Detailed information for compound 1512595

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.432 | Formula: C20H16N4OS
  • H donors: 1 H acceptors: 4 LogP: 3.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1sc2c(n1)ccc(c2)c1ccnc(n1)Cc1ccccc1
  • InChi: 1S/C20H16N4OS/c1-13(25)22-20-24-17-8-7-15(12-18(17)26-20)16-9-10-21-19(23-16)11-14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,22,24,25)
  • InChiKey: GAIUSUOTDDXAJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0125 0.4929 0.4457
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0043 0.0851 0.0817
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Brugia malayi hypothetical protein 0.0059 0.1637 0.1926
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0125 0.4929 0.3972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0125 0.4929 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Brugia malayi nuclear receptor NHR-67 0.0059 0.1637 0.1926
Brugia malayi nuclear hormone receptor family member nhr-6 0.0059 0.1637 0.1926
Brugia malayi Nuclear hormone receptor E75 0.0059 0.1637 0.1926
Brugia malayi ecdysone receptor 0.0059 0.1637 0.1926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0125 0.4929 0.534
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Toxoplasma gondii target of rapamycin (TOR), putative 0.0044 0.0892 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0125 0.4929 0.3972
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0125 0.4929 0.4457
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.8792 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0059 0.1637 0.1926
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0495 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Loa Loa (eye worm) hypothetical protein 0.0125 0.4929 0.534
Brugia malayi nuclear receptor RXR 0.0066 0.1989 0.279
Trypanosoma cruzi target of rapamycin kinase 3 0.0047 0.1034 0.1243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0125 0.4929 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.2704 0.4545
Echinococcus multilocularis thyroid hormone receptor alpha 0.0125 0.4929 0.3972
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.119 0.1918
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0059 0.1637 0.0059
Giardia lamblia GTOR 0.0058 0.1587 0.9047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0059 0.1637 0.0059
Echinococcus granulosus Nuclear hormone receptor HR96 0.0059 0.1637 0.0059
Loa Loa (eye worm) hypothetical protein 0.0042 0.0782 0.0338
Echinococcus multilocularis nuclear receptor nhr 48 0.0059 0.1637 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0125 0.4929 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0125 0.4929 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0125 0.4929 1
Schistosoma mansoni nuclear hormone receptor 0.0059 0.1637 0.0858
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0059 0.1637 0.1926
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0059 0.1637 0.0858
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.4438 0.911
Loa Loa (eye worm) nuclear receptor NHR-67 0.0059 0.1637 0.137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0338 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0125 0.4929 0.4457
Echinococcus multilocularis FTZ F1 alpha 0.0125 0.4929 0.3972
Echinococcus granulosus FTZ F1 alpha 0.0125 0.4929 0.3972
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0125 0.4929 0.534
Loa Loa (eye worm) hypothetical protein 0.0125 0.4929 0.534
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0058 0.1587 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0635 0.0671
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0059 0.1637 0.137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0125 0.4929 0.3972
Brugia malayi nuclear receptor NHR-88 0.0059 0.1637 0.1926
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0059 0.1637 0.0059
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0125 0.4929 0.3972
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0125 0.4929 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.3908 0.7498
Entamoeba histolytica hypothetical protein 0.0098 0.358 0.6931
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0125 0.4929 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Schistosoma mansoni nuclear hormone receptor 0.0125 0.4929 0.4457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.1587 0.281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0047 0.1034 0.6514
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0058 0.1587 0.0804
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0125 0.4929 0.534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Brugia malayi nuclear hormone receptor 0.0125 0.4929 1
Loa Loa (eye worm) DR-78 0.0059 0.1637 0.137
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0125 0.4929 0.3972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.1587 0.281
Brugia malayi orphan nuclear receptor NR2E1 0.0059 0.1637 0.1926
Brugia malayi nuclear receptor NHR-88 0.0125 0.4929 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0058 0.1587 0.1869
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.1989 0.1244
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0066 0.1989 0.1795
Brugia malayi ecdysteroid receptor 0.0125 0.4929 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0125 0.4929 0.534
Loa Loa (eye worm) hypothetical protein 0.0125 0.4929 0.534
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.1587 0.1805
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0061 0.1728 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0122 0.4789 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0851 0.1157
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0693 0.0803
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0125 0.4929 0.4457
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0058 0.1587 0.2533
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0125 0.4929 0.4457
Loa Loa (eye worm) hypothetical protein 0.0125 0.4929 0.534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0125 0.4929 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0495 0.0356
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0122 0.4789 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.008 0.2704 0.1328
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0125 0.4929 0.3972
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0043 0.0851 0.1157
Brugia malayi nuclear receptor RXR 0.0059 0.1637 0.1926
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Schistosoma mansoni coup transcription factor 0.0125 0.4929 0.4457
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0059 0.1637 0.0059
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0058 0.1587 0.1869
