Detailed information for compound 1511162

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.097 | Formula: C17H12Br2N2O3
  • H donors: 2 H acceptors: 4 LogP: 3.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(=NCCc2cc(Br)c(c(c2)Br)O)C=C(c2c1nccc2)O
  • InChi: 1S/C17H12Br2N2O3/c18-11-6-9(7-12(19)16(11)23)3-5-20-13-8-14(22)10-2-1-4-21-15(10)17(13)24/h1-2,4,6-8,22-23H,3,5H2
  • InChiKey: VTOWHMMNCQGARC-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosyl-DNA phosphodiesterase 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2) Dengue virus type 2 NS3 protein Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Theileria parva ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus rrna methyltransferase 3 Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein Get druggable targets OG5_131766 All targets in OG5_131766
Loa Loa (eye worm) ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania donovani glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis 6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ribosomal RNA large subunit methyltransferase J protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum ribosomal RNA large subunit methyltransferase J, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium yoelii FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Onchocerca volvulus Putative ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum Spb1p-like, FtsJ methylase Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis FtsJ cell division protein Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans similar to S. cerevisiae MRM2 (YGL136C) mitochondrial rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus granulosus traf and tnf receptor associated protein Get druggable targets OG5_131766 All targets in OG5_131766
Schistosoma mansoni ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Theileria parva glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Entamoeba histolytica ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus putative ribosomal RNA methyltransferase/cell division FtsJ protein Get druggable targets OG5_126871 All targets in OG5_126871
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Putative rRNA methyltransferase 3, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis traf and tnf receptor associated protein Get druggable targets OG5_131766 All targets in OG5_131766
Plasmodium berghei ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni cell division protein ftsj Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ribosomal RNA methyltransferase (FtsJ) family protein Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax FtsJ-like methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase Get druggable targets OG5_131766 All targets in OG5_131766
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum ftsJ-like methyltransferase domain-containing protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania infantum FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum ko:K00599 rRNA methyltransferase Spb1 [EC:2.1.1.-], putative Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Treponema pallidum cell division protein (ftsJ) Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei gambiense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K02427 cell division protein methyltransferase FtsJ, putative Get druggable targets OG5_126871 All targets in OG5_126871
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_126871 All targets in OG5_126871
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania infantum glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ribosomal RNA large subunit methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum endonuclease/exonuclease/phosphatase domain- containing protein, putative Get druggable targets OG5_131766 All targets in OG5_131766
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei 2'-O-ribose RNA methyltransferase SPB1 homolog Get druggable targets OG5_126871 All targets in OG5_126871
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein Get druggable targets OG5_131766 All targets in OG5_131766
Plasmodium falciparum ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax ribosomal RNA large subunit methyltransferase J, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium yoelii FtsJ cell division protein Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium yoelii Glucose-6-phosphate dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ribosomal RNA large subunit methyltransferase J family protein Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis rrna methyltransferase 3 Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126871 All targets in OG5_126871
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma brucei KREX1 tyrosyl-DNA phosphodiesterase 2 362 aa 321 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0023 0.0059
Schistosoma mansoni hypothetical protein 0.0058 0.0131 0.1089
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0137 0.0361 0.3005
Schistosoma mansoni lipoxygenase 0.0067 0.0156 0.1294
Schistosoma mansoni kinase 0.0058 0.013 0.1082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0087 0.0727
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0002 0.0005
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0163 0.0141
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0163 0.1358
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Echinococcus multilocularis caspase 2 0.0071 0.0169 0.1403
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.002 0.0163
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0049 0.0129
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0005 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0048 0.0399
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0423 0.1202 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.038
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0208 0.0571 0.0569
Trypanosoma cruzi Peptide deformylase 2, putative 0.1305 0.3791 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0863
Brugia malayi hypothetical protein 0.0024 0.003 0.0229
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0005 0.0022
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0423 0.1202 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0054 0.0428
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0036 0.0296
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0023 0.0059
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.003 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0023 0.0111
Echinococcus granulosus ezrin 0.0033 0.0058 0.0484
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Brugia malayi MH2 domain containing protein 0.0144 0.0383 0.3173
Echinococcus granulosus single minded 2 0.0043 0.0088 0.0728
