Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Butyrylcholinesterase | 602 aa | 560 aa | 29.3 % |
Loa Loa (eye worm) | hypothetical protein | Butyrylcholinesterase | 602 aa | 573 aa | 26.2 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Butyrylcholinesterase | 602 aa | 636 aa | 34.9 % |
Echinococcus multilocularis | neuroligin | Butyrylcholinesterase | 602 aa | 493 aa | 26.0 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Butyrylcholinesterase | 602 aa | 547 aa | 29.4 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 551 aa | 30.1 % | |
Echinococcus granulosus | BC026374 protein S09 family | Butyrylcholinesterase | 602 aa | 649 aa | 34.2 % |
Onchocerca volvulus | Putative nuclear protein | Butyrylcholinesterase | 602 aa | 573 aa | 41.4 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 578 aa | 25.4 % | |
Brugia malayi | Carboxylesterase family protein | Butyrylcholinesterase | 602 aa | 549 aa | 29.5 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Butyrylcholinesterase | 602 aa | 554 aa | 35.9 % |
Loa Loa (eye worm) | hypothetical protein | Butyrylcholinesterase | 602 aa | 574 aa | 26.3 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 587 aa | 27.1 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Butyrylcholinesterase | 602 aa | 590 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.6184 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6184 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.6184 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.6184 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6184 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.6184 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.6184 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.6184 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.6184 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.6184 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.6184 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.6184 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14.3 uM | Inhibition of equine BChE incubated with compounf for 5 mins before addition of substrate S-butyrylthiocholine iodide by Ellman's method | ChEMBL. | 21429752 |
IC50 (binding) | = 25.5 uM | Inhibition of human AChE incubated with compounf for 5 mins before addition of substrate acetylthiocholine iodide by Ellman's method | ChEMBL. | 21429752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.