Detailed information for compound 1510203

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.245 | Formula: C18H17IN2O
  • H donors: 0 H acceptors: 2 LogP: 3.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C=C/c1ccc(nc1)I)/C=C/c1ccc(cc1)N(C)C
  • InChi: 1S/C18H17IN2O/c1-21(2)16-8-3-14(4-9-16)5-10-17(22)11-6-15-7-12-18(19)20-13-15/h3-13H,1-2H3/b10-5+,11-6+
  • InChiKey: OPLXTZIAYIRERS-YOYBCKCWSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Echinococcus granulosus oxysterol binding protein 9 0.0038 0.0027 0.0032
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.005 0.0073 0.0411
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Trypanosoma cruzi PH domain containing protein, putative 0.0038 0.0027 0.1895
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Toxoplasma gondii hypothetical protein 0.0038 0.0027 0.1895
Trypanosoma brucei PH domain containing protein, putative 0.0038 0.0027 0.1895
Echinococcus granulosus myotubularin protein 13 0.0038 0.0027 0.0032
Echinococcus granulosus roundabout 2 0.0082 0.0202 0.0242
Schistosoma mansoni goodpasture antigen-binding protein 0.0038 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Schistosoma mansoni goodpasture antigen-binding protein 0.0038 0.0027 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0415 0.1518 0.1518
Echinococcus multilocularis dynamin 1 0.0038 0.0027 0.0032
Loa Loa (eye worm) rho-GTPase-activating 0.0038 0.0027 0.0025
Echinococcus multilocularis GRB2 associated binding protein 3 0.0038 0.0027 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0038 0.0027 0.0103
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0038 0.0027 0.0103
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Brugia malayi IPT/TIG domain containing protein 0.005 0.0073 0.0053
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Trypanosoma cruzi PH domain containing protein, putative 0.0038 0.0027 0.1895
Entamoeba histolytica hypothetical protein 0.0038 0.0027 0.0178
Entamoeba histolytica protein kinase, putative 0.0049 0.0068 0.045
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0027 0.0006
Echinococcus granulosus exocyst complex component 2 0.005 0.0073 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0073 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0049 0.0068 0.4799
Entamoeba histolytica PH domain containing protein kinase, putative 0.0049 0.0068 0.045
Trypanosoma cruzi Protein kinase B 0.0049 0.0068 0.4799
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0415 0.1518 1
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0142 0.0938
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0038 0.0027 0.1895
Echinococcus granulosus GRB2 associated binding protein 3 0.0038 0.0027 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Loa Loa (eye worm) PH domain-containing protein 0.0038 0.0027 0.0025
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Schistosoma mansoni hypothetical protein 0.0038 0.0027 0.0027
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0038 0.0027 0.0032
Trypanosoma cruzi hypothetical protein 0.0038 0.0027 0.1895
Entamoeba histolytica cell surface protease gp63, putative 0.005 0.0073 0.0484
Echinococcus granulosus regulator of G protein signaling 3 0.0415 0.1518 0.1816
Entamoeba histolytica protein kinase , putative 0.0067 0.0142 0.0938
Entamoeba histolytica PH domain containing protein 0.0038 0.0027 0.0178
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0038 0.0027 0.1895
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0415 0.1518 0.1816
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0038 0.0027 0.0027
Brugia malayi Pleckstrin Homology Domain 0.0038 0.0027 0.0006
Echinococcus granulosus pdz domain containing protein 0.0038 0.0027 0.0032
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0027 0.0027
Echinococcus granulosus defective proboscis extension response 0.0082 0.0202 0.0242
Plasmodium falciparum serine/threonine protein kinase, putative 0.0067 0.0142 1
Schistosoma mansoni hypothetical protein 0.005 0.0073 0.0073
Toxoplasma gondii aurora kinase 0.0067 0.0142 1
Echinococcus granulosus transcription factor collier 0.005 0.0073 0.0088
Echinococcus multilocularis expressed protein 0.0415 0.1518 0.1816
Loa Loa (eye worm) AUR protein kinase 0.0067 0.0142 0.014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Echinococcus multilocularis regulator of G protein signaling 0.0415 0.1518 0.1816
