Detailed information for compound 1510196

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 509.036 | Formula: C29H33ClN2O4
  • H donors: 1 H acceptors: 1 LogP: 5.51 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)[C@H]1CN(C[C@@H]1CNC(=O)c1ccccc1Cl)CCc1ccc(c(c1)OC)OC
  • InChi: 1S/C29H33ClN2O4/c1-34-23-11-9-21(10-12-23)25-19-32(15-14-20-8-13-27(35-2)28(16-20)36-3)18-22(25)17-31-29(33)24-6-4-5-7-26(24)30/h4-13,16,22,25H,14-15,17-19H2,1-3H3,(H,31,33)/t22-,25+/m0/s1
  • InChiKey: BGBREARCDHTETM-WIOPSUGQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Echinococcus granulosus Pleckstrin y 0.005 0.0056 0.005
Brugia malayi plexin A 0.0504 0.1409 0.1397
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.005 0.0056 0.005
Echinococcus granulosus pleckstrin y domain containing family A 0.005 0.0056 0.005
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0026 0.0014
Leishmania major protein kinase, putative 0.0069 0.0112 1
Schistosoma mansoni axis inhibition protein axin 0.0549 0.1542 0.1522
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.005 0.0056 0.0056
Echinococcus granulosus GRB2 associated binding protein 3 0.005 0.0056 0.005
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Schistosoma mansoni regulator of G protein signaling 0.0549 0.1542 0.1522
Brugia malayi Oxysterol-binding protein 0.005 0.0056 0.0042
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.005 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Loa Loa (eye worm) sema domain-containing protein 0.0182 0.045 0.045
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0112 0.0112
Echinococcus granulosus oxysterol binding protein 3 0.005 0.0056 0.005
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0064 0.0097 0.8202
Schistosoma mansoni axis inhibition protein axin 0.0549 0.1542 0.1522
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Brugia malayi Oxysterol binding protein 0.005 0.0056 0.0042
Echinococcus granulosus regulator of G protein signaling 3 0.0549 0.1542 0.183
Schistosoma mansoni hypothetical protein 0.005 0.0056 0.0032
Loa Loa (eye worm) hypothetical protein 0.0549 0.1542 0.1542
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0144 0.0892
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.008 0.0144 0.0892
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.005 0.0056 0.005
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Brugia malayi Regulator of G protein signaling domain containing protein 0.0549 0.1542 0.153
Trichomonas vaginalis conserved hypothetical protein 0.0549 0.1542 1
Entamoeba histolytica hypothetical protein 0.005 0.0056 0.0196
Schistosoma mansoni plexin 0.0424 0.1171 0.1149
Brugia malayi probable spectrin beta chain 0.005 0.0056 0.0042
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0064 0.0097 0.8202
Echinococcus granulosus cytohesin 1 0.005 0.0056 0.005
Onchocerca volvulus 0.0182 0.045 0.3534
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.005 0.0056 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0549 0.1542 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Brugia malayi Plekhf2 protein 0.005 0.0056 0.0042
Brugia malayi hypothetical protein 0.0549 0.1542 0.153
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Trypanosoma cruzi PH domain containing protein, putative 0.005 0.0056 0.346
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0064 0.0097 0.8202
Echinococcus granulosus axis inhibition protein axin 0.0549 0.1542 0.183
Echinococcus multilocularis transcription factor collier 0.008 0.0144 0.0155
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Schistosoma mansoni regulator of G protein signaling 0.0549 0.1542 0.1522
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Echinococcus granulosus calcium dependent secretion activator 1 0.005 0.0056 0.005
Entamoeba histolytica protein kinase, putative 0.0069 0.0112 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0144 0.0892
Trypanosoma cruzi hypothetical protein 0.005 0.0056 0.346
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.005 0.0056 0.005
Schistosoma mansoni hypothetical protein 0.0242 0.0627 0.0604
Loa Loa (eye worm) hypothetical protein 0.0182 0.045 0.045
Loa Loa (eye worm) RhoGEF domain-containing protein 0.005 0.0056 0.0056
Entamoeba histolytica protein kinase, putative 0.0064 0.0097 0.0465
Entamoeba histolytica hypothetical protein 0.005 0.0056 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Schistosoma mansoni hypothetical protein 0.005 0.0056 0.0032
Leishmania major folate/biopterin transporter, putative 0.0064 0.0097 0.8202
