Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 1 | References | |
Homo sapiens | adrenoceptor beta 2, surface | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0029 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0029 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0029 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0029 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.5 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0029 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0029 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0029 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0029 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0029 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0029 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0029 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0029 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0029 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 28.2 % | Maximal follow rate showing the contractile frequencies of atria to electrical stimulation 10 min after incubation with right atria of guinea pig. | ChEMBL. | 6147415 |
Kd (binding) | = 5.63 | Beta adrenergic receptor blocking activity measured by the inotropic effect was determined 1 hr after pretreament of the right atria in guinea pig | ChEMBL. | 6147415 |
Kd (binding) | = 5.66 | Beta adrenergic receptor blocking activity measured by the chronotropic effect was determined 1 hr after pretreatment of the right atria in guinea pig | ChEMBL. | 6147415 |
pA2 (binding) | = 5.63 | Beta adrenergic receptor blocking activity measured by the inotropic effect was determined 1 hr after pretreament of the right atria in guinea pig | ChEMBL. | 6147415 |
pA2 (binding) | = 5.66 | Beta adrenergic receptor blocking activity measured by the chronotropic effect was determined 1 hr after pretreatment of the right atria in guinea pig | ChEMBL. | 6147415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.