Schistosoma mansoni fibrocystin l 0.005 0.0073 0.0073
Brugia malayi serine/threonine protein kinase 6 0.0067 0.0142 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.1964 0.7637 0.7637
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0038 0.0027 0.0178
Schistosoma mansoni vav2 0.0038 0.0027 0.0027
Echinococcus granulosus beta 1 syntrophin 0.0038 0.0027 0.0032
Brugia malayi Probable exocyst complex component Sec5 0.005 0.0073 0.0053
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Loa Loa (eye worm) PXA domain-containing protein 0.0415 0.1518 0.1516
Echinococcus multilocularis neuroglian 0.0082 0.0202 0.0242
Schistosoma mansoni regulator of G protein signaling 0.0415 0.1518 0.1518
Brugia malayi Immunoglobulin I-set domain containing protein 0.0082 0.0202 0.0182
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0038 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0021 0.0025
Brugia malayi hypothetical protein 0.0415 0.1518 0.15
Entamoeba histolytica hypothetical protein 0.005 0.0073 0.0484
Trichomonas vaginalis centaurin/arf, putative 0.0038 0.0027 0.0103
Brugia malayi Fibronectin type III domain containing protein 0.0082 0.0202 0.0182
Echinococcus granulosus serine/threonine protein kinase 0.0049 0.0068 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0038 0.0027 0.0032
Entamoeba histolytica PH domain containing protein kinase, putative 0.0049 0.0068 0.045
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.005 0.0073 0.0411
Echinococcus granulosus beta-adrenergic receptor kinase 0.1964 0.7637 0.9136
Brugia malayi Regulator of G protein signaling domain containing protein 0.0415 0.1518 0.15
Leishmania major protein kinase, putative 0.0049 0.0068 0.4799
Echinococcus multilocularis actin binding protein anillin 0.0038 0.0027 0.0032
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2147 0.8359 0.8355
Entamoeba histolytica hypothetical protein 0.005 0.0073 0.0484
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0038 0.0027 0.0027
Leishmania major protein kinase, putative 0.0067 0.0142 1
Echinococcus granulosus aurora kinase A 0.0067 0.0142 0.017
Echinococcus granulosus expressed protein 0.0415 0.1518 0.1816
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0067 0.0142 0.0938
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Entamoeba histolytica protein kinase, putative 0.0067 0.0142 0.0938
Entamoeba histolytica tyrosin kinase, putative 0.0071 0.0156 0.1026
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Echinococcus multilocularis pdz domain containing protein 0.0038 0.0027 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0073 0.0411
Loa Loa (eye worm) hypothetical protein 0.0415 0.1518 0.1516
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0049 0.0068 0.4799
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1549 0.5995 0.7172
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0049 0.0068 0.4799
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0038 0.0027 0.0032
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0038 0.0027 0.1895
Echinococcus multilocularis regulator of G protein signaling 7 0.0415 0.1518 0.1816
Trichomonas vaginalis centaurin beta, putative 0.0038 0.0027 0.0103
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Echinococcus multilocularis aurora kinase A 0.0067 0.0142 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0415 0.1518 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0415 0.1518 0.1816
Echinococcus granulosus Pleckstrin y 0.0038 0.0027 0.0032
Echinococcus multilocularis oxysterol binding protein 9 0.0038 0.0027 0.0032
Echinococcus granulosus dynamin 1 0.0038 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Brugia malayi Cadps2 protein 0.0038 0.0027 0.0006
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0072
Trichomonas vaginalis alpha chimerin, putative 0.0038 0.0027 0.0103
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0067 0.0142 0.017
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0072
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0067 0.0142 0.017
Toxoplasma gondii Oxysterol-binding protein 0.0038 0.0027 0.1895
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Echinococcus granulosus oxysterol binding protein 1 0.0038 0.0027 0.0032