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.008 0.0144 0.0892
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.0112 1
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Brugia malayi regulator of G-protein signaling rgs-7 0.0549 0.1542 0.153
Schistosoma mansoni protein kinase 0.004 0.0026 0.0002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0064 0.0097 0.8202
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.008 0.0144 0.0892
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0112 0.0112
Brugia malayi PXA domain containing protein 0.0549 0.1542 0.153
Loa Loa (eye worm) PXA domain-containing protein 0.0549 0.1542 0.1542
Entamoeba histolytica hypothetical protein, conserved domain containing 0.005 0.0056 0.0196
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Echinococcus multilocularis Pleckstrin y 0.005 0.0056 0.005
Echinococcus granulosus Rho GTPase activating protein 24 0.005 0.0056 0.005
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.005 0.0056 0.005
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0144 0.0892
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.0112 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0144
Echinococcus multilocularis Immunoglobulin 0.0046 0.0044 0.0036
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0064 0.0097 0.8202
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0144 0.0892
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0064 0.0097 0.8202
Trichomonas vaginalis protein transport protein sec7, putative 0.005 0.0056 0.0317
Brugia malayi Variant SH3 domain containing protein 0.005 0.0056 0.0042
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.005 0.0056 0.005
Entamoeba histolytica PH domain containing protein 0.005 0.0056 0.0196
Echinococcus multilocularis regulator of G protein signaling 7 0.0549 0.1542 0.183
Trichomonas vaginalis alpha chimerin, putative 0.005 0.0056 0.0317
Brugia malayi Protein kinase domain containing protein 0.0279 0.0738 0.0725
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2836 0.8363 1
Entamoeba histolytica hypothetical protein 0.008 0.0144 0.0778
Loa Loa (eye worm) hypothetical protein 0.0549 0.1542 0.1542
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0549 0.1542 0.1522
Entamoeba histolytica protein kinase, putative 0.0064 0.0097 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Trypanosoma cruzi hypothetical protein 0.005 0.0056 0.346
Echinococcus granulosus oxysterol binding protein 1 0.005 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.0182 0.045 0.045
Echinococcus multilocularis myotubularin protein 13 0.005 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.0222 0.0568 0.0568
Echinococcus granulosus semaphorin 5B 0.0182 0.045 0.0522
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2836 0.8363 1
Echinococcus granulosus semaphorin 1A 0.0182 0.045 0.0522
Schistosoma mansoni hypothetical protein 0.0182 0.045 0.0427
Leishmania major hypothetical protein, conserved 0.005 0.0056 0.346
Echinococcus granulosus activin receptor type 0.004 0.0026 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0144 0.0892
Schistosoma mansoni rhogef and pleckstrin domain protein 0.005 0.0056 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Trichomonas vaginalis centaurin gamma, putative 0.005 0.0056 0.0317
Echinococcus granulosus roundabout 2 0.0046 0.0044 0.0036
Brugia malayi DNA-binding protein LAG-1 0.008 0.0144 0.013
Schistosoma mansoni protein kinase 0.0069 0.0112 0.0088
Entamoeba histolytica protein kinase , putative 0.0069 0.0112 0.0567
Toxoplasma gondii aurora kinase 0.0069 0.0112 1
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Echinococcus multilocularis expressed protein 0.0549 0.1542 0.183
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0144
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0549 0.1542 0.1522
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Brugia malayi Cytohesin 3 0.005 0.0056 0.0042
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.0112 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.2594 0.7643 0.7638
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Echinococcus multilocularis Rho GTPase activating protein 24 0.005 0.0056 0.005
Brugia malayi Syntrophin-1 0.005 0.0056 0.0042
Schistosoma mansoni oxysterol-binding protein 1 0.005 0.0056 0.0032
Brugia malayi Variant SH3 domain containing protein 0.005 0.0056 0.0042
Loa Loa (eye worm) AGC/AKT protein kinase 0.0064 0.0097 0.0097
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.005 0.0056 0.346
