Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | S100 calcium binding protein A10 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | outer membrane protein PmpE | 0.0222 | 0.3547 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.027 | 0.5034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.5034 | 1 |
Chlamydia trachomatis | outer membrane protein PmpF | 0.0222 | 0.3547 | 0.5 |
Chlamydia trachomatis | outer membrane protein PmpD | 0.0222 | 0.3547 | 0.5 |
Chlamydia trachomatis | outer membrane protein PmpC | 0.0222 | 0.3547 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0127 | 0.0598 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0121 | 0.0409 | 0.0295 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.027 | 0.5034 | 0.5 |
Chlamydia trachomatis | outer membrane protein PmpB | 0.0222 | 0.3547 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.027 | 0.5034 | 0.4975 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.027 | 0.5034 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.027 | 0.5034 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.027 | 0.5034 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.027 | 0.5034 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.027 | 0.5034 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0121 | 0.0409 | 0.0295 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0127 | 0.0598 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.027 | 0.5034 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0127 | 0.0598 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0127 | 0.0598 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.57 | Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay | ChEMBL. | 21375334 |
IC50 (binding) | = 3 uM | Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay | ChEMBL. | 21375334 |
Inhibition (binding) | = 126 % | Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control | ChEMBL. | 21375334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.