Detailed information for compound 151130

Basic information

Technical information
  • TDR Targets ID: 151130
  • Name: 2,3,5-trimethyl-6-[phenyl(pyridin-3-yl)methyl ]cyclohexa-2,5-diene-1,4-dione
  • MW: 317.381 | Formula: C21H19NO2
  • H donors: 0 H acceptors: 3 LogP: 3.47 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1=C(C)C(=O)C(=C(C1=O)C)C(c1cccnc1)c1ccccc1
  • InChi: 1S/C21H19NO2/c1-13-14(2)21(24)18(15(3)20(13)23)19(16-8-5-4-6-9-16)17-10-7-11-22-12-17/h4-12,19H,1-3H3
  • InChiKey: SGIHYXJMITWKGI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3,5-trimethyl-6-[phenyl(3-pyridyl)methyl]-1,4-benzoquinone
  • 2,3,5-trimethyl-6-[phenyl(3-pyridyl)methyl]-p-benzoquinone
  • 2,3,5-trimethyl-6-(phenyl-pyridin-3-ylmethyl)cyclohexa-2,5-diene-1,4-dione
  • 2,3,5-trimethyl-6-[phenyl-(3-pyridyl)methyl]-1,4-benzoquinone
  • 2,3,5-trimethyl-6-[phenyl-(3-pyridyl)methyl]-p-benzoquinone
  • 2,3,5-trimethyl-6-(phenyl-pyridin-3-yl-methyl)cyclohexa-2,5-diene-1,4-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0035 0.0239 0.0459
Onchocerca volvulus 0.0046 0.0343 0.0726
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0011 0.0011
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0236 0.0513
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0011 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0239 0.1069
Brugia malayi RasGEF domain containing protein 0.0012 0.0024 0.0053
Onchocerca volvulus 0.0027 0.0169 0.0347
Echinococcus granulosus son of sevenless 1 0.0012 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0103 0.0897 0.1022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0368
Schistosoma mansoni sodium/solute symporter 0.004 0.0294 0.0327
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0011 0.0001
Echinococcus multilocularis pyruvate kinase 0.0018 0.0075 0.0075
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0292 0.2184
Echinococcus multilocularis pyruvate kinase 0.0034 0.0236 0.0236
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0075 0.0093
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0138 0.0301
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0481 0.4506 1
Echinococcus granulosus dihydrofolate reductase 0.0478 0.4479 0.4478
Loa Loa (eye worm) Smad1 0.0024 0.0138 0.0301
Schistosoma mansoni hypothetical protein 0.0048 0.0365 0.0409
Schistosoma mansoni pyruvate kinase 0.0034 0.0236 0.026
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0154 0.0334
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0154 0.0335
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0395 0.0839
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0012 0.0024 0.0024
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0169 0.0367
Onchocerca volvulus 0.0017 0.0072 0.0135
Loa Loa (eye worm) thymidylate synthase 0.0238 0.2184 0.4751
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0012 0.0024 0.0063
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0395 0.0443
Loa Loa (eye worm) dihydrofolate reductase 0.0478 0.4479 0.9743
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0012 0.0019 0.001
Brugia malayi nuclear hormone receptor 0.0024 0.0137 0.0297
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0357
Brugia malayi hypothetical protein 0.0016 0.0057 0.0123
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0748 0.1605
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0329 0.0716
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0033 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0395 0.0395
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.1339 0.2913
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0239 0.0462
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0897 0.1951
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.1339 0.1339
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0136 0.0936
Brugia malayi tailless protein 0.0024 0.0137 0.0297
Loa Loa (eye worm) beta-lactamase 0.0035 0.0239 0.052
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0236 0.1054
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0138 0.0138
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0395 0.0395
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0395 0.0395
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0549 0.1152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0368
Echinococcus multilocularis cpg binding protein 0.003 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Brugia malayi RasGEF domain containing protein 0.0012 0.0024 0.0053
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0017 0.0072 0.0072
Echinococcus multilocularis GPCR, family 2 0.0048 0.0365 0.0364
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0138 0.0138
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1715 0.1965
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0156
Schistosoma mansoni polycystin 1-related 0.0046 0.0343 0.0384
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0395 0.0395
Brugia malayi thymidylate synthase 0.0238 0.2184 0.4751
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0239 0.0479
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0034 0.0021
Brugia malayi conserved hypotetical protein 0.0024 0.0137 0.0297
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0302
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.001 0.0022
Brugia malayi Cytochrome P450 family protein 0.0018 0.0074 0.0161
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0541 0.0541
Onchocerca volvulus 0.0035 0.0239 0.05
