Detailed information for compound 1511869

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.461 | Formula: C23H15N5O4S
  • H donors: 2 H acceptors: 4 LogP: 3.72 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1ccc(cc1)[N+](=O)[O-])Nc1ccc2c(c1)nc(c(n2)c1ccco1)c1ccco1
  • InChi: 1S/C23H15N5O4S/c29-28(30)16-8-5-14(6-9-16)24-23(33)25-15-7-10-17-18(13-15)27-22(20-4-2-12-32-20)21(26-17)19-3-1-11-31-19/h1-13H,(H2,24,25,33)
  • InChiKey: WSFUVIFDBHPMMA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Echinococcus multilocularis partitioning defective protein 6 0.0037 0.0279 0.0279
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0051 0.0453 0.4272
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0204 0.0203
Brugia malayi hypothetical protein 0.0149 0.1666 0.2375
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0045 0.0064
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.021 0.021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Echinococcus multilocularis serine:threonine protein kinase N2 0.0052 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0049 0.0432 0.0616
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Brugia malayi Protein kinase domain containing protein 0.0187 0.2134 0.3043
Schistosoma mansoni tyrosine kinase 0.0314 0.3693 0.3692
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0568 0.0568
Onchocerca volvulus 0.0031 0.0204 0.1094
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0052 0.0467 0.0666
Brugia malayi Furin-like cysteine rich region family protein 0.0582 0.7005 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0248 0.0248
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0204 0.1094
Plasmodium vivax heat shock protein 90, putative 0.0031 0.021 0.1021
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0267 0.0809
Loa Loa (eye worm) AGC/PKN protein kinase 0.0052 0.0467 0.0666
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0031 0.0204 0.1791
Echinococcus multilocularis heat shock protein 90 0.0047 0.0405 0.0405
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0204 0.4062
Brugia malayi Hr1 repeat family protein 0.0052 0.0467 0.0662
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Onchocerca volvulus Cathepsin F homolog 0.0031 0.0204 0.1094
Toxoplasma gondii cathepsin CPL 0.0031 0.0204 0.0897
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.0342 0.0342
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0337 0.0481
Echinococcus granulosus protein kinase c iota type 0.0591 0.7121 0.7121
Onchocerca volvulus 0.0038 0.0293 0.1635
Trypanosoma cruzi ISWI complex protein 0.0031 0.0204 0.0616
Schistosoma mansoni hypothetical protein 0.0518 0.6216 0.6215
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.0321 0.2959
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Plasmodium vivax vivapain-2 0.0031 0.0204 0.0991
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0278 0.5742
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0267 0.0382
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0405 0.1231
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0052 0.0467 0.0467
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0187 0.2134 0.2134
Trypanosoma brucei heat shock protein, putative 0.0047 0.0405 0.2443
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0016 0.0024 0.0103
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Echinococcus multilocularis protein kinase c eta type 0.0037 0.0278 0.0278
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0246 0.2207
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0031 0.0204 0.0291
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0026 0.0145 0.2721
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0204 0.4062
Onchocerca volvulus 0.0037 0.0278 0.1547
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.021 0.4196
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0024 0.0023
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0061 0.0182
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0016 0.0024 0.0103
Brugia malayi cathepsin L precursor 0.0016 0.0024 0.003
Schistosoma mansoni zinc finger protein 0.0043 0.0352 0.035
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0045 0.0045
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0405 0.1901
Loa Loa (eye worm) endoplasmin 0.0047 0.0405 0.0578
Plasmodium vivax vivapain-3 0.0031 0.0204 0.0991
Brugia malayi C1-like domain containing protein 0.0038 0.0292 0.0412
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0204 0.4062
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0263 0.0376
Echinococcus granulosus heat shock protein 90 0.004 0.0321 0.0321
Brugia malayi Protein kinase domain containing protein 0.0052 0.0467 0.0662
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Echinococcus granulosus protein tyrosine kinase 0.0249 0.2902 0.2902
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0024 0.003
Onchocerca volvulus 0.0037 0.0279 0.1551
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0204 0.4062
Loa Loa (eye worm) fibroinase 0.0031 0.0204 0.0291
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0162 0.137
Brugia malayi Cathepsin L-like precursor 0.0031 0.0204 0.0286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0264 0.0376
Schistosoma mansoni hypothetical protein 0.0518 0.6216 0.6215
