Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.00484845 | 0.0404397 | 0.0626822 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.00484845 | 0.0404397 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0286949 | 0.645155 | 0.6302 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0426879 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.00484845 | 0.0404397 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0426879 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0286949 | 0.645155 | 0.6302 |
Loa Loa (eye worm) | carboxylesterase | 0.0286949 | 0.645155 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00484845 | 0.0404397 | 0.5 |
Onchocerca volvulus | 0.00484845 | 0.0404397 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.00484845 | 0.0404397 | 0.0626822 |
Brugia malayi | hypothetical protein | 0.00484845 | 0.0404397 | 0.0626822 |
Loa Loa (eye worm) | hypothetical protein | 0.00484845 | 0.0404397 | 0.0626822 |
Trypanosoma cruzi | cytochrome P450, putative | 0.00325374 | 0 | 0.5 |
Onchocerca volvulus | 0.00484845 | 0.0404397 | 0.5 | |
Onchocerca volvulus | 0.00484845 | 0.0404397 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.00484845 | 0.0404397 | 0.0626822 |
Brugia malayi | Carboxylesterase family protein | 0.00484845 | 0.0404397 | 0.0626822 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0286949 | 0.645155 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.00484845 | 0.0404397 | 0.0626822 |
Brugia malayi | Carboxylesterase family protein | 0.0286949 | 0.645155 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.00484845 | 0.0404397 | 0.0626822 |
Loa Loa (eye worm) | hypothetical protein | 0.00484845 | 0.0404397 | 0.0626822 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00484845 | 0.0404397 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.00484845 | 0.0404397 | 0.0626822 |
Brugia malayi | Carboxylesterase family protein | 0.00484845 | 0.0404397 | 0.0626822 |
Echinococcus multilocularis | acetylcholinesterase | 0.0286949 | 0.645155 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0286949 | 0.645155 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0286949 | 0.645155 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.00484845 | 0.0404397 | 0.0626822 |
Brugia malayi | Carboxylesterase family protein | 0.0286949 | 0.645155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286949 | 0.645155 | 1 |
Echinococcus granulosus | neuropeptide receptor | 0.0426879 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.00325374 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.00484845 | 0.0404397 | 0.0626822 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0286949 | 0.645155 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0426879 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.00484845 | 0.0404397 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0286949 | 0.645155 | 0.6302 |
Loa Loa (eye worm) | carboxylesterase | 0.00484845 | 0.0404397 | 0.0626822 |
Trypanosoma brucei | cytochrome P450, putative | 0.00325374 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0286949 | 0.645155 | 0.6302 |
Onchocerca volvulus | 0.00484845 | 0.0404397 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.00484845 | 0.0404397 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.00325374 | 0 | 0.5 |
Onchocerca volvulus | 0.00484845 | 0.0404397 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 42 uM | Cytotoxicity against HFF after 48 hrs by MTS assay | ChEMBL. | 21428405 |
IC50 (functional) | = 15 uM | Antiparasitic activity against Toxoplasma gondii 2F-1 expressing yellow fluorescent protein infected in HFF after 4 days | ChEMBL. | 21428405 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 21428405 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.