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0194 0.0212
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.052
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0236 0.0493
Brugia malayi nuclear receptor RXR 0.0024 0.0137 0.0297
Leishmania major pyruvate kinase 0.0034 0.0236 0.0452
Echinococcus granulosus thymidylate synthase 0.0238 0.2184 0.2184
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0139 0.0256
Giardia lamblia Pyruvate kinase 0.0034 0.0236 0.1706
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0177 0.0177
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0072 0.0072
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0137 0.0136
Schistosoma mansoni intermediate filament proteins 0.0027 0.0169 0.0183
Brugia malayi hypothetical protein 0.0027 0.0164 0.0357
Schistosoma mansoni hypothetical protein 0.0917 0.8689 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Schistosoma mansoni hypothetical protein 0.0048 0.0365 0.0409
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0866 0.0865
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0236 0.0452
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1355 0.2948
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1875 0.4078
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0012 0.0024 0.0024
Toxoplasma gondii hypothetical protein 0.0017 0.0072 0.0085
Plasmodium falciparum pyruvate kinase 0.0034 0.0236 0.0452
Echinococcus multilocularis dihydrofolate reductase 0.0478 0.4479 0.4478
Plasmodium vivax kinesin-5 0.0137 0.1217 0.2646
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0053
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0236 0.0493
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0074 0.009
Echinococcus multilocularis pyruvate kinase 0.0034 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0075 0.0093
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0183 0.0398
Schistosoma mansoni rab6-interacting 0.0046 0.0343 0.0384
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0357
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0169 0.0367
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0024 0.0136 0.0296
Brugia malayi hypothetical protein 0.0017 0.0072 0.0157
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.052
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.001 0.001
Schistosoma mansoni transient receptor potential channel 0.0066 0.0541 0.0612
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0478 0.4479 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0011 0.0011
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0137 0.0136
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0395 0.0858
Loa Loa (eye worm) acetyltransferase 0.015 0.1339 0.2912
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.052
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0164 0.0357
Brugia malayi Cytochrome P450 family protein 0.0018 0.0074 0.0161
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0236 0.0452
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1355 0.2948
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0194 0.0212
Schistosoma mansoni lamin 0.0027 0.0169 0.0183
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0481 0.4506 1
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0074 0.011
Echinococcus granulosus ras GTP exchange factor 0.0012 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0048 0.0365 0.0409
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0154 0.0268
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0154 0.1014
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0006 0.0013
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0024 0.0017
Plasmodium falciparum thioredoxin reductase 0.0039 0.0275 0.0539
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.028 0.028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0395 0.0395
Brugia malayi MH1 domain containing protein 0.0013 0.0035 0.0075
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0541 0.0541
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0748 0.1605
Giardia lamblia Pyruvate kinase 0.0018 0.0075 0.035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0365 0.0793
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0072 0.0072
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0343 0.0343
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0549 0.1159
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.001 0.0021
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0011 0.0011
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0275 0.0539
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0164 0.0357
Loa Loa (eye worm) hypothetical protein 0.0103 0.0897 0.195
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0137 0.0297
Loa Loa (eye worm) runx1 0.0061 0.0494 0.1075
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0154 0.0166
Leishmania major trypanothione reductase 0.0039 0.0275 0.0539
Brugia malayi Kinesin motor domain containing protein 0.0137 0.1217 0.2649
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1715 0.1965
Trichomonas vaginalis ras GTP exchange factor, putative 0.0012 0.0024 0.0063
Schistosoma mansoni coup transcription factor 0.0051 0.0395 0.0443
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0137 0.0146
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0395 0.0443
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0478 0.4479 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0137 0.0146