Schistosoma mansoni cathepsin s 0.0015 0.0003 0.0002
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0024 0.0023
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0204 0.0286
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0267 0.2423
Loa Loa (eye worm) RasGEF domain-containing protein 0.0037 0.0278 0.0397
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0052 0.0467 0.0666
Schistosoma mansoni protein kinase C mu 0.0037 0.0278 0.0277
Brugia malayi Cathepsin L-like precursor 0.0031 0.0204 0.0286
Loa Loa (eye worm) AGC/NDR protein kinase 0.0052 0.0467 0.0666
Echinococcus multilocularis cathepsin b 0.0279 0.3267 0.3267
Brugia malayi cathepsin F-like cysteine proteinase 0.0016 0.0024 0.003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0152 0.1275
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0204 0.0615
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0024 0.0035
Brugia malayi Partitioning defective-6 homolog alpha 0.0037 0.0279 0.0393
Schistosoma mansoni cell polarity protein 0.0037 0.0279 0.0278
Echinococcus granulosus cathepsin b 0.0279 0.3267 0.3267
Schistosoma mansoni unc-13 (munc13) 0.0037 0.0278 0.0277
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0016 0.0024 0.003
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0024 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0098 0.1027 0.1026
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0037 0.0278 0.0278
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0204 0.0203
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0016 0.0024 0.0023
Schistosoma mansoni rac gtpase activating protein 0.0037 0.0278 0.0277
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0016
Toxoplasma gondii hypothetical protein 0.0019 0.0061 0.0182
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0405 0.1231
Echinococcus multilocularis Diacylglycerol kinase theta 0.0037 0.0278 0.0278
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0279 0.5756
Schistosoma mansoni serine/threonine kinase 0.0052 0.0467 0.0465
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0187 0.2134 0.2134
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0204 0.0615
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0077 0.0778 0.1111
Echinococcus granulosus Protein kinase C brain isozyme 0.0089 0.0921 0.0921
Brugia malayi RhoGEF domain containing protein 0.0037 0.0278 0.0393
Brugia malayi Protein kinase domain containing protein 0.0052 0.0467 0.0662
Trypanosoma cruzi cruzipain precursor, putative 0.0031 0.0204 0.0615
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0204 0.4062
Echinococcus multilocularis heat shock protein 90 0.004 0.0321 0.0321
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Plasmodium falciparum heat shock protein 90, putative 0.0179 0.2027 1
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Schistosoma mansoni cathepsin B (C01 family) 0.0016 0.0024 0.0023
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0001 0.0001
Echinococcus granulosus cathepsin l1 0.0016 0.0024 0.0024
Echinococcus granulosus serine:threonine protein kinase N2 0.0052 0.0467 0.0467
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Echinococcus granulosus cathepsin L 0.0031 0.0204 0.0204
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Echinococcus granulosus insulin receptor 0.0187 0.2134 0.2134
Echinococcus multilocularis protein kinase c iota type 0.0591 0.7121 0.7121
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0061 0.0283
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Loa Loa (eye worm) cysteine protease 0.0031 0.0204 0.0291
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.0331 0.1003
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0568 0.5418
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0003 0.0005
Echinococcus multilocularis cathepsin L 0.0031 0.0204 0.0204
Echinococcus multilocularis cathepsin L cysteine protease 0.0031 0.0204 0.0204
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.0369 1
Schistosoma mansoni cpg binding protein 0.0065 0.0626 0.0625
Brugia malayi Cathepsin L-like precursor 0.0016 0.0024 0.003
Mycobacterium ulcerans heat shock protein 90 0.0044 0.0369 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Entamoeba histolytica hypothetical protein 0.0037 0.0278 0.5742
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0016 0.0024 0.0103
Echinococcus multilocularis cpg binding protein 0.0065 0.0626 0.0626
Schistosoma mansoni tyrosine kinase 0.0582 0.7005 0.7005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0023
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0405 0.2443
Loa Loa (eye worm) hypothetical protein 0.0089 0.0925 0.1321
Trypanosoma brucei ISWI complex protein 0.0031 0.0204 0.0005
Trypanosoma cruzi PB1 domain containing protein, putative 0.0037 0.0279 0.0844
Onchocerca volvulus 0.0149 0.1666 1
Loa Loa (eye worm) PAR-6 protein 0.0037 0.0279 0.0398
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Schistosoma mansoni zinc finger protein 0.0031 0.0204 0.0203
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0052 0.0467 0.0467
Schistosoma mansoni protein kinase C 0.0037 0.0278 0.0277
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Echinococcus granulosus myotubularin protein 13 0.0037 0.0278 0.0278
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0098 0.1027 1
