Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Tubulin alpha-2 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 2 | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0125 | 0.1672 | 0.1672 |
Schistosoma mansoni | tubulin subunit alpha | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.012 | 0.1296 | 0.1296 |
Loa Loa (eye worm) | alpha-tubulin | 0.0174 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0174 | 0.5571 | 0.5571 |
Giardia lamblia | Alpha-tubulin | 0.0174 | 0.5571 | 0.4682 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0174 | 0.5571 | 0.5571 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.012 | 0.1296 | 0.1296 |
Schistosoma mansoni | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | alpha-tubulin | 0.0174 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | hypothetical protein | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0125 | 0.1672 | 0.1672 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0174 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0125 | 0.1672 | 0.1672 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0174 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0174 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 1 | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha-2 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin subunit TubB | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1296 | 0.1296 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0125 | 0.1672 | 0.1672 |
Trypanosoma brucei | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.012 | 0.1296 | 0.1296 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.012 | 0.1296 | 0.1296 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0174 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0174 | 0.5571 | 0.5571 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.0174 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha chain - mouse | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0174 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0174 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0174 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0174 | 0.5571 | 0.5571 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | > 100 uM | Cytotoxicity against human THP1 cells using cell count reagent SF | ChEMBL. | 21524580 |
ED50 (functional) | > 100 uM | Immunomodulatory activity in human THP1 cells assessed as differentiation of monocyte to macrophage after 4 days by MTT assay | ChEMBL. | 21524580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.