Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein phosphatase 2C containing protein | 0.0028 | 0.1374 | 0.1374 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0131 | 0.896 | 0.896 |
Brugia malayi | cyclin-dependent kinase 9 | 0.0044 | 0.2507 | 0.2507 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.2874 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3711 | 0.3711 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3851 | 0.3851 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0049 | 0.2874 | 0.2874 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0677 | 0.0756 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0131 | 0.896 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0049 | 0.2874 | 0.3208 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0055 | 0.3342 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0677 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2874 | 0.2874 |
Echinococcus granulosus | protein phosphatase 1b | 0.0028 | 0.1374 | 0.1534 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0044 | 0.2507 | 0.2798 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0113 | 0.7603 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0083 | 0.5423 | 0.5423 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0035 | 0.1831 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0677 | 0.0756 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0131 | 0.896 | 0.896 |
Brugia malayi | hypothetical protein | 0.0083 | 0.5423 | 0.5423 |
Echinococcus multilocularis | protein phosphatase 1b | 0.0025 | 0.1108 | 0.1237 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3711 | 0.3711 |
Echinococcus granulosus | protein phosphatase 1b | 0.0025 | 0.1108 | 0.1237 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0083 | 0.5423 | 0.5423 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0677 | 0.0756 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3711 | 0.3711 |
Echinococcus multilocularis | acetylcholinesterase | 0.0049 | 0.2874 | 0.3208 |
Echinococcus multilocularis | acetylcholinesterase | 0.0049 | 0.2874 | 0.3208 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.5423 | 0.5423 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3851 | 0.3851 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0035 | 0.1831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2874 | 0.2874 |
Brugia malayi | Telomerase reverse transcriptase | 0.0092 | 0.6081 | 0.6081 |
Echinococcus granulosus | acetylcholinesterase | 0.0049 | 0.2874 | 0.3208 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2307 | 0.2307 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0052 | 0.307 | 0.3427 |
Schistosoma mansoni | protein phosphatase 2C | 0.0025 | 0.1108 | 0.1237 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2307 | 0.2575 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0677 | 0.0677 |
Onchocerca volvulus | 0.0083 | 0.5423 | 0.5423 | |
Schistosoma mansoni | kinase | 0.0044 | 0.2507 | 0.2798 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0023 | 0.1004 | 0.1121 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3851 | 0.3851 |
Brugia malayi | hypothetical protein | 0.0083 | 0.5423 | 0.5423 |
Echinococcus granulosus | acetylcholinesterase | 0.0049 | 0.2874 | 0.3208 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0035 | 0.1831 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3711 | 0.3711 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.2874 | 0.3208 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0677 | 0.0756 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0083 | 0.5423 | 0.5423 |
Brugia malayi | hypothetical protein | 0.0062 | 0.3851 | 0.3851 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0113 | 0.7603 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0083 | 0.5423 | 0.5423 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0052 | 0.307 | 0.3427 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0677 | 0.0756 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0035 | 0.1831 | 1 |
Brugia malayi | LBP/BPI | 0.0062 | 0.3851 | 0.3851 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.5423 | 0.5423 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0131 | 0.896 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0127 | 0.8639 | 0.8639 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.2874 | 0.2874 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0083 | 0.5423 | 0.5423 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0023 | 0.1004 | 0.1121 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0023 | 0.1004 | 0.1121 |
Schistosoma mansoni | protein phosphatase 2C | 0.0028 | 0.1374 | 0.1534 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0677 | 0.0756 |
Schistosoma mansoni | protein phosphatase 2C | 0.0025 | 0.1108 | 0.1237 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0677 | 0.0756 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0035 | 0.1831 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0035 | 0.1831 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0055 | 0.3342 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0049 | 0.2874 | 0.2874 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0049 | 0.2874 | 0.3208 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.2507 | 0.2798 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.5423 | 0.5423 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2307 | 0.2307 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0044 | 0.2507 | 0.2798 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0113 | 0.7603 | 1 |
Loa Loa (eye worm) | protein phosphatase 2C containing protein | 0.0028 | 0.1374 | 0.1374 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0035 | 0.1831 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0131 | 0.896 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3851 | 0.3851 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0055 | 0.3342 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.5423 | 0.5423 |
Onchocerca volvulus | 0.0062 | 0.3851 | 0.3851 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0677 | 0.0677 |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.0044 | 0.2507 | 0.2507 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.5423 | 0.5423 |
Onchocerca volvulus | 0.0083 | 0.5423 | 0.5423 | |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0677 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0677 | 0.0677 |
Echinococcus multilocularis | protein phosphatase 1b | 0.0028 | 0.1374 | 0.1534 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0677 | 0.0756 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0023 | 0.1004 | 0.1121 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0677 | 0.0677 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 29 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by parasite lactate dehydrogenase assay | ChEMBL. | 21396749 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.