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0038 0.0027 0.0178
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0038 0.0027 0.0032
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0049 0.0068 0.4799
Echinococcus multilocularis regulator of G protein signaling 3 0.0415 0.1518 0.1816
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0049 0.0068 0.4799
Loa Loa (eye worm) hypothetical protein 0.0146 0.0452 0.0451
Echinococcus multilocularis Immunoglobulin 0.0082 0.0202 0.0242
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2147 0.8359 0.8358
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0415 0.1518 0.1516
Echinococcus granulosus axis inhibition protein axin 0.0415 0.1518 0.1816
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Schistosoma mansoni hypothetical protein 0.0038 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Entamoeba histolytica protein kinase, putative 0.0049 0.0068 0.045
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0038 0.0027 0.0025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0103 0.0285 0.0264
Schistosoma mansoni hypothetical protein 0.0114 0.0326 0.0326
Brugia malayi hypothetical protein 0.0114 0.0326 0.0306
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2147 0.8359 1
Echinococcus granulosus twitchin 0.0093 0.0244 0.0291
Loa Loa (eye worm) sema domain-containing protein 0.0114 0.0326 0.0324
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0049 0.0068 0.4799
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0082 0.0202 0.0242
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0021 0.0025
Entamoeba histolytica protein kinase, putative 0.0049 0.0068 0.045
Trichomonas vaginalis hypothetical protein 0.0038 0.0027 0.0103
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0038 0.0027 0.1895
Loa Loa (eye worm) plexin A 0.0309 0.1099 0.1097
Trypanosoma cruzi hypothetical protein 0.0038 0.0027 0.1895
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0038 0.0027 0.0032
Echinococcus multilocularis Regulator of G protein signaling 20 0.0415 0.1518 0.1816
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0142 0.0869
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0038 0.0027 0.0006
Schistosoma mansoni axis inhibition protein axin 0.0415 0.1518 0.1518
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0038 0.0027 0.0032
Entamoeba histolytica hypothetical protein 0.0038 0.0027 0.0178
Trypanosoma brucei rac serine-threonine kinase, putative 0.0049 0.0068 0.4799
Brugia malayi Cytohesin 3 0.0038 0.0027 0.0006
Loa Loa (eye worm) sema domain-containing protein 0.0114 0.0326 0.0324
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0142 0.0869
Loa Loa (eye worm) RGS-3 protein 0.0415 0.1518 0.1516
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0049 0.0068 0.4799
Entamoeba histolytica hypothetical protein 0.0038 0.0027 0.0178
Schistosoma mansoni rho gtpase activating protein 0.0038 0.0027 0.0027
Echinococcus multilocularis pleckstrin y domain containing family A 0.0038 0.0027 0.0032
Brugia malayi regulator of G-protein signaling rgs-7 0.0415 0.1518 0.15
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0038 0.0027 0.0032
Schistosoma mansoni z-protein (S1r protein) 0.0415 0.1518 0.1518
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.0156 0.1026
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0073 0.0411
Trypanosoma cruzi hypothetical protein 0.0038 0.0027 0.1895
Entamoeba histolytica hypothetical protein 0.0415 0.1518 1
Trichomonas vaginalis conserved hypothetical protein 0.0415 0.1518 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Schistosoma mansoni plexin 0.026 0.0902 0.0902
Loa Loa (eye worm) uncoordinated protein 104 0.0038 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Schistosoma mansoni dynamin 0.0038 0.0027 0.0027
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0049 0.0068 0.4799
Trypanosoma cruzi PH domain containing protein, putative 0.0038 0.0027 0.1895
Echinococcus granulosus Pleckstrin y 0.0038 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0114 0.0326 0.0324
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0415 0.1518 0.1518
Echinococcus multilocularis Pleckstrin y 0.0038 0.0027 0.0032
Trichomonas vaginalis kinesin light chain, putative 0.0038 0.0027 0.0103
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0038 0.0027 0.0006
