Detailed information for compound 1511490

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 422.503 | Formula: C21H22N6O2S
  • H donors: 2 H acceptors: 3 LogP: 3.12 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1cnc2c(c1)c(ccc2)NC(=S)Nc1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C21H22N6O2S/c1-25-8-10-26(11-9-25)17-13-18-19(22-14-17)6-3-7-20(18)24-21(30)23-15-4-2-5-16(12-15)27(28)29/h2-7,12-14H,8-11H2,1H3,(H2,23,24,30)
  • InChiKey: LMBLHZDMOYSPNG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0927 0.133
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Echinococcus granulosus geminin 0.0342 0.5037 0.5034
Loa Loa (eye worm) TAR-binding protein 0.0192 0.2792 0.4582
Brugia malayi protein kinase C II. 0.0022 0.0238 0.0384
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0437 0.0711
Mycobacterium leprae Probable lipase LipE 0.0035 0.0437 0.5
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0927 0.133
Echinococcus multilocularis GPCR, family 2 0.0017 0.0164 0.016
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0437 0.5
Leishmania major hypothetical protein, conserved 0.0035 0.0437 0.208
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0301 0.0427
Entamoeba histolytica protein kinase 2, putative 0.0042 0.0545 0.3547
Echinococcus multilocularis tar DNA binding protein 0.0192 0.2792 0.2789
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0238 0.0238
Leishmania major basic transcription factor 3a, putative 0.0034 0.0426 0.1999
Brugia malayi hypothetical protein 0.0009 0.0042 0.0061
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0608 0.0608
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0426 0.2766
Brugia malayi MH2 domain containing protein 0.0124 0.1776 0.2912
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0927 0.133
Brugia malayi Hr1 repeat family protein 0.0022 0.0238 0.0384
Echinococcus multilocularis serine:threonine protein kinase 38 0.0022 0.0238 0.0234
Mycobacterium tuberculosis Conserved protein 0.0035 0.0437 0.092
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.1528 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.0151 0.0959
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0151 0.0959
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0597 0.0593
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0437 0.0711
Echinococcus granulosus protein kinase c epsilon type 0.0022 0.0238 0.0234
Brugia malayi p70 ribosomal S6 kinase beta 0.0064 0.0864 0.1413
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3267 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0798 0.1304
Loa Loa (eye worm) AGC/PKN protein kinase 0.0022 0.0238 0.0384
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0597 0.0597
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0151 0.024
Plasmodium vivax SET domain protein, putative 0.0059 0.0798 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.1528 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Echinococcus multilocularis rac serine:threonine kinase 0.0046 0.0608 0.0603
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0608 0.3958
Brugia malayi MH1 domain containing protein 0.0008 0.0039 0.0057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0164 0.016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.6088 1
Brugia malayi Protein kinase domain containing protein 0.0022 0.0238 0.0384
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.1528 0.1528
Mycobacterium ulcerans beta-lactamase 0.0035 0.0437 1
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0068 0.0927 0.1516
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0039
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0042 0.0061
Toxoplasma gondii histone deacetylase SIR2-like 0.0016 0.0151 0.1324
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0426 0.4255
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.071 0.1159
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0437 0.0433
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.0151 0.024
Onchocerca volvulus 0.0009 0.0042 0.0054
Brugia malayi beta-lactamase 0.0035 0.0437 0.0711
Echinococcus multilocularis transcription factor btf3 0.0034 0.0426 0.0422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0798 0.0798
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0039 0.0057
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0108 0.1528 0.1524
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0437 0.284
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.0151 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0238 0.0238
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.1528 0.1528
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0046 0.0608 0.3958
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0042 0.0037
Echinococcus granulosus nervana 2 0.0042 0.0538 0.0534
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0608 0.3958
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0005 0.0005
Trichomonas vaginalis esterase, putative 0.0035 0.0437 0.0624
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0151 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0238 0.0238
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0021 0.0231 0.0327
Brugia malayi N-terminal motif family protein 0.0176 0.2545 0.4175
Loa Loa (eye worm) hypothetical protein 0.0035 0.0437 0.0711
Brugia malayi TAR-binding protein 0.0192 0.2792 0.4582
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1776 0.2912
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0765 0.0761
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0238 0.0238
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0437 0.0433
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0039
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0022 0.0238 0.0384
Brugia malayi MH2 domain containing protein 0.0008 0.0039 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2792 0.2792
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0238 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0927 0.133
Entamoeba histolytica protein kinase, putative 0.0022 0.0238 0.1535
Onchocerca volvulus 0.0035 0.0437 0.0624
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0022 0.0238 0.0234
Brugia malayi Pre-SET motif family protein 0.0059 0.0798 0.1304
Echinococcus multilocularis geminin 0.0342 0.5037 0.5034
Schistosoma mansoni Smad4 0.0008 0.0039 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0597 0.0597
Giardia lamblia Kinase, AGC PKA 0.0042 0.0545 0.2863
Echinococcus granulosus Glutaredoxin protein 5 0.0042 0.0538 0.0534
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0042 0.0061
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0437 0.0624
Loa Loa (eye worm) beta-lactamase 0.0035 0.0437 0.0711
Schistosoma mansoni hypothetical protein 0.0017 0.0164 0.0164
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0042 0.0545 0.6092
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0022 0.0238 0.0234
