Detailed information for compound 1513214

Basic information

Technical information
  • TDR Targets ID: 1513214
  • Name: Neuro_000180
  • MW: 325.271 | Formula: C14H15NO8
  • H donors: 6 H acceptors: 6 LogP: -1.6 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC1C(O)C(O)C2C(C1O)NC(=O)c1c2cc2OCOc2c1O
  • InChi: 1S/C14H15NO8/c16-8-5-3-1-4-13(23-2-22-4)9(17)6(3)14(21)15-7(5)10(18)12(20)11(8)19/h1,5,7-8,10-12,16-20H,2H2,(H,15,21)
  • InChiKey: VREZDOWOLGNDPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens paired box 8 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0127 0.0127
Brugia malayi CXXC zinc finger family protein 0.0029 0.0288 0.0288
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0167 0.0381
Brugia malayi Patched related family protein 12 0.0006 0.0007 0.0007
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1148 0.1154
Echinococcus granulosus expressed conserved protein 0.0093 0.1074 0.127
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0167 0.0166
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0055 0.0934
Schistosoma mansoni hypothetical protein 0.0019 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0226
Echinococcus granulosus Ankyrin 0.0032 0.0325 0.0383
Brugia malayi Myosin head containing protein 0.0006 0.0007 0.0007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0167 0.0381
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0609 0.0612
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0226 0.0534
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Brugia malayi jmjC domain containing protein 0.0016 0.0127 0.0127
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0019 0.0019
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.8447 0.85
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0019 0.0021
Brugia malayi Patched related family protein 4 0.0006 0.0007 0.0007
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.006 0.067 0.067
Brugia malayi jmjC domain containing protein 0.0016 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.0032 0.0324 0.0381
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.8447 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0167 0.0196
Brugia malayi Patched protein homolog 1 0.0006 0.0007 0.0007
Echinococcus granulosus GPCR family 2 0.0019 0.0167 0.0195
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0019 0.0409
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.0032 0.0324 0.0324
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0679 0.0802
Echinococcus multilocularis Smad4 0.001 0.0054 0.0052
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1167 0.138
Echinococcus multilocularis nibrin 0.001 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0055
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0055 0.0934
Brugia malayi MH1 domain containing protein 0.001 0.0054 0.0054
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0226 0.183
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0167 0.0196
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0127 0.0126
Loa Loa (eye worm) patched family protein 0.0006 0.0007 0.0007
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0167 0.7297
Loa Loa (eye worm) hypothetical protein 0.0018 0.0152 0.0152
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0022 0.002
Echinococcus multilocularis GPCR, family 2 0.0019 0.0167 0.0166
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0324 0.0381
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0323 0.3889 1
Echinococcus granulosus replication factor c subunit 1 0.001 0.0055 0.0063
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0055 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0226 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0019 0.0546
Echinococcus granulosus cpg binding protein 0.0031 0.0308 0.0363
Echinococcus granulosus Smad4 0.001 0.0054 0.0062
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0306 0.074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0226 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0306 0.074
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0127 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0226 0.0226
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0055 0.08
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0101 0.01
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0127 0.2005
Treponema pallidum DNA ligase (lig) 0.001 0.0055 0.5
Loa Loa (eye worm) patched family protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.9937 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0055 0.0934
Schistosoma mansoni survival motor neuron protein 0.0049 0.0529 0.0624
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Schistosoma mansoni topbp1 0.001 0.0055 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0465 0.0549
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0167 0.0166
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0055 0.08
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Onchocerca volvulus 0.001 0.0055 0.0153
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1669 0.1678
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0679 0.0679
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0127 0.0278
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0055 0.0092
Loa Loa (eye worm) patched family protein 0.0006 0.0007 0.0007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0226 1
Schistosoma mansoni hypothetical protein 0.0041 0.0437 0.0515
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0022 0.002
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0127 0.0126
Entamoeba histolytica hypothetical protein 0.0043 0.0465 0.3948
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) patched family protein 0.0006 0.0007 0.0007
Onchocerca volvulus 0.0006 0.0007 0.0016
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0055
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Brugia malayi Uncoordinated protein 44 0.0032 0.0324 0.0324
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0659 0.0778
Brugia malayi jmjC domain containing protein 0.0016 0.0127 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0609 0.072
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Onchocerca volvulus 0.0006 0.0007 0.0016