Giardia lamblia Kinesin-5 0.0137 0.1217 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0395 0.0858
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0154 0.0335
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0011 0.0011
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0481 0.4506 1
Chlamydia trachomatis dihydrofolate reductase 0.0478 0.4479 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0395 0.0859
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0395 0.0443
Schistosoma mansoni kinesin eg-5 0.0137 0.1217 0.1391
Loa Loa (eye worm) hypothetical protein 0.049 0.4597 1
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1715 0.1965
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0841 0.1817
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0024 0.0053
Brugia malayi hypothetical protein 0.0027 0.0164 0.0357
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0001
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0154 0.0268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0395 0.0395
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0024 0.0017
Echinococcus granulosus pyruvate kinase 0.0018 0.0075 0.0075
Echinococcus multilocularis lamin 0.0027 0.0169 0.0169
Echinococcus granulosus RUN 0.0046 0.0343 0.0343
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0072 0.0157
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0011 0.0001
Schistosoma mansoni lozenge 0.0061 0.0494 0.0558
Brugia malayi hypothetical protein 0.0113 0.099 0.2153
Schistosoma mansoni high-affinity choline transporter 0.004 0.0294 0.0327
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.1715 0.3732
Schistosoma mansoni lipoxygenase 0.0121 0.1068 0.1219
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0137 0.0276
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0395 0.0395
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0275 0.0542
Schistosoma mansoni cpg binding protein 0.0028 0.0177 0.0192
Onchocerca volvulus 0.0028 0.0177 0.0364
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0034 0.0074
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0841 0.1817
Brugia malayi hypothetical protein 0.0024 0.0137 0.0297
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0395 0.0443
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0137 0.0297
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0867 0.8208 0.8208
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0395 0.0395
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0239 0.0459
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0138 0.0138
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0292 0.2246
Loa Loa (eye worm) doublecortin family protein 0.0046 0.0343 0.0745
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0858
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0294 0.0293
Loa Loa (eye worm) transcription factor SMAD2 0.0356 0.3316 0.7214
Onchocerca volvulus 0.003 0.0194 0.04
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0137 0.0136
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0137 0.0136
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0139 0.0235
Echinococcus multilocularis son of sevenless 1 0.0012 0.0024 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0549 0.1159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0395 0.0443
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0238 0.2184 0.4837
Brugia malayi Smad1 0.0024 0.0138 0.0301
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0549 0.1159
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0072 0.0072
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0154 0.0268
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0012 0.0024 0.0024
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0395 0.0858
Echinococcus granulosus pyruvate kinase 0.0034 0.0236 0.0236
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1299 0.1298
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0194 0.0357
Treponema pallidum NADH oxidase 0.0013 0.0034 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0549 0.0621
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0541 0.0541
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0138 0.0148
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0154 0.0154
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0352 0.3278 0.7125
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0263 0.0263
Onchocerca volvulus 0.0012 0.0024 0.0032
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0012 0.0024 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0327 0.1483
Onchocerca volvulus 0.0035 0.0239 0.05
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0395 0.0858
Mycobacterium tuberculosis Conserved protein 0.0035 0.0239 0.0462
Trypanosoma brucei trypanothione reductase 0.0039 0.0275 0.0539
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0395 0.0859
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0368
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0011 0.0011
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0263 0.0572
Loa Loa (eye worm) hypothetical protein 0.0048 0.0365 0.0793
Echinococcus multilocularis kinesin family 1 0.1054 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0549 0.0549
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0075 0.0093
Brugia malayi beta-lactamase family protein 0.0035 0.0239 0.052
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0327 0.1483
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0357