Entamoeba histolytica rodhanase-like domain containing protein 0.0137 0.0361 0.1792
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0163 0.1358
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0023 0.002
Trypanosoma brucei unspecified product 0.0047 0.0097 0.0254
Onchocerca volvulus 0.0137 0.0361 0.5454
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0023 0.0111
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0006 0.0049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0175 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0126 0.0622
Echinococcus multilocularis H17g protein, tegumental antigen 0.0061 0.0138 0.1148
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.0106 0.0881
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0097 0.0479
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0383 0.3173
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0175 0.0153
Echinococcus multilocularis dna polymerase eta 0.0077 0.0187 0.1556
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0798 0.6639
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.003 0.0027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0006 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0383 0.3173
Onchocerca volvulus 0.006 0.0135 0.1996
Schistosoma mansoni lipoxygenase 0.0024 0.003 0.0248
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.07 0.2014 1
Mycobacterium leprae putative cytochrome p450 0.0021 0.0023 0.0018
Schistosoma mansoni cytochrome P450 0.0021 0.0023 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0023 0.0111
Schistosoma mansoni hypothetical protein 0.0021 0.0023 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Plasmodium falciparum metacaspase-like protein 0.0021 0.0023 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0097 0.0786
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0049 0.0047
Leishmania major hypothetical protein, conserved 0.003 0.0049 0.0129
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0002 0.002
Brugia malayi Cytochrome P450 family protein 0.0032 0.0054 0.0428
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0097 0.0805
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0097 0.0074
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.0023 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0097 0.0074
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0005 0.0022
Onchocerca volvulus 0.005 0.0106 0.1548
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0005 0.0039
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0088 0.0085
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0036 0.0276
Loa Loa (eye worm) RecQ helicase 0.0026 0.0036 0.0276
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0023 0.002
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0137 0.0361 0.1792
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0097 0.0479
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0021 0.0023 0.0188
Brugia malayi Cytochrome P450 family protein 0.0067 0.0158 0.1296
Entamoeba histolytica rodhanase-like domain containing protein 0.0137 0.0361 0.1792
Loa Loa (eye worm) hypothetical protein 0.0182 0.0495 0.411
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0163 0.1358
Onchocerca volvulus 0.0024 0.003 0.0384
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0049
Brugia malayi hypothetical protein 0.002 0.0018 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0023 0.0111
Echinococcus granulosus caspase 2 0.0071 0.0169 0.1403
Brugia malayi neurofibromatosis homolog protein 1 0.0035 0.0062 0.0498
Trypanosoma cruzi metacaspase, putative 0.0021 0.0023 0.0059
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0175 0.0173
Schistosoma mansoni polycystin 1-related 0.0024 0.003 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0022
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0105 0.0855
Brugia malayi Doublecortin family protein 0.0024 0.003 0.0229
Schistosoma mansoni hypothetical protein 0.0034 0.0059 0.0492
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0023 0.002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0023 0.002
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0002 0.0005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Echinococcus granulosus traf and tnf receptor associated protein 0.0218 0.06 0.4995
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0024 0.0197
Schistosoma mansoni rab6-interacting 0.0024 0.003 0.0248
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0113 0.029 0.2416
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0024 0.0061
Loa Loa (eye worm) hypothetical protein 0.0286 0.0798 0.6632
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0005 0.0012
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0023 0.002
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0216
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0574 0.4761
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0093 0.009
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0295 0.4436
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0023 0.0059
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0023 0.002
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0097 0.0094
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0023 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0006 0.0029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0024 0.0061
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0021 0.0023 0.0169
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0054 0.0141
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0024 0.0669
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0074 0.0176 0.0173
Schistosoma mansoni hypothetical protein 0.005 0.0106 0.0881
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0175 0.0461
Brugia malayi hypoxia-induced factor 1 0.0182 0.0494 0.4094
Schistosoma mansoni caspase-3 (C14 family) 0.0021 0.0023 0.0188
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0137 0.0361 0.1792
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0132 0.1101
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0023 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0175 0.0173
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0049 0.0047
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0295 0.1462
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0295 0.2437
Echinococcus multilocularis RUN 0.0024 0.003 0.0248
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0097 0.0805
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0005 0.002
Trypanosoma brucei metacaspase 5, putative 0.0021 0.0023 0.0059
Plasmodium falciparum metacaspase 1 0.0021 0.0023 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0423 0.1202 1
Brugia malayi hypothetical protein 0.0024 0.003 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0054 0.0142