Brugia malayi Uncoordinated protein 104 0.005 0.0056 0.0042
Entamoeba histolytica cell surface protease gp63, putative 0.008 0.0144 0.0778
Loa Loa (eye worm) hypothetical protein 0.0549 0.1542 0.1542
Trichomonas vaginalis conserved hypothetical protein 0.0549 0.1542 1
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0144 0.0892
Brugia malayi GTP-ase activating protein for Arf containing protein 0.005 0.0056 0.0042
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Echinococcus multilocularis axis inhibition protein axin 0.0549 0.1542 0.183
Echinococcus granulosus dual specificity testis-specific protein kinase 0.004 0.0026 0.0014
Entamoeba histolytica protein kinase, putative 0.0064 0.0097 0.0465
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0144 0.0892
Trichomonas vaginalis kinesin light chain, putative 0.005 0.0056 0.0317
Echinococcus multilocularis Ras associated and pleckstrin y 0.005 0.0056 0.005
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.005 0.0056 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Echinococcus multilocularis beta adrenergic receptor kinase 0.2594 0.7643 0.9137
Entamoeba histolytica hypothetical protein 0.0064 0.0097 0.0465
Echinococcus multilocularis dynamin 1 0.005 0.0056 0.005
Echinococcus granulosus regulator of G protein signaling 7 0.0549 0.1542 0.183
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0112 0.0088
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2836 0.8363 0.8363
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.005 0.0056 0.0317
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0112 0.0683
Brugia malayi Dynamin 0.005 0.0056 0.0042
Echinococcus granulosus aurora kinase A 0.0069 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0549 0.1542 0.1542
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0014 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0112 0.0683
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Echinococcus granulosus pdz domain containing protein 0.005 0.0056 0.005
Entamoeba histolytica hypothetical protein 0.008 0.0144 0.0778
Echinococcus granulosus exocyst complex component 2 0.008 0.0144 0.0155
Loa Loa (eye worm) oxysterol binding protein 0.005 0.0056 0.0056
Schistosoma mansoni myotubularin-related protein 0.005 0.0056 0.0032
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0064 0.0097 0.725
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Schistosoma mansoni z-protein (S1r protein) 0.0549 0.1542 0.1522
Echinococcus granulosus defective proboscis extension response 0.0046 0.0044 0.0036
Entamoeba histolytica protein kinase, putative 0.0064 0.0097 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Echinococcus granulosus G protein coupled receptor kinase 1 0.2046 0.6007 0.7177
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0064 0.0097 0.8202
Plasmodium falciparum PH domain-containing protein, putative 0.005 0.0056 0.346
Schistosoma mansoni oxysterol-binding protein 1 0.005 0.0056 0.0032
Echinococcus multilocularis oxysterol binding protein 9 0.005 0.0056 0.005
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.008 0.0144 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Entamoeba histolytica hypothetical protein, conserved 0.005 0.0056 0.0196
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0064 0.0097 0.0582
Leishmania major protein kinase, putative 0.0064 0.0097 0.8202
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.005 0.0056 0.346
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.005 0.0056 0.346
Brugia malayi hypothetical protein 0.0046 0.0044 0.003
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0046 0.0044 0.002
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Echinococcus granulosus Oxysterol binding protein 11 0.005 0.0056 0.005
Brugia malayi Protein kinase domain containing protein 0.0064 0.0097 0.0082
Schistosoma mansoni goodpasture antigen-binding protein 0.005 0.0056 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0549 0.1542 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.005 0.0056 0.005
Entamoeba histolytica hypothetical protein, conserved domain containing 0.005 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Echinococcus granulosus Pleckstrin domain containing protein family B 0.005 0.0056 0.005
Schistosoma mansoni protein kinase 0.004 0.0026 0.0002
Entamoeba histolytica PH domain containing protein kinase, putative 0.0064 0.0097 0.0465
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Brugia malayi Fibronectin type III domain containing protein 0.0046 0.0044 0.003
