Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0019 | 0.0516 | 0.0516 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.3039 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.3039 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3537 | 0.3537 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.3039 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.3039 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.3537 | 0.6116 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.3039 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.3537 | 0.3537 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Schistosoma mansoni | lamin | 0.0031 | 0.3537 | 0.6116 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.3039 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.3537 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.5545 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.3039 | 0.3039 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.3039 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.3537 | 0.6116 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.3537 | 0.3537 |
Echinococcus multilocularis | musashi | 0.0031 | 0.3537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3039 | 0.3039 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.3537 | 0.3537 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.5545 | 0.5545 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.3039 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.3537 | 0.5 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Onchocerca volvulus | 0.0031 | 0.3537 | 0.5 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.3537 | 0.3537 |
Echinococcus multilocularis | lamin | 0.0031 | 0.3537 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.3537 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.3537 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.3537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.5545 | 0.5545 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 150 uM | Ex vivo immunosuppressive activity in Drosophila larvae assessed as inhibition of IMD signaling pathway by beta-galactosidase reporter gene assay | ChEMBL. | 21334120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.