TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 404.465 | Formula: C22H24N6O2
H donors: 3 H acceptors: 4 LogP: 2.03 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CNc1ncnc(c1)c1c[nH]c(=O)c(c1)NC(=O)c1ccc(cc1)N1CCCCC1
InChi: 1S/C22H24N6O2/c1-23-20-12-18(25-14-26-20)16-11-19(22(30)24-13-16)27-21(29)15-5-7-17(8-6-15)28-9-3-2-4-10-28/h5-8,11-14H,2-4,9-10H2,1H3,(H,24,30)(H,27,29)(H,23,25,26)
InChiKey: FHTBSCKDUYIEAH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Starlite/ChEMBL	References
Homo sapiens	IL2-inducible T-cell kinase	Starlite/ChEMBL	References
Homo sapiens	fms-related tyrosine kinase 3	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	Get druggable targets OG5_132967	All targets in OG5_132967
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0095	0.0301	1
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0095	0.0301	0.0286
Toxoplasma gondii	subtilisin SUB1	0.0095	0.0301	1
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0095	0.0301	1
Toxoplasma gondii	subtilisin SUB7	0.0095	0.0301	1
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0172	0.0725	0.0679
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0049	0.0049	0.0046
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0056	0.0085	0.0082
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0049	0.0049	0.0046
Schistosoma mansoni	tyrosine kinase	0.0056	0.0085	0.0036
Loa Loa (eye worm)	MBOAT family protein	0.0049	0.0049	0.0046
Trypanosoma brucei	subtilisin peptidase	0.0095	0.0301	1
Echinococcus granulosus	Furin 1	0.0603	0.3084	0.3083
Brugia malayi	MBOAT family protein	0.0049	0.0049	0.0034
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0095	0.0301	0.0253
Plasmodium vivax	subtilisin-like protease 1	0.0095	0.0301	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0056	0.0085	0.0082
Brugia malayi	MBOAT family protein	0.0049	0.0049	0.0034
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0181	0.077	0.0979
Echinococcus multilocularis	integrin beta 2	0.0228	0.1028	0.1306
Entamoeba histolytica	vacuolar protein sorting 26	0.0049	0.0049	1
Echinococcus granulosus	glycoprotein Antigen 5	0.0092	0.0286	0.0284
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0603	0.3084	0.5875
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1843	0.1841
Toxoplasma gondii	subtilisin SUB9	0.0095	0.0301	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0992	0.5216	0.5214
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0301	0.0487
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0049	0.0049	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0095	0.0301	0.5
Loa Loa (eye worm)	integrin beta-2	0.0307	0.1464	0.1462
Echinococcus granulosus	membrane bound transcription factor site 1	0.0095	0.0301	0.0298
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0049	0.0049	0.0063
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0603	0.3084	0.5875
Loa Loa (eye worm)	MBOAT family protein	0.0049	0.0049	0.0046
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.0014	0.0018
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0056	0.0085	0.0108
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0049	0.0046
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0095	0.0301	1
Loa Loa (eye worm)	hypothetical protein	0.095	0.4988	0.4987
Brugia malayi	Integrin beta pat-3 precursor	0.0307	0.1464	0.1451
Schistosoma mansoni	hypothetical protein	0.043	0.2139	0.21
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0095	0.0301	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0301	0.0298
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Plasmodium vivax	subtilisin-like serine protease, putative	0.0095	0.0301	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0049	0.0049	0.0046
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0041	0.0003	0.0004
Brugia malayi	MBOAT family protein	0.0049	0.0049	0.0034
Toxoplasma gondii	subtilisin SUB6	0.0095	0.0301	1
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0095	0.0301	0.0382
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0095	0.0301	0.0286
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0603	0.3084	0.5875
Echinococcus granulosus	neuroendocrine convertase 2	0.1475	0.7869	0.7868
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Brugia malayi	Furin-like cysteine rich region family protein	0.0337	0.1628	0.1615
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0056	0.0085	0.0082
Trypanosoma cruzi	subtilisin peptidase	0.0095	0.0301	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0049	0.0049	0.0046
Loa Loa (eye worm)	hhat protein	0.0049	0.0049	0.0046
Echinococcus multilocularis	sterol O acyltransferase 1	0.0504	0.2542	0.3231
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0049	0.0049	0.0063
Brugia malayi	SRC-1	0.0056	0.0085	0.007
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0056	0.0085	0.0108
