Detailed information for compound 1514529

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 613.232 | Formula: C37H45ClN4O2
  • H donors: 0 H acceptors: 1 LogP: 7.44 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)Cc1nn(C2CCCN(CC2)Cc2ccc(cc2)OCCCN2CCCCCC2)c(=O)c2c1cccc2
  • InChi: 1S/C37H45ClN4O2/c38-31-16-12-29(13-17-31)27-36-34-10-3-4-11-35(34)37(43)42(39-36)32-9-7-23-41(25-20-32)28-30-14-18-33(19-15-30)44-26-8-24-40-21-5-1-2-6-22-40/h3-4,10-19,32H,1-2,5-9,20-28H2
  • InChiKey: QYAXGGUCDQSHIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H1 Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1B Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1A Starlite/ChEMBL References
Homo sapiens histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0403 0.0524
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.003 0.0129 0.0168
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Schistosoma mansoni neuropeptide receptor 0.0101 0.1068 0.1163
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0457 0.0595
Brugia malayi CXXC zinc finger family protein 0.0028 0.0101 0.0131
Schistosoma mansoni heat shock protein 0.0032 0.0154 0.016
Schistosoma mansoni tar DNA-binding protein 0.0381 0.4781 0.5237
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Plasmodium vivax hypothetical protein, conserved 0.0071 0.067 1
Echinococcus granulosus sex peptide receptor 0.0101 0.1068 0.1061
Onchocerca volvulus 0.0101 0.1068 0.1668
Echinococcus granulosus g protein coupled receptor 0.0101 0.1068 0.1061
Toxoplasma gondii thioredoxin reductase 0.005 0.0391 0.5793
Onchocerca volvulus 0.0095 0.0993 0.1548
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0025 0.0018
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0101 0.1068 0.1061
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0487 0.0479
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0598 0.059
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0276 0.0402
Loa Loa (eye worm) hypothetical protein 0.0248 0.3028 0.3941
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.009
Schistosoma mansoni hypothetical protein 0.0395 0.4974 0.5449
Echinococcus granulosus neuropeptide receptor 0.0101 0.1068 0.1061
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0993 0.1292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.051 0.055
Schistosoma mansoni nAChR subunit 0.0039 0.0254 0.0269
Brugia malayi hypothetical protein 0.0039 0.0254 0.033
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.2467 0.3211
Onchocerca volvulus 0.0101 0.1068 0.1668
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0403 0.6004
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0237 0.0976
Plasmodium falciparum phd finger protein, putative 0.0057 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0471 0.0614
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0101 0.1068 0.1163
Echinococcus multilocularis GPCR, family 2 0.0065 0.0598 0.0647
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.051 0.055
Schistosoma mansoni lamin 0.0055 0.0457 0.0493
Echinococcus multilocularis neuropeptide receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0206 0.2467 0.3211
Onchocerca volvulus 0.0101 0.1068 0.1668
Entamoeba histolytica hypothetical protein 0.0023 0.0036 0.0237
Onchocerca volvulus 0.0039 0.0254 0.0366
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.067 0.1134
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Echinococcus granulosus RUN 0.0022 0.0025 0.0017
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0101 0.1068 0.1163
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Echinococcus multilocularis conserved hypothetical protein 0.0673 0.8665 0.9499
Schistosoma mansoni amine GPCR 0.0101 0.1068 0.1163
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3729 0.4853
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0403 0.0592
Schistosoma mansoni biogenic amine receptor 0.0101 0.1068 0.1163
Brugia malayi jmjC domain containing protein 0.007 0.0666 0.0867
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Brugia malayi Pre-SET motif family protein 0.0059 0.051 0.0663
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0095 0.0993 0.0985
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0107
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.1068 0.1061
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0101 0.1068 0.139
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0095 0.0993 0.1292
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1068 0.1163
Onchocerca volvulus 0.0055 0.0457 0.0692
Schistosoma mansoni importin beta-1 0.0028 0.0107 0.0108
Brugia malayi Serotonin receptor 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0101 0.1068 0.1163
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0095 0.0993 0.108
Loa Loa (eye worm) glutathione reductase 0.005 0.0391 0.051
Brugia malayi hypothetical protein 0.0025 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0068 0.0103
Echinococcus multilocularis endoplasmin 0.0025 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1068 0.1163
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0058 0.1166
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0254 0.033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1068 0.1163
Schistosoma mansoni hypothetical protein 0.0051 0.0405 0.0435
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.1068 0.1163
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0154 0.1235
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0107 0.0271
Echinococcus granulosus heat shock protein 90 0.0032 0.0154 0.0146
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0154 0.0401