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0113 0.029 0.2416
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0087 0.0727
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0002 0.0005
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0123 0.032 0.0318
Onchocerca volvulus 0.0024 0.003 0.0384
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Trypanosoma cruzi metacaspase, putative 0.0021 0.0023 0.0059
Loa Loa (eye worm) moesin 0.0061 0.0138 0.1131
Entamoeba histolytica rodhanase-like domain containing protein 0.0137 0.0361 0.1792
Schistosoma mansoni hypothetical protein 0.0205 0.056 0.4663
Echinococcus multilocularis caspase 0.0021 0.0023 0.0188
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.032 0.1586
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Schistosoma mansoni DNA polymerase eta 0.0077 0.0187 0.1556
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0023 0.002
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0163 0.043
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0218 0.06 0.4985
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0423 0.1202 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.006 0.0135 0.1107
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Echinococcus multilocularis traf and tnf receptor associated protein 0.0218 0.06 0.4995
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0054 0.0141
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0023 0.002
Trypanosoma brucei Peptide deformylase 2 0.1305 0.3791 1
Brugia malayi hypothetical protein 0.0182 0.0495 0.411
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0187 0.0492
Loa Loa (eye worm) hypothetical protein 0.0126 0.033 0.273
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0097 0.0254
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0024 0.0021
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0006 0.0014
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0023 0.002
Onchocerca volvulus 0.003 0.0048 0.0661
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0175 0.1457
Brugia malayi hypothetical protein 0.0043 0.0087 0.0709
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0006 0.0014
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0023 0.0059
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0054 0.0141
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.0137 0.0361 0.2991
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0295 0.2452
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0295 0.1462
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0049 0.0129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0175 0.0173
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0024 0.0021
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.029 0.0765
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0295 0.1462
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0113 0.029 0.2401
Trypanosoma brucei Polypeptide deformylase 1 0.1305 0.3791 1
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0113 0.029 0.2416
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0135 0.1125
Brugia malayi hypothetical protein 0.0197 0.0538 0.4468
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0137 0.0361 0.1792
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0049
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0011 0.0009
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0023 0.002
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0005 0.0022
Echinococcus granulosus bloom syndrome protein 0.0026 0.0036 0.0296
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0097 0.0254
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0023 0.0059
Onchocerca volvulus 0.0137 0.0361 0.5454
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0087 0.0727
Schistosoma mansoni dual specificity protein phosphatase 0.0014 0.0001 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0187 0.0492
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0097 0.0805
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0163 0.0161
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0039 0.0075 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0002 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0163 0.0161
Echinococcus granulosus H17g protein tegumental antigen 0.0061 0.0138 0.1148
Entamoeba histolytica hypothetical protein 0.0043 0.0087 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0054 0.0142
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.1305 0.3791 1
Onchocerca volvulus 0.0238 0.0658 1
Brugia malayi hypothetical protein 0.0023 0.0028 0.0216
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.003 0.0248
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0036 0.0175
Trichomonas vaginalis cdc25c, putative 0.0137 0.0361 0.1792
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0113 0.029 0.0267
Onchocerca volvulus 0.0043 0.0088 0.1267
Schistosoma mansoni ap endonuclease 0.0022 0.0024 0.0197
Schistosoma mansoni caspase-7 (C14 family) 0.0071 0.0169 0.1403
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.001 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0006 0.0049
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0024 0.0177
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0175 0.1457
Leishmania major DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Echinococcus granulosus radixin 0.0033 0.0058 0.0484
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0158 0.1296
Trypanosoma cruzi metacaspase, putative 0.0021 0.0023 0.0059
Trypanosoma cruzi Peptide deformylase 2, putative 0.1305 0.3791 1
Trypanosoma brucei metacaspase 0.0021 0.0023 0.0059
Onchocerca volvulus 0.0058 0.0131 0.193
Loa Loa (eye worm) hypothetical protein 0.0137 0.0361 0.2991
Brugia malayi glucose-6-phosphate dehydrogenase 0.0113 0.029 0.2401
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0113 0.029 0.0288
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0005 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.003 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0169
Trichomonas vaginalis cdc25b, putative 0.0137 0.0361 0.1792
Echinococcus granulosus tumor protein p63 0.0408 0.1157 0.9629
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0093 0.0244
Loa Loa (eye worm) hypothetical protein 0.0077 0.0187 0.1539
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Echinococcus multilocularis ezrin 0.0033 0.0058 0.0484
Leishmania major DNA polymerase eta, putative 0.0077 0.0187 0.0492
Schistosoma mansoni rab6-interacting 0.0024 0.003 0.0248
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0295 0.0777
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0295 0.1462
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0229