Loa Loa (eye worm) raf kinase 0.0037 0.0278 0.0397
Schistosoma mansoni heat shock protein 0.0031 0.021 0.0209
Schistosoma mansoni tyrosine kinase 0.0314 0.3693 0.3692
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0267 0.5493
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0204 0.4062
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0037 0.0278 0.0397
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0044 0.0369 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0246 0.2207
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Trypanosoma cruzi PB1 domain containing protein, putative 0.0037 0.0279 0.0844
Schistosoma mansoni tyrosine kinase 0.0308 0.363 0.3629
Brugia malayi Variant SH3 domain containing protein 0.0037 0.0278 0.0393
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.0321 0.0321
Schistosoma mansoni bromodomain containing protein 0.0131 0.1439 0.1438
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Plasmodium vivax unspecified product 0.0016 0.0024 0.0103
Echinococcus multilocularis N chimaerin 0.0037 0.0278 0.0278
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0467 0.0465
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.1688 0.2406
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0568 0.5418
Schistosoma mansoni cpg binding protein 0.0065 0.0626 0.0625
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0204 0.0615
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0038 0.0292 0.0292
Echinococcus granulosus epidermal growth factor receptor 0.0314 0.3693 0.3693
Echinococcus multilocularis 0.018 0.204 0.204
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0405 0.2443
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0405 0.1231
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0204 0.0615
Echinococcus granulosus cathepsin b 0.0279 0.3267 0.3267
Brugia malayi Cathepsin L-like cysteine proteinase 0.0016 0.0024 0.003
Brugia malayi Bromodomain containing protein 0.0077 0.0777 0.1104
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.0331 0.3055
Echinococcus multilocularis protein kinase c epsilon type 0.0089 0.0921 0.0921
Echinococcus multilocularis protein TFG 0.0037 0.0279 0.0279
Trypanosoma brucei heat shock protein, putative 0.0047 0.0405 0.2443
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.0369 0.2009
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0098 0.1027 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0024 0.0023
Schistosoma mansoni hypothetical protein 0.0034 0.0239 0.0238
Echinococcus granulosus heat shock protein 90 0.0047 0.0405 0.0405
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0204 0.0615
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Leishmania major basic transcription factor 3a, putative 0.0036 0.0267 0.0769
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0342 0.034
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0718 0.0718
Echinococcus multilocularis cysteine protease 0.0031 0.0204 0.0204
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0278 0.0277
Loa Loa (eye worm) cathepsin B 0.0098 0.1027 0.1466
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0331 0.3055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0152 0.0213
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.021 0.0927
Entamoeba histolytica protein kinase, putative 0.0052 0.0467 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0314 0.3693 0.3693
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0204 0.4062
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0061 0.0182
Onchocerca volvulus Protein TFG homolog 0.0037 0.0279 0.1551
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0267 0.1304
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0204 0.0615
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0024 0.003
Brugia malayi Endoplasmin precursor 0.0047 0.0405 0.0574
Echinococcus multilocularis epidermal growth factor receptor 0.0314 0.3693 0.3693
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Loa Loa (eye worm) hypothetical protein 0.0031 0.0204 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0031 0.0204 0.0204
Echinococcus granulosus N chimaerin 0.0037 0.0278 0.0278
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0405 0.3796
Trypanosoma brucei cysteine peptidase C (CPC) 0.0098 0.1027 1
Toxoplasma gondii cathepsin B 0.0098 0.1027 0.5008
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0031 0.0204 0.1791
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0016 0.0024 0.0103
Schistosoma mansoni atypical protein kinase C 0.0628 0.7576 0.7576
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0024 0.0023
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0016 0.0024 0.0103
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0016
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0321 0.0973
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0279 0.3267 0.3266
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0052 0.0467 0.0666
Entamoeba histolytica protein kinase, putative 0.0052 0.0467 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0279 0.3267 0.3266
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0024 0.003
Onchocerca volvulus 0.0031 0.0204 0.1094
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0204 0.0615
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0024 0.0064
