Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | neuropeptide receptor | Cannabinoid CB2 receptor | 360 aa | 337 aa | 24.0 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Cannabinoid CB2 receptor | 360 aa | 370 aa | 23.5 % |
Loa Loa (eye worm) | neuropeptide F receptor | Cannabinoid CB2 receptor | 360 aa | 348 aa | 24.7 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Cannabinoid CB2 receptor | 360 aa | 360 aa | 23.1 % |
Onchocerca volvulus | Phospholipase d-related homolog | Cannabinoid CB2 receptor | 360 aa | 309 aa | 23.3 % |
Echinococcus multilocularis | neuropeptide receptor | Cannabinoid CB2 receptor | 360 aa | 299 aa | 24.7 % |
Echinococcus granulosus | allatostatin A receptor | Cannabinoid CB2 receptor | 360 aa | 363 aa | 22.9 % |
Onchocerca volvulus | Cannabinoid CB2 receptor | 360 aa | 330 aa | 20.9 % | |
Onchocerca volvulus | Cannabinoid CB2 receptor | 360 aa | 327 aa | 19.6 % | |
Onchocerca volvulus | Cannabinoid CB2 receptor | 360 aa | 297 aa | 21.9 % | |
Schistosoma mansoni | opsin-like receptor | Cannabinoid CB2 receptor | 360 aa | 314 aa | 22.0 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Cannabinoid CB2 receptor | 360 aa | 323 aa | 22.6 % |
Onchocerca volvulus | Cannabinoid CB2 receptor | 360 aa | 389 aa | 21.1 % | |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Cannabinoid CB2 receptor | 360 aa | 311 aa | 20.6 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Cannabinoid CB2 receptor | 360 aa | 370 aa | 23.8 % |
Echinococcus multilocularis | allatostatin A receptor | Cannabinoid CB2 receptor | 360 aa | 342 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.008 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.008 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.008 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.008 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.008 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.008 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | 0.008 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.008 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.008 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.008 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 66 % | Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP level relative to control | ChEMBL. | 21420860 |
Emax (functional) | = 87 % | Agonist activity at rat CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP level relative to control | ChEMBL. | 21420860 |
Emax (functional) | = 94 % | Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP level relative to control | ChEMBL. | 21420860 |
Emax (functional) | = 104 % | Agonist activity at rat CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP level relative to control | ChEMBL. | 21420860 |
IC50 (functional) | = 5 nM | Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP level | ChEMBL. | 21420860 |
IC50 (functional) | = 11 nM | Agonist activity at rat CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP level | ChEMBL. | 21420860 |
IC50 (functional) | = 1068 nM | Agonist activity at rat CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP level | ChEMBL. | 21420860 |
IC50 (functional) | = 2565 nM | Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP level | ChEMBL. | 21420860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.