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0072 0.0072
Mycobacterium ulcerans lipase LipD 0.0035 0.0239 0.0462
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0327 0.0656
Brugia malayi Sodium:solute symporter family protein 0.004 0.0294 0.0639
Loa Loa (eye worm) nuclear factor I 0.0013 0.0035 0.0075
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0061
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0169 0.0368
Loa Loa (eye worm) hypothetical protein 0.049 0.4597 1
Echinococcus granulosus Protein son of sevenless 0.0012 0.0024 0.0024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0365 0.0364
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0858
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0203 0.1854 0.1854
Plasmodium vivax glutathione reductase, putative 0.0039 0.0275 0.0539
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0395 0.0859
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0137 0.0136
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0236 0.0513
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0137 0.0136
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0834 0.0833
Brugia malayi dihydrofolate reductase family protein 0.0478 0.4479 0.9743
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0395 0.0443
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0053
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0365 0.0793
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0154 0.0268
Schistosoma mansoni inositol transporter 0.004 0.0294 0.0327
Onchocerca volvulus 0.0027 0.0169 0.0347
Loa Loa (eye worm) hypothetical protein 0.01 0.0866 0.1883
Mycobacterium ulcerans hypothetical protein 0.0035 0.0239 0.0462
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0356 0.3316 0.3809
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0011 0.0001
Echinococcus multilocularis Protein son of sevenless 0.0012 0.0024 0.0024
Brugia malayi regulator of G-protein signaling egl-10 0.0017 0.0072 0.0157
Onchocerca volvulus 0.0046 0.0343 0.0726
Schistosoma mansoni transient receptor potential channel 0.0066 0.0541 0.0612
Brugia malayi Pre-SET motif family protein 0.0206 0.1875 0.4078
Schistosoma mansoni inositol transporter 0.004 0.0294 0.0327
Brugia malayi ecdysone receptor 0.0024 0.0137 0.0297
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0365 0.0364
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.099 0.4585
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0239 0.0264
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0858
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0074 0.016
Echinococcus granulosus cpg binding protein 0.003 0.0192 0.0192
Echinococcus granulosus Pleckstrin G protein interacting region 0.0017 0.0072 0.0072
Echinococcus granulosus GPCR family 2 0.0048 0.0365 0.0364
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0395 0.0859
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0138 0.0301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0137 0.0136
Entamoeba histolytica kinesin, putative 0.0137 0.1217 1
Mycobacterium tuberculosis Hypothetical protein 0.0113 0.099 0.215
Echinococcus multilocularis high affinity choline transporter 1 0.004 0.0294 0.0293
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0011 0.0011
Onchocerca volvulus 0.004 0.0294 0.0618
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0841 0.1817
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1355 0.2948
Loa Loa (eye worm) hypothetical protein 0.0034 0.0231 0.0502
Onchocerca volvulus 0.0234 0.2146 0.4657
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0357
Echinococcus multilocularis musashi 0.0027 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0046 0.0343 0.0745
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0866 0.0986
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0239 0.1069
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0034 0.0021
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0343 0.0343
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0236 0.0454
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0239 0.0239
Echinococcus multilocularis Protein lozenge 0.0061 0.0494 0.0494
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0071
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0164 0.0164
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0239 0.0462
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0156
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0294 0.0293
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0154 0.1086
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0011 0.0011 0.0024
Plasmodium vivax SET domain protein, putative 0.003 0.0194 0.0357
Echinococcus granulosus Smad4 0.0024 0.0138 0.0138
Toxoplasma gondii kinesin motor domain-containing protein 0.0137 0.1217 0.2646
Plasmodium falciparum glutathione reductase 0.0039 0.0275 0.0539
Loa Loa (eye worm) TAR-binding protein 0.0189 0.1715 0.3732
Mycobacterium leprae Probable lipase LipE 0.0035 0.0239 0.0008
Schistosoma mansoni nuclear receptor 0.0024 0.0137 0.0146
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0034 0.0108
Schistosoma mansoni Smad4 0.0024 0.0138 0.0148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0263 0.0572
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0841 0.1427
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0164 0.0164
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0343 0.0343
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0137 0.0146
Onchocerca volvulus 0.0051 0.0395 0.0839