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0248 0.0247
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0267 0.0769
Echinococcus granulosus transcription factor btf3 0.0036 0.0267 0.0267
Entamoeba histolytica hypothetical protein 0.0036 0.0267 0.5493
Plasmodium vivax heat shock protein, putative 0.0179 0.2027 1
Brugia malayi fibroinase precursor 0.0016 0.0024 0.003
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0024 0.0103
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0405 0.1901
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1338 0.191
Trypanosoma brucei heat shock protein, putative 0.0047 0.0405 0.2443
Brugia malayi protein kinase C II. 0.0089 0.0921 0.1311
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0425 0.0424
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0467 0.0465
Trypanosoma brucei PB1 domain containing protein, putative 0.0037 0.0279 0.091
Schistosoma mansoni endoplasmin 0.0047 0.0405 0.0404
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0015
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0152 0.1275
Brugia malayi heat shock protein 90 0.0047 0.0405 0.0574
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0279 0.3267 0.3266
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0921 0.092
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0369 0.344
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0292 0.0291
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0151 0.1688 0.241
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0369 0.344
Echinococcus multilocularis serine:threonine protein kinase 38 0.0052 0.0467 0.0467
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Schistosoma mansoni heat shock protein 0.0047 0.0405 0.0404
Brugia malayi cathepsin L-like precursor 0.0016 0.0024 0.003
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0037 0.0278 0.0397
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0204 0.0286
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0538 0.0768
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Loa Loa (eye worm) TK/FAK protein kinase 0.0252 0.2938 0.4194
Echinococcus multilocularis cathepsin b 0.0279 0.3267 0.3267
Onchocerca volvulus 0.0031 0.0204 0.1094
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0024 0.0023
Plasmodium falciparum cysteine proteinase falcipain 3 0.0031 0.0204 0.0897
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0405 0.3796
Echinococcus multilocularis heat shock protein 0.0047 0.0405 0.0405
Brugia malayi Cathepsin L-like precursor 0.0031 0.0204 0.0286
Echinococcus granulosus Diacylglycerol kinase theta 0.0037 0.0278 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0476 0.4506
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0067 0.0195
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0405 0.1985
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1338 0.191
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0089 0.0123
Leishmania major hypothetical protein, conserved 0.0031 0.0204 0.0005
Loa Loa (eye worm) heat shock protein 75 0.0031 0.021 0.03
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0038 0.0292 0.0417
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0162 0.0686
Loa Loa (eye worm) hypothetical protein 0.0149 0.1666 0.2378
Schistosoma mansoni cathepsin S (C01 family) 0.0016 0.0024 0.0023
Schistosoma mansoni cpg binding protein 0.0058 0.0538 0.0537
Loa Loa (eye worm) ctsf protein 0.0031 0.0204 0.0291
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0264 0.0264
Echinococcus multilocularis cysteine protease 0.0031 0.0204 0.0204
Echinococcus granulosus protein kinase C gamma type 0.0052 0.0467 0.0467
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0568 0.1729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Loa Loa (eye worm) TK/INSR protein kinase 0.0187 0.2134 0.3046
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0037 0.0278 0.0397
Brugia malayi Protein kinase domain containing protein 0.0038 0.0292 0.0412
Echinococcus multilocularis Rac GTPase activating protein 1 0.0037 0.0278 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0264 0.0262
Brugia malayi Cathepsin L-like precursor 0.0031 0.0204 0.0286
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0267 0.2423
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0432 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Echinococcus multilocularis serine:threonine protein kinase N2 0.0052 0.0467 0.0467
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.135 0.135
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0052 0.0467 0.0467
Echinococcus granulosus cysteine protease 0.0031 0.0204 0.0204
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0024 0.0035
Onchocerca volvulus 0.0058 0.0538 0.313
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0568 0.4418
Giardia lamblia Grp94/Hsp90 0.0044 0.0369 0.344
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0016 0.0024 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Brugia malayi protein kinase C3,putative 0.054 0.6492 0.9267
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0279 0.3267 0.3266
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0052 0.0467 0.0467
Brugia malayi Cathepsin L-like precursor 0.0031 0.0204 0.0286
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0016
