TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 285.338 | Formula: C17H19NO3
H donors: 1 H acceptors: 1 LogP: 3.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Nc1cc(=O)oc(c1)C1CCCC1
InChi: 1S/C17H19NO3/c1-20-15-8-6-13(7-9-15)18-14-10-16(21-17(19)11-14)12-4-2-3-5-12/h6-12,18H,2-5H2,1H3
InChiKey: GUGBRHVXNWUDFW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nAChR subunit	0.0037	0.0143	0.0472
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0052	0.0333	0.1098
Onchocerca volvulus		0.0037	0.0143	0.1645
Toxoplasma gondii	heat shock protein hslv, putative	0.0052	0.0333	0.1098
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0204	0.228	0.7528
Brugia malayi	Death domain containing protein	0.0066	0.0513	0.1695
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0037	0.0143	0.0472
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0137	0.1421	0.4693
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0204	0.228	0.228
Toxoplasma gondii	proteasome subunit	0.0052	0.0333	0.1098
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0048	0.0284	0.0938
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0052	0.0333	0.1098
Brugia malayi	proteasome subunit alpha type 4	0.0052	0.0333	0.1098
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0052	0.0333	0.0333
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0052	0.0333	0.0008
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0263	0.3029	1
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0126	0.1289	0.4254
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0052	0.0333	0.1098
Leishmania major	proteasome alpha 1 subunit, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	cathepsin b	0.0137	0.1421	0.1421
Onchocerca volvulus		0.0037	0.0143	0.1645
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0126	0.1289	0.1289
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0052	0.0333	0.1098
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0052	0.0333	0.1098
Brugia malayi	Uncoordinated protein 44	0.0066	0.0513	0.1695
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0037	0.0143	0.0358
Brugia malayi	Proteasome subunit alpha type 1	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0052	0.0333	0.1098
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0204	0.228	0.7528
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0037	0.0143	0.0472
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0037	0.0143	0.0143
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0204	0.228	0.7528
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0263	0.3029	1
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0204	0.228	0.7528
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0052	0.0333	0.1098
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0518	0.1297
Leishmania major	proteasome alpha 2 subunit, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0051	0.033	0.0827
Schistosoma mansoni	nAChR subunit	0.0037	0.0143	0.0472
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0037	0.0143	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0126	0.1289	0.3224
Onchocerca volvulus		0.0037	0.0143	0.1645
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0126	0.1289	0.4254
Echinococcus multilocularis	Ankyrin	0.0066	0.0518	0.0518
Toxoplasma gondii	proteasome subunit beta type, putative	0.0263	0.3029	1
Trypanosoma cruzi	20S proteasome subunit	0.0126	0.1289	0.4254
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0204	0.228	0.7528
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0037	0.0143	0.0143
Brugia malayi	proteasome subunit beta type 1	0.0204	0.228	0.7528
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0052	0.0333	0.1098
Giardia lamblia	20S proteasome alpha subunit 2	0.0052	0.0333	0.0176
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0513	0.1695
Brugia malayi	Proteasome A-type and B-type family protein	0.0263	0.3029	1
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0204	0.228	0.7528
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0037	0.0143	0.0143
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0052	0.0333	0.1098
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0052	0.0333	0.0176
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0052	0.0333	0.1098
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	LGC-31 protein	0.0037	0.0143	0.0358
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.1421	0.4693
Schistosoma mansoni	nAChR subunit	0.0037	0.0143	0.0472
Loa Loa (eye worm)	matrix metalloproteinase	0.0042	0.0213	0.0532
Schistosoma mansoni	nAChR subunit	0.0037	0.0143	0.0472
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0037	0.0143	0.0472
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0037	0.0143	0.0472
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0037	0.0143	0.0143
Brugia malayi	Matrixin family protein	0.0042	0.0213	0.0703
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0037	0.0143	0.0358
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0052	0.0333	0.0333
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0037	0.0143	0.0143
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0052	0.0333	0.1098
Leishmania major	proteasome beta 5 subunit, putative	0.0263	0.3029	1
Brugia malayi	Matrixin family protein	0.0102	0.0978	0.3229
Echinococcus granulosus	Proteasome subunit alpha beta	0.0052	0.0333	0.0333
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0052	0.0333	0.1098
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0052	0.0333	0.1098
Schistosoma mansoni	hypothetical protein	0.006	0.0438	0.1447
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0052	0.0333	0.0333
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0052	0.0333	0.0832
Plasmodium falciparum	proteasome subunit beta type-5	0.0263	0.3029	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0052	0.0333	0.1098
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0037	0.0143	0.0143
Echinococcus granulosus	proteasome subunit beta type 7	0.0052	0.0333	0.0333
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0052	0.0333	0.1098