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0054 0.0054
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0226 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Brugia malayi DKFZp564C0469 protein 0.001 0.0055 0.0055
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1776 0.1786
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0019 0.0546
Brugia malayi hypothetical protein 0.0238 0.2851 0.2851
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0609 0.072
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0306 0.074
Schistosoma mansoni cpg binding protein 0.0031 0.0308 0.0363
Brugia malayi isocitrate dehydrogenase 0.0019 0.0167 0.0167
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0019 0.0546
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) paired box protein 0.0006 0.0002 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0167 0.0166
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0055 0.0934
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0306 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0226 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0679 0.0802
Brugia malayi protein C24B5.3 0.0006 0.0007 0.0007
Brugia malayi hypothetical protein 0.003 0.0306 0.0306
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0019 0.0546
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0055 0.0055
Onchocerca volvulus 0.0006 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.014 0.6071
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0055
Echinococcus granulosus phd:f box containing protein 0.0016 0.0127 0.0148
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0167 0.5348
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1148 1
Brugia malayi CHE-14 protein 0.0043 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0226 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0055 0.0092
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0043 0.0042
Onchocerca volvulus 0.0006 0.0007 0.0016
Schistosoma mansoni cpg binding protein 0.0029 0.0288 0.0339
Schistosoma mansoni DNA ligase IV 0.001 0.0055 0.0063
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0055 0.0054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0226 0.183
Brugia malayi Patched related family protein 10 0.0006 0.0007 0.0007
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0127 0.0126
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0167 0.0381
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0167 0.0166
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0324 0.0324
Schistosoma mansoni hypothetical protein 0.0041 0.0436 0.0514
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0101 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0055 0.0934
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0127 0.0148
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0226 0.0534
Brugia malayi 'Paired box' domain containing protein 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.0024 0.0226 1
Brugia malayi 'Paired box' domain containing protein 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Schistosoma mansoni smad 0.001 0.0054 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0055 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0055 0.0934
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0167 0.0167
Echinococcus multilocularis Ankyrin 0.0032 0.0325 0.0326
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0226 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) oxidoreductase 0.0007 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0043 0.0465 0.3948
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0226 0.0226
Brugia malayi MH2 domain containing protein 0.0144 0.1697 0.1697
Brugia malayi Smad1 0.001 0.0054 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0127 0.0127
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0659 0.0662
Loa Loa (eye worm) Smad1 0.001 0.0054 0.0054
Leishmania major hypothetical protein, conserved 0.003 0.0306 0.074
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0055 0.16
Echinococcus granulosus smad 0.001 0.0054 0.0062
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0659 0.0778
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0679 0.0802
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0019 0.0546
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0019 0.0205
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0455 0.0537
Echinococcus multilocularis expressed conserved protein 0.0093 0.1074 0.108
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0127 0.0278
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0127 0.0148
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0019 0.0546
Brugia malayi Pax transcription factor protein 2 0.0291 0.3489 0.3489
Entamoeba histolytica hypothetical protein 0.001 0.0055 0.0315
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0055
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1669 0.1975
Schistosoma mansoni topbp1 0.001 0.0055 0.0063
Schistosoma mansoni patched 1 0.0043 0.0455 0.0537
Loa Loa (eye worm) hypothetical protein 0.0018 0.0152 0.0152
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0167 0.0381
Entamoeba histolytica hypothetical protein 0.0043 0.0465 0.3948
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0306 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0226 0.0226
Schistosoma mansoni hypothetical protein 0.0041 0.0436 0.0514
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0465 0.0549
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Onchocerca volvulus 0.0007 0.0019 0.0051
Brugia malayi hypothetical protein 0.0043 0.0465 0.0465
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0019 0.0019
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0455 0.0537
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Echinococcus granulosus microtubule associated protein 2 0.0696 0.8447 1
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0019 0.0546
Schistosoma mansoni hypothetical protein 0.0043 0.0465 0.0549
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0529 0.0529
Brugia malayi MH2 domain containing protein 0.001 0.0054 0.0054
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0055 0.0315
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0055 0.0092
