Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0063 | 0.0402 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0402 | 0.1462 |
Mycobacterium tuberculosis | Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) | 0.0009 | 0.0002 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.0165 | 0.0594 | |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0013 | 0.0013 |
Mycobacterium tuberculosis | Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) | 0.0009 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0063 | 0.0402 | 0.1462 |
Brugia malayi | nuclear hormone receptor | 0.0063 | 0.0402 | 0.1462 |
Loa Loa (eye worm) | DR-78 | 0.0022 | 0.01 | 0.0357 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0165 | 0.0165 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0041 | 0.0241 | 0.0241 |
Giardia lamblia | Hypothetical protein | 0.0009 | 0.0002 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.2966 | 0.2966 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0063 | 0.0402 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0063 | 0.0402 | 0.0402 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0063 | 0.0402 | 0.1462 |
Onchocerca volvulus | 0.0022 | 0.01 | 0.0357 | |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0041 | 0.0241 | 0.0241 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0165 | 0.0165 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0063 | 0.0402 | 0.0402 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0063 | 0.0402 | 0.0402 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0063 | 0.0402 | 0.1462 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0063 | 0.0402 | 0.0402 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0063 | 0.0402 | 0.1462 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0152 | 0.0152 |
Schistosoma mansoni | nuclear hormone receptor | 0.0063 | 0.0402 | 0.0402 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0041 | 0.0241 | 0.0873 |
Giardia lamblia | Hypothetical protein | 0.0009 | 0.0002 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.0871 | 0.0871 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0063 | 0.0402 | 0.1462 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0022 | 0.01 | 0.01 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0022 | 0.01 | 0.01 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0022 | 0.01 | 0.01 |
Onchocerca volvulus | 0.0029 | 0.0152 | 0.0546 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0241 | 0.0873 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0022 | 0.01 | 0.0357 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0063 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Echinococcus granulosus | FTZ F1 alpha | 0.0063 | 0.0402 | 0.0402 |
Mycobacterium ulcerans | sulfatase | 0.0009 | 0.0002 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0022 | 0.01 | 0.0357 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0063 | 0.0402 | 0.1462 |
Brugia malayi | conserved hypotetical protein | 0.0022 | 0.01 | 0.0357 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0022 | 0.01 | 0.01 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0022 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0402 | 0.1462 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0022 | 0.01 | 0.0357 |
Mycobacterium ulcerans | arylsulfatase AtsB | 0.0009 | 0.0002 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0022 | 0.01 | 0.01 |
Brugia malayi | tailless protein | 0.0022 | 0.01 | 0.0357 |
Mycobacterium ulcerans | arylsulfatase AtsD | 0.0009 | 0.0002 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0063 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.1697 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0152 | 0.0546 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0063 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0063 | 0.0402 | 0.0402 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0241 | 0.0873 |
Brugia malayi | ecdysone receptor | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | nuclear receptor NHR-67 | 0.0022 | 0.01 | 0.0357 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0165 | 0.0165 |
Brugia malayi | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0241 | 0.0873 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0241 | 0.0873 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0063 | 0.0402 | 0.1462 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0022 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0402 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0837 | 0.3056 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0063 | 0.0402 | 0.0402 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.0871 | 0.0871 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0013 | 0.0013 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0022 | 0.01 | 0.01 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0063 | 0.0402 | 0.1462 |
Echinococcus granulosus | dnaJ subfamily B | 0.041 | 0.2966 | 0.2966 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0402 | 0.1462 |
Mycobacterium ulcerans | hydrolase | 0.0009 | 0.0002 | 0.5 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0063 | 0.0402 | 0.1462 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0063 | 0.0402 | 0.0402 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0022 | 0.01 | 0.01 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0022 | 0.01 | 0.0357 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0063 | 0.0402 | 0.1462 |
Schistosoma mansoni | nuclear receptor | 0.0022 | 0.01 | 0.01 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0165 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0165 | 0.0594 |