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0113 0.099 0.2154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0395 0.0395
Echinococcus granulosus intermediate filament protein 0.0027 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0356 0.3316 0.3809
Brugia malayi nuclear hormone receptor 0.0051 0.0395 0.0859
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0748 0.1605
Echinococcus multilocularis pyruvate kinase 0.0018 0.0075 0.0075
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0236 0.0513
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0395 0.0443
Trichomonas vaginalis ras GTP exchange factor, putative 0.0012 0.0024 0.0063
Leishmania major pyruvate kinase 0.0034 0.0236 0.0452
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.001 0.001
Echinococcus multilocularis tar DNA binding protein 0.0189 0.1715 0.1715
Brugia malayi hypothetical protein 0.0046 0.0343 0.0746
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0139 0.0235
Echinococcus granulosus pyruvate kinase 0.0018 0.0075 0.0075
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0239 0.0462
Schistosoma mansoni smad1 5 8 and 0.0024 0.0138 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0395 0.0859
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0294 0.0293
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0034 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0395 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0395 0.0859
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0021
Loa Loa (eye worm) hypothetical protein 0.0352 0.3278 0.7131
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0858
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0238 0.2184 0.2505
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0395 0.0858
Brugia malayi hypothetical protein 0.049 0.4597 1
Brugia malayi MH2 domain containing protein 0.0024 0.0138 0.0301
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.052
Brugia malayi hypothetical protein 0.0046 0.0343 0.0746
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0421
Echinococcus multilocularis solute carrier family 5 0.004 0.0294 0.0293
Echinococcus granulosus tar DNA binding protein 0.0189 0.1715 0.1715
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.0024 0.0138 0.0301
Schistosoma mansoni dep domain containing protein 0.0017 0.0072 0.0072
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0465 0.0963
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0017 0.0072 0.0072
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Loa Loa (eye worm) glutathione reductase 0.0039 0.0275 0.0598
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0072 0.0072
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0034 0.0021
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.028 0.028
Schistosoma mansoni pyruvate kinase 0.0018 0.0075 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0011 0.0001
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0236 0.0493
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1715 0.1965
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0239 0.0239
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0012 0.0024 0.0032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0239 0.052
Plasmodium falciparum LCCL domain-containing protein 0.0046 0.0343 0.0691
Mycobacterium tuberculosis Probable reductase 0.0088 0.0748 0.1605
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0024 0.0017
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0011 0.0023
Brugia malayi glutathione reductase 0.0039 0.0275 0.0598
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0239 0.0462
Schistosoma mansoni z-protein (S1r protein) 0.0017 0.0072 0.0072
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0239 0.0462
Schistosoma mansoni cpg binding protein 0.003 0.0192 0.021
Echinococcus multilocularis RUN 0.0046 0.0343 0.0343
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0236 0.0513
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0012 0.0024 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0395 0.0858
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0154 0.0289
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0395 0.0395
Brugia malayi MH1 domain containing protein 0.0013 0.0035 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0239 0.0479
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0011 0.0011
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0011 0.0011
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0047 0.0102
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0395 0.0443
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0156
Brugia malayi hypothetical protein 0.0017 0.0072 0.0157
Loa Loa (eye worm) hypothetical protein 0.004 0.0294 0.0638
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0137 0.0136
Schistosoma mansoni loxhd1 0.0046 0.0343 0.0384
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0203 0.1854 0.1854
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0047 0.0102
Brugia malayi intermediate filament protein 0.0027 0.0169 0.0368
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0063 0.0509 0.1106
Brugia malayi Doublecortin family protein 0.0046 0.0343 0.0746
Brugia malayi hypothetical protein 0.0024 0.0139 0.0303
Loa Loa (eye worm) hypothetical protein 0.0034 0.0236 0.0513
Loa Loa (eye worm) hypothetical protein 0.0046 0.0343 0.0745
Brugia malayi RNA binding protein 0.0189 0.1715 0.3732
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0072 0.0157
