Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.3339 | 0.5076 |
Trypanosoma cruzi | 3-phosphoglycerate kinase, glycosomal | 0.006 | 0.0304 | 0.0555 |
Giardia lamblia | Aldose reductase | 0.0389 | 0.5482 | 1 |
Onchocerca volvulus | 0.0389 | 0.5482 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.3945 | 0.7196 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.006 | 0.0304 | 0.0555 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0164 | 0.1941 | 0.5 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0164 | 0.1941 | 0.1901 |
Echinococcus multilocularis | insulin receptor | 0.0093 | 0.0821 | 0.0775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.1772 | 0.1477 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1969 | 0.1928 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Trypanosoma cruzi | aldo-keto reductase | 0.0389 | 0.5482 | 1 |
Onchocerca volvulus | 0.0389 | 0.5482 | 1 | |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0164 | 0.1941 | 0.1865 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0164 | 0.1941 | 0.1865 |
Treponema pallidum | phosphoglycerate kinase | 0.0164 | 0.1941 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0389 | 0.5482 | 1 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0164 | 0.1941 | 0.1901 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1969 | 0.1928 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0113 | 0.1129 | 0.1987 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0164 | 0.1941 | 0.1901 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.006 | 0.0304 | 0.0555 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0157 | 0.182 | 0.1779 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1969 | 0.1928 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0389 | 0.5482 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.1969 | 0.1928 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0164 | 0.1941 | 1 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0164 | 0.1941 | 0.1865 |
Loa Loa (eye worm) | oxidoreductase | 0.0389 | 0.5482 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0389 | 0.5482 | 1 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0164 | 0.1941 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0389 | 0.5482 | 1 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0164 | 0.1941 | 0.1865 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1969 | 0.1928 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0113 | 0.1129 | 0.192 |
Mycobacterium ulcerans | oxidoreductase | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0113 | 0.1129 | 0.1085 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Onchocerca volvulus | 0.0389 | 0.5482 | 1 | |
Echinococcus granulosus | hypothetical protein | 0.0389 | 0.5482 | 0.5459 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0292 | 0.3945 | 0.7196 |
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.182 | 0.1779 |
Echinococcus multilocularis | aldo keto reductase | 0.0389 | 0.5482 | 0.5459 |
Echinococcus multilocularis | aldo keto reductase | 0.0389 | 0.5482 | 0.5459 |
Loa Loa (eye worm) | oxidoreductase | 0.0389 | 0.5482 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.1527 | 0.2786 |
Echinococcus granulosus | insulin receptor | 0.0093 | 0.0821 | 0.0775 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.3339 | 0.5076 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0277 | 0.3707 | 0.5922 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1969 | 0.1928 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0389 | 0.5482 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.1527 | 0.2362 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0113 | 0.1129 | 0.1085 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Entamoeba histolytica | aldose reductase, putative | 0.0389 | 0.5482 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0389 | 0.5482 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0389 | 0.5482 | 0.5459 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0389 | 0.5482 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0113 | 0.1129 | 0.1085 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0164 | 0.1941 | 0.3162 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1969 | 0.1928 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0164 | 0.1941 | 0.5 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0164 | 0.1941 | 0.3162 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0164 | 0.1941 | 0.3541 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.1794 | 0.1753 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0164 | 0.1941 | 0.3541 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0389 | 0.5482 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0093 | 0.0821 | 0.1419 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.006 | 0.0304 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0389 | 0.5482 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0093 | 0.0821 | 0.0775 |
Trypanosoma brucei | phosphoglycerate kinase, putative | 0.006 | 0.0304 | 0.0555 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Brugia malayi | NADH-dependent xylose reductase | 0.0113 | 0.1129 | 0.1987 |
Echinococcus multilocularis | aldo keto reductase | 0.0389 | 0.5482 | 0.5459 |
Trypanosoma brucei | phosphoglycerate kinase | 0.006 | 0.0304 | 0.0555 |
Brugia malayi | Protein kinase domain containing protein | 0.0093 | 0.0821 | 0.1419 |
Onchocerca volvulus | 0.0389 | 0.5482 | 1 | |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0389 | 0.5482 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0164 | 0.1941 | 0.3541 |
