Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | topoisomerase (DNA) I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1017 | 0.1449 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.6016 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.1017 | 0.1449 | 0.1372 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0226 | 0.0097 | 0.0007 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.1017 | 0.1449 | 0.1372 |
Schistosoma mansoni | alpha-amylase | 0.0222 | 0.009 | 0.009 |
Schistosoma mansoni | alpha-amylase | 0.0222 | 0.009 | 0.009 |
Brugia malayi | Carboxylesterase family protein | 0.1017 | 0.1449 | 0.1372 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0226 | 0.0097 | 0.0007 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1017 | 0.1449 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.6016 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1017 | 0.1449 | 1 |
Onchocerca volvulus | 0.1017 | 0.1449 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.6016 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.6016 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.1017 | 0.1449 | 0.1372 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1017 | 0.1449 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.6016 | 1 | 1 |
Plasmodium falciparum | topoisomerase I | 0.0226 | 0.0097 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.1017 | 0.1449 | 0.1449 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0169 | 0 | 0.5 |
Onchocerca volvulus | 0.1017 | 0.1449 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.6016 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.1017 | 0.1449 | 0.1372 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1017 | 0.1449 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1017 | 0.1449 | 0.1372 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.1017 | 0.1449 | 0.1449 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1017 | 0.1449 | 0.1449 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0169 | 0 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.1017 | 0.1449 | 0.1372 |
Schistosoma mansoni | acetylcholinesterase | 0.1017 | 0.1449 | 0.1449 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0226 | 0.0097 | 0.0007 |
Schistosoma mansoni | alpha-amylase | 0.0222 | 0.009 | 0.009 |
Schistosoma mansoni | alpha-amylase | 0.0222 | 0.009 | 0.009 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0226 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.6016 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.6016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 0.1449 | 0.1372 |
Brugia malayi | DNA topoisomerase I | 0.0226 | 0.0097 | 0.0007 |
Schistosoma mansoni | gliotactin | 0.1017 | 0.1449 | 0.1449 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1017 | 0.1449 | 0.1449 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0222 | 0.009 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 0.1449 | 0.1372 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 0.1449 | 0.1372 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.1017 | 0.1449 | 0.1372 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.3204 | 0.519 | 0.519 |
Brugia malayi | hypothetical protein | 0.1017 | 0.1449 | 0.1372 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0169 | 0 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.1017 | 0.1449 | 0.1372 |
Echinococcus multilocularis | carboxylesterase 5A | 0.6016 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1017 | 0.1449 | 0.1372 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1017 | 0.1449 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 0.1449 | 0.1372 |
Brugia malayi | Carboxylesterase family protein | 0.1017 | 0.1449 | 0.1372 |
Loa Loa (eye worm) | carboxylesterase | 0.1017 | 0.1449 | 0.1372 |
Echinococcus granulosus | carboxylesterase 5A | 0.6016 | 1 | 1 |
Onchocerca volvulus | 0.1017 | 0.1449 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.6016 | 1 | 1 |
Onchocerca volvulus | 0.1017 | 0.1449 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.1017 | 0.1449 | 0.1372 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0222 | 0.009 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0222 | 0.009 | 0.009 |
Brugia malayi | Carboxylesterase family protein | 0.6016 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1017 | 0.1449 | 0.1449 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0226 | 0.0097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 0.1449 | 0.1372 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 0.1449 | 0.1372 |
Onchocerca volvulus | 0.1017 | 0.1449 | 0.5 | |
Plasmodium vivax | topoisomerase I, putative | 0.0226 | 0.0097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 0.1449 | 0.1372 |
Loa Loa (eye worm) | carboxylesterase | 0.1017 | 0.1449 | 0.1372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 38 % | Tumor volume in HT-29 cells after subcutaneous administration on days 16,20,23,27,30,34,37,41,44,48 at dose of 3.5 mg/kg | ChEMBL. | 8410981 |
Control (functional) | = 51 % | Number of metastases in K1735-M2 murine melanoma cells after subcutaneous administration on days1,4,6,8 at dose of 3.5 mg/kg | ChEMBL. | 8410981 |
Control (functional) | = 98 % | Number of metastases in K1735-M2 murine melanoma cells after subcutaneous administration on days1,4,6,8 at dose of 6 mg/kg | ChEMBL. | 8410981 |
IC50 (binding) | = 4.3 uM | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | ChEMBL. | 8410981 |
IC50 (binding) | = 5.5 uM | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | ChEMBL. | 8410981 |
IC50 (binding) | = 5.5 uM | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | ChEMBL. | 8410981 |
IC50 (binding) | > 30 uM | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | ChEMBL. | 8410981 |
T/C (functional) | = 1.4 | Relative survival in RAW117-H10 cells implanted mice in comparison to control at dose of 6 mg/kg | ChEMBL. | 8410981 |
T/C (functional) | = 1.78 | Relative survival in L1210 lymphoid leukemic mice after subcutaneous administration on days1,4,6,8 at dose of 6 mg/kg | ChEMBL. | 8410981 |
T/C (functional) | = 1.4 | Relative survival in RAW117-H10 cells implanted mice in comparison to control at dose of 6 mg/kg | ChEMBL. | 8410981 |
T/C (functional) | = 1.75 | Relative survival in RAW117-H10 cells implanted mice in comparison to control at dose of 3.5 mg/kg | ChEMBL. | 8410981 |
T/C (functional) | = 1.78 | Relative survival in L1210 lymphoid leukemic mice after subcutaneous administration on days1,4,6,8 at dose of 6 mg/kg | ChEMBL. | 8410981 |
T/C (functional) | = 2.56 | Relative survival in L1210 lymphoid leukemic mice after subcutaneous administration on days 1,4,6,8 at dose of 3.5 mg/kg | ChEMBL. | 8410981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.