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.1989 0.279
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0059 0.1637 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.1989 0.279
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0125 0.4929 0.3972
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0851 0.1157
Brugia malayi tailless protein 0.0059 0.1637 0.1926
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0058 0.1587 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0043 0.0851 0.5364
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0122 0.4789 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1989 0.1795
Brugia malayi Nuclear hormone receptor E75 0.0059 0.1637 0.1926
Brugia malayi nuclear hormone receptor 0.0059 0.1637 0.1926
Brugia malayi hypothetical protein 0.0066 0.1989 0.279
Loa Loa (eye worm) nuclear hormone receptor 0.0059 0.1637 0.137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Loa Loa (eye worm) hypothetical protein 0.008 0.2704 0.2658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.1587 0.281
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0125 0.4929 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0058 0.1587 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0059 0.1637 0.0059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0125 0.4929 0.3972
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0066 0.1989 0.1244
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0122 0.4789 1
Brugia malayi conserved hypotetical protein 0.0059 0.1637 0.1926
Loa Loa (eye worm) hypothetical protein 0.0125 0.4929 0.534
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0125 0.4929 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.1496 0.1637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0479 0.032
Onchocerca volvulus Protein ultraspiracle homolog 0.0125 0.4929 1
Brugia malayi hypothetical protein 0.0066 0.1989 0.279
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0085 0.2936 0.5839
Schistosoma mansoni nuclear hormone receptor 0.0059 0.1637 0.0858
Loa Loa (eye worm) hypothetical protein 0.0125 0.4929 0.534
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0125 0.4929 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0066 0.1989 0.0478
Loa Loa (eye worm) hypothetical protein 0.0125 0.4929 0.534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0125 0.4929 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0066 0.1989 0.0478
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0122 0.4789 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0085 0.2936 0.5839
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.008 0.2704 0.1328
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0125 0.4929 0.3972
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0125 0.4929 0.3972
Onchocerca volvulus Bile acid receptor homolog 0.0125 0.4929 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0125 0.4929 0.534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0479 0.032
Schistosoma mansoni nuclear receptor 0.0059 0.1637 0.0858
Echinococcus granulosus thyroid hormone receptor alpha 0.0059 0.1637 0.0059
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Echinococcus multilocularis ecdysone induced protein 78C 0.0125 0.4929 0.3972
Loa Loa (eye worm) hypothetical protein 0.0066 0.1989 0.1795
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0125 0.4929 0.3972
Echinococcus granulosus nuclear receptor nhr 48 0.0059 0.1637 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Schistosoma mansoni retinoic acid receptor RXR 0.0125 0.4929 0.4457
Schistosoma mansoni thyroid hormone receptor 0.0125 0.4929 0.4457
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0058 0.1587 0.2533
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0029 0.0156 0.0985
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Loa Loa (eye worm) steroid hormone receptor 0.0125 0.4929 0.534
Schistosoma mansoni nuclear receptor nhr-48 0.0059 0.1637 0.0858
Loa Loa (eye worm) hypothetical protein 0.0125 0.4929 0.534
Brugia malayi hypothetical protein 0.0059 0.1637 0.1926
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0495 0.0356
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0125 0.4929 0.3972
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0059 0.1637 0.0858
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Schistosoma mansoni thyroid hormone receptor 0.0125 0.4929 0.4457
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.358 0.6931
Loa Loa (eye worm) hypothetical protein 0.0059 0.1637 0.137
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.4789 0.9657
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0125 0.4929 0.3972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Brugia malayi Nuclear hormone receptor-like 1 0.0125 0.4929 1
Onchocerca volvulus 0.0125 0.4929 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0125 0.4929 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0125 0.4929 0.4457
Echinococcus granulosus ecdysone induced protein 78C 0.0125 0.4929 0.3972
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0125 0.4929 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0058 0.1587 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1989 0.1795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0338 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0125 0.4929 0.534
Schistosoma mansoni nuclear receptor 0.0059 0.1637 0.0858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0338 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0125 0.4929 1
Brugia malayi steroid hormone receptor 0.0125 0.4929 1
Schistosoma mansoni zinc finger protein 0.0059 0.1637 0.0858
Loa Loa (eye worm) hypothetical protein 0.0066 0.1989 0.1795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0125 0.4929 0.4457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0338 0.0005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0059 0.1637 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0125 0.4929 0.534
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0059 0.1637 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0125 0.4929 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0122 0.4789 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1989 0.1795
Schistosoma mansoni steroid hormone receptor ad4bp 0.0125 0.4929 0.4457
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.1587 0.131

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 6000 nM Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay ChEMBL. 21332118
Ki (binding) = 605 nM Inhibition of human PI3Kalpha expressed in Sf9 cells ChEMBL. 21332118

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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