Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.436 | 0.3849 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.3477 | 0.3477 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0122 | 0.2649 | 0.6076 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0086 | 0.1139 | 0.2613 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0187 | 0.5324 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | G-protein coupled receptor | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | AKH receptor | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | G-protein coupled receptor | 0.0086 | 0.1139 | 0.2613 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0187 | 0.5324 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.9506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0086 | 0.1139 | 0.2613 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.3477 | 0.3477 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | Dopamine receptor | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.436 | 0.7696 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.436 | 0.7696 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | Dopamine receptor protein 1 | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.436 | 1 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.436 | 1 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | sulfakinin receptor protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0086 | 0.1139 | 0.2613 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0158 | 0.4139 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.4139 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.436 | 0.7696 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | neuropeptide F receptor | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | RE15519p | 0.0086 | 0.1139 | 0.2613 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0142 | 0.3477 | 0.3477 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0086 | 0.1139 | 0.2613 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.436 | 0.7696 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | Melatonin receptor type 1A | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | GnHR receptor homolog | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.436 | 1 |
Brugia malayi | ORL1-like opioid receptor | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | putative neuropeptide receptor | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | follicle stimulating hormone receptor | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | G protein-coupled receptor | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | larval opioid receptor | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Brugia malayi | Dopamine receptor protein 2 | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.436 | 0.7696 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0086 | 0.1139 | 0.5 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | Cytochrome P450 family protein | 0.0122 | 0.2649 | 0.6076 |
Brugia malayi | Serotonin receptor | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.436 | 0.7696 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.436 | 1 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0086 | 0.1139 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0086 | 0.1139 | 0.2613 |
Onchocerca volvulus | 0.0086 | 0.1139 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1139 | 0.2613 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.436 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.247 uM | Inhibition of equine BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (binding) | = 0.582 uM | Inhibition of bovine AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.