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0052	0.0333	0.1098
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0052	0.0333	0.1098
Schistosoma mansoni	nAChR subunit	0.0037	0.0143	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	death domain containing protein	0.0066	0.0513	0.0513
Echinococcus granulosus	netrin receptor unc 5	0.0066	0.0513	0.0513
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0263	0.3029	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0037	0.0143	0.0472
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0066	0.0513	0.1695
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0037	0.0143	0.0472
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0037	0.0143	0.0472
Brugia malayi	Hemopexin family protein	0.006	0.0438	0.1447
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0204	0.228	0.228
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0513	0.1285
Echinococcus multilocularis	nAChR subunit	0.0037	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0213	0.0532
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0204	0.228	0.7528
Toxoplasma gondii	peptidase, T1 family protein	0.0052	0.0333	0.1098
Leishmania major	proteasome alpha 7 subunit, putative	0.0052	0.0333	0.1098
Brugia malayi	Matrixin family protein	0.0042	0.0213	0.0703
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0263	0.3029	1
Echinococcus granulosus	proteasome subunit beta t family	0.0052	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0126	0.1289	0.4254
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0143	0.0472
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0052	0.0333	0.1098
Onchocerca volvulus		0.0037	0.0143	0.1645
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0037	0.0143	0.0143
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0263	0.3029	1
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0052	0.0333	0.1098
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0052	0.0333	0.0008
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0052	0.0333	0.0333
Onchocerca volvulus	Putative nachr subunit	0.0037	0.0143	0.1645
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0052	0.0333	0.1098
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0037	0.0143	0.0472
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0048	0.0284	0.0938
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0052	0.0333	0.1098
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	glycine receptor subunit beta	0.0037	0.0143	0.0143
Echinococcus granulosus	nAChR subunit	0.0037	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Leishmania major	proteasome alpha 3 subunit, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	proteasome subunit beta type 6	0.0052	0.0333	0.0333
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0052	0.0333	0.0832
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0052	0.0333	0.0333
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0052	0.0333	0.0333
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0052	0.0333	0.1098
Toxoplasma gondii	cathepsin B	0.0048	0.0284	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Brugia malayi	proteasome subunit alpha type 1	0.0052	0.0333	0.1098
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0052	0.0333	0.1098
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0037	0.0143	0.0472
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0052	0.0333	0.1098
Brugia malayi	20S proteasome alpha5 subunit	0.0052	0.0333	0.1098
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0052	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0263	0.3029	0.7578
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0052	0.0333	0.1098
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0263	0.3029	1
Echinococcus multilocularis	netrin receptor unc 5	0.0066	0.0513	0.0513
Echinococcus multilocularis	proteasome subunit beta type 6	0.0052	0.0333	0.0333
Schistosoma mansoni	hypothetical protein	0.0066	0.0513	0.1695
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	proteasome prosome macropain	0.0263	0.3029	0.3029
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0126	0.1289	0.4254
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0052	0.0333	0.1098
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0263	0.3029	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0037	0.0143	0.0358
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0052	0.0333	0.1098
Onchocerca volvulus		0.0037	0.0143	0.1645
Loa Loa (eye worm)	PAS-3 protein	0.0052	0.0333	0.0832
Onchocerca volvulus	Notchless protein homolog	0.0052	0.0333	0.3822
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1421	0.3556
Loa Loa (eye worm)	matrixin family protein	0.0102	0.0978	0.2447
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0037	0.0143	0.0472
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0037	0.0143	0.0472
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0052	0.0333	0.0832
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0052	0.0333	0.1098
Trypanosoma brucei	proteasome beta 6 subunit	0.0204	0.228	0.7528
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0204	0.228	0.7528
Schistosoma mansoni	netrin receptor unc5	0.0066	0.0513	0.1695
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0052	0.0333	0.1098
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0052	0.0333	0.1098
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0143	0.0472
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0037	0.0143	0.0143
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0052	0.0333	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0037	0.0143	0.0358
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0052	0.0333	0.1098
Brugia malayi	cathepsin B-like cysteine proteinase	0.0137	0.1421	0.4693
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0037	0.0143	0.0472
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0052	0.0333	0.1098
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0052	0.0333	0.1098
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0052	0.0333	0.1098
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0126	0.1289	0.4254
