Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Mus musculus | fructose bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Toxoplasma gondii | fructose-bisphospatase I | fructose bisphosphatase 1 | 338 aa | 326 aa | 29.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0514 | 0.9691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.6135 | 0.9938 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0378 | 0.6156 | 0.0059 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0378 | 0.6156 | 0.6156 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0514 | 0.9691 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0378 | 0.6156 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0378 | 0.6156 | 0.5954 |
Brugia malayi | WGR domain containing protein | 0.0514 | 0.9691 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0514 | 0.9691 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0377 | 0.6135 | 0.9966 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0377 | 0.6135 | 0.3116 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0377 | 0.6135 | 0.593 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0377 | 0.6135 | 0.9966 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0377 | 0.6135 | 0.9966 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0378 | 0.6156 | 0.0059 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.6156 | 1 |
Leishmania major | 0.0378 | 0.6156 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.4508 | 0.5144 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0378 | 0.6156 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0514 | 0.9691 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.6156 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0378 | 0.6156 | 0.3156 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 12 uM | Reduction of glucose production in mouse hepatocytes after 6 hrs by glucose oxidase assay | ChEMBL. | 21550236 |
IC50 (binding) | = 0.22 uM | Inhibition of human liver fructose-1,6-bisphosphatase | ChEMBL. | 21550236 |
IC50 (binding) | = 2.6 uM | Inhibition of mouse liver fructose-1,6-bisphosphatase | ChEMBL. | 21550236 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 21550236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.