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0164 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0137 0.0136
Brugia malayi ecdysteroid receptor 0.0051 0.0395 0.0859
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0365 0.0364
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0074 0.016
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0395 0.0859
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0011 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0329 0.0715
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0239 0.1069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0194 0.0212
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0239 0.052
Plasmodium vivax multidomain scavenger receptor, putative 0.0046 0.0343 0.0691
Schistosoma mansoni nuclear receptor 0.0024 0.0137 0.0146
Brugia malayi MH2 domain containing protein 0.0356 0.3316 0.7214
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0239 0.0462
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0294 0.0293
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0858
Echinococcus granulosus solute carrier family 5 0.004 0.0294 0.0293
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0365 0.0793
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0074 0.011
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0275 0.0598
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0034 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0154 0.067
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0748 0.1206
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0395 0.0839
Echinococcus granulosus lamin 0.0027 0.0169 0.0169
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0481 0.4506 1
Brugia malayi N-terminal motif family protein 0.0012 0.0024 0.0053
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0238 0.2184 0.4591
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.001 0.001
Brugia malayi beta-lactamase family protein 0.0035 0.0239 0.052
Brugia malayi RasGEF domain containing protein 0.0012 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.052
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0072 0.0072
Loa Loa (eye worm) kinesin-like protein KLP2 0.0137 0.1217 0.2648
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0834 0.0833
Chlamydia trachomatis pyruvate kinase 0.0034 0.0236 0.0454
Echinococcus granulosus Polycystic kidney disease protein 0.0046 0.0343 0.0343
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2146 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0327 0.0656
Schistosoma mansoni rab6-interacting 0.0046 0.0343 0.0384
Brugia malayi GH02984p 0.004 0.0294 0.0639
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0292 0.0578
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2033 0.4498
Brugia malayi N-terminal motif family protein 0.0012 0.0024 0.0053
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0137 0.0297
Mycobacterium tuberculosis Conserved protein 0.0035 0.0239 0.0462
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0481 0.4506 1
Schistosoma mansoni transient receptor potential channel 0.01 0.0866 0.0986
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0024 0.0053
Brugia malayi beta-lactamase 0.0035 0.0239 0.052
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0858
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0137 0.0297
Mycobacterium ulcerans beta-lactamase 0.0035 0.0239 0.0462
Echinococcus multilocularis lamin dm0 0.0027 0.0169 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0239 0.1069
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0395 0.0839
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0395 0.0395
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0194 0.0193
Echinococcus granulosus pyruvate kinase 0.0018 0.0075 0.0075
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0395 0.0443
Schistosoma mansoni ras GTP exchange factor 0.0012 0.0024 0.0017
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0748 0.1605
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0239 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0164 0.0178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0329 0.0329
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0236 0.0472
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0072 0.0072
Brugia malayi nuclear receptor RXR 0.0027 0.0164 0.0357
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0011 0.0001
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0137 0.0297
Onchocerca volvulus 0.0024 0.0137 0.0276
Echinococcus multilocularis smad 0.0024 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0357
Brugia malayi TAR-binding protein 0.0189 0.1715 0.3732
Echinococcus multilocularis pyruvate kinase 0.0027 0.0166 0.0166
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0343 0.0343
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0177 0.0384
Brugia malayi steroid hormone receptor 0.0051 0.0395 0.0859
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0021
Brugia malayi DIX domain containing protein 0.0017 0.0072 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0356 0.3316 0.7214
Loa Loa (eye worm) DIX domain-containing protein 0.0017 0.0072 0.0156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0239 0.0264
Onchocerca volvulus 0.0035 0.0239 0.05
Brugia malayi Cytochrome P450 family protein 0.0029 0.0183 0.0398
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0395 0.0859
Echinococcus multilocularis Polycystic kidney disease protein 0.0046 0.0343 0.0343
