Detailed information for compound 1509820

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.319 | Formula: C17H14N4O2
  • H donors: 3 H acceptors: 4 LogP: 2.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)c1cnc(c(n1)C(=O)Nc1ccccc1)N
  • InChi: 1S/C17H14N4O2/c18-16-15(17(23)20-12-6-2-1-3-7-12)21-14(10-19-16)11-5-4-8-13(22)9-11/h1-10,22H,(H2,18,19)(H,20,23)
  • InChiKey: SRBBFIPPPXGQQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, DNA-activated, catalytic polypeptide Starlite/ChEMBL References
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL References
Homo sapiens ATR serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase Get druggable targets OG5_128386 All targets in OG5_128386
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination Get druggable targets OG5_128386 All targets in OG5_128386
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium hominis ataxia telangiectasia and Rad3-related protein Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania mexicana phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma brucei gambiense phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family Get druggable targets OG5_128386 All targets in OG5_128386
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128386 All targets in OG5_128386
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Babesia bovis phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania braziliensis phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum Serine/threonine-protein kinase atr, putative Get druggable targets OG5_128386 All targets in OG5_128386
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_128386 All targets in OG5_128386
Candida albicans potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination Get druggable targets OG5_128386 All targets in OG5_128386
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128386 All targets in OG5_128386
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania major phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128386 All targets in OG5_128386
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K06640 ataxia telangiectasia and Rad3 related, putative Get druggable targets OG5_128386 All targets in OG5_128386
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Cryptosporidium parvum FRP1 like protein involved in DNA repair with a FAT domain and a phosphatidylinositol kinase domain at the C-terminus Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128386 All targets in OG5_128386
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Schistosoma japonicum Serine/threonine-protein kinase ATR, putative Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0078 0.0989 0.3607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Loa Loa (eye worm) hypothetical protein 0.0044 0.0296 0.0296
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0066 0.0732 0.126
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0066 0.0732 0.2637
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0296 0.0509
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0066 0.0732 0.2637
Brugia malayi nuclear receptor RXR 0.0044 0.0296 0.0296
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0037 0.0166 0.0286
Loa Loa (eye worm) hypothetical protein 0.0068 0.0773 0.0773
Leishmania major malonyl-coa decarboxylase-like protein 0.0164 0.2682 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0068 0.0773 0.0773
Echinococcus granulosus ecdysone induced protein 78C 0.0068 0.0773 0.133
Plasmodium vivax importin-beta 2, putative 0.003 0.0027 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Loa Loa (eye worm) hypothetical protein 0.0041 0.025 0.025
Leishmania major hypothetical protein, conserved 0.0122 0.1857 0.6884
Loa Loa (eye worm) hypothetical protein 0.0044 0.0296 0.0296
Echinococcus multilocularis snurportin 1 0.0319 0.5763 0.9914
Schistosoma mansoni retinoic acid receptor RXR 0.0068 0.0773 0.1342
Loa Loa (eye worm) hypothetical protein 0.0044 0.0296 0.0296
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0066 0.0732 0.2658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0068 0.0773 0.0773
Schistosoma mansoni hypothetical protein 0.0319 0.5763 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0068 0.0773 0.1342
Loa Loa (eye worm) hypothetical protein 0.0068 0.0773 0.0773
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0296 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0166 0.168
Loa Loa (eye worm) hypothetical protein 0.0068 0.0773 0.0773
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0068 0.0773 0.133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0068 0.0773 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0068 0.0773 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0068 0.0773 0.0773
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.0417 0.77 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0068 0.0773 0.1342
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0068 0.0773 0.0773
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0068 0.0773 0.1342
Loa Loa (eye worm) hypothetical protein 0.0068 0.0773 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0068 0.0773 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0166 0.168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0517 0.5222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0041 0.025 0.084
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.005 0.0423 0.4536
Loa Loa (eye worm) hypothetical protein 0.0042 0.0267 0.0267
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0068 0.0773 0.133
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0773 0.1342
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0068 0.0773 0.133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0773 0.133
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0166 0.0166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0773 0.133
Brugia malayi putative malonyl-CoA decarboxylase 0.0417 0.77 0.77
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0068 0.0773 0.0773
Brugia malayi Nuclear hormone receptor-like 1 0.0068 0.0773 0.0773
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0296 0.0509
Loa Loa (eye worm) hypothetical protein 0.0417 0.77 0.77
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0068 0.0773 0.1342
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0055 0.0517 0.0896
Echinococcus granulosus snurportin 1 0.0319 0.5763 0.9914
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0322 0.5814 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0068 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0044 0.0296 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0068 0.0773 0.0773
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0055 0.0517 0.1822
Brugia malayi photoreceptor-specific nuclear receptor 0.0068 0.0773 0.0773
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0066 0.0732 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0126 0.1936 0.7184
Plasmodium falciparum importin beta, putative 0.003 0.0027 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Schistosoma mansoni RAR-like nuclear receptor 0.0068 0.0773 0.1342
Loa Loa (eye worm) hypothetical protein 0.0068 0.0773 0.0773
