Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0099 | 0.0099 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0532 | 0.405 | 0.3991 |
Schistosoma mansoni | patched 1 | 0.0532 | 0.405 | 0.3991 |
Brugia malayi | CHE-14 protein | 0.0532 | 0.405 | 0.405 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0532 | 0.405 | 0.3991 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0532 | 0.405 | 0.3991 |
Echinococcus multilocularis | protein patched | 0.0532 | 0.405 | 0.3991 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1293 | 1 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0532 | 0.405 | 0.405 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0099 | 0.0099 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0607 | 0.4631 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0532 | 0.405 | 0.3991 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0532 | 0.405 | 0.3991 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1293 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 0.405 | 0.405 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1293 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1293 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1293 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1293 | 1 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1293 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1293 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0532 | 0.405 | 0.3991 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0099 | 0.0099 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0607 | 0.4631 | 1 |
Onchocerca volvulus | 0.0027 | 0.0099 | 0.5 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.0532 | 0.405 | 0.3991 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0607 | 0.4631 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.1293 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0607 | 0.4631 | 1 |
Onchocerca volvulus | 0.0027 | 0.0099 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED150 (functional) | = 5.3 mg kg-1 | Effective dose against aconitine-induced arrhythmia after intravenal administration in anesthetized rats | ChEMBL. | 3806567 |
LD50 (ADMET) | = 65 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
LD50 (ADMET) | = 65 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
No. of positive cases (functional) | = 7 | Incidence of arrhythmias in rats after a intravenal administration at 4mg/kg, expressed as no. of positive cases out of no. of tested cases (10) | ChEMBL. | 3806567 |
Relative potency (functional) | = 2.2 | Relative potency with reference to quinidine | ChEMBL. | 3806567 |
Therapeutic index (ADMET) | = 12.3 | Therapeutic index calculated as the ratio of LD50 in mice to ED 150 in rat when administered intravenously | ChEMBL. | 3806567 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.