Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.325 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0014 | 0.1238 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.325 | 0.325 |
Brugia malayi | cytochrome P450 | 0.0014 | 0.1238 | 0.08 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0014 | 0.1238 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.325 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5444 | 0.5444 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0014 | 0.1238 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.325 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0014 | 0.1238 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.6578 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.325 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.6578 | 0.6407 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.6578 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.6013 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.7367 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0014 | 0.1238 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.325 | 0.2912 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.1238 | 0.1105 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0014 | 0.1238 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0477 | 0.0477 |
Schistosoma mansoni | cytochrome P450 | 0.0014 | 0.1238 | 0.1105 |
Loa Loa (eye worm) | cytochrome P450 | 0.0014 | 0.1238 | 0.1238 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.7367 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.6013 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0014 | 0.1238 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0014 | 0.1238 | 0.1248 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0014 | 0.1238 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.325 | 0.325 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.325 | 0.2912 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0014 | 0.1238 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0014 | 0.1238 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.1238 | 0.08 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.325 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0014 | 0.1238 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.325 | 0.325 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0014 | 0.1238 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0014 | 0.1238 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.6578 | 0.6578 |
Echinococcus multilocularis | 0.0014 | 0.1238 | 0.1248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.