosoma mansoni | zinc finger protein | 0.024 | 0.1165 | 0.2318 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0568 | 0.3109 | 0.6819 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0724 | 0.4032 | 0.8954 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0238 | 0.1157 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0146 | 0.0611 | 0.126 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0238 | 0.1157 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0609 | 0.3355 | 0.3295 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0609 | 0.3355 | 0.7388 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0609 | 0.3355 | 0.7388 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0609 | 0.3355 | 0.3295 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0609 | 0.3355 | 0.7484 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0568 | 0.3109 | 0.6407 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.024 | 0.1165 | 0.2599 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0435 | 0.0348 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0609 | 0.3355 | 0.7388 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0609 | 0.3355 | 0.3295 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.037 | 0.1937 | 0.3992 |
Brugia malayi | hypothetical protein | 0.0083 | 0.0241 | 0.0153 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | nuclear receptor NHR-88 | 0.0609 | 0.3355 | 0.3295 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0568 | 0.3109 | 0.3047 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Brugia malayi | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Brugia malayi | Presenilin spe-4 | 0.0083 | 0.0241 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.3355 | 0.3295 |
Schistosoma mansoni | thyroid hormone receptor | 0.0755 | 0.4219 | 0.9388 |
Brugia malayi | hypothetical protein | 0.037 | 0.1937 | 0.1864 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.0435 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1937 | 0.1864 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0238 | 0.1157 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0755 | 0.4219 | 0.9411 |
Echinococcus granulosus | microtubule associated protein 2 | 0.08 | 0.4483 | 0.9239 |
Schistosoma mansoni | microtubule-associated protein tau | 0.08 | 0.4483 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1232 | 0.7042 | 0.7016 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.0164 | 0.0338 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0609 | 0.3355 | 0.3295 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.037 | 0.1937 | 0.4105 |
Brugia malayi | conserved hypotetical protein | 0.024 | 0.1165 | 0.1086 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0609 | 0.3355 | 0.7484 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.024 | 0.1165 | 0.1086 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.024 | 0.1165 | 0.2402 |
Brugia malayi | hypothetical protein | 0.0116 | 0.0435 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1937 | 0.1864 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.0083 | 0.0241 | 0.0153 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0238 | 0.1157 | 1 |
Brugia malayi | nuclear receptor RXR | 0.024 | 0.1165 | 0.1086 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0609 | 0.3355 | 0.7484 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0221 | 0.1057 | 0.9136 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0609 | 0.3355 | 0.3295 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0224 | 0.1071 | 0.2389 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.024 | 0.1165 | 0.2318 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0609 | 0.3355 | 0.7388 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0609 | 0.3355 | 0.3295 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0609 | 0.3355 | 0.6914 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.024 | 0.1165 | 0.2599 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.024 | 0.1165 | 0.2599 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0609 | 0.3355 | 0.3295 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1165 | 0.1086 |
Brugia malayi | nuclear hormone receptor | 0.0609 | 0.3355 | 0.3295 |
Echinococcus multilocularis | presenilin | 0.0238 | 0.1157 | 0.2582 |
Schistosoma mansoni | nuclear hormone receptor | 0.024 | 0.1165 | 0.2318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.