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0113 0.029 0.0765
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0029
Echinococcus granulosus dna polymerase eta 0.0077 0.0187 0.1556
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0026 0.0024
Onchocerca volvulus 0.0137 0.0361 0.5454
Echinococcus multilocularis GPCR, family 2 0.0016 0.0006 0.0049
Schistosoma mansoni loxhd1 0.0024 0.003 0.0248
Entamoeba histolytica dual specificity protein phosphatase, putative 0.07 0.2014 1
Trypanosoma brucei unspecified product 0.0032 0.0054 0.0142
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0023 0.002
Schistosoma mansoni single-minded 0.0059 0.0132 0.1101
Toxoplasma gondii exonuclease III APE 0.0022 0.0024 0.0021
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0036 0.0066 0.0174
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0137 0.0361 0.1792
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0023 0.002
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0123 0.032 0.0318
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0024 0.0061
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0295 0.2437
Loa Loa (eye worm) cytochrome P450 0.0021 0.0023 0.0169
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Brugia malayi hypothetical protein 0.0286 0.0798 0.6632
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0054 0.0428
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0023 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0024 0.0116
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Brugia malayi Cytochrome P450 family protein 0.0032 0.0054 0.0428
Echinococcus granulosus RUN 0.0024 0.003 0.0248
Trypanosoma cruzi metacaspase, putative 0.0021 0.0023 0.0059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0024 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0391
Leishmania major DNA polymerase kappa, putative 0.0014 0.0002 0.0005
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0123 0.032 0.1586
Echinococcus multilocularis 0.0021 0.0023 0.0188
Echinococcus granulosus caspase 0.0021 0.0023 0.0188
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0149
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0097 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0295 0.1462
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0023 0.002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0097 0.0254
Leishmania major metacaspase, putative 0.0021 0.0023 0.0059
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0037 0.0069 0.0182
Schistosoma mansoni caspase-7 (C14 family) 0.0021 0.0023 0.0188
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0113 0.029 0.0286
Brugia malayi Rhodanese-like domain containing protein 0.0137 0.0361 0.2991
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0024 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0048 0.0399
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0295 0.2452
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0006 0.0029
Leishmania major protein kinase, putative 0.0016 0.0006 0.0014
Brugia malayi Cytochrome P450 family protein 0.0021 0.0023 0.0169
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0023 0.002
Brugia malayi hypothetical protein 0.005 0.0106 0.0863
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0295 0.2452
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0048 0.0399
Leishmania major polypeptide deformylase-like protein, putative 0.1305 0.3791 1
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0002 0.0005
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0023 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0131 0.1071
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0005 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0187 0.1539
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0059 0.0473
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0021 0.0023 0.0188
Brugia malayi Pre-SET motif family protein 0.0209 0.0574 0.4761
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0295 0.1462
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0126 0.0622
Leishmania major cytochrome p450-like protein 0.0032 0.0054 0.0141
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0048 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0295 0.1462
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0658 0.3267
Brugia malayi cytochrome P450 0.0021 0.0023 0.0169
Entamoeba histolytica hypothetical protein 0.0043 0.0087 0.0432
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0023 0.0018
Echinococcus granulosus dna polymerase kappa 0.0047 0.0097 0.0805
Onchocerca volvulus 0.0137 0.0361 0.5454
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0024 0.0116
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0054 0.0051
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.0494 0.4094
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0049 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.003 0.0248
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0105 0.0855
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.003 0.0248
Echinococcus granulosus caspase 8 0.0021 0.0023 0.0188
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0023 0.002
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0061 0.0138 0.1148
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0123 0.032 1
Brugia malayi Moesin/ezrin/radixin homolog 1 0.0061 0.0138 0.1131
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0097 0.0805
Echinococcus multilocularis geminin 0.0205 0.056 0.4663
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0045 0.0372
Trypanosoma brucei metacaspase MCA2 0.0021 0.0023 0.0059
Onchocerca volvulus 4.1 G protein, putative homolog 0.0018 0.0011 0.0102
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0005 0.0039
Echinococcus multilocularis caspase 8 0.0021 0.0023 0.0188
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0024 0.0197
Trypanosoma brucei metacaspase MCA3 0.0021 0.0023 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0229
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0006 0.0049
Brugia malayi PAS domain containing protein 0.0059 0.0132 0.1083
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0023 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0023 0.0111
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0137 0.0361 0.3005
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0156 0.1294
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0054 0.0142
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0021 0.0023 0.0188
Loa Loa (eye worm) hypothetical protein 0.0126 0.033 0.273
Brugia malayi Rhodanese-like domain containing protein 0.0137 0.0361 0.2991
Leishmania major DNA polymerase eta, putative 0.0045 0.0093 0.0244
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0175 0.1457
