TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 505.963 | Formula: C23H24ClN11O
H donors: 1 H acceptors: 4 LogP: 1.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: Clc1cccc(c1)Cn1nc2n(c1=O)c(N)nc1c2cnn1CCN1CCN(CC1)c1cnccn1
InChi: 1S/C23H24ClN11O/c24-17-3-1-2-16(12-17)15-34-23(36)35-21(30-34)18-13-28-33(20(18)29-22(35)25)11-8-31-6-9-32(10-7-31)19-14-26-4-5-27-19/h1-5,12-14H,6-11,15H2,(H2,25,29)
InChiKey: FTTCWIMLUNQMNO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adenosine A2a receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	follicle stimulating hormone receptor	adenosine A2a receptor	412 aa	336 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0146	0.0476	0.0476
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0146	0.0476	0.0593
Leishmania major	silent information regulator 2, putative	0.0433	0.1735	1
Trypanosoma brucei	subtilisin peptidase	0.0099	0.0271	0.1166
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0433	0.1735	1
Schistosoma mansoni	furin-1 (S08 family)	0.1009	0.4258	0.4258
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0103	0.0288	0.1267
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Toxoplasma gondii	aspartyl protease ASP5	0.0114	0.0338	0.7627
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0099	0.0271	0.6409
Trypanosoma cruzi	subtilisin peptidase	0.0099	0.0271	0.1166
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0099	0.0271	0.6409
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Brugia malayi	SWIRM domain containing protein	0.0072	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0152	0.0152
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Echinococcus multilocularis	solute carrier family 5	0.0146	0.0476	0.0593
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Toxoplasma gondii	subtilisin SUB6	0.0099	0.0271	0.612
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0271	0.0262
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0064	0.0117	0.0117
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Echinococcus granulosus	epidermal growth factor receptor	0.0056	0.0082	0.0082
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0064	0.0117	0.0117
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0064	0.0117	0.0117
Echinococcus granulosus	neuroendocrine convertase 2	0.1457	0.6223	0.6223
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0137	0.0439	0.0547
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0103	0.0288	0.1267
Toxoplasma gondii	histone deacetylase SIR2	0.0064	0.0117	0.2638
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0099	0.0271	0.6409
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0099	0.0271	0.0271
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0099	0.0271	0.0338
Schistosoma mansoni	hypothetical protein	0.0449	0.1803	0.1803
Schistosoma mansoni	tyrosine kinase	0.0056	0.0082	0.0082
Brugia malayi	neuroendocrine convertase 1 precursor	0.1457	0.6223	0.6223
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0449	0.1803	0.2859
Giardia lamblia	High cysteine membrane protein Group 2	0.0862	0.3613	1
Schistosoma mansoni	inositol transporter	0.0146	0.0476	0.0476
Leishmania major	subtilisin-like serine peptidase	0.0099	0.0271	0.1166
Giardia lamblia	Furin precursor putative serine protease	0.0449	0.1803	0.4821
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0433	0.1735	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0056	0.0082	0.0082
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0099	0.0271	0.0271
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0548	0.2237	0.3596
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0433	0.1735	1
Onchocerca volvulus		0.0099	0.0271	0.612
Loa Loa (eye worm)	proprotein convertase 2	0.0548	0.2237	0.2237
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0064	0.0117	0.0235
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0271	0.0271
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0064	0.0117	0.0235
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0433	0.1735	0.1735
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0433	0.1735	0.2744
Schistosoma mansoni	chromatin regulatory protein sir2	0.0064	0.0117	0.0117
Echinococcus granulosus	solute carrier family 5	0.0146	0.0476	0.0476
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0066	0.0127	0.0127
Schistosoma mansoni	protein kinase	0.0137	0.0439	0.0439
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0099	0.0271	0.0271
Schistosoma mansoni	chromatin regulatory protein sir2	0.0064	0.0117	0.0117
Plasmodium falciparum	subtilisin-like protease 1	0.0099	0.0271	0.5716
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0064	0.0117	0.2016
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0099	0.0271	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Plasmodium vivax	subtilisin-like protease 1	0.0099	0.0271	0.5716
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0271	0.0262
Toxoplasma gondii	subtilisin SUB12	0.0099	0.0271	0.612
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Schistosoma mansoni	chromatin regulatory protein sir2	0.0064	0.0117	0.0117
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Loa Loa (eye worm)	transcriptional regulator	0.0064	0.0117	0.0117
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0443	0.0443
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Brugia malayi	prolyl oligopeptidase family protein	0.0138	0.0443	0.0443
Toxoplasma gondii	subtilisin SUB10	0.0099	0.0271	0.612
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0548	0.2237	0.3596
Brugia malayi	celfurPC protein	0.1871	0.8034	0.8034
Schistosoma mansoni	protein kinase	0.0137	0.0439	0.0439
Schistosoma mansoni	chromatin regulatory protein sir2	0.0433	0.1735	0.1735
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0433	0.1735	0.1735
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0449	0.1803	0.2859
Loa Loa (eye worm)	hypothetical protein	0.091	0.3823	0.3823
Trypanosoma cruzi	prolyl endopeptidase	0.0138	0.0443	0.2204
Trypanosoma brucei	prolyl endopeptidase	0.0138	0.0443	0.2204
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0138	0.0443	0.0443
Loa Loa (eye worm)	transcriptional regulator	0.0433	0.1735	0.1735
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0099	0.0271	1
Echinococcus granulosus	Furin 1	0.0548	0.2237	0.2237
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0127	0.0127
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0064	0.0117	0.1292
Plasmodium falciparum	plasmepsin V	0.0126	0.0387	1
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0099	0.0271	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0127	0.0127
Schistosoma mansoni	protein kinase	0.0137	0.0439	0.0439