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0226 0.0534
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0167 0.0195
Schistosoma mansoni netrin receptor unc5 0.0032 0.0324 0.0381
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0324 0.0381
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0042 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0167 0.0166
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0306 1
Loa Loa (eye worm) patched family protein 0.0006 0.0007 0.0007
Onchocerca volvulus 0.0291 0.3489 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0455 0.0455
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0054 0.0054
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0324 0.0324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0167 0.0195
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0605 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0323 0.3889 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0226
Brugia malayi 'Paired box' domain containing protein 0.0006 0.0002 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0043 0.0049
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0055 0.0934
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0019 0.0127
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0127 0.0148
Onchocerca volvulus 0.0007 0.0019 0.0051
Loa Loa (eye worm) vab-3 0.0006 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0019 0.0051
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0019 0.0019
Brugia malayi hypothetical protein 0.001 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1148 0.1148
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0019 0.0127
Echinococcus granulosus nibrin 0.001 0.0055 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0127
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Brugia malayi MH2 domain containing protein 0.001 0.0054 0.0054
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0022 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1697 0.1697
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0226 0.183
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0152 0.6421
Schistosoma mansoni hypothetical protein 0.0412 0.4979 0.5894
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0465 0.0466
Brugia malayi hypothetical protein 0.002 0.0174 0.0174
Brugia malayi paired box protein 0.0006 0.0002 0.0002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0455 0.0455
Echinococcus granulosus nuclear factor of activated T cells 5 0.0312 0.3749 0.4438
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0055 0.0934
Brugia malayi jmjC domain containing protein 0.0059 0.0659 0.0659
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1697 0.1697
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0127 0.2005
Echinococcus multilocularis geminin 0.0171 0.2024 0.2035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.067 0.067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0609 0.0612
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Onchocerca volvulus 0.0006 0.0007 0.0016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0022 0.0024
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0127 0.0148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0167 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0455 1
Brugia malayi MH1 domain containing protein 0.001 0.0054 0.0054
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0226 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0054 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0437 0.0437
Echinococcus granulosus muscleblind protein 0.0151 0.1776 0.2101
Loa Loa (eye worm) hypothetical protein 0.0151 0.1776 0.1776
Leishmania major malonyl-coa decarboxylase-like protein 0.0323 0.3889 1
Brugia malayi jmjC domain containing protein 0.0016 0.0127 0.0127
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0055 0.16
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2851 0.3374
Schistosoma mansoni hypothetical protein 0.0019 0.0167 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0325 0.0383
Onchocerca volvulus 0.0006 0.0007 0.0016
Echinococcus multilocularis protein dispatched 1 0.0049 0.0528 0.053
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.067 0.067
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0324 0.0324
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0167 0.0167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0609 0.072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0685 0.0809
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0226 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0152 0.6617
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0019 0.0546
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.4979 0.501
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0288 0.0288
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0167 0.2673
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0127
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0055 0.1722
Loa Loa (eye worm) hypothetical protein 0.0018 0.0152 0.0152
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0167 0.5348
Brugia malayi topoisomerase 0.001 0.0055 0.0055
Echinococcus multilocularis muscleblind protein 0.0151 0.1776 0.1786
Brugia malayi jmjC domain containing protein 0.0061 0.0679 0.0679
Schistosoma mansoni hypothetical protein 0.0014 0.0101 0.0117
Onchocerca volvulus Protein patched homolog 0.0006 0.0007 0.0016
Brugia malayi Gooseberry protein 0.0006 0.0002 0.0002
Echinococcus multilocularis protein patched 0.0043 0.0455 0.0456
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0151 0.1776 0.1776
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0019 0.0019
Schistosoma mansoni smad1 5 8 and 0.001 0.0054 0.0062
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0054 0.0052
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0019 0.0205
Brugia malayi Death domain containing protein 0.0032 0.0324 0.0324
Brugia malayi hypothetical protein 0.0006 0.0007 0.0007
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0127 0.0148
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0019 0.0546
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0127
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0019 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0609 0.0609