Trypanosoma brucei polo-like protein kinase 0.0114 0.0295 0.0777
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.003 0.0248
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0048 0.0399
Loa Loa (eye worm) hypothetical protein 0.0049 0.0105 0.0855
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0049 0.0129
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0005 0.0022
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0097 0.0479
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0024 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0798 0.6639
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0023 0.0111
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0002 0.0005
Leishmania major cytochrome p450-like protein 0.0021 0.0023 0.0059
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0023 0.002
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0006 0.0014
Trypanosoma brucei Metacaspase-4 0.0021 0.0023 0.0059
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0137 0.0361 0.3005
Giardia lamblia DINP protein human, muc B family 0.0047 0.0097 0.2972
Leishmania major protein kinase, putative 0.0016 0.0006 0.0014
Entamoeba histolytica hypothetical protein 0.0043 0.0087 0.0432
Echinococcus multilocularis tumor protein p63 0.0408 0.1157 0.9629
Onchocerca volvulus Cell death protein 3 homolog 0.0071 0.0169 0.2508
Leishmania major DNA damage repair protein, putative 0.0014 0.0002 0.0005
Brugia malayi hypothetical protein 0.003 0.0049 0.0391
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0005 0.0039
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0002 0.0005
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0037 0.007 0.0579
Trypanosoma brucei unspecified product 0.0032 0.0054 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0023 0.0111
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0023 0.002
Entamoeba histolytica hypothetical protein 0.0043 0.0087 0.0432
Plasmodium vivax metacaspase 1, putative 0.0021 0.0023 0.002
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0295 0.0777
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0123 0.032 0.0318
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0074 0.0176 0.0173
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0023 0.002
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.1305 0.3791 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0036 0.0175
Schistosoma mansoni hypothetical protein 0.0043 0.0087 0.0727
Schistosoma mansoni hypothetical protein 0.0205 0.056 0.4663
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0002 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0423 0.1202 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0048 0.0399
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0163 0.1341
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Loa Loa (eye worm) hypothetical protein 0.0197 0.0538 0.4468
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0097 0.0805
Loa Loa (eye worm) doublecortin family protein 0.0024 0.003 0.0229
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0105 0.0855
Echinococcus granulosus geminin 0.0205 0.056 0.4663
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.0023 0.0059
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.032 0.1586
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0005 0.0022
Brugia malayi Cell death protein 3 precursor 0.0071 0.0169 0.1386
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0022
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0088 0.071
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0088 0.0728
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0295 0.0777
Echinococcus granulosus GPCR family 2 0.0016 0.0006 0.0049
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0023 0.002
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0156 0.1294
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0024 0.0021
Echinococcus multilocularis radixin 0.0033 0.0058 0.0484
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0137 0.0361 0.1792
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0005 0.0022
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0005 0.0012
Schistosoma mansoni hypothetical protein 0.0024 0.003 0.0248
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0049 0.0047
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0024 0.0001
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0216
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0097 0.0254
Schistosoma mansoni survival motor neuron protein 0.0058 0.0131 0.1089
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0023 0.002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0097 0.0786
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0006 0.0029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0175 0.1457
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0054 0.0428
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.015 0.1227
Giardia lamblia Kinase, PLK 0.0114 0.0295 0.9208
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0215 0.0591 0.4906
Brugia malayi Pre-SET motif family protein 0.003 0.0048 0.038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0048 0.0399
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.003 0.0248
Trichomonas vaginalis cdc25b, putative 0.0137 0.0361 0.1792
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0006 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0295 0.1462
Leishmania major cytochrome p450-like protein 0.0021 0.0023 0.0059
Plasmodium vivax SET domain protein, putative 0.003 0.0048 0.0046
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.0106 0.0881
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.029 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0097 0.0254
Onchocerca volvulus 0.0182 0.0495 0.7508
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0169 0.1386
Schistosoma mansoni ap endonuclease 0.0022 0.0024 0.0197
Schistosoma mansoni merlin/moesin/ezrin/radixin 0.0054 0.0118 0.0982

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.35 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (binding) 5.037 uM PubChem BioAssay. Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 12.22 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
IC50 (functional) = 25.2 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 94.153 uM PubChem BioAssay. Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6679 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 7.5193 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.1821 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.5227 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 30.1313 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 60.1198 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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