Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0089 | 0.6495 | 0.6495 |
Onchocerca volvulus | 0.0089 | 0.6495 | 0.5582 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0089 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.2067 | 0.2067 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2067 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0089 | 0.6495 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0089 | 0.6495 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0089 | 0.6495 | 0.5582 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0089 | 0.6495 | 0.6495 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0089 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.006 | 0.2067 | 0.2067 |
Brugia malayi | Cathepsin L-like precursor | 0.0089 | 0.6495 | 0.6495 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.6495 | 0.5582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0089 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0089 | 0.6495 | 0.6495 |
Onchocerca volvulus | Cathepsin L homolog | 0.0089 | 0.6495 | 0.5582 |
Echinococcus granulosus | cathepsin l1 | 0.006 | 0.2067 | 0.3182 |
Onchocerca volvulus | 0.0089 | 0.6495 | 0.5582 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0089 | 0.6495 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0089 | 0.6495 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0089 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0089 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0089 | 0.6495 | 0.6495 |
Brugia malayi | cathepsin L-like precursor | 0.006 | 0.2067 | 0.2067 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2067 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.2067 | 0.2067 |
Onchocerca volvulus | 0.0089 | 0.6495 | 0.5582 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0089 | 0.6495 | 0.6495 |
Echinococcus multilocularis | cysteine protease | 0.0089 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.006 | 0.2067 | 0.2067 |
Brugia malayi | Cathepsin L-like precursor | 0.0089 | 0.6495 | 0.6495 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0089 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.006 | 0.2067 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0089 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0089 | 0.6495 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0089 | 0.6495 | 0.5582 |
Brugia malayi | Cathepsin L-like precursor | 0.0089 | 0.6495 | 0.6495 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Onchocerca volvulus | 0.0089 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0089 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Onchocerca volvulus | 0.0089 | 0.6495 | 0.5582 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0089 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0089 | 0.6495 | 0.6495 |
Leishmania major | cathepsin L-like protease | 0.0089 | 0.6495 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0089 | 0.6495 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0089 | 0.6495 | 1 |
Plasmodium vivax | vivapain-2 | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0089 | 0.6495 | 0.5582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0089 | 0.6495 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0089 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0089 | 0.6495 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.6314 | 0.5354 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.006 | 0.2067 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0089 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Onchocerca volvulus | 0.0089 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0089 | 0.6495 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0089 | 0.6495 | 0.5582 |
Onchocerca volvulus | 0.0089 | 0.6495 | 0.5582 | |
Loa Loa (eye worm) | ctsf protein | 0.0089 | 0.6495 | 0.5582 |
Leishmania major | cathepsin L-like protease | 0.0089 | 0.6495 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0089 | 0.6495 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0089 | 0.6495 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0089 | 0.6495 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0089 | 0.6495 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 80 % | Inhibition of human recombinant NR1/NR2B receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | ChEMBL. | 21334205 |
Activity (binding) | = 80 % | Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | ChEMBL. | 21334205 |
IC50 (binding) | > 3.6 | Inhibition of human recombinant NR1/NR2B receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | ChEMBL. | 21334205 |
IC50 (binding) | = 4.4 | Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | ChEMBL. | 21334205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.