TDR Targets

Basic information

Technical information

TDR Targets ID: 1511984
Name: 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N -[2-morpholin-4-yl-5-(trifluoromethyl)phenyl] acetamide
MW: 454.443 | Formula: C21H25F3N4O4
H donors: 2 H acceptors: 3 LogP: 2.28 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cc(ccc1N1CCOCC1)C(F)(F)F)CN1C(=O)NC2(C1=O)CCCCC2
InChi: 1S/C21H25F3N4O4/c22-21(23,24)14-4-5-16(27-8-10-32-11-9-27)15(12-14)25-17(29)13-28-18(30)20(26-19(28)31)6-2-1-3-7-20/h4-5,12H,1-3,6-11,13H2,(H,25,29)(H,26,31)
InChiKey: RSRCMRQNNHVMKD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-[2-morpholino-5-(trifluoromethyl)phenyl]acetamide
2-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)-N-[2-morpholino-5-(trifluoromethyl)phenyl]acetamide
2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]ethanamide
T5587981

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.006	0.0046
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.017	0.0692	1
Onchocerca volvulus		0.0027	0.0018	0.0003
Brugia malayi	hypothetical protein	0.0027	0.0018	0.0003
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0027	0.0018	0.0265
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0027	0.0018	0.0003
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.017	0.0692	0.0677
Schistosoma mansoni	hypothetical protein	0.0027	0.0018	0.0003
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0027	0.0018	0.0018
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0027	0.0018	0.0003
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0048	0.0032
Onchocerca volvulus		0.0027	0.0018	0.0003
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.017	0.0692	0.0677
Schistosoma mansoni	cathepsin D (A01 family)	0.033	0.1449	0.1436
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0048	0.0032
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0133	0.036
Plasmodium falciparum	plasmepsin I	0.0112	0.0419	0.597
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0048	0.0434
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0027	0.0018	0.0003
Plasmodium vivax	potassium channel, putative	0.0027	0.0018	0.0043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0151	0.0136
Onchocerca volvulus		0.0027	0.0018	0.0003
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0027	0.0018	0.0003
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.017	0.0692	0.0677
Echinococcus granulosus	pyruvate kinase	0.0033	0.0048	0.0029
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.017	0.0692	1
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.017	0.0692	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0048	0.0032
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0112	0.0419	0.0405
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.017	0.0692	0.2058
Plasmodium falciparum	plasmepsin VI	0.0112	0.0419	0.597
Echinococcus granulosus	Dipeptidyl peptidase 9	0.072	0.3289	0.3277
Brugia malayi	hypothetical protein	0.055	0.2488	0.2476
Brugia malayi	prolyl oligopeptidase family protein	0.017	0.0692	0.0677
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0027	0.0018	0.0018
Trypanosoma brucei	prolyl oligopeptidase, putative	0.017	0.0692	0.2058
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.017	0.0692	0.0677
Mycobacterium tuberculosis	Probable peptidase	0.017	0.0692	1
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0048	0.0475
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.0716	0.0702
Loa Loa (eye worm)	TWK-28 protein	0.0027	0.0018	0.0018
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.0716	0.0703
Trypanosoma brucei	prolyl endopeptidase	0.017	0.0692	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Onchocerca volvulus	Prolyl endopeptidase homolog	0.017	0.0692	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Schistosoma mansoni	twik family of potassium channels-related	0.0027	0.0018	0.0003
Giardia lamblia	Pyruvate kinase	0.0033	0.0048	0.0434
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0112	0.0419	0.5953
Leishmania major	pyruvate kinase	0.0033	0.0048	0.0089
Leishmania major	oligopeptidase b	0.017	0.0692	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Schistosoma mansoni	cathepsin D (A01 family)	0.033	0.1449	0.1436
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0048	0.0434
Schistosoma mansoni	calcium-activated potassium channel	0.0027	0.0018	0.0003
Loa Loa (eye worm)	aspartyl protease 6	0.0026	0.0015	0.0015
Echinococcus multilocularis	twik family of potassium channels	0.0027	0.0018	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.017	0.0692	0.0692
Onchocerca volvulus		0.0027	0.0018	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Toxoplasma gondii	ion channel protein	0.0027	0.0018	0.0009
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0113	0.1407
Onchocerca volvulus		0.0027	0.0018	0.0003
Schistosoma mansoni	hypothetical protein	0.0673	0.3066	0.3056
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0027	0.0018	0.0003
Onchocerca volvulus		0.0027	0.0018	0.0003
Echinococcus granulosus	acylamino acid releasing enzyme	0.017	0.0692	0.0675
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.072	0.3289	0.328