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0052	0.0333	0.1098
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0052	0.0333	0.5
Loa Loa (eye worm)	matrixin family protein	0.0094	0.087	0.2177
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0143	0.0472
Echinococcus granulosus	glycine receptor subunit beta	0.0037	0.0143	0.0143
Brugia malayi	Proteasome subunit alpha type 7-1	0.0052	0.0333	0.1098
Giardia lamblia	20S proteasome alpha subunit 5	0.0052	0.0333	0.0176
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0037	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0052	0.0333	0.1098
Brugia malayi	Matrixin family protein	0.0042	0.0213	0.0703
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0037	0.0143	0.0472
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0066	0.0513	0.1285
Plasmodium falciparum	proteasome subunit beta type-4	0.0052	0.0333	0.1098
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0052	0.0333	0.1098
Schistosoma mansoni	nAChR subunit	0.0037	0.0143	0.0472
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0126	0.1289	0.4254
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0052	0.0333	0.1098
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0154	0.1635	0.1635
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.0284	0.0938
Brugia malayi	proteasome subunit beta type 3	0.0052	0.0333	0.1098
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0052	0.0333	0.1098
Schistosoma mansoni	ankyrin 23/unc44	0.0066	0.0513	0.1695
Loa Loa (eye worm)	hypothetical protein	0.0339	0.3997	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0037	0.0143	0.0143
Onchocerca volvulus	Netrin receptor homolog	0.0066	0.0513	0.5901
Brugia malayi	Cation transporter family protein	0.0037	0.0143	0.0472
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0037	0.0143	0.0143
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	cathepsin B	0.0048	0.0284	0.0711
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0052	0.0333	0.1098
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0052	0.0333	0.0832
Giardia lamblia	20S proteasome alpha subunit 1	0.0052	0.0333	0.0176
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0052	0.0333	0.0832
Schistosoma mansoni	nAChR subunit	0.0037	0.0143	0.0472
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0037	0.0143	0.0143
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0052	0.0333	0.0333
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0263	0.3029	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0052	0.0333	0.1098
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0052	0.0333	0.0333
Brugia malayi	proteasome subunit alpha type 3	0.0052	0.0333	0.1098
Leishmania major	proteasome beta-1 subunit, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	ACC-1 protein	0.0037	0.0143	0.0358
Giardia lamblia	20S proteasome alpha subunit 4	0.0052	0.0333	0.0176
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0052	0.0333	0.0333
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0052	0.0333	0.1098
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0048	0.0284	0.0938
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0037	0.0143	0.0143
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0154	0.1635	0.1635
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0052	0.0333	0.1098
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0137	0.1421	0.4693
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0052	0.0333	0.1098
Onchocerca volvulus		0.0037	0.0143	0.1645
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0052	0.0333	0.1098
Mycobacterium ulcerans	proteasome PrcB	0.0263	0.3029	1
Giardia lamblia	20S proteasome alpha subunit 3	0.0052	0.0333	0.0176
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0143	0.0472
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0052	0.0333	0.1098
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0126	0.1289	0.4254
Echinococcus granulosus	proteasome subunit alpha type 6	0.0052	0.0333	0.0333
Echinococcus multilocularis	glycine receptor subunit beta	0.0037	0.0143	0.0143
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0052	0.0333	0.1098
Brugia malayi	excitatory GABA receptor EXP-1A	0.0037	0.0143	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0263	0.3029	0.3029
Brugia malayi	proteasome subunit alpha type 2	0.0052	0.0333	0.1098
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0052	0.0333	0.1098
Onchocerca volvulus	Matrilysin homolog	0.0094	0.087	1
Brugia malayi	proteasome subunit alpha type 6	0.0052	0.0333	0.1098
Brugia malayi	Cation transporter family protein	0.0037	0.0143	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0052	0.0333	0.1098
Brugia malayi	Matrixin family protein	0.0042	0.0213	0.0703
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0052	0.0333	0.0176
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0052	0.0333	0.1098
Leishmania major	proteasome alpha 1 subunit, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	proteasome subunit beta type 7	0.0052	0.0333	0.0333
Leishmania major	proteasome beta 3 subunit, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.1421	0.4693
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.1421	0.4693
Brugia malayi	Cation transporter family protein	0.0037	0.0143	0.0472
Leishmania major	proteasome alpha 7 subunit, putative	0.0052	0.0333	0.1098
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0094	0.087	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0037	0.0143	0.0143
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0052	0.0333	0.0333
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0052	0.0333	0.0333
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0037	0.0143	0.0143
Onchocerca volvulus		0.006	0.0438	0.5038
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0052	0.0333	0.0832
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0052	0.0333	0.1098
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0052	0.0333	0.1098
Onchocerca volvulus		0.0042	0.0213	0.2446
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0066	0.0513	0.0513