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0043 0.0043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0167 0.0167
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0167 0.0166
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0167 0.0381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0609 0.072
Onchocerca volvulus 0.0024 0.0226 0.0643
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0019 0.0018
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0127 0.0148
Loa Loa (eye worm) hypothetical protein 0.0099 0.1148 0.1148
Onchocerca volvulus 0.0007 0.0019 0.0051
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0127 0.0148
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0127 0.0126
Brugia malayi vab-3 gene. 0.0006 0.0002 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0127 0.0127
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0019 0.0205
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0019 0.0546
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0152 0.485
Schistosoma mansoni Smad4 0.001 0.0054 0.0062
Schistosoma mansoni hypothetical protein 0.0171 0.2024 0.2395
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0455 0.0456
Echinococcus granulosus geminin 0.0171 0.2024 0.2395
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0054 0.0062
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0306 0.4999
Loa Loa (eye worm) hypothetical protein 0.0019 0.0167 0.0167
Onchocerca volvulus Protein patched homolog 0.0006 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1148 0.1358
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0306
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0019
Onchocerca volvulus 0.0006 0.0007 0.0016
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0054 0.0062
Echinococcus granulosus dnaJ subfamily B 0.0412 0.4979 0.5894
Plasmodium vivax JmjC domain containing protein 0.0016 0.0127 0.4011
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.3489 0.3489
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0659 0.0662
Onchocerca volvulus 0.0049 0.0529 0.1511
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0054 0.0062
Entamoeba histolytica hypothetical protein 0.0043 0.0465 0.3948
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0226 1
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0323 0.3889 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0127 0.4011
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0324 0.0324
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0312 0.3749 0.3772
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0152 0.485
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0022 0.0024
Schistosoma mansoni hypothetical protein 0.0019 0.0167 0.0195
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.014 0.6071
Schistosoma mansoni hypothetical protein 0.0019 0.0167 0.0195
Brugia malayi hypothetical protein 0.0006 0.0007 0.0007
Echinococcus granulosus death domain containing protein 0.0032 0.0324 0.0381
Brugia malayi hypothetical protein 0.001 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0324 0.0924
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0031 0.0308 0.0363
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0032 0.0324 0.0324
Leishmania major hypothetical protein, conserved 0.0016 0.0127 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0019
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0019 0.0409
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0041 0.0436 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0055 0.0934
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0147 0.0147
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0055 0.1722
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0167 0.2673
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0019
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0147 0.0172
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0127 0.0148
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0226 1
Onchocerca volvulus 0.0029 0.0288 0.0821
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0238 0.2851 0.2851
Echinococcus multilocularis smad 0.001 0.0054 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.014 0.6071
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0019
Brugia malayi Patched family protein 0.0006 0.0007 0.0007
Brugia malayi paired box pox-meso protein 0.0006 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0609 0.072
Brugia malayi protein C24B5.3 0.0006 0.0007 0.0007
Brugia malayi hypothetical protein 0.0006 0.0007 0.0007
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0324 0.0381
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.014 0.6071
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2851 0.2868
Giardia lamblia Replication factor C, subunit 1 0.001 0.0055 0.5
Brugia malayi hypothetical protein 0.0006 0.0007 0.0007
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0152 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0054 0.0062
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0019 0.0546
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0055 0.0092
Brugia malayi Muscleblind-like protein 0.0151 0.1776 0.1776
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0041 0.0436 0.0514
Schistosoma mansoni hypothetical protein 0.0049 0.0529 0.0624
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0171 0.2024 0.2395

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) < 0.26 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 49.806 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and receptor-interacting serine-threonine kinase 2 (RIPK2): Fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0651 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1032 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1259 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 0.1413 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 0.15 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1836 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4611 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.92 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1.2995 uM PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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