Trichomonas vaginalis centaurin/arf, putative 0.005 0.0056 0.0317
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0064 0.0097 0.8202
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0112 0.0683
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.005 0.0056 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Echinococcus multilocularis neuroglian 0.0046 0.0044 0.0036
Echinococcus multilocularis rac serine:threonine kinase 0.0064 0.0097 0.0098
Echinococcus granulosus regulator of G protein signaling 7 0.0549 0.1542 0.183
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0124 0.011
Echinococcus multilocularis roundabout 2 0.0046 0.0044 0.0036
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.005 0.0056 0.346
Trichomonas vaginalis centaurin/arf, putative 0.005 0.0056 0.0317
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0064 0.0097 0.8202
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.005 0.0056 0.005
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0046 0.0044 0.002
Echinococcus granulosus Pleckstrin y 0.005 0.0056 0.005
Echinococcus multilocularis beta 1 syntrophin 0.005 0.0056 0.005
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.005 0.0056 0.0056
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0064 0.0097 0.8202
Loa Loa (eye worm) hypothetical protein 0.0549 0.1542 0.1542
Giardia lamblia Aurora kinase 0.0069 0.0112 0.5
Schistosoma mansoni rho gtpase activating protein 0.005 0.0056 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0549 0.1542 0.1542
Echinococcus granulosus Pleckstrin y 0.005 0.0056 0.005
Schistosoma mansoni hypothetical protein 0.005 0.0056 0.0032
Loa Loa (eye worm) variant SH3 domain-containing protein 0.005 0.0056 0.0056
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0046 0.0044 0.0036
Trypanosoma cruzi hypothetical protein 0.005 0.0056 0.346
Brugia malayi GTP-ase activating protein for Arf containing protein 0.005 0.0056 0.0042
Entamoeba histolytica hypothetical protein, conserved domain containing 0.005 0.0056 0.0196
Echinococcus multilocularis Regulator of G protein signaling 20 0.0549 0.1542 0.183
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Entamoeba histolytica hypothetical protein 0.008 0.0144 0.0778
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Brugia malayi Cadps2 protein 0.005 0.0056 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0549 0.1542 1
Echinococcus multilocularis Pleckstrin y 0.005 0.0056 0.005
Schistosoma mansoni vesicular amine transporter 0.0049 0.0051 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.005 0.0056 0.346
Echinococcus multilocularis Oxysterol binding protein 11 0.005 0.0056 0.005
Entamoeba histolytica PH domain containing protein 0.005 0.0056 0.0196
Entamoeba histolytica PH domain containing protein kinase, putative 0.0064 0.0097 0.0465
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Echinococcus multilocularis calcium dependent secretion activator 1 0.005 0.0056 0.005
Schistosoma mansoni regulator of G protein signaling 0.0549 0.1542 0.1522
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Echinococcus multilocularis activin receptor type 0.004 0.0026 0.0014
Toxoplasma gondii phosphatidylinositol transfer protein 0.005 0.0056 0.346
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2836 0.8363 0.8361
Echinococcus granulosus neuroglian 0.0046 0.0044 0.0036
Echinococcus multilocularis pleckstrin y domain containing family A 0.005 0.0056 0.005
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0549 0.1542 0.183
Echinococcus granulosus serine/threonine protein kinase 0.0064 0.0097 0.0098
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Entamoeba histolytica hypothetical protein 0.005 0.0056 0.0196
Schistosoma mansoni hypothetical protein 0.005 0.0056 0.0032
Echinococcus granulosus DCC interacting protein 13 beta 0.005 0.0056 0.005
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0064 0.0097 0.8202
Trypanosoma brucei protein kinase, putative 0.0064 0.0097 0.8202
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Toxoplasma gondii AtPH1 family protein 0.005 0.0056 0.346
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0046 0.0044 0.0036
Echinococcus multilocularis regulator of G protein signaling 0.0549 0.1542 0.183
Onchocerca volvulus 0.0424 0.1171 1
Brugia malayi IPT/TIG domain containing protein 0.008 0.0144 0.013
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Brugia malayi MAX-1A 0.005 0.0056 0.0042
Schistosoma mansoni cell adhesion molecule 0.0046 0.0044 0.002
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.0112 0.0567