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0037	0.0143	0.0143
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0263	0.3029	1
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0052	0.0333	0.1098
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0052	0.0333	0.1098
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0204	0.228	0.7528
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0037	0.0143	0.0143
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0052	0.0333	0.1098
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0066	0.0513	0.0513
Echinococcus multilocularis	cathepsin b	0.0137	0.1421	0.1421
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0037	0.0143	0.0143
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0037	0.0143	0.0472
Giardia lamblia	Proteasome subunit beta type 2	0.0126	0.1289	0.3659
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0042	0.0213	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Brugia malayi	proteasome subunit beta type 2	0.0126	0.1289	0.4254
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0052	0.0333	0.1098
Trypanosoma brucei	proteasome alpha 7 subunit	0.0052	0.0333	0.1098
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0052	0.0333	0.1098
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0126	0.1289	0.4254
Onchocerca volvulus	Matrilysin homolog	0.0042	0.0213	0.2446
Giardia lamblia	Proteasome subunit beta type 1	0.0204	0.228	0.7273
Echinococcus multilocularis	glycine receptor subunit beta	0.0037	0.0143	0.0143
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0066	0.0518	0.1712
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0052	0.0333	0.0832
Leishmania major	proteasome beta 2 subunit, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0052	0.0333	0.0333
Brugia malayi	Proteasome A-type and B-type family protein	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0052	0.0333	0.1098
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0126	0.1289	0.4254
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0052	0.0333	0.1098
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0213	0.0532
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0143	0.0472
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0052	0.0333	0.0333
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0052	0.0333	0.0333
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0052	0.0333	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0213	0.0532
Trypanosoma brucei	proteasome beta 7 subunit	0.0052	0.0333	0.1098
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0052	0.0333	0.1098
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0052	0.0333	0.1098
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0037	0.0143	0.0472
Leishmania major	proteasome beta 7 subunit, putative	0.0052	0.0333	0.1098
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0052	0.0333	0.1098
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0052	0.0333	0.0333
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0052	0.0333	0.1098
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0037	0.0143	0.0143
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0143	0.0472
Mycobacterium ulcerans	proteasome PrcA	0.0052	0.0333	0.0008
Toxoplasma gondii	proteasome beta subunit	0.0052	0.0333	0.1098
Giardia lamblia	Proteasome subunit beta type 3	0.0052	0.0333	0.0176
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0052	0.0333	0.0176
Echinococcus granulosus	Ankyrin	0.0066	0.0518	0.0518
Echinococcus multilocularis	cathepsin b	0.0137	0.1421	0.1421
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0052	0.0333	0.1098
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0052	0.0333	0.1098
Brugia malayi	Proteasome A-type and B-type family protein	0.0052	0.0333	0.1098
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0037	0.0143	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0052	0.0333	0.1098
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0284	0.0938
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0037	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0052	0.0333	0.1098
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0052	0.0333	0.0832
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0037	0.0143	0.0143
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	cathepsin b	0.0137	0.1421	0.1421
Giardia lamblia	20S proteasome alpha subunit 7	0.0052	0.0333	0.0176
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0052	0.0333	0.1098
Loa Loa (eye worm)	ACC-1 protein	0.0037	0.0143	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0126	0.1289	0.4254
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0052	0.0333	0.0832
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0052	0.0333	0.0832
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0263	0.3029	1
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0051	0.033	0.1091
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0204	0.228	0.5705
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0052	0.0333	0.1098
Giardia lamblia	20S proteasome alpha subunit 6	0.0052	0.0333	0.0176
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0037	0.0143	0.0358
Leishmania major	proteasome beta 2 subunit, putative	0.0126	0.1289	0.4254
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0052	0.0333	0.1098
Echinococcus granulosus	proteasome subunit alpha type 2	0.0052	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0143	0.0358
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0126	0.1289	0.1289

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 4.73 uM	Cytotoxicity against human SKBR3 cells after 72 hrs by MTT assay	ChEMBL.	21420855
ED50 (functional)	= 5.42 uM	Cytotoxicity against human A549 cells after 72 hrs by MTT assay	ChEMBL.	21420855
ED50 (functional)	= 5.42 uM	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	ChEMBL.	21420855
ED50 (functional)	= 8.38 uM	Cytotoxicity against human KB cells after 72 hrs by MTT assay	ChEMBL.	21420855

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1760744

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1510648