Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0061 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0061 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0061 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0061 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0061 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0061 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0061 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0061 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0061 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0061 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0061 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0061 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0061 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | uM | Inhibitory activity against cPLA2 (cytosolic Phospholipase A2) by measuring the calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets; Not active at highest conc tested 33 uM | ChEMBL. | 9276015 |
IC50 (functional) | NA 0 uM | Inhibitory activity against cPLA2 (cytosolic Phospholipase A2) by measuring the calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets; Not active at highest conc tested 33 uM | ChEMBL. | 9276015 |
Lysis (functional) | = 0 % | The cell lytic potency at a compound concentration of 33 uM in bovine platelets was determined | ChEMBL. | 9276015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.