Schistosoma mansoni cathepsin C 0.0016 0.0024 0.0023
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0015
Trypanosoma cruzi heat shock protein, putative 0.0031 0.021 0.0633
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0292 0.0291
Echinococcus multilocularis cathepsin L cysteine protease 0.0031 0.0204 0.0204
Entamoeba histolytica protein kinase, putative 0.0052 0.0467 1
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0038 0.0292 0.0412
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Onchocerca volvulus 0.0037 0.0278 0.1547
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Plasmodium vivax vivapain-1 0.0031 0.0204 0.0991
Echinococcus granulosus protein TFG 0.0037 0.0279 0.0279
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0204 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0016
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Loa Loa (eye worm) hypothetical protein 0.0279 0.3267 0.4663
Echinococcus granulosus protein kinase c eta type 0.0037 0.0278 0.0278
Brugia malayi Protein kinase domain containing protein 0.0038 0.0293 0.0413
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Trypanosoma brucei heat shock protein, putative 0.0047 0.0405 0.2443
Echinococcus multilocularis zinc finger protein 0.0043 0.0352 0.0352
Plasmodium vivax vivapain-2 0.0031 0.0204 0.0991
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0016 0.0024 0.0103
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0425 0.0425
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0425 0.0425
Brugia malayi Cathepsin L-like precursor 0.0031 0.0204 0.0286
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0037 0.0278 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Onchocerca volvulus 0.0031 0.0204 0.1094
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0052 0.0467 0.0467
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0405 0.1231
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0037 0.0278 0.0277
Onchocerca volvulus Tyrosine kinase homolog 0.0141 0.1569 0.9408
Toxoplasma gondii hypothetical protein 0.0053 0.0476 0.2257
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0267 0.1213
Onchocerca volvulus 0.0134 0.1477 0.8849
Brugia malayi PHD-finger family protein 0.0054 0.0484 0.0687
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0037 0.0278 0.0278
Echinococcus multilocularis endoplasmin 0.0044 0.0369 0.0369
Brugia malayi diacylglycerol kinase 0.0037 0.0278 0.0393
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0568 0.4418
Trypanosoma brucei heat shock protein, putative 0.0047 0.0405 0.2443
Giardia lamblia Cathepsin B precursor 0.0098 0.1027 1
Schistosoma mansoni protein kinase C mu 0.0038 0.0292 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Echinococcus granulosus cathepsin L 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0143 0.1583 0.226
Onchocerca volvulus 0.0031 0.0204 0.1094
Brugia malayi cathepsin B-like cysteine proteinase 0.0279 0.3267 0.4661
Giardia lamblia Cathepsin B precursor 0.0098 0.1027 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0052 0.0467 0.0662
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0568 0.1729
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0279 0.3267 1
Echinococcus multilocularis geminin 0.0518 0.6216 0.6216
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.0018
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0405 0.1231
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0267 0.0809
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0152 0.0151
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Schistosoma mansoni unc-13 (munc13) 0.0037 0.0278 0.0277
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Schistosoma mansoni tyrosine kinase 0.0308 0.363 0.3629
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.021 0.1131
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0405 0.8608
Brugia malayi RhoGAP domain containing protein 0.0037 0.0278 0.0393
Trypanosoma brucei heat shock protein, putative 0.0047 0.0405 0.2443
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0204 0.0615
Brugia malayi cathepsin L-like cysteine proteinase 0.0016 0.0024 0.003
Brugia malayi diacylglycerol kinase 0.0037 0.0278 0.0393
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0568 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0568 0.5418
Schistosoma mansoni tyrosine kinase 0.0187 0.2134 0.2133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0024 0.0023
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Echinococcus multilocularis serine threonine protein kinase 0.0052 0.0467 0.0467
Onchocerca volvulus 0.0037 0.0278 0.1547
Echinococcus granulosus endoplasmin 0.0044 0.0369 0.0369
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0267 0.1213
Brugia malayi Protein kinase domain containing protein 0.0252 0.2938 0.4191
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0467 0.0465
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.135 0.135
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0204 0.0897
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0037 0.0278 0.0278
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0152 0.1275
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0037 0.0278 0.0277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Echinococcus granulosus cathepsin l1 0.0031 0.0204 0.0204