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0027	0.0018	0.0003
Plasmodium falciparum	plasmepsin II	0.0112	0.0419	0.597
Schistosoma mansoni	twik family of potassium channels-related	0.0027	0.0018	0.0003
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0048	0.0033
Toxoplasma gondii	prolyl endopeptidase	0.017	0.0692	0.2066
Echinococcus granulosus	prolyl endopeptidase	0.017	0.0692	0.0675
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0026	0.0015	0.0015
Trypanosoma cruzi	oligopeptidase b	0.017	0.0692	0.2058
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0048	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0151	0.0136
Schistosoma mansoni	twik family of potassium channels-related	0.0027	0.0018	0.0003
Schistosoma mansoni	calcium-activated potassium channel	0.0529	0.2387	0.2375
Plasmodium falciparum	peptidase, putative	0.017	0.0692	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0027	0.0018	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0279	0.1206	0.1206
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0027	0.0018	0.0003
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0133	0.1708
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0133	0.1708
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0151	0.0133
Loa Loa (eye worm)	acetyltransferase	0.0175	0.0716	0.0716
Onchocerca volvulus		0.0027	0.0018	0.0003
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0048	0.0033
Echinococcus multilocularis	calcium activated potassium channel variant	0.0027	0.0018	0.0004
Loa Loa (eye worm)	hypothetical protein	0.017	0.0692	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0133	0.0115
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0151	0.0133
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0048	0.0048
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.0716	0.0702
Trypanosoma cruzi	prolyl endopeptidase	0.017	0.0692	0.2058
Echinococcus granulosus	pyruvate kinase	0.0033	0.0048	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Schistosoma mansoni	hypothetical protein	0.0036	0.006	0.0045
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0048	0.0089
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0048	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.017	0.0692	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.081	0.3711	0.3702
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0027	0.0018	0.0003
Schistosoma mansoni	twik family of potassium channels-related	0.0027	0.0018	0.0003
Loa Loa (eye worm)	prolyl oligopeptidase	0.017	0.0692	0.0692
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0048	0.0032
Leishmania major	pyruvate kinase	0.0033	0.0048	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0036	0.006	0.0866
Brugia malayi	hypothetical protein	0.0027	0.0018	0.0003
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.072	0.3289	1
Echinococcus multilocularis	twik family of potassium channels	0.0027	0.0018	0.0004
Entamoeba histolytica	prolyl oligopeptidase family protein	0.017	0.0692	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.072	0.3289	1
Schistosoma mansoni	twik family of potassium channels-related	0.0027	0.0018	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.072	0.3289	1
Schistosoma mansoni	calcium-activated potassium channel	0.0027	0.0018	0.0003
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0112	0.0419	0.1233
Toxoplasma gondii	aspartyl protease ASP1	0.0112	0.0419	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0048	0.0434
Loa Loa (eye worm)	uncoordinated protein 58	0.0027	0.0018	0.0018
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.017	0.0692	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0027	0.0018	0.0003
Schistosoma mansoni	pyruvate kinase	0.0033	0.0048	0.0032
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.017	0.0692	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0048	0.0098
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0048	0.0048
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0112	0.0419	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0419	0.0419
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0133	0.036
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.072	0.3289	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.0692	0.0692
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.017	0.0692	1
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0048	0.0089
Trypanosoma cruzi	oligopeptidase b	0.017	0.0692	0.2058
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.017	0.0692	0.2058
Schistosoma mansoni	twik family of potassium channels-related	0.0027	0.0018	0.0003
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.017	0.0692	0.2058
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0151	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Toxoplasma gondii	ion channel protein	0.0027	0.0018	0.0009
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.017	0.0692	0.2066
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0027	0.0018	0.0003
Giardia lamblia	Alanyl dipeptidyl peptidase	0.017	0.0692	1
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.017	0.0692	0.2058
