Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1597 | 0.1597 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0316 | 0.0316 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0049 | 0.0049 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0316 | 0.0369 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0463 | 0.0572 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0463 | 0.0572 |
Echinococcus multilocularis | Smad4 | 0.0016 | 0.0316 | 0.0369 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0463 | 0.0572 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0049 | 0.0049 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1597 | 0.2136 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0016 | 0.0316 | 0.0369 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0316 | 0.0316 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0463 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0316 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0049 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0463 | 0.0463 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0049 | 0.0049 |
Schistosoma mansoni | Smad4 | 0.0016 | 0.0316 | 0.0369 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0463 | 0.0463 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0049 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | Smad1 | 0.0016 | 0.0316 | 0.0316 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0463 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0463 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.274 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0463 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0463 | 0.0572 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0016 | 0.0316 | 0.0369 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.7294 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Echinococcus multilocularis | smad | 0.0016 | 0.0316 | 0.0369 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0316 | 0.0369 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0016 | 0.0316 | 0.0369 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0049 | 0.0049 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.274 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0049 | 0.0049 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0016 | 0.0316 | 0.0369 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0463 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.274 | 0.3714 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0049 | 0.0049 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0463 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0049 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.7294 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0016 | 0.0316 | 0.0316 |
Echinococcus granulosus | smad | 0.0016 | 0.0316 | 0.0369 |
Schistosoma mansoni | smad | 0.0016 | 0.0316 | 0.0369 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0049 | 0.0049 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0463 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0049 | 0.0049 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0049 | 0.0049 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1597 | 0.2136 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.274 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0049 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1597 | 0.2136 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0463 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0049 | 0.0049 |
Echinococcus multilocularis | geminin | 0.0171 | 0.7294 | 1 |
Echinococcus granulosus | Smad4 | 0.0016 | 0.0316 | 0.0369 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0463 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1597 | 0.2136 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0463 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0049 | 0.0049 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1597 | 0.2136 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1597 | 0.2136 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1597 | 0.2136 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0016 | 0.0316 | 0.0369 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0049 | 0.0049 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0049 | 0.0049 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0049 | 0.0049 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0049 | 0.0049 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0463 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0463 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.274 | 0.3714 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.274 | 0.3714 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.274 | 0.3714 |
Echinococcus granulosus | geminin | 0.0171 | 0.7294 | 1 |
Brugia malayi | hypothetical protein | 0.007 | 0.274 | 0.274 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Onchocerca volvulus | 0.001 | 0.0049 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1597 | 0.1597 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0463 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0049 | 0.0049 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0049 | 0.0049 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.274 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0016 | 0.0316 | 0.0316 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0316 | 0.0316 |
Brugia malayi | Smad1 | 0.0016 | 0.0316 | 0.0316 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0049 | 0.0049 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0463 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0049 | 0.0049 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0049 | 0.0049 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.