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Toxoplasma gondii	subtilisin SUB11	0.0095	0.0301	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0056	0.0085	0.0082
Plasmodium falciparum	subtilisin-like protease 1	0.0095	0.0301	1
Loa Loa (eye worm)	SRC-1	0.0056	0.0085	0.0082
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Brugia malayi	Subtilase family protein	0.0095	0.0301	0.0286
Loa Loa (eye worm)	subtilase	0.0095	0.0301	0.0298
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0047	0.0035	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Schistosoma mansoni	integrin beta subunit	0.0181	0.0772	0.0726
Onchocerca volvulus		0.0078	0.0204	0.617
Schistosoma mansoni	furin-1 (S08 family)	0.0968	0.5085	0.5061
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0337	0.1628	0.1625
Loa Loa (eye worm)	hhat protein	0.0049	0.0049	0.0046
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0049	0.0049	1
Echinococcus multilocularis	neuroendocrine convertase 2	0.1475	0.7869	1
Trichomonas vaginalis	hypothetical protein	0.043	0.2139	0.4044
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0672	0.3465	0.3463
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0172	0.0725	0.1308
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0092	0.0286	0.0238
Schistosoma mansoni	tyrosine kinase	0.0056	0.0085	0.0036
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0056	0.0085	0.0082
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0455	0.2272	0.227
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0049	0.0049	0.0063
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0095	0.0301	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0049	0.0046
Brugia malayi	Kelch motif family protein	0.0047	0.0035	0.002
Brugia malayi	celfurPC protein	0.1434	0.7641	0.7637
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.0014	0.0011
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0049	0.0049	0.0046
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0035	0.0033
Brugia malayi	MBOAT family protein	0.0049	0.0049	0.0034
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0992	0.5216	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0056	0.0085	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.043	0.2139	0.4044
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0095	0.0301	0.5
Schistosoma mansoni	sterol O-acyltransferase 1	0.0504	0.2542	0.2505
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0044	0.0056
Echinococcus multilocularis	Furin 1	0.0603	0.3084	0.392
Toxoplasma gondii	subtilisin SUB12	0.0095	0.0301	1
Schistosoma mansoni	tyrosine kinase	0.0173	0.0729	0.0684
Plasmodium falciparum	subtilisin-like protease 2	0.0095	0.0301	1
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0508	0.2563	0.4866
Toxoplasma gondii	subtilisin SUB5	0.0095	0.0301	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0049	0.0049	0.0046
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0049	0.0049	0.0063
Echinococcus multilocularis	Mastin	0.0092	0.0286	0.0364
Brugia malayi	diacylglycerol acyltransferase	0.0049	0.0049	0.0034
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0049	0.0049	0.0063
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0603	0.3084	0.5875
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0095	0.0301	0.0253
Treponema pallidum	alginate O-acetylation protein (algI)	0.0049	0.0049	0.5
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0095	0.0301	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0095	0.0301	0.0298
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0508	0.2563	0.4866
Plasmodium vivax	subtilisin-like protease 2, putative	0.0095	0.0301	1
Toxoplasma gondii	subtilisin SUB2	0.0095	0.0301	1
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0049	0.0049	0.0046
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0056	0.0085	0.0108
Echinococcus multilocularis	enteropeptidase	0.0092	0.0286	0.0364
Toxoplasma gondii	subtilisin SUB10	0.0095	0.0301	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0142	0.014
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0181	0.077	0.0767
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0095	0.0301	0.5
Leishmania major	subtilisin-like serine peptidase	0.0095	0.0301	1
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0049	0.0049	0.0046
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0992	0.5216	0.6628
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0049	0.0049	0.0046
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0095	0.0301	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Plasmodium falciparum	subtilisin-like protease 3	0.0095	0.0301	1
Brugia malayi	neuroendocrine convertase 1 precursor	0.1774	0.9508	0.9507
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0056	0.0085	0.0108