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0433	0.1735	1
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.141	0.6014	0.7485
Plasmodium vivax	plasmepsin V, putative	0.0126	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0117	0.0117
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0103	0.0288	0.1267
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0271	0.0262
Onchocerca volvulus		0.0072	0.0152	0.3426
Echinococcus multilocularis	prolyl endopeptidase	0.0138	0.0443	0.0552
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0433	0.1735	1
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0124	0.038	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.141	0.6014	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0548	0.2237	0.3596
Schistosoma mansoni	chromatin regulatory protein sir2	0.0433	0.1735	0.1735
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0099	0.0271	0.0271
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0099	0.0271	1
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0099	0.0271	0.0338
Trypanosoma brucei	SIR2-like protein 4, putative	0.0064	0.0117	0.0235
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0064	0.0117	0.0117
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0433	0.1735	0.216
Echinococcus granulosus	membrane bound transcription factor site 1	0.0099	0.0271	0.0271
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0121	0.0366	0.0366
Toxoplasma gondii	subtilisin SUB9	0.0099	0.0271	0.612
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Plasmodium vivax	subtilisin-like serine protease, putative	0.0099	0.0271	0.5716
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0548	0.2237	0.3596
Leishmania major	sir2-family protein-like protein	0.0064	0.0117	0.0235
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0449	0.1803	0.2859
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0099	0.0271	1
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0064	0.0117	0.0235
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Echinococcus granulosus	prolyl endopeptidase	0.0138	0.0443	0.0443
Loa Loa (eye worm)	sirtuin 4	0.0064	0.0117	0.0117
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0064	0.0117	0.0145
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0548	0.2237	0.2237
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0064	0.0117	0.0145
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0064	0.0117	0.0235
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0137	0.0439	0.0439
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0099	0.0271	0.0271
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0064	0.0117	0.0117
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0099	0.0271	0.1166
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0146	0.0476	0.0476
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0548	0.2237	0.3596
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0066	0.0127	0.0158
Plasmodium falciparum	subtilisin-like protease 3	0.0099	0.0271	0.5716
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0099	0.0271	0.6409
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Echinococcus granulosus	sodium:glucose cotransporter	0.0146	0.0476	0.0476
Toxoplasma gondii	prolyl endopeptidase	0.0138	0.0443	1
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Brugia malayi	Subtilase family protein	0.0099	0.0271	0.0271
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0138	0.0443	0.0443
Giardia lamblia	Hypothetical protein	0.0433	0.1735	0.4628
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0138	0.0443	1
Trichomonas vaginalis	hypothetical protein	0.0449	0.1803	0.2859
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0099	0.0271	1
Toxoplasma gondii	histone deacetylase SIR2-like	0.0064	0.0117	0.2638
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0066	0.0127	0.0127
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0099	0.0271	0.0271
Brugia malayi	Furin-like cysteine rich region family protein	0.0056	0.0082	0.0082
Echinococcus multilocularis	epidermal growth factor receptor	0.0056	0.0082	0.0101
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0548	0.2237	0.3596
Loa Loa (eye worm)	transcriptional regulator	0.0064	0.0117	0.0117
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0271	0.0262
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Schistosoma mansoni	inositol transporter	0.0146	0.0476	0.0476
Echinococcus multilocularis	Furin 1	0.0548	0.2237	0.2784
Mycobacterium leprae	Possible secreted protease	0.0099	0.0271	1
Toxoplasma gondii	subtilisin SUB2	0.0099	0.0271	0.612
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0146	0.0476	0.0593
Toxoplasma gondii	subtilisin SUB1	0.0099	0.0271	0.612
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0121	0.0366	0.0366
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0064	0.0117	0.0145
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.141	0.6014	0.6014
Echinococcus granulosus	chromatin regulatory protein sir2	0.0433	0.1735	0.1735
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Brugia malayi	proprotein convertase 2	0.1457	0.6223	0.6223
Echinococcus multilocularis	neuroendocrine convertase 2	0.1457	0.6223	0.7746
Schistosoma mansoni	chromatin regulatory protein sir2	0.0433	0.1735	0.1735
Plasmodium vivax	subtilisin-like protease 2, putative	0.0099	0.0271	0.5716
Toxoplasma gondii	subtilisin SUB4	0.0099	0.0271	0.612
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.141	0.6014	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0064	0.0117	0.2016
Schistosoma mansoni	chromatin regulatory protein sir2	0.0064	0.0117	0.0117
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0138	0.0443	0.2204
Toxoplasma gondii	subtilisin SUB11	0.0099	0.0271	0.612
Echinococcus multilocularis		0.1871	0.8034	1
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0271	0.0262
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0433	0.1735	0.2744
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0064	0.0117	0.0117
Plasmodium falciparum	subtilisin-like protease 2	0.0099	0.0271	0.5716
Loa Loa (eye worm)	subtilase	0.0099	0.0271	0.0271
Toxoplasma gondii	subtilisin SUB5	0.0099	0.0271	0.612
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0433	0.1735	0.216
Toxoplasma gondii	subtilisin SUB8	0.0099	0.0271	0.612
Toxoplasma gondii	subtilisin SUB7	0.0099	0.0271	0.612
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0099	0.0271	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.1803	0.2859

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (functional)	= 12.9 nM	Antagonist activity against human adenosine A2A receptor	ChEMBL.	21398125

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1762637

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1511628