Entamoeba histolytica PH domain containing protein kinase, putative 0.0064 0.0097 0.0465
Brugia malayi hypothetical protein 0.0549 0.1542 0.153
Echinococcus multilocularis pdz domain containing protein 0.005 0.0056 0.005
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.005 0.0056 0.005
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.005 0.0056 0.346
Leishmania major protein kinase, putative 0.0064 0.0097 0.8202
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Brugia malayi Regulator of G protein signaling domain containing protein 0.0549 0.1542 0.153
Entamoeba histolytica p21-activated kinase 0.0064 0.0097 0.0465
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0549 0.1542 0.183
Echinococcus multilocularis exocyst complex component 2 0.008 0.0144 0.0155
Schistosoma mansoni plexin 0.0242 0.0627 0.0604
Loa Loa (eye worm) Plekhf2 protein 0.005 0.0056 0.0056
Schistosoma mansoni goodpasture antigen-binding protein 0.005 0.0056 0.0032
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.0112 0.0567
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Schistosoma mansoni dynamin 0.005 0.0056 0.0032
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.0112 1
Schistosoma mansoni regulator of G protein signaling 0.0549 0.1542 0.1522
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0064 0.0097 0.8202
Brugia malayi serine/threonine protein kinase 6 0.0069 0.0112 0.0098
Entamoeba histolytica hypothetical protein 0.0549 0.1542 1
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.005 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.0242 0.0627 0.0627
Schistosoma mansoni nephrin 0.0046 0.0044 0.002
Echinococcus multilocularis oxysterol binding protein 1 0.005 0.0056 0.005
Trypanosoma cruzi PH domain containing protein, putative 0.005 0.0056 0.346
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Loa Loa (eye worm) rho-GTPase-activating 0.005 0.0056 0.0056
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.0112 0.0098
Entamoeba histolytica protein kinase, putative 0.0064 0.0097 0.0465
Trypanosoma cruzi PH domain containing protein, putative 0.005 0.0056 0.346
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Trichomonas vaginalis centaurin beta, putative 0.005 0.0056 0.0317
Schistosoma mansoni hypothetical protein 0.008 0.0144 0.012
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0064 0.0097 0.8202
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Brugia malayi A-kinase anchor protein 10, precursor 0.0549 0.1542 0.153
Entamoeba histolytica hypothetical protein 0.008 0.0144 0.0778
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0112 0.0683
Echinococcus multilocularis regulator of G protein signaling 3 0.0549 0.1542 0.183
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.005 0.0056 0.0317
Brugia malayi hypothetical protein 0.0182 0.045 0.0436
Schistosoma mansoni dynamin 0.005 0.0056 0.0032
Trichomonas vaginalis centaurin alpha, putative 0.005 0.0056 0.0317
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.0112 1
Schistosoma mansoni hypothetical protein 0.0182 0.045 0.0427
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0549 0.1542 0.1522
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.005 0.0056 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Brugia malayi Probable exocyst complex component Sec5 0.008 0.0144 0.013
Trypanosoma cruzi Protein kinase B 0.0064 0.0097 0.8202
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Loa Loa (eye worm) hypothetical protein 0.0182 0.045 0.045
Echinococcus granulosus oxysterol binding protein 9 0.005 0.0056 0.005
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2046 0.6007 0.7177
Trichomonas vaginalis hypothetical protein 0.005 0.0056 0.0317
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0144
Entamoeba histolytica hypothetical protein 0.0064 0.0097 0.0465
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0044 0.003
Entamoeba histolytica PH domain containing protein kinase, putative 0.0064 0.0097 0.0465
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Echinococcus granulosus axis inhibition protein axin 0.0549 0.1542 0.183
Entamoeba histolytica PH domain containing protein kinase, putative 0.0064 0.0097 0.0465
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Echinococcus granulosus expressed protein 0.0549 0.1542 0.183
Brugia malayi Dynamin 0.005 0.0056 0.0042
Entamoeba histolytica PH domain containing protein 0.005 0.0056 0.0196
Echinococcus multilocularis actin binding protein anillin 0.005 0.0056 0.005
