Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | No references |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Clearance (ADMET) | = 61 ml min-1 kg-1 | Plasma clearance of the compound was estimated from the AUC after 5 mg/kg intravenous dosing in rats | ChEMBL. | No reference |
IC50 (binding) | 0.5 nM | Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2 | ChEMBL. | No reference |
IC50 (binding) | 0.5 nM | Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2 | ChEMBL. | No reference |
IC50 (binding) | = 0.8 nM | Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1 | ChEMBL. | No reference |
IC50 (binding) | = 0.8 nM | Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.