Brugia malayi	hypothetical protein	0.0047	0.0035	0.002
Echinococcus granulosus	epidermal growth factor receptor	0.0337	0.1628	0.1625
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0044	0.0042
Brugia malayi	proprotein convertase 2	0.1475	0.7869	0.7866
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0018	0.0003
Loa Loa (eye worm)	TK/ROR protein kinase	0.0043	0.0018	0.0015
Echinococcus multilocularis		0.1434	0.7641	0.971
Schistosoma mansoni	tyrosine kinase	0.0337	0.1628	0.1586
Brugia malayi	Hhat protein	0.0049	0.0049	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0204	0.0299
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0043	0.0015	0.0012
Brugia malayi	protein-tyrosine kinase	0.0048	0.0044	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Entamoeba histolytica	hypothetical protein	0.0049	0.0049	1
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0095	0.0301	0.5
Mycobacterium leprae	Possible secreted protease	0.0095	0.0301	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0049	0.0049	1
Brugia malayi	MBOAT family protein	0.0049	0.0049	0.0034
Echinococcus granulosus	tyrosine kinase	0.0048	0.0044	0.0042
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0056	0.0085	0.0108
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0048	0.0044	0.0056
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0095	0.0301	1
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Toxoplasma gondii	subtilisin SUB8	0.0095	0.0301	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0056	0.0085	0.0108
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0603	0.3084	0.305
Echinococcus granulosus	integrin beta 2	0.0228	0.1028	0.1025
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0301	0.0487
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0992	0.5216	1
Loa Loa (eye worm)	proprotein convertase 2	0.0603	0.3084	0.3083
Echinococcus multilocularis	epidermal growth factor receptor	0.0337	0.1628	0.2068
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0301	0.0487
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0056	0.0085	0.0108
Echinococcus granulosus	sterol O acyltransferase 1	0.0504	0.2542	0.254
Echinococcus granulosus	enteropeptidase	0.0092	0.0286	0.0284
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0049	0.0049	0.0063
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0049	0.0049	1
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Loa Loa (eye worm)	MBOAT family protein	0.0049	0.0049	0.0046
Onchocerca volvulus		0.0095	0.0301	1
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0095	0.0301	0.5
Giardia lamblia	Furin precursor putative serine protease	0.0508	0.2563	1
Echinococcus granulosus	Mastin	0.0092	0.0286	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0504	0.2542	0.254
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0095	0.0301	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.043	0.2139	0.4044
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0095	0.0301	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0048	0.0044	0.0056
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0049	0.0049	0.0046
Echinococcus multilocularis	glycoprotein Antigen 5	0.0092	0.0286	0.0364
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0049	0.0046
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0056	0.0085	0.0082
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0603	0.3084	0.5875
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0056	0.0085	0.0108
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.0301	0.0487
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0301	0.0487
Echinococcus granulosus	tyrosine protein kinase Blk	0.0048	0.0044	0.0042
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0049	0.0049	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0301	0.0487
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0056	0.0085	0.0082
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0603	0.3084	0.5875
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0056	0.0085	0.0108
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0049	0.0049	0.0063
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0048	0.0044	0.0042
Toxoplasma gondii	subtilisin SUB4	0.0095	0.0301	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.02 uM	Inhibition of Flt3 after 20 mins by radiometric phosphate incorporation assay	ChEMBL.	21391610
Ki (binding)	= 0.046 uM	Inhibition of Itk after 40 mins by radiometric phosphate incorporation assay	ChEMBL.	21391610
Ki (binding)	= 0.083 uM	Inhibition of c-Kit after 45 mins by radiometric phosphate incorporation assay	ChEMBL.	21391610
Ki (binding)	= 1.2 uM	Inhibition of Src after 10 mins by radiometric phosphate incorporation assay	ChEMBL.	21391610

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1765775

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1512844