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Brugia malayi CXXC zinc finger family protein 0.0058 0.0538 0.0764
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0001 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.0018
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Loa Loa (eye worm) AGC/AKT protein kinase 0.0052 0.0467 0.0666
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1236 0.6052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0432 0.0611
Echinococcus granulosus Rac GTPase activating protein 1 0.0037 0.0278 0.0278
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Trypanosoma cruzi ISWI complex protein 0.0031 0.0204 0.0616
Plasmodium falciparum heat shock protein 90 0.0047 0.0405 0.1901
Toxoplasma gondii Hsp90 domain-containing protein 0.0179 0.2027 1
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0921 0.092
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0204 0.1791
Brugia malayi Hsp90 protein 0.0031 0.021 0.0295
Echinococcus granulosus protein kinase c epsilon type 0.0089 0.0921 0.0921
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0568 0.0567
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0038 0.0292 0.0292
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0089 0.0921 0.1315
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0204 0.1094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0024 0.0023
Echinococcus multilocularis myotubularin protein 13 0.0037 0.0278 0.0278
Echinococcus granulosus cathepsin L cysteine proteinase 0.0031 0.0204 0.0204
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0152 0.0213
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0577 0.6947 0.9917
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1339 0.1338
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0016 0.0024 0.0103
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0239 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0921 0.092
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0405 0.2443
Echinococcus granulosus unc 13 munc13 0.0037 0.0278 0.0278
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Plasmodium falciparum endoplasmin, putative 0.0034 0.0246 0.1105
Loa Loa (eye worm) zinc finger protein 0.0037 0.0279 0.0398
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0031 0.0204 0.0897
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0098 0.1027 0.3137
Brugia malayi beta-NAC-like protein 0.0036 0.0267 0.0377
Trypanosoma brucei heat shock protein, putative 0.0047 0.0405 0.2443
Echinococcus multilocularis epidermal growth factor receptor 0.0582 0.7005 0.7005
Trypanosoma brucei heat shock protein, putative 0.0047 0.0405 0.2443
Echinococcus granulosus cpg binding protein 0.0065 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0217
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0568 0.1729
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0031 0.0204 0.0204
Brugia malayi Pleckstrin Homology Domain 0.0037 0.0278 0.0393
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Plasmodium vivax unspecified product 0.0031 0.0204 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0476 0.4506
Echinococcus granulosus epidermal growth factor receptor 0.0582 0.7005 0.7005
Echinococcus multilocularis transcription factor btf3 0.0036 0.0267 0.0267
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0016 0.0024 0.0035
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0239 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0405 0.0578
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0467 0.0465
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0016 0.0024 0.0103
Schistosoma mansoni tyrosine kinase 0.0308 0.363 0.3629
Echinococcus granulosus NDR protein kinase 0.0052 0.0467 0.0467
Echinococcus multilocularis unc 13 (munc13) 0.0037 0.0278 0.0278
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0016
Brugia malayi MH2 domain containing protein 0.0123 0.1338 0.1907
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Schistosoma mansoni tyrosine kinase 0.0249 0.2902 0.2901
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0152 0.0152
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0038 0.0293 0.0418
Entamoeba histolytica protein kinase, putative 0.0052 0.0467 1
Toxoplasma gondii diacylglycerol kinase, putative 0.0037 0.0278 0.1268
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0024 0.0103
Schistosoma mansoni transcription factor btf3 0.0036 0.0267 0.0266
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0398
Toxoplasma gondii AGC kinase 0.0052 0.0467 0.2209
Schistosoma mansoni vav2 0.0037 0.0278 0.0277
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0718 0.0718
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0024 0.0064
Echinococcus multilocularis insulin receptor 0.0187 0.2134 0.2134
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0152 0.0152
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0045 0.0045
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0248 0.0247
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0204 0.0286
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Loa Loa (eye worm) TK/EGFR protein kinase 0.0582 0.7005 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0037 0.0278 0.0277
Leishmania major heat shock protein, putative 0.0031 0.021 0.0072
