Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4225 | 0.4225 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.6311 | 0.6311 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.6311 | 0.6311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.6311 | 0.6311 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.4225 | 0.4225 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.6311 | 0.6311 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.4225 | 0.4225 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.4225 | 0.4225 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.4225 | 0.4225 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.6311 | 0.6311 |
Schistosoma mansoni | kinase | 0.0048 | 0.4493 | 0.4493 |
Brugia malayi | RNA binding protein | 0.0064 | 0.6311 | 0.6311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.6311 | 0.6311 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.6311 | 0.6311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.6311 | 0.6311 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4225 | 0.4225 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.4225 | 0.4225 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.6311 | 0.6311 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4225 | 0.4225 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.6311 | 0.6311 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.4225 | 0.4225 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.6311 | 0.6311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.6311 | 0.6311 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Induction of HO1 activity in mouse RAW264.7 cells at 30 to 100 nM after 16 hrs | ChEMBL. | 21441026 | |
CD (binding) | = 0.4 nM | Induction of NQO1 activity in mouse Hepa-1c1c7 cells assessed as concentration require to double the specific enzyme activity after 48 hrs | ChEMBL. | 21441026 |
IC50 (functional) | = 2 nM | Inhibition of NO production in INFgamma-stimulated mouse RAW264.7 cells measured after 24 hrs by Griess reaction method | ChEMBL. | 21441026 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 21441026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.