Mycobacterium ulcerans hypothetical protein 0.0035 0.0437 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.1528 0.2197
Echinococcus granulosus chromatin regulatory protein sir2 0.0108 0.1528 0.1524
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0042 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0597 0.0593
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0597 0.0593
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0597 0.0974
Entamoeba histolytica protein kinase, putative 0.0064 0.0864 0.5642
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0437 0.0624
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0042 0.0037
Brugia malayi beta-lactamase family protein 0.0035 0.0437 0.0711
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0437 0.0711
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0042 0.0037
Echinococcus multilocularis chromatin regulatory protein sir2 0.0108 0.1528 0.1524
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0022 0.0238 0.0384
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0426 0.6984
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0426 0.1999
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0426 0.2766
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0042 0.0061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0597 0.0974
Brugia malayi Pre-SET motif family protein 0.0412 0.6088 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0426 0.0608
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0437 0.092
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0034 0.0426 0.2766
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0426 0.0693
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0798 0.9195
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Echinococcus granulosus protein kinase C gamma type 0.0022 0.0238 0.0234
Echinococcus granulosus smad 0.0008 0.0039 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0238 0.0337
Toxoplasma gondii histone deacetylase SIR2 0.0016 0.0151 0.1324
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1776 0.2912
Brugia malayi beta-NAC-like protein 0.0034 0.0426 0.0693
Loa Loa (eye worm) hypothetical protein 0.0036 0.0457 0.0744
Echinococcus granulosus transcription factor btf3 0.0034 0.0426 0.0422
Loa Loa (eye worm) transcriptional regulator 0.0108 0.1528 0.2505
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0151 0.024
Echinococcus multilocularis nervana 2 0.0042 0.0538 0.0534
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0061
Schistosoma mansoni transcription factor btf3 0.0034 0.0426 0.0426
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0437 0.092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0798 0.0798
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0798 0.0794
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0042 0.0042
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.1528 0.2197
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0437 0.092
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0042 0.0545 0.3547
Mycobacterium ulcerans lipase LipD 0.0035 0.0437 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0022 0.0238 0.0234
Loa Loa (eye worm) RNA binding protein 0.0192 0.2792 0.4582
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0042 0.0037
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0022 0.0238 0.0234
Schistosoma mansoni hypothetical protein 0.0017 0.0164 0.0164
Brugia malayi DIX domain containing protein 0.0009 0.0042 0.0061
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0042 0.0061
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0437 0.092
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0022 0.0238 0.0384
Echinococcus multilocularis nervana 2 0.0042 0.0538 0.0534
Loa Loa (eye worm) Smad1 0.0008 0.0039 0.0057
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0016 0.0151 0.0959
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0042 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0437 0.284
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0437 0.0624
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0238 0.0238
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0151 0.0151
Trichomonas vaginalis set domain proteins, putative 0.0469 0.6942 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0005 0.0005
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.0151 0.0146
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0151 0.024
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0039 0.0035
Echinococcus granulosus tar DNA binding protein 0.0192 0.2792 0.2789
Echinococcus granulosus Protein kinase C brain isozyme 0.0022 0.0238 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0927 0.133
Onchocerca volvulus 0.0469 0.6942 1
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0608 0.0608
Schistosoma mansoni serine/threonine kinase 0.0022 0.0238 0.0238
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0437 0.092
Schistosoma mansoni atypical protein kinase C 0.0022 0.0238 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0238 0.0337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0798 0.0798
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0927 0.133
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2792 0.2792
Schistosoma mansoni hypothetical protein 0.0017 0.0164 0.0164
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.071 0.1159
Brugia malayi MH1 domain containing protein 0.0008 0.0039 0.0057
Loa Loa (eye worm) hypothetical protein 0.0176 0.2545 0.4175
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0164 0.016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0164 0.0263
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0035 0.0437 0.0711
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.0151 0.0959
Brugia malayi MH2 domain containing protein 0.0008 0.0039 0.0057
Echinococcus granulosus NDR protein kinase 0.0022 0.0238 0.0234
Echinococcus granulosus serine threonine protein kinase nrc 0.0042 0.0545 0.0541
Onchocerca volvulus 0.0035 0.0437 0.0624
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0042 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2792 0.2792
Mycobacterium tuberculosis Conserved protein 0.0035 0.0437 0.092
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2792 0.2792
Echinococcus multilocularis protein kinase c iota type 0.0022 0.0238 0.0234
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0039 0.0035
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0798 0.0794
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0108 0.1528 0.1524
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0042 0.0061
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0042 0.0037
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0022 0.0238 0.0234
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0798 0.0798
Leishmania major silent information regulator 2, putative 0.0108 0.1528 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.071 0.1159
Echinococcus multilocularis Glutaredoxin protein 5 0.0042 0.0538 0.0534