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0773 0.133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0296 0.0296
Brugia malayi RNA, U transporter 1 0.0085 0.112 0.112
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0068 0.0773 0.133
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0164 0.2682 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0068 0.0773 0.133
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0773 0.1342
Loa Loa (eye worm) hypothetical protein 0.0044 0.0296 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0068 0.0773 0.0773
Schistosoma mansoni fkbp-rapamycin associated protein 0.0037 0.0166 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.025 0.2526
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0322 0.5814 1
Entamoeba histolytica hypothetical protein 0.0055 0.0517 0.6189
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0423 0.4276
Schistosoma mansoni steroid hormone receptor ad4bp 0.0068 0.0773 0.1342
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0066 0.0732 0.2658
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0066 0.0732 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0517 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Echinococcus granulosus importin subunit beta 1 0.003 0.0027 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Echinococcus granulosus serine protein kinase ATM 0.0055 0.0517 0.0889
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0041 0.025 0.3162
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0164 0.2682 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Echinococcus granulosus FTZ F1 alpha 0.0068 0.0773 0.133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0166 0.168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0068 0.0773 0.0773
Brugia malayi hypothetical protein 0.0044 0.0296 0.0296
Echinococcus multilocularis ecdysone induced protein 78C 0.0068 0.0773 0.133
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0066 0.0732 0.126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0066 0.0732 0.2658
Toxoplasma gondii target of rapamycin (TOR), putative 0.0066 0.0732 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0027 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0068 0.0773 0.133
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0068 0.0773 0.1342
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0126 0.1936 0.336
Echinococcus multilocularis FTZ F1 alpha 0.0068 0.0773 0.133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0068 0.0773 0.0773
Echinococcus multilocularis thyroid hormone receptor alpha 0.0068 0.0773 0.133
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0126 0.1936 0.7184
Loa Loa (eye worm) hypothetical protein 0.0068 0.0773 0.0773
Schistosoma mansoni coup transcription factor 0.0068 0.0773 0.1342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Echinococcus multilocularis serine protein kinase ATM 0.0055 0.0517 0.0889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0989 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0068 0.0773 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0066 0.0732 0.2658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0068 0.0773 0.0773
Toxoplasma gondii FATC domain-containing protein 0.0055 0.0517 0.6942
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0066 0.0732 0.1271
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0068 0.0773 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.025 0.2526
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0126 0.1936 0.3331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0068 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0068 0.0773 0.0773
Giardia lamblia GTOR 0.0066 0.0732 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0126 0.1936 0.1936
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0068 0.0773 0.0773
Trypanosoma cruzi target of rapamycin kinase 3 0.0066 0.0732 0.2637
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0296 0.0296
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0078 0.0989 0.3625
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0068 0.0773 0.133
Echinococcus multilocularis importin subunit beta 1 0.003 0.0027 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0166 0.168
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0296 0.0514
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0068 0.0773 0.0773
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0267 0.0879
Brugia malayi nuclear hormone receptor 0.0068 0.0773 0.0773
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0037 0.0166 0.0286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0773 0.133
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0066 0.0732 0.2637
Brugia malayi Steroid receptor seven-up type 2 0.0068 0.0773 0.0773
Loa Loa (eye worm) phosphatidylinositol 3 0.0078 0.0989 0.0989
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Brugia malayi hypothetical protein 0.0044 0.0296 0.0296
Loa Loa (eye worm) steroid hormone receptor 0.0068 0.0773 0.0773
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.0732 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0166 0.168
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0296 0.0514
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0066 0.0732 0.2637
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0037 0.0166 0.0499
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0066 0.0732 0.2637
Brugia malayi nuclear receptor NHR-88 0.0068 0.0773 0.0773
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0068 0.0773 0.1342
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0068 0.0773 0.133
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0773 0.1342
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.0732 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0166 0.168
Brugia malayi Importin beta-1 subunit 0.003 0.0027 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1607 0.594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404
Schistosoma mansoni importin beta-1 0.003 0.0027 0.0046
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0164 0.2682 1
Brugia malayi steroid hormone receptor 0.0068 0.0773 0.0773
Leishmania major phosphatidylinositol 3-kinase, putative 0.0066 0.0732 0.2637
Loa Loa (eye worm) hypothetical protein 0.0037 0.0166 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0068 0.0773 0.0773
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0068 0.0773 0.133
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0126 0.1936 0.3331
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0055 0.0517 0.1845
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.5763 0.5763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0732 0.7404

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.54 uM Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assay ChEMBL. 21413798
IC50 (binding) = 2.2 uM Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assay ChEMBL. 21413798
IC50 (binding) > 8 uM Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay ChEMBL. 21413798

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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