Echinococcus multilocularis | 0.009 | 0.0775 | 0.0729 | |
Echinococcus multilocularis | aldehyde reductase | 0.0277 | 0.3707 | 0.3675 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.2109 | 0.2252 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.3339 | 0.5076 |
Echinococcus granulosus | aldo keto reductase | 0.0389 | 0.5482 | 0.5459 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.3339 | 0.5076 |
Schistosoma mansoni | tyrosine kinase | 0.0292 | 0.3943 | 0.3912 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Onchocerca volvulus | 0.0389 | 0.5482 | 1 | |
Echinococcus granulosus | aldo keto reductase | 0.0389 | 0.5482 | 0.5459 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Schistosoma mansoni | aldo-keto reductase | 0.0389 | 0.5482 | 0.5459 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0292 | 0.3943 | 0.3912 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Echinococcus granulosus | aldehyde reductase | 0.0277 | 0.3707 | 0.3675 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0113 | 0.1129 | 0.206 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0113 | 0.1129 | 0.1594 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0164 | 0.1941 | 0.3427 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0389 | 0.5482 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.1794 | 0.1753 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0051 | 0.015 | 0.0184 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0157 | 0.182 | 0.1779 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.1794 | 0.1753 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.3339 | 0.5076 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0164 | 0.1941 | 0.1901 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.006 | 0.0304 | 0.0555 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.2109 | 0.2252 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0292 | 0.3945 | 0.7031 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0093 | 0.0821 | 0.0775 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0113 | 0.1129 | 0.1987 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0164 | 0.1941 | 0.1865 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0253 | 0.3339 | 0.6055 |
Entamoeba histolytica | aldose reductase, putative | 0.0389 | 0.5482 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0164 | 0.1941 | 0.3427 |
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.182 | 0.1779 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0389 | 0.5482 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0389 | 0.5482 | 0.5459 |
Leishmania major | aldo-keto reductase-like protein | 0.0389 | 0.5482 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.006 | 0.0304 | 0.0468 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0113 | 0.1129 | 0.1085 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0253 | 0.3339 | 0.6055 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0292 | 0.3943 | 0.7167 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0292 | 0.3943 | 0.7167 |
Leishmania major | prostaglandin f synthase, putative | 0.0389 | 0.5482 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.1527 | 0.2786 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0113 | 0.1129 | 0.192 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0389 | 0.5482 | 1 |
Schistosoma mansoni | pol-related | 0.0389 | 0.5482 | 0.5459 |
Loa Loa (eye worm) | oxidoreductase | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.3339 | 0.5076 |
Brugia malayi | Cytochrome P450 family protein | 0.0051 | 0.015 | 0.0184 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0164 | 0.1941 | 0.1865 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.1772 | 0.1477 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0157 | 0.182 | 0.1779 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.3945 | 0.7196 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0389 | 0.5482 | 0.5459 |
Toxoplasma gondii | aldose reductase, putative | 0.0389 | 0.5482 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0093 | 0.0821 | 0.0775 |
Giardia lamblia | Aldose reductase | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0389 | 0.5482 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0093 | 0.0821 | 0.0775 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1941 | 0.3482 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0113 | 0.1129 | 0.206 |
Trypanosoma brucei | prostaglandin f synthase | 0.0389 | 0.5482 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0389 | 0.5482 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0164 | 0.1941 | 0.3541 |
Toxoplasma gondii | aldo-keto reductase | 0.0113 | 0.1129 | 0.192 |
Schistosoma mansoni | aldo-keto reductase | 0.0389 | 0.5482 | 0.5459 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0292 | 0.3943 | 0.3912 |
Brugia malayi | Phosphoglycerate kinase | 0.0164 | 0.1941 | 0.3482 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1969 | 0.1928 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0141 | 0.0258 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0389 | 0.5482 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0389 | 0.5482 | 0.5459 |
Onchocerca volvulus | 0.0389 | 0.5482 | 1 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0389 | 0.5482 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 4.6 | Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF | ChEMBL. | 21486695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.