Schistosoma mansoni hypothetical protein 0.0048 0.0365 0.0409
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0549 0.1152
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0866 0.0865
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0239 0.0462
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0137 0.0146
Echinococcus granulosus lamin dm0 0.0027 0.0169 0.0169
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0275 0.0559
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0294 0.0293
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0395 0.0395
Brugia malayi N-terminal motif family protein 0.0352 0.3278 0.7131
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0491 0.0554
Mycobacterium ulcerans thymidylate synthase 0.0238 0.2184 0.4837
Schistosoma mansoni hypothetical protein 0.0046 0.0343 0.0384
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0549 0.1159
Plasmodium falciparum kinesin-5 0.0137 0.1217 0.2646
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0239 0.0462
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0236 0.1054
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0294 0.0293
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0294 0.0293
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0239 0.1069
Echinococcus granulosus geminin 0.0356 0.3316 0.3316
Leishmania major hypothetical protein, conserved 0.0035 0.0239 0.0459
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0541 0.0541
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0012 0.0024 0.0024
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0395 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0395 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0395 0.0859
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0395 0.0395
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0138 0.0138
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0011 0.0011
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0154 0.0166
Echinococcus granulosus pyruvate kinase 0.0034 0.0236 0.0236
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.1339 0.1531
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0395 0.0859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0395 0.0858
Schistosoma mansoni smad1 5 8 and 0.0024 0.0138 0.0148
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.052
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0137 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0395 0.0859
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.004 0.0294 0.0638
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0154 0.0166
Trichomonas vaginalis esterase, putative 0.0035 0.0239 0.1069
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0137 0.0297
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0395 0.0443
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0011 0.0001
Schistosoma mansoni smad1 5 8 and 0.0024 0.0138 0.0148
Loa Loa (eye worm) hypothetical protein 0.0151 0.1355 0.2948
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0023
Brugia malayi MH1 domain containing protein 0.0024 0.0138 0.0301
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0011 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0137 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0395 0.0859
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0074 0.0089
Trichomonas vaginalis chaperonin, putative 0.0026 0.0154 0.067
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0017 0.0072 0.0156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0194 0.0212
Schistosoma mansoni lamin 0.0027 0.0169 0.0183
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0137 0.0297
Schistosoma mansoni dihydrofolate reductase 0.0478 0.4479 0.5149
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0395 0.0395
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0075
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0365 0.0364
Toxoplasma gondii thioredoxin reductase 0.0039 0.0275 0.0539
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0549 0.0621
Brugia malayi MH1 domain containing protein 0.0024 0.0138 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0395 0.0858
Echinococcus multilocularis Smad4 0.0024 0.0138 0.0138
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0154 0.0268
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0327 0.0327
Leishmania major cytochrome p450-like protein 0.0018 0.0074 0.0089
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0236 0.0513
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0478 0.4479 1
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0061
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0137 0.0297
Schistosoma mansoni zinc finger protein 0.0024 0.0137 0.0146
Echinococcus multilocularis pyruvate kinase 0.0018 0.0075 0.0075
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.1715 0.3732
Brugia malayi hypothetical protein 0.0024 0.0137 0.0297
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0139 0.0235
Brugia malayi Dihydrofolate reductase 0.0478 0.4479 0.9743
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0194 0.0193
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0139 0.0235
Mycobacterium tuberculosis Conserved protein 0.0035 0.0239 0.0462
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0395 0.0395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0329 0.0329
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0236 0.0452
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0034 0.5
