Detailed information for compound 1513444

Basic information

Technical information
  • TDR Targets ID: 1513444
  • Name: 3-(4-ethylpiperazin-1-yl)-N-(3-methoxyphenyl) propanamide
  • MW: 291.389 | Formula: C16H25N3O2
  • H donors: 1 H acceptors: 1 LogP: 1.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)CCC(=O)Nc1cccc(c1)OC
  • InChi: 1S/C16H25N3O2/c1-3-18-9-11-19(12-10-18)8-7-16(20)17-14-5-4-6-15(13-14)21-2/h4-6,13H,3,7-12H2,1-2H3,(H,17,20)
  • InChiKey: QOMKLXICBPQQKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-ethyl-1-piperazinyl)-N-(3-methoxyphenyl)propanamide
  • 3-(4-ethylpiperazin-1-yl)-N-(3-methoxyphenyl)propionamide
  • BAS 03086689
  • Oprea1_192893
  • Oprea1_198338
  • ST5015845

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-lactamase 0.0035 0.0019 0.0056
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0108 0.0989 0.1854
Loa Loa (eye worm) hypothetical protein 0.0063 0.0391 0.1164
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.005 0.0149
Loa Loa (eye worm) hypothetical protein 0.0034 0.0006 0.0017
Trichomonas vaginalis esterase, putative 0.0035 0.0019 0.5
Echinococcus granulosus tar DNA binding protein 0.0067 0.0446 0.0817
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0019 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0019 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0108 0.0989 0.0971
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0446 0.1327
Loa Loa (eye worm) hypothetical protein 0.0126 0.123 0.3659
Schistosoma mansoni transient receptor potential channel 0.01 0.0886 0.7203
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0019 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0126 0.123 1
Entamoeba histolytica hypothetical protein 0.0037 0.0054 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0292 0.237
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0842 0.1573
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0886 0.1658
Schistosoma mansoni hypothetical protein 0.0058 0.0332 0.2696
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0292 0.0867
Mycobacterium ulcerans lipase LipD 0.0035 0.0019 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0054 0.0438
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0332 0.0986
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2518 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0019 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0108 0.0989 0.294
Loa Loa (eye worm) hypothetical protein 0.0286 0.3362 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0292 0.237
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0108 0.0989 0.294
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0108 0.0989 0.0971
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0436 0.0797
Brugia malayi beta-lactamase family protein 0.0035 0.0019 0.0056
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0886 0.7203
Brugia malayi beta-lactamase family protein 0.0035 0.0019 0.0056
Brugia malayi hypothetical protein 0.0037 0.0054 0.016
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.005 0.006
Echinococcus multilocularis serotonin receptor 0.0126 0.123 0.1214
Brugia malayi hypothetical protein 0.0286 0.3362 1
Brugia malayi Transient-receptor-potential like protein 0.0037 0.005 0.0149
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0019 0.5
Schistosoma mansoni hypothetical protein 0.0037 0.0054 0.0438
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0019 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0292 0.237
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0446 0.3627
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0292 0.0521
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0886 0.0869
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0842 0.0825
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0446 0.3627
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0108 0.0989 0.8034
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3362 0.335
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0446 0.0428
Echinococcus multilocularis serotonin receptor 0.0126 0.123 0.1214
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0436 0.0797
Brugia malayi RNA binding protein 0.0067 0.0446 0.1327
Schistosoma mansoni transient receptor potential channel 0.0066 0.0436 0.354
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.0049 0.0206 0.0612
Mycobacterium ulcerans hypothetical protein 0.0035 0.0019 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0292 0.0521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0292 0.0273
Onchocerca volvulus 0.0058 0.0332 1
Brugia malayi TAR-binding protein 0.0067 0.0446 0.1327
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0019 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0126 0.123 0.2316
Mycobacterium leprae Probable lipase LipE 0.0035 0.0019 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0206 0.0612
Entamoeba histolytica hypothetical protein 0.0037 0.0054 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0206 0.0612
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0436 0.0418
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.005 0.0031
Schistosoma mansoni hypothetical protein 0.0086 0.0704 0.5723
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0054 0.0035
Entamoeba histolytica hypothetical protein 0.0037 0.0054 0.5
Schistosoma mansoni transient receptor potential channel 0.0066 0.0436 0.354
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0056
Entamoeba histolytica hypothetical protein 0.0037 0.0054 0.5
Brugia malayi beta-lactamase 0.0035 0.0019 0.0056
Loa Loa (eye worm) RNA binding protein 0.0067 0.0446 0.1327
Leishmania major hypothetical protein, conserved 0.0035 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.123 0.3659
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0436 0.0418
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3362 0.6392
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0446 0.3627
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0019 0.5
Mycobacterium ulcerans beta-lactamase 0.0035 0.0019 0.5
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0446 0.3627
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0056
Schistosoma mansoni survival motor neuron protein 0.0058 0.0332 0.2696
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0292 0.0273
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0446 0.3627
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0292 0.0867
Loa Loa (eye worm) hypothetical protein 0.0108 0.0989 0.294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0019 0.0153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0056
Echinococcus granulosus FTZ F1 alpha 0.0427 0.525 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0054 0.0067
Toxoplasma gondii ABC1 family protein 0.0035 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.01 0.0886 0.2636
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0446 0.1327
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0019 0.0056
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0446 0.1327
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0019 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0019 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0206 0.0612

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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