Brugia malayi | nuclear receptor RXR | 0.0041 | 0.0241 | 0.0873 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0041 | 0.0241 | 0.0873 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0241 | 0.0873 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0041 | 0.0241 | 0.0873 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0165 | 0.0594 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.2735 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0063 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0152 | 0.0546 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0063 | 0.0402 | 0.0402 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0063 | 0.0402 | 0.0402 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0063 | 0.0402 | 0.0402 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0063 | 0.0402 | 0.0402 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0022 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.0871 | 0.0871 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0063 | 0.0402 | 0.1462 |
Schistosoma mansoni | thyroid hormone receptor | 0.0189 | 0.1334 | 0.1334 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0152 | 0.0152 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0022 | 0.01 | 0.01 |
Schistosoma mansoni | thyroid hormone receptor | 0.0189 | 0.1334 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Echinococcus multilocularis | dnaJ subfamily B | 0.041 | 0.2966 | 0.2966 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0041 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0063 | 0.0402 | 0.1462 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.1484 | 0.5422 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0063 | 0.0402 | 0.0402 |
Brugia malayi | nuclear receptor NHR-88 | 0.0063 | 0.0402 | 0.1462 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0063 | 0.0402 | 0.1462 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0164 | 0.0164 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0063 | 0.0402 | 0.0402 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0063 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0013 | 0.0039 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0063 | 0.0402 | 0.0402 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.0398 | 0.0398 |
Mycobacterium ulcerans | arylsulfatase AtsD | 0.0009 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0402 | 0.1462 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0063 | 0.0402 | 0.1462 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0063 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0063 | 0.0402 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0063 | 0.0402 | 0.1462 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0063 | 0.0402 | 0.0402 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0022 | 0.01 | 0.01 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0022 | 0.01 | 0.01 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0063 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0241 | 0.0873 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.01 | 0.01 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0063 | 0.0402 | 0.1462 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.01 | 0.01 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0189 | 0.1334 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0063 | 0.0402 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Mycobacterium tuberculosis | Probable sulfatase | 0.0009 | 0.0002 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0063 | 0.0402 | 0.1462 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0041 | 0.0241 | 0.0241 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.01 | 0.0357 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0012 | 0.0036 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0063 | 0.0402 | 0.0402 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0165 | 0.0165 |
Onchocerca volvulus | 0.0238 | 0.1697 | 0.6201 | |
Brugia malayi | ecdysteroid receptor | 0.0378 | 0.2735 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0378 | 0.2735 | 1 |
Brugia malayi | hypothetical protein | 0.0287 | 0.2061 | 0.7534 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0241 | 0.0873 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0022 | 0.01 | 0.01 |
Brugia malayi | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Onchocerca volvulus | 0.0063 | 0.0402 | 0.1462 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0063 | 0.0402 | 0.1462 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0063 | 0.0402 | 0.1462 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0165 | 0.0165 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0009 | 0.0002 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0063 | 0.0402 | 0.1462 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.01 | 0.01 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.1484 | 0.5422 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0402 | 0.1462 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0063 | 0.0402 | 0.0402 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0164 | 0.0164 |
Onchocerca volvulus | 0.0022 | 0.01 | 0.0357 | |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0022 | 0.01 | 0.0357 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0022 | 0.01 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0402 | 0.1462 |
Schistosoma mansoni | coup transcription factor | 0.0063 | 0.0402 | 0.0402 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0063 | 0.0402 | 0.1462 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0022 | 0.01 | 0.0357 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.01 | 0.01 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0063 | 0.0402 | 0.1462 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.01 | 0.0357 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0063 | 0.0402 | 0.0402 |
Brugia malayi | steroid hormone receptor | 0.0063 | 0.0402 | 0.1462 |
Mycobacterium ulcerans | arylsulfatase, AslA | 0.0009 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.01 | 0.0357 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0165 | 0.0165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.