Brugia malayi nuclear receptor NHR-88 0.0051 0.0395 0.0859
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0021
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0011 0.001
Echinococcus multilocularis ras GTP exchange factor 0.0012 0.0024 0.0024
Schistosoma mansoni dishevelled 0.0017 0.0072 0.0072
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0395 0.0395
Brugia malayi Pre-SET motif family protein 0.003 0.0194 0.0421
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0137 0.0136
Onchocerca volvulus 0.0024 0.0137 0.0276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0395 0.0395
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0137 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0297
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0236 0.0454
Echinococcus granulosus high affinity choline transporter 1 0.004 0.0294 0.0293
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0021
Loa Loa (eye worm) RNA binding protein 0.0189 0.1715 0.3732
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0236 0.0472
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0072 0.0072
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0017 0.0072 0.0135
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0239 0.0459
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0023
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0327 0.0656
Brugia malayi CXXC zinc finger family protein 0.0028 0.0177 0.0385
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0137 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1715 0.1965
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0164 0.0357
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0011 0.0001
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0481 0.4506 1
Leishmania major hypothetical protein, conserved 0.0024 0.0139 0.0235
Schistosoma mansoni dishevelled 0.0017 0.0072 0.0072
Brugia malayi MH2 domain containing protein 0.0011 0.001 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0034 0.0021
Onchocerca volvulus 0.049 0.4597 1
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0236 0.0452
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0139 0.0256
Echinococcus multilocularis geminin 0.0356 0.3316 0.3316
Schistosoma mansoni cpg binding protein 0.003 0.0192 0.021
Brugia malayi Thioredoxin reductase 0.0039 0.0275 0.0598
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0011 0.0001
Schistosoma mansoni lipoxygenase 0.0203 0.1854 0.2125
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0011 0.0024
Brugia malayi nuclear receptor NHR-67 0.0024 0.0137 0.0297
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0011 0.0011 0.0023
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0033 0.0033
Echinococcus granulosus smad 0.0024 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0858
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0395 0.0443
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0137 0.0297
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0024 0.0053
Brugia malayi nuclear receptor NHR-88 0.0024 0.0137 0.0297
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0011 0.0011
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0011 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0194 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0395 0.0859
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0294 0.058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0395 0.0859
Schistosoma mansoni smad 0.0024 0.0138 0.0148
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0136 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0858
Onchocerca volvulus 0.0238 0.2184 0.474
Schistosoma mansoni pyruvate kinase 0.0034 0.0236 0.026
Echinococcus multilocularis thymidylate synthase 0.0238 0.2184 0.2184
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0169 0.0367
Loa Loa (eye worm) DR-78 0.0024 0.0137 0.0297
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0748 0.1605
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0011 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0239 0.0462
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0357
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0139 0.0235

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.00000086 M Reduction of lipid peroxide formed in rat brain homogenates. ChEMBL. 1992126
IC50 (functional) = 0.00000086 M Reduction of lipid peroxide formed in rat brain homogenates. ChEMBL. 1992126
IC50 (functional) = 0.0000076 M The concentration of the compound required to reduce by 50% the amount of LTB4 formed by RBL-1 cells ChEMBL. 1992126
Inhibition (functional) NT 0 % Inhibitory activity of compound against thromboxane A2 synthase evaluated as molar concentration required to reduce thromboxane B2 formed by 50% after incubating PGH-2 with horse platelet microsomes ChEMBL. 1992126
Inhibition (functional) = 29 % Inhibitory activity against horse thromboxane A2 synthase ChEMBL. 1992126
Inhibition (functional) = 29 % Inhibitory activity against horse thromboxane A2 synthase ChEMBL. 1992126
Inhibition (functional) = 73 % In vivo percent inhibition of lipid peroxidation in rat brain homogenates at 10e-6 M ChEMBL. 1992126
Inhibition (functional) = 73 % In vivo percent inhibition of lipid peroxidation in rat brain homogenates at 10e-6 M ChEMBL. 1992126
logP (ADMET) = 4.48 Partition coefficient (logP) ChEMBL. 1992126

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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