Echinococcus multilocularis cytohesin 1 0.0038 0.0027 0.0032
Brugia malayi regulator of G-protein signaling egl-10 0.0415 0.1518 0.15
Loa Loa (eye worm) Plekhf2 protein 0.0038 0.0027 0.0025
Entamoeba histolytica protein kinase, putative 0.0049 0.0068 0.045
Loa Loa (eye worm) hypothetical protein 0.0415 0.1518 0.1516
Echinococcus granulosus neuroglian 0.0082 0.0202 0.0242
Echinococcus granulosus Oxysterol binding protein 11 0.0038 0.0027 0.0032
Schistosoma mansoni regulator of G protein signaling 0.0415 0.1518 0.1518
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Schistosoma mansoni nephrin 0.0082 0.0202 0.0202
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0067 0.0142 0.0938
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0049 0.0068 0.4799
Brugia malayi Sema domain containing protein 0.0114 0.0326 0.0306
Schistosoma mansoni plexin 0.0146 0.0452 0.0452
Entamoeba histolytica hypothetical protein 0.005 0.0073 0.0484
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Echinococcus granulosus calcium dependent secretion activator 1 0.0038 0.0027 0.0032
Echinococcus multilocularis Ras associated and pleckstrin y 0.0038 0.0027 0.0032
Echinococcus multilocularis Oxysterol binding protein 11 0.0038 0.0027 0.0032
Entamoeba histolytica hypothetical protein 0.0049 0.0068 0.045
Echinococcus multilocularis Pleckstrin y 0.0038 0.0027 0.0032
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0082 0.0202 0.0202
Echinococcus multilocularis exocyst complex component 2 0.005 0.0073 0.0088
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0142 0.0869
Schistosoma mansoni serine/threonine-protein kinase 0.0049 0.0068 0.0068
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0049 0.0068 0.4799
Echinococcus granulosus semaphorin 5B 0.0114 0.0326 0.039
Schistosoma mansoni axis inhibition protein axin 0.0415 0.1518 0.1518
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0038 0.0027 0.1895
Brugia malayi hypothetical protein 0.0082 0.0202 0.0182
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0415 0.1518 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0326 0.0324
Entamoeba histolytica PH domain containing protein kinase, putative 0.0049 0.0068 0.045
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0073 0.0411
Entamoeba histolytica PH domain containing protein kinase, putative 0.0049 0.0068 0.045
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.005 0.0073 0.0411
Brugia malayi Uncoordinated protein 104 0.0038 0.0027 0.0006
Brugia malayi Oxysterol binding protein 0.0038 0.0027 0.0006
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0038 0.0027 0.0032
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0067 0.0142 1
Echinococcus multilocularis plexin a4 0.0309 0.1099 0.1315
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Schistosoma mansoni hypothetical protein 0.005 0.0073 0.0073
Echinococcus multilocularis calcium dependent secretion activator 1 0.0038 0.0027 0.0032
Entamoeba histolytica hypothetical protein 0.0415 0.1518 1
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0038 0.0027 0.1895
Brugia malayi Protein kinase domain containing protein 0.0049 0.0068 0.0047
Loa Loa (eye worm) hypothetical protein 0.0415 0.1518 0.1516
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0103 0.0285 0.0283
Schistosoma mansoni hypothetical protein 0.0038 0.0027 0.0027
Brugia malayi PXA domain containing protein 0.0415 0.1518 0.15
Loa Loa (eye worm) syntrophin-1 0.0038 0.0027 0.0025
Schistosoma mansoni oxysterol-binding protein 1 0.0038 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0049 0.0068 0.045
Loa Loa (eye worm) hypothetical protein 0.0114 0.0326 0.0324
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0038 0.0027 0.0032
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0038 0.0027 0.0178
Entamoeba histolytica hypothetical protein 0.005 0.0073 0.0484
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1964 0.7637 0.7636
Entamoeba histolytica protein kinase, putative 0.0049 0.0068 0.045
Trichomonas vaginalis protein transport protein sec7, putative 0.0038 0.0027 0.0103
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Giardia lamblia Aurora kinase 0.0067 0.0142 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Brugia malayi DNA-binding protein LAG-1 0.005 0.0073 0.0053
Echinococcus multilocularis hypothetical protein 0.0114 0.0326 0.039