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.005 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Schistosoma mansoni centaurin alpha 0.005 0.0056 0.0032
Entamoeba histolytica protein kinase, putative 0.0069 0.0112 0.0567
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0064 0.0097 0.8202
Trypanosoma cruzi hypothetical protein 0.005 0.0056 0.346
Loa Loa (eye worm) RGS-3 protein 0.0549 0.1542 0.1542
Echinococcus granulosus Immunoglobulin 0.0046 0.0044 0.0036
Schistosoma mansoni protein kinase 0.004 0.0026 0.0002
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.2594 0.7643 0.7643
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.005 0.0056 0.0042
Echinococcus granulosus twitchin 0.006 0.0085 0.0085
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Schistosoma mansoni serine/threonine-protein kinase 0.0064 0.0097 0.0072
Brugia malayi regulator of G-protein signaling egl-10 0.0549 0.1542 0.153
Schistosoma mansoni hypothetical protein 0.008 0.0144 0.012
Entamoeba histolytica tyrosin kinase, putative 0.0107 0.0224 0.1304
Trypanosoma cruzi NIMA-related kinase, putative 0.0064 0.0097 0.8202
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Echinococcus multilocularis Pleckstrin y 0.005 0.0056 0.005
Loa Loa (eye worm) TK/ALK protein kinase 0.0279 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0182 0.045 0.045
Schistosoma mansoni semaphorin 5-related 0.0182 0.045 0.0427
Trichomonas vaginalis protein transport protein sec7, putative 0.005 0.0056 0.0317
Trypanosoma cruzi hypothetical protein 0.005 0.0056 0.346
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Schistosoma mansoni regulator of G protein signaling 0.0549 0.1542 0.1522
Schistosoma mansoni fibrocystin l 0.008 0.0144 0.012
Entamoeba histolytica ARF GTPase activating protein, putative 0.005 0.0056 0.0196
Loa Loa (eye worm) PH domain-containing protein 0.005 0.0056 0.0056
Toxoplasma gondii protein kinase domain-containing protein 0.0064 0.0097 0.8202
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Schistosoma mansoni zinc finger protein 0.005 0.0056 0.0032
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.005 0.0056 0.346
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Echinococcus multilocularis GRB2 associated binding protein 3 0.005 0.0056 0.005
Schistosoma mansoni syntrophin 0.005 0.0056 0.0032
Echinococcus granulosus myotubularin protein 13 0.005 0.0056 0.005
Echinococcus granulosus plexin a4 0.0504 0.1409 0.167
Brugia malayi hypothetical protein 0.005 0.0056 0.0042
Echinococcus granulosus beta 1 syntrophin 0.005 0.0056 0.005
Loa Loa (eye worm) plexin A 0.0504 0.1409 0.1409
Echinococcus multilocularis oxysterol binding protein 3 0.005 0.0056 0.005
Echinococcus multilocularis dual specificity testis specific protein kinase 0.004 0.0026 0.0014
Toxoplasma gondii hypothetical protein 0.005 0.0056 0.346
Brugia malayi Plexin repeat family protein 0.0424 0.1171 0.1158
Trichomonas vaginalis conserved hypothetical protein 0.0549 0.1542 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0064 0.0097 0.8202
Schistosoma mansoni growth factor receptor-bound protein 0.005 0.0056 0.0032
Schistosoma mansoni guanyl-nucleotide exchange factor 0.005 0.0056 0.0032
Schistosoma mansoni hypothetical protein 0.005 0.0056 0.0032
Echinococcus multilocularis cytohesin 1 0.005 0.0056 0.005
Echinococcus multilocularis Immunoglobulin 0.0046 0.0044 0.0036
Echinococcus granulosus transcription factor collier 0.008 0.0144 0.0155
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Entamoeba histolytica hypothetical protein 0.005 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.008 0.0144 0.0892
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Leishmania major serine/threonine-protein kinase a, putative 0.0064 0.0097 0.8202
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0073 0.0124 0.0124
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2836 0.8363 0.8363
Trichomonas vaginalis conserved hypothetical protein 0.0549 0.1542 1
Trypanosoma cruzi hypothetical protein 0.005 0.0056 0.346
Plasmodium falciparum oxysterol-binding protein, putative 0.005 0.0056 0.346
Loa Loa (eye worm) uncoordinated protein 104 0.005 0.0056 0.0056
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0549 0.1542 0.1542
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Brugia malayi Sema domain containing protein 0.0182 0.045 0.0436
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.005 0.0056 0.005
Brugia malayi Sema domain containing protein 0.0182 0.045 0.0436
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.005 0.0056 0.0317
