Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | insulin-like growth factor 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0158 | 0.2881 | 0.2844 |
Schistosoma mansoni | nuclear hormone receptor | 0.0158 | 0.2893 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3654 | 0.3654 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0158 | 0.2893 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3654 | 0.3654 |
Brugia malayi | nuclear hormone receptor | 0.0158 | 0.2893 | 0.2857 |
Brugia malayi | nuclear receptor RXR | 0.0158 | 0.2893 | 0.2857 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0158 | 0.2893 | 0.0018 |
Brugia malayi | ecdysone receptor | 0.0158 | 0.2893 | 0.2857 |
Brugia malayi | hypothetical protein | 0.0158 | 0.2893 | 0.2857 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0177 | 0.3654 | 0.1087 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0158 | 0.2893 | 0.0018 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0158 | 0.2881 | 0.2881 |
Brugia malayi | hypothetical protein | 0.0177 | 0.3654 | 0.3622 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0158 | 0.2893 | 0.0018 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0177 | 0.3654 | 0.3654 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0158 | 0.2893 | 0.0018 |
Schistosoma mansoni | nuclear hormone receptor | 0.0158 | 0.2893 | 0.0018 |
Brugia malayi | hypothetical protein | 0.0158 | 0.2893 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Brugia malayi | hypothetical protein | 0.0177 | 0.3654 | 0.3622 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0158 | 0.2893 | 0.0018 |
Brugia malayi | tailless protein | 0.0158 | 0.2893 | 0.2857 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0177 | 0.3654 | 0.1087 |
Schistosoma mansoni | nuclear receptor | 0.0158 | 0.2893 | 0.0018 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0158 | 0.2893 | 0.0018 |
Brugia malayi | nuclear receptor NHR-67 | 0.0158 | 0.2893 | 0.2857 |
Brugia malayi | nuclear receptor RXR | 0.0177 | 0.3654 | 0.3622 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0158 | 0.2893 | 0.2857 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0158 | 0.2893 | 0.2893 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0177 | 0.3654 | 0.1087 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0158 | 0.2893 | 0.0018 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0158 | 0.2893 | 0.0018 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0158 | 0.2893 | 0.0018 |
Brugia malayi | nuclear receptor NHR-88 | 0.0158 | 0.2893 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3654 | 0.3654 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0158 | 0.2893 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0158 | 0.2893 | 0.0018 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0177 | 0.3654 | 0.3622 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0177 | 0.3654 | 0.3622 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0158 | 0.2893 | 0.2857 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0158 | 0.2893 | 0.0018 |
Brugia malayi | conserved hypotetical protein | 0.0158 | 0.2893 | 0.2857 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0158 | 0.2893 | 0.2857 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0158 | 0.2893 | 0.2857 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0177 | 0.3654 | 0.1087 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0158 | 0.2893 | 0.2857 |
Loa Loa (eye worm) | DR-78 | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0158 | 0.2893 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3654 | 0.3654 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2893 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3654 | 0.3654 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0158 | 0.2893 | 0.2857 |
Schistosoma mansoni | zinc finger protein | 0.0158 | 0.2893 | 0.0018 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0158 | 0.2893 | 0.0018 |
Schistosoma mansoni | nuclear receptor | 0.0158 | 0.2893 | 0.0018 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay | ChEMBL. | 21441024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.