Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0139 | 0.1137 | 0.1137 |
Echinococcus multilocularis | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Schistosoma mansoni | tubulin subunit alpha | 0.0205 | 0.4886 | 0.3686 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0205 | 0.4886 | 0.4886 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0205 | 0.4886 | 0.3686 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0139 | 0.1137 | 0.1137 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0205 | 0.4886 | 0.4886 |
Brugia malayi | tubulin alpha-2 chain | 0.0205 | 0.4886 | 0.3686 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0205 | 0.4886 | 0.4886 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0152 | 0.1901 | 0.1901 |
Echinococcus multilocularis | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0205 | 0.4886 | 0.4886 |
Brugia malayi | alpha-tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Trypanosoma brucei | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0205 | 0.4886 | 0.3686 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0205 | 0.4886 | 0.3686 |
Loa Loa (eye worm) | alpha-tubulin | 0.0205 | 0.4886 | 0.4886 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0139 | 0.1137 | 0.1137 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0205 | 0.4886 | 0.4886 |
Echinococcus granulosus | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Plasmodium falciparum | alpha tubulin 2 | 0.0205 | 0.4886 | 0.3686 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0205 | 0.4886 | 0.4886 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0152 | 0.1901 | 0.1901 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0152 | 0.1901 | 0.1901 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Trypanosoma brucei | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0205 | 0.4886 | 0.3686 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0139 | 0.1137 | 0.1137 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0205 | 0.4886 | 0.3686 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0205 | 0.4886 | 0.4886 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0205 | 0.4886 | 0.3686 |
Plasmodium falciparum | alpha tubulin 1 | 0.0205 | 0.4886 | 0.3686 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0152 | 0.1901 | 0.1901 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0205 | 0.4886 | 0.4886 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0205 | 0.4886 | 0.4886 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | hypothetical protein | 0.0205 | 0.4886 | 0.3686 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0205 | 0.4886 | 0.3686 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0205 | 0.4886 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1137 | 0.1137 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0205 | 0.4886 | 0.3686 |
Brugia malayi | Tubulin alpha-2 chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0205 | 0.4886 | 0.3686 |
Brugia malayi | tubulin alpha chain - mouse | 0.0205 | 0.4886 | 0.3686 |
Brugia malayi | Tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0205 | 0.4886 | 0.3686 |
Schistosoma mansoni | tubulin subunit alpha | 0.0205 | 0.4886 | 0.3686 |
Giardia lamblia | Alpha-tubulin | 0.0205 | 0.4886 | 0.3686 |
Loa Loa (eye worm) | alpha-tubulin | 0.0205 | 0.4886 | 0.4886 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Schistosoma mansoni | tubulin subunit alpha | 0.0205 | 0.4886 | 0.3686 |
Brugia malayi | Tubulin alpha-2 chain | 0.0205 | 0.4886 | 0.3686 |
Trypanosoma brucei | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Giardia lamblia | Alpha-tubulin | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Schistosoma mansoni | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Schistosoma mansoni | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Leishmania major | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0205 | 0.4886 | 0.4886 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0205 | 0.4886 | 0.3686 |
Trypanosoma brucei | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0205 | 0.4886 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.4886 | 0.4886 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0205 | 0.4886 | 0.3686 |
Schistosoma mansoni | alpha tubulin | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | tubulin alpha chain | 0.0205 | 0.4886 | 0.3686 |
Echinococcus granulosus | tubulin subunit TubB | 0.0205 | 0.4886 | 0.3686 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0205 | 0.4886 | 0.3686 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0205 | 0.4886 | 0.3686 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | > 100 uM | Cytotoxicity against human THP1 cells using cell count reagent SF | ChEMBL. | 21524580 |
ED50 (functional) | = 27.9 uM | Immunomodulatory activity in human THP1 cells assessed as differentiation of monocyte to macrophage after 4 days by MTT assay | ChEMBL. | 21524580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.