Echinococcus multilocularis DCC interacting protein 13 beta 0.005 0.0056 0.005
Schistosoma mansoni vav2 0.005 0.0056 0.0032
Echinococcus multilocularis regulator of G protein signaling 3 0.0549 0.1542 0.183
Entamoeba histolytica hypothetical protein 0.0549 0.1542 1
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Loa Loa (eye worm) syntrophin-1 0.005 0.0056 0.0056
Echinococcus granulosus beta-adrenergic receptor kinase 0.2594 0.7643 0.9137
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.0112 0.0567
Echinococcus multilocularis regulator of G protein signaling 7 0.0549 0.1542 0.183
Brugia malayi hypothetical protein 0.0182 0.045 0.0436
Echinococcus multilocularis aurora kinase A 0.0069 0.0112 0.0117
Entamoeba histolytica hypothetical protein 0.005 0.0056 0.0196
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.005 0.0056 0.005
Echinococcus multilocularis hypothetical protein 0.0182 0.045 0.0522
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.005 0.0056 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0549 0.1542 1
Entamoeba histolytica protein kinase domain containing protein 0.0107 0.0224 0.1304
Trypanosoma brucei rac serine-threonine kinase, putative 0.0064 0.0097 0.8202
Brugia malayi Pleckstrin Homology Domain 0.005 0.0056 0.0042
Echinococcus granulosus Regulator of G protein signaling 20 0.0549 0.1542 0.183
Echinococcus multilocularis semaphorin 5B 0.0182 0.045 0.0522
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Trypanosoma cruzi NIMA-related kinase, putative 0.0064 0.0097 0.8202
Trypanosoma brucei PH domain containing protein, putative 0.005 0.0056 0.346
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0097 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Loa Loa (eye worm) cytohesin 3 0.005 0.0056 0.0056
Echinococcus granulosus dynamin 1 0.005 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Brugia malayi serine/threonine kinase 12 0.0069 0.0112 0.0098
Echinococcus multilocularis plexin a4 0.0504 0.1409 0.167
Entamoeba histolytica protein kinase, putative 0.0064 0.0097 0.0465
Entamoeba histolytica protein kinase, putative 0.0064 0.0097 0.0465
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0056
Brugia malayi PXA domain containing protein 0.0549 0.1542 0.153
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0056 0.0317
Plasmodium falciparum calcium-dependent protein kinase 7 0.0064 0.0097 0.8202
Echinococcus granulosus regulator of G protein signaling 3 0.0549 0.1542 0.183
Schistosoma mansoni serine/threonine-protein kinase 0.0064 0.0097 0.0072
Loa Loa (eye worm) hypothetical protein 0.0182 0.045 0.045
Toxoplasma gondii Oxysterol-binding protein 0.005 0.0056 0.346
Echinococcus multilocularis axis inhibition protein axin 0.0549 0.1542 0.183
Leishmania major hypothetical protein, conserved 0.005 0.0056 0.346
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.005 0.0056 0.0032
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0064 0.0097 0.0582
Schistosoma mansoni zinc finger protein 0.005 0.0056 0.0032
Loa Loa (eye worm) hypothetical protein 0.0182 0.045 0.045
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0064 0.0097 0.8202
Brugia malayi PH domain containing protein 0.005 0.0056 0.0042
Trypanosoma cruzi PH domain containing protein, putative 0.005 0.0056 0.346
Schistosoma mansoni serine/threonine protein kinase 0.2594 0.7643 0.7638
Entamoeba histolytica hypothetical protein, conserved domain containing 0.005 0.0056 0.0196
Brugia malayi TBC domain containing protein 0.005 0.0056 0.0042
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.005 0.0056 0.0196
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.0112 0.0117
Entamoeba histolytica PH domain containing protein kinase, putative 0.0064 0.0097 0.0465
Loa Loa (eye worm) sema domain-containing protein 0.0182 0.045 0.045
Trypanosoma cruzi hypothetical protein 0.005 0.0056 0.346
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.005 0.0056 0.0317
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.005 0.0056 0.005
Entamoeba histolytica hypothetical protein, conserved domain containing 0.005 0.0056 0.0196
Toxoplasma gondii hypothetical protein 0.005 0.0056 0.346
Trypanosoma brucei aurora B kinase 0.0069 0.0112 1
Loa Loa (eye worm) hypothetical protein 0.0424 0.1171 0.1171

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM Antagonist activity at MCHR1 by aequorin bioluminescence assay ChEMBL. 21414780

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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