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0048	0.0032
Echinococcus multilocularis	small conductance calcium activated potassium	0.0673	0.3066	0.3056
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.072	0.3289	1
Brugia malayi	prolyl oligopeptidase family protein	0.017	0.0692	0.0677
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.0692	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0112	0.0419	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0027	0.0018	0.0003
Loa Loa (eye worm)	TWK-7 protein	0.0027	0.0018	0.0018
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0027	0.0018	0.0004
Plasmodium falciparum	plasmepsin IV	0.0112	0.0419	0.597
Schistosoma mansoni	twik family of potassium channels-related	0.0027	0.0018	0.0003
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.072	0.3289	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.0453	0.0453
Onchocerca volvulus		0.0027	0.0018	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.006	0.0045
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0113	0.1444
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0151	0.0151
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0048	0.0434
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0036	0.006	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0151	0.0136
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0027	0.0018	0.0003
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.0453	0.0453
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Echinococcus multilocularis	prolyl endopeptidase	0.017	0.0692	0.0678
Trypanosoma cruzi	hypothetical protein, conserved	0.017	0.0692	0.2058
Trypanosoma cruzi	hypothetical protein, conserved	0.017	0.0692	0.2058
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0027	0.0018	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0113	0.1635
Echinococcus multilocularis	potassium channel subfamily K 8	0.0027	0.0018	0.0004
Loa Loa (eye worm)	hypothetical protein	0.055	0.2488	0.2488
Echinococcus multilocularis	potassium channel subfamily K 8	0.0027	0.0018	0.0004
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0133	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Entamoeba histolytica	prolyl oligopeptidase family protein	0.017	0.0692	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0151	0.0137
Schistosoma mansoni	calcium-activated potassium channel	0.0673	0.3066	0.3056
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0048	0.0089
Plasmodium vivax	plasmepsin IV, putative	0.0112	0.0419	0.597
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0027	0.0018	0.0003
Brugia malayi	hypothetical protein	0.0036	0.006	0.0045
Schistosoma mansoni	twik family of potassium channels-related	0.0027	0.0018	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0442	0.0442
Entamoeba histolytica	prolyl oligopeptidase family protein	0.017	0.0692	1
Plasmodium vivax	aspartyl proteinase, putative	0.0112	0.0419	0.597
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.072	0.3289	0.3279
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0027	0.0018	0.0003
Plasmodium falciparum	potassium channel	0.0027	0.0018	0.0043
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0112	0.0419	0.0419
Schistosoma mansoni	pyruvate kinase	0.0033	0.0048	0.0032
Plasmodium vivax	potassium channel, putative	0.0027	0.0018	0.0043
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0027	0.0018	0.0003
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0027	0.0018	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Plasmodium falciparum	potassium channel	0.0027	0.0018	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0673	0.3066	0.3066
Entamoeba histolytica	hypothetical protein	0.0036	0.006	0.0866
Plasmodium vivax	hypothetical protein, conserved	0.017	0.0692	1
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.017	0.0692	1
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.017	0.0692	0.2058
Brugia malayi	prolyl oligopeptidase family protein	0.017	0.0692	0.0677
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.006	0.0042
Echinococcus granulosus	small conductance calcium activated potassium	0.0673	0.3066	0.3054
Entamoeba histolytica	hypothetical protein, conserved	0.017	0.0692	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.0693	0.0676
Giardia lamblia	Alanyl dipeptidyl peptidase	0.017	0.0692	1
Loa Loa (eye worm)	hypothetical protein	0.025	0.1071	0.1071
Plasmodium falciparum	pyruvate kinase	0.0033	0.0048	0.0475
Brugia malayi	prolyl oligopeptidase family protein	0.072	0.3289	0.3279
Brugia malayi	MH2 domain containing protein	0.0119	0.0453	0.0438
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0151	0.0137
Echinococcus multilocularis	acylamino acid releasing enzyme	0.017	0.0692	0.0678
Trypanosoma brucei	oligopeptidase b	0.017	0.0692	0.2058
Toxoplasma gondii	hypothetical protein	0.017	0.0692	0.2066
Entamoeba histolytica	hypothetical protein	0.0036	0.006	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Echinococcus multilocularis	potassium channel subfamily K	0.0027	0.0018	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1736509

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1511984