Schistosoma mansoni serine/threonine-protein kinase 0.0049 0.0068 0.0068
Brugia malayi MAX-1A 0.0038 0.0027 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Echinococcus granulosus DCC interacting protein 13 beta 0.0038 0.0027 0.0032
Schistosoma mansoni zinc finger protein 0.0038 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0073 0.0411
Loa Loa (eye worm) hypothetical protein 0.026 0.0902 0.09
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0038 0.0027 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.1964 0.7637 0.7637
Echinococcus multilocularis Pleckstrin y 0.0038 0.0027 0.0032
Schistosoma mansoni protein kinase 0.0067 0.0142 0.0142
Plasmodium falciparum calcium-dependent protein kinase 7 0.0049 0.0068 0.4799
Loa Loa (eye worm) cytohesin 3 0.0038 0.0027 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Loa Loa (eye worm) hypothetical protein 0.0415 0.1518 0.1516
Echinococcus granulosus Immunoglobulin 0.0082 0.0202 0.0242
Toxoplasma gondii protein kinase domain-containing protein 0.0049 0.0068 0.4799
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0072
Schistosoma mansoni vesicular amine transporter 0.0085 0.0212 0.0212
Echinococcus multilocularis beta 1 syntrophin 0.0038 0.0027 0.0032
Echinococcus multilocularis semaphorin 5B 0.0114 0.0326 0.039
Schistosoma mansoni hypothetical protein 0.0146 0.0452 0.0452
Echinococcus granulosus Rho GTPase activating protein 24 0.0038 0.0027 0.0032
Schistosoma mansoni semaphorin 5-related 0.0114 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Plasmodium falciparum oxysterol-binding protein, putative 0.0038 0.0027 0.1895
Echinococcus multilocularis regulator of G protein signaling 7 0.0415 0.1518 0.1816
Echinococcus multilocularis roundabout 2 0.0082 0.0202 0.0242
Entamoeba histolytica PH domain containing protein 0.0038 0.0027 0.0178
Brugia malayi TBC domain containing protein 0.0038 0.0027 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Entamoeba histolytica hypothetical protein, conserved 0.0038 0.0027 0.0178
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0038 0.0027 0.0025
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0038 0.0027 0.1895
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0038 0.0027 0.0103
Entamoeba histolytica protein kinase, putative 0.0049 0.0068 0.045
Echinococcus granulosus plexin a4 0.0309 0.1099 0.1315
Schistosoma mansoni hypothetical protein 0.0038 0.0027 0.0027
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0038 0.0027 0.0178
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0038 0.0027 0.0103
Brugia malayi plexin A 0.0309 0.1099 0.108
Trypanosoma cruzi PH domain containing protein, putative 0.0038 0.0027 0.1895
Leishmania major hypothetical protein, conserved 0.0038 0.0027 0.1895
Schistosoma mansoni oxysterol-binding protein 1 0.0038 0.0027 0.0027
Brugia malayi Plexin repeat family protein 0.026 0.0902 0.0883
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Schistosoma mansoni regulator of G protein signaling 0.0415 0.1518 0.1518
Trypanosoma cruzi hypothetical protein 0.0038 0.0027 0.1895
Toxoplasma gondii AtPH1 family protein 0.0038 0.0027 0.1895
Entamoeba histolytica hypothetical protein 0.0038 0.0027 0.0178
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0038 0.0027 0.0032
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0082 0.0202 0.0242
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0038 0.0027 0.0032
Schistosoma mansoni centaurin alpha 0.0038 0.0027 0.0027
Loa Loa (eye worm) oxysterol binding protein 0.0038 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0073 0.0411
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0142 0.0142
Trypanosoma cruzi NIMA-related kinase, putative 0.0049 0.0068 0.4799
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2147 0.8359 0.8358
Brugia malayi probable spectrin beta chain 0.0038 0.0027 0.0006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0415 0.1518 0.1518
Brugia malayi hypothetical protein 0.0038 0.0027 0.0006
Brugia malayi Plekhf2 protein 0.0038 0.0027 0.0006
Echinococcus multilocularis axis inhibition protein axin 0.0415 0.1518 0.1816
Brugia malayi Sema domain containing protein 0.0114 0.0326 0.0306
Entamoeba histolytica PH domain containing protein kinase, putative 0.0049 0.0068 0.045