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0164 0.0263
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.0151 0.0959
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Loa Loa (eye worm) hypothetical protein 0.0016 0.0151 0.024
Giardia lamblia Hypothetical protein 0.0108 0.1528 1
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.2792 0.4582
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0437 0.4427
Loa Loa (eye worm) hypothetical protein 0.0035 0.0437 0.0711
Schistosoma mansoni hypothetical protein 0.0342 0.5037 0.5037
Trypanosoma cruzi Protein kinase B 0.0046 0.0608 0.3958
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0039 0.0035
Echinococcus multilocularis serine threonine protein kinase 0.0022 0.0238 0.0234
Schistosoma mansoni dishevelled 0.0009 0.0042 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0238 0.0337
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0039 0.0035
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0042 0.0037
Loa Loa (eye worm) AGC/NDR protein kinase 0.0022 0.0238 0.0384
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0437 0.092
Echinococcus granulosus nervana 2 0.0042 0.0538 0.0534
Brugia malayi Protein kinase domain containing protein 0.0022 0.0238 0.0384
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0437 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0022 0.0238 0.0234
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0042 0.0538 0.0534
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0039 0.0039
Onchocerca volvulus 0.0035 0.0437 0.0624
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.0151 0.0146
Schistosoma mansoni hypothetical protein 0.0036 0.0457 0.0457
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0597 0.0597
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0042 0.0054
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.071 0.1159
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0437 0.0624
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0426 0.4673
Entamoeba histolytica protein kinase, putative 0.0068 0.0927 0.6053
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0927 0.133
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.2545 0.3662
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0238 0.0238
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0039 0.0057
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0042 0.0545 0.0541
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0164 0.016
Echinococcus granulosus Smad4 0.0008 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0437 0.0711
Loa Loa (eye worm) AGC/AKT protein kinase 0.0068 0.0927 0.1516
Echinococcus granulosus protein kinase c iota type 0.0022 0.0238 0.0234
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.0151 0.0146
Echinococcus granulosus serine/threonine protein kinase 0.0046 0.0608 0.0603
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0151 0.0151
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0151 0.0211
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0426 0.2766
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0022 0.0238 0.0234
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0022 0.0238 0.0384
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.1528 0.1528
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0022 0.0238 0.0234
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0108 0.1528 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0437 0.0624
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.2792 0.4582
Echinococcus multilocularis protein kinase c epsilon type 0.0022 0.0238 0.0234
Brugia malayi RNA binding protein 0.0192 0.2792 0.4582
Schistosoma mansoni hypothetical protein 0.0342 0.5037 0.5037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0238 0.0384
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0042 0.0042
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0151 0.024
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0064 0.0864 0.1413
Brugia malayi beta-lactamase family protein 0.0035 0.0437 0.0711
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0437 0.0437
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.1528 1
Schistosoma mansoni dishevelled 0.0009 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0426 0.0608
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2792 0.2792
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0042 0.0037
Entamoeba histolytica protein kinase, putative 0.0068 0.0927 0.6053
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0042 0.0538 0.0534
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0798 0.0794
Schistosoma mansoni dep domain containing protein 0.0009 0.0042 0.0042
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.0151 0.0146
Loa Loa (eye worm) hypothetical protein 0.0035 0.0437 0.0711
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0597 0.0593
Onchocerca volvulus 0.0059 0.0798 0.1144
Brugia malayi Smad1 0.0008 0.0039 0.0057
Brugia malayi hypothetical protein 0.0009 0.0042 0.0061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0164 0.016
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0042 0.0545 0.0541
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0263
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0039
Toxoplasma gondii ABC1 family protein 0.0035 0.0437 0.4808
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0457 0.0744
Echinococcus multilocularis serine:threonine protein kinase N2 0.0022 0.0238 0.0234
Mycobacterium tuberculosis Conserved protein 0.0035 0.0437 0.092
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.0151 0.0146
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0437 0.208
Toxoplasma gondii AGC kinase 0.0064 0.0864 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0022 0.0238 0.0234
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.1528 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0426 0.0608
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0437 0.0437
Echinococcus multilocularis smad 0.0008 0.0039 0.0035
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0164 0.0263
Echinococcus multilocularis Smad4 0.0008 0.0039 0.0035
Loa Loa (eye worm) sirtuin 4 0.0016 0.0151 0.024
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0437 1
Schistosoma mansoni hypothetical protein 0.0017 0.0164 0.0164
Trypanosoma brucei rac serine-threonine kinase, putative 0.0068 0.0927 0.5634
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0042 0.0545 1
Schistosoma mansoni smad 0.0008 0.0039 0.0039
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0437 0.092
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.1528 0.2505
Echinococcus granulosus GPCR family 2 0.0017 0.0164 0.016

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 12.4 % Inhibition of purified recombinant c-Met at 10 uM after 60 mins by ELISA ChEMBL. 21405128

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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