Brugia malayi Cathepsin L-like precursor 0.0016 0.0024 0.003
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0052 0.0467 0.0467
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0432 0.0616
Schistosoma mansoni hypothetical protein 0.0042 0.0337 0.0336
Brugia malayi Protein kinase c protein 2 0.0038 0.0292 0.0412
Echinococcus granulosus zinc finger protein 0.0043 0.0352 0.0352
Echinococcus granulosus heat shock protein 0.0047 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0405 0.8608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0204 0.4062
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0278 0.0277
Schistosoma mansoni tyrosine kinase 0.0187 0.2134 0.2133
Schistosoma mansoni endoplasmin 0.0047 0.0405 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.0342 0.0342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0264 0.0262
Leishmania major heat shock protein 83-1 0.0047 0.0405 0.2443
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0248 0.0248
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0001 0.0001
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0031 0.0204 0.0897
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0023
Trichomonas vaginalis heat shock protein, putative 0.004 0.0321 0.2959
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0267 0.2423
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0061 0.0363
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0204 0.0204
Echinococcus multilocularis cathepsin L 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397
Leishmania major hypothetical protein, conserved 0.0037 0.0279 0.091
Trypanosoma brucei rac serine-threonine kinase, putative 0.0052 0.0467 0.3191
Onchocerca volvulus 0.0031 0.0204 0.1094
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0476 0.4506
Plasmodium vivax endoplasmin, putative 0.0047 0.0405 0.1985
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0016 0.0024 0.0023
Toxoplasma gondii hypothetical protein 0.0019 0.0061 0.0182
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0204 0.0203
Brugia malayi Bromodomain containing protein 0.0155 0.173 0.2466
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0568 0.5418
Schistosoma mansoni hypothetical protein 0.0031 0.0204 0.0203
Echinococcus granulosus cathepsin l cysteine peptidase 0.0031 0.0204 0.0204
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.021 0.021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0024 0.0023
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0052 0.0467 0.0666
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0024 0.0103
Entamoeba histolytica cysteine protease, putative 0.0031 0.0204 0.4062
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.0321 0.0973
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.021 0.0072
Loa Loa (eye worm) hypothetical protein 0.0082 0.0837 0.1195
Onchocerca volvulus 0.0031 0.0204 0.1094
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0204 0.0615
Echinococcus multilocularis protein tyrosine kinase 0.0249 0.2902 0.2902
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Loa Loa (eye worm) hypothetical protein 0.0052 0.0467 0.0666
Echinococcus granulosus geminin 0.0518 0.6216 0.6216
Treponema pallidum heat shock protein 90 0.0044 0.0369 0.5
Brugia malayi Protein kinase domain containing protein 0.0052 0.0467 0.0662
Schistosoma mansoni heat shock protein 0.0047 0.0405 0.0404
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0467 0.4411
Brugia malayi Ras association domain family 1 isoform A 0.0037 0.0278 0.0393
Brugia malayi RhoGAP domain containing protein 0.0037 0.0278 0.0393
Giardia lamblia Cathepsin B precursor 0.0098 0.1027 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0204 0.0203
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0568 0.5418
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0089 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0204 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0204 0.1791
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0278 0.5742
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.0369 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0035
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0397

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 9 % Growth inhibition of human MDA-MB-231 cells at 20 uM after 72 hrs by alamar blue assay ChEMBL. 21376584
GI (functional) = 19.2 % Growth inhibition of human A549 cells at 20 uM after 72 hrs by alamar blue assay ChEMBL. 21376584
GI (functional) = 32.2 % Growth inhibition of human U2OS cells at 20 uM after 72 hrs by alamar blue assay ChEMBL. 21376584
GI (functional) = 42 % Growth inhibition of human HT-29 cells at 20 uM after 72 hrs by alamar blue assay ChEMBL. 21376584
GI (functional) = 43.4 % Growth inhibition of human PC3 cells at 20 uM after 72 hrs by alamar blue assay ChEMBL. 21376584
Inhibition (binding) Inhibition of Mcl-1 in doxycyclin-stimulated human HeLa cells overexpressing Bad3SA assessed as increase in caspase3/7 activity at 10 uM after 6 hrs by luminescence analysis ChEMBL. 22386982
Inhibition (binding) Inhibition of Mcl-1 in human HeLa cells overexpressing Bad3SA assessed as increase in caspase3/7 activity at 10 uM after 6 hrs by luminescence analysis ChEMBL. 22386982

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.