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0038 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0114 0.0326 0.0324
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0038 0.0027 0.0103
Echinococcus multilocularis DCC interacting protein 13 beta 0.0038 0.0027 0.0032
Entamoeba histolytica PH domain containing protein 0.0038 0.0027 0.0178
Brugia malayi PXA domain containing protein 0.0415 0.1518 0.15
Trichomonas vaginalis conserved hypothetical protein 0.0415 0.1518 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0049 0.0068 0.4799
Echinococcus multilocularis oxysterol binding protein 3 0.0038 0.0027 0.0032
Echinococcus multilocularis beta adrenergic receptor kinase 0.1964 0.7637 0.9136
Trypanosoma cruzi hypothetical protein 0.0038 0.0027 0.1895
Trypanosoma cruzi aurora B kinase, putative 0.0067 0.0142 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0415 0.1518 0.1816
Onchocerca volvulus 0.0114 0.0326 0.3418
Brugia malayi serine/threonine kinase 12 0.0067 0.0142 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0415 0.1518 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0326 0.0324
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0049 0.0068 0.4799
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0034 0.0034
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0038 0.0027 0.0006
Trichomonas vaginalis centaurin alpha, putative 0.0038 0.0027 0.0103
Brugia malayi Dynamin 0.0038 0.0027 0.0006
Trypanosoma cruzi hypothetical protein 0.0038 0.0027 0.1895
Entamoeba histolytica protein kinase, putative 0.0067 0.0142 0.0938
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Schistosoma mansoni zinc finger protein 0.0038 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Brugia malayi Oxysterol-binding protein 0.0038 0.0027 0.0006
Loa Loa (eye worm) hypothetical protein 0.0415 0.1518 0.1516
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Brugia malayi serine/threonine-protein kinase 6 0.0067 0.0142 0.0122
Echinococcus granulosus regulator of G protein signaling 7 0.0415 0.1518 0.1816
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0038 0.0027 0.0032
Brugia malayi hypothetical protein 0.0114 0.0326 0.0306
Echinococcus granulosus cytohesin 1 0.0038 0.0027 0.0032
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0049 0.0068 0.4799
Echinococcus multilocularis transcription factor collier 0.005 0.0073 0.0088
Loa Loa (eye worm) hypothetical protein 0.0114 0.0326 0.0324
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0049 0.0068 0.4799
Schistosoma mansoni regulator of G protein signaling 0.0415 0.1518 0.1518
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0082 0.0202 0.0202
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0027 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Schistosoma mansoni hypothetical protein 0.0114 0.0326 0.0326
Brugia malayi Dynamin 0.0038 0.0027 0.0006
Echinococcus granulosus G protein coupled receptor kinase 1 0.1549 0.5995 0.7172
Loa Loa (eye worm) AUR protein kinase 0.0067 0.0142 0.014
Echinococcus multilocularis rac serine:threonine kinase 0.0049 0.0068 0.0082
Trichomonas vaginalis centaurin/arf, putative 0.0038 0.0027 0.0103
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.005 0.0073 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0073 0.0411
Brugia malayi hypothetical protein 0.0415 0.1518 0.15
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0049 0.0068 0.4799
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0038 0.0027 0.0032
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0415 0.1518 1
Echinococcus multilocularis myotubularin protein 13 0.0038 0.0027 0.0032
Trichomonas vaginalis centaurin gamma, putative 0.0038 0.0027 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Leishmania major serine/threonine-protein kinase a, putative 0.0049 0.0068 0.4799
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Schistosoma mansoni hypothetical protein 0.0038 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0067 0.0142 0.0938
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Echinococcus granulosus regulator of G protein signaling 7 0.0415 0.1518 0.1816
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0038 0.0027 0.0032
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0038 0.0027 0.0103
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0038 0.0027 0.0032
Toxoplasma gondii hypothetical protein 0.0038 0.0027 0.1895
