Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hexokinase | 0.0554 | 0.9085 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0554 | 0.9085 | 0.5 |
Brugia malayi | hexokinase | 0.0554 | 0.9085 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0172 | 0.2693 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.6142 | 0.6761 |
Echinococcus multilocularis | hexokinase | 0.0554 | 0.9085 | 1 |
Onchocerca volvulus | 0.0348 | 0.5636 | 0.6203 | |
Entamoeba histolytica | hexokinase 1 | 0.0554 | 0.9085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2772 | 0.3051 |
Echinococcus granulosus | hexokinase | 0.0554 | 0.9085 | 1 |
Toxoplasma gondii | hexokinase | 0.0554 | 0.9085 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0554 | 0.9085 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0348 | 0.5636 | 0.6203 |
Echinococcus multilocularis | hexokinase | 0.0554 | 0.9085 | 1 |
Brugia malayi | Hexokinase family protein | 0.0172 | 0.2693 | 0.2964 |
Leishmania major | hexokinase, putative | 0.0554 | 0.9085 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0554 | 0.9085 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0554 | 0.9085 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2772 | 0.3051 |
Trypanosoma brucei | hexokinase | 0.0554 | 0.9085 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0554 | 0.9085 | 0.5 |
Brugia malayi | hexokinase type II | 0.0176 | 0.2772 | 0.3051 |
Plasmodium vivax | hexokinase, putative | 0.0554 | 0.9085 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0554 | 0.9085 | 1 |
Brugia malayi | Hexokinase family protein | 0.0554 | 0.9085 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0554 | 0.9085 | 1 |
Leishmania major | hexokinase, putative | 0.0554 | 0.9085 | 0.5 |
Onchocerca volvulus | 0.0554 | 0.9085 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0554 | 0.9085 | 0.5 |
Onchocerca volvulus | Hexokinase homolog | 0.0348 | 0.5636 | 0.6203 |
Entamoeba histolytica | hexokinase 2 | 0.0554 | 0.9085 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0554 | 0.9085 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0554 | 0.9085 | 1 |
Echinococcus granulosus | hexokinase | 0.0554 | 0.9085 | 1 |
Onchocerca volvulus | 0.0554 | 0.9085 | 1 | |
Onchocerca volvulus | 0.0554 | 0.9085 | 1 | |
Schistosoma mansoni | hexokinase | 0.0554 | 0.9085 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0554 | 0.9085 | 1 |
Brugia malayi | Hexokinase family protein | 0.0348 | 0.5636 | 0.6203 |
Echinococcus granulosus | hexokinase type 2 | 0.0554 | 0.9085 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1237 nM | Displacement of [3H]estrone human recombinant 17beta-HSD1 expressed in Escherichia coli BL21 (DE3)-RIL by scintillation counting in presence of bacterial homogenate | ChEMBL. | 21138273 |
Inhibition (binding) | Displacement of [3H]estradiol human recombinant 17beta-HSD2 expressed in Escherichia coli BL21 (DE3)-RIL at 60 uM by scintillation counting in presence of NAD+ | ChEMBL. | 21138273 | |
Inhibition (binding) | Displacement of [3H]estradiol human recombinant 17beta-HSD2 expressed in Escherichia coli BL21 (DE3)-RIL at 6 uM by scintillation counting in presence of NAD+ | ChEMBL. | 21138273 | |
Inhibition (binding) | Displacement of [3H]estradiol human recombinant 17beta-HSD2 expressed in Escherichia coli BL21 (DE3)-RIL at 0.6 uM by scintillation counting in presence of NAD+ | ChEMBL. | 21138273 | |
Inhibition (binding) | = 40 % | Displacement of [3H]estrone human recombinant 17beta-HSD1 expressed in Escherichia coli BL21 (DE3)-RIL at 0.6 uM by scintillation counting in presence of NADPH | ChEMBL. | 21138273 |
Inhibition (binding) | = 72 % | Displacement of [3H]estrone human recombinant 17beta-HSD1 expressed in Escherichia coli BL21 (DE3)-RIL at 6 uM by scintillation counting in presence of NADPH | ChEMBL. | 21138273 |
Ki (binding) | = 585 nM | Displacement of [3H]estrone human recombinant 17beta-HSD1 expressed in Escherichia coli BL21 (DE3)-RIL by competitive inhibition assay in presence of bacterial homogenate | ChEMBL. | 21138273 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.