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0038 0.0027 0.0032
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Echinococcus multilocularis Rho GTPase activating protein 24 0.0038 0.0027 0.0032
Echinococcus multilocularis axis inhibition protein axin 0.0415 0.1518 0.1816
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Echinococcus multilocularis Immunoglobulin 0.0082 0.0202 0.0242
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0049 0.0068 0.4799
Brugia malayi A-kinase anchor protein 10, precursor 0.0415 0.1518 0.15
Echinococcus granulosus Pleckstrin y 0.0038 0.0027 0.0032
Entamoeba histolytica PH domain containing protein kinase, putative 0.0049 0.0068 0.045
Schistosoma mansoni myotubularin-related protein 0.0038 0.0027 0.0027
Entamoeba histolytica protein kinase, putative 0.0049 0.0068 0.045
Leishmania major protein kinase, putative 0.0049 0.0068 0.4799
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.005 0.0073 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0103
Trypanosoma brucei protein kinase, putative 0.0049 0.0068 0.4799
Entamoeba histolytica p21-activated kinase 0.0049 0.0068 0.045
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0038 0.0027 0.0025
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0049 0.0068 0.0377
Entamoeba histolytica hypothetical protein 0.0415 0.1518 1
Echinococcus granulosus pleckstrin y domain containing family A 0.0038 0.0027 0.0032
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2147 0.8359 1
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0038 0.0027 0.0178
Plasmodium falciparum PH domain-containing protein, putative 0.0038 0.0027 0.1895
Brugia malayi Regulator of G protein signaling domain containing protein 0.0415 0.1518 0.15
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Brugia malayi PH domain containing protein 0.0038 0.0027 0.0006
Brugia malayi Syntrophin-1 0.0038 0.0027 0.0006
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0038 0.0027 0.0178
Leishmania major hypothetical protein, conserved 0.0038 0.0027 0.1895
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0049 0.0068 0.0377
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0068 0.0377
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0049 0.0068 0.3582
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0021 0.0019
Echinococcus granulosus regulator of G protein signaling 3 0.0415 0.1518 0.1816
Onchocerca volvulus 0.026 0.0902 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0202 0.02
Trichomonas vaginalis protein transport protein sec7, putative 0.0038 0.0027 0.0103
Toxoplasma gondii phosphatidylinositol transfer protein 0.0038 0.0027 0.1895
Entamoeba histolytica hypothetical protein 0.0038 0.0027 0.0178
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0072
Trypanosoma brucei aurora B kinase 0.0067 0.0142 1
Loa Loa (eye worm) hypothetical protein 0.0415 0.1518 0.1516
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0034 0.0034
Entamoeba histolytica ARF GTPase activating protein, putative 0.0038 0.0027 0.0178
Echinococcus granulosus oxysterol binding protein 3 0.0038 0.0027 0.0032
Leishmania major folate/biopterin transporter, putative 0.0049 0.0068 0.4799
Trypanosoma cruzi hypothetical protein 0.0038 0.0027 0.1895
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0415 0.1518 0.1518
Echinococcus granulosus Regulator of G protein signaling 20 0.0415 0.1518 0.1816
Trypanosoma cruzi NIMA-related kinase, putative 0.0049 0.0068 0.4799
Schistosoma mansoni cell adhesion molecule 0.0082 0.0202 0.0202
Echinococcus granulosus semaphorin 1A 0.0114 0.0326 0.039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Echinococcus multilocularis oxysterol binding protein 1 0.0038 0.0027 0.0032
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0038 0.0027 0.0178
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0025
Loa Loa (eye worm) AUR protein kinase 0.0067 0.0142 0.014
Schistosoma mansoni dynamin 0.0038 0.0027 0.0027
Schistosoma mansoni syntrophin 0.0038 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0142 0.0869
Echinococcus granulosus axis inhibition protein axin 0.0415 0.1518 0.1816
Loa Loa (eye worm) AGC/AKT protein kinase 0.0049 0.0068 0.0066

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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