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.3654 1
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1068 0.1163
Echinococcus granulosus lamin dm0 0.0055 0.0457 0.045
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0095 0.0993 0.1292
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.1068 0.139
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.0011
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0107 0.1493
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0101 0.1068 0.1668
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0598 0.0778
Brugia malayi Melatonin receptor type 1A 0.0101 0.1068 0.139
Echinococcus multilocularis lamin dm0 0.0055 0.0457 0.0493
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.1068 0.1061
Onchocerca volvulus 0.0039 0.0254 0.0366
Schistosoma mansoni nAChR subunit 0.0039 0.0254 0.0269
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0237 0.0229
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0471 0.0614
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0184 0.0868
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1068 0.1163
Treponema pallidum heat shock protein 90 0.0025 0.0068 0.5
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0184 0.0205
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0095 0.0993 0.108
Loa Loa (eye worm) hypothetical protein 0.0059 0.051 0.0663
Schistosoma mansoni acetylcholine receptor-related 0.0039 0.0254 0.0269
Schistosoma mansoni biogenic amine receptor 0.0101 0.1068 0.1163
Schistosoma mansoni neuropeptide f receptor 76f 0.0101 0.1068 0.1163
Echinococcus granulosus neuropeptide FF receptor 2 0.0101 0.1068 0.1061
Onchocerca volvulus 0.0071 0.067 0.1032
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0068 0.0165
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0107 0.0271
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.2467 0.3211
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.1068 0.139
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0099 0.0099
Schistosoma mansoni rab6-interacting 0.0022 0.0025 0.0018
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0154 0.3055
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0471 0.0614
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.0872
Echinococcus granulosus glycine receptor subunit alpha 1 0.0095 0.0993 0.0985
Echinococcus granulosus tar DNA binding protein 0.0381 0.4781 0.4777
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.0872
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0276 0.046
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0359 0.0385
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus heat shock protein 90 0.0025 0.0068 0.006
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Leishmania major hypothetical protein, conserved 0.0034 0.0178 0.0466
Brugia malayi Tachykinin-like peptides receptor 99D 0.0101 0.1068 0.139
Brugia malayi beta-lactamase 0.0071 0.067 0.0872
Mycobacterium ulcerans beta-lactamase 0.0071 0.067 0.3478
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0101 0.1068 0.1163
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0487 0.7231
Schistosoma mansoni lamin 0.0055 0.0457 0.0493
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus neuropeptide s receptor 0.0584 0.7479 0.7477
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0095 0.0993 0.108
Schistosoma mansoni hypothetical protein 0.0101 0.1068 0.1163
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0359 0.0351
Onchocerca volvulus 0.0101 0.1068 0.1668
Echinococcus multilocularis fmrfamide receptor 0.0101 0.1068 0.1163
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0101 0.1068 0.1163
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0101 0.1068 0.139
Schistosoma mansoni hypothetical protein 0.0101 0.1068 0.1163
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0082 0.0082
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.1068 0.139
Echinococcus granulosus glycine receptor subunit beta 0.0095 0.0993 0.0985
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0101 0.1068 0.1163
Echinococcus granulosus dnaJ subfamily B 0.0395 0.4974 0.497
Schistosoma mansoni hypothetical protein 0.0071 0.0673 0.0729
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Schistosoma mansoni nAChR subunit 0.0095 0.0993 0.108
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0178 0.0232
Trypanosoma brucei heat shock protein, putative 0.0032 0.0154 0.0401
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0391 0.0421
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.1192 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0598 0.0647
Echinococcus granulosus microtubule associated protein 2 0.0667 0.8576 0.8574
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.1068 0.1061
Brugia malayi GnHR receptor homolog 0.0101 0.1068 0.139
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0666 0.0722
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.1068 0.1163
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.067 0.0872
Onchocerca volvulus 0.0101 0.1068 0.1668
Onchocerca volvulus 0.0101 0.1068 0.1668
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0058 0.0137
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0391 0.0384
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.3654 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0107 0.0139
Echinococcus granulosus expressed conserved protein 0.0103 0.1104 0.1096
Schistosoma mansoni hypothetical protein 0.0141 0.1602 0.1749
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0154 0.2209
Echinococcus multilocularis somatostatin receptor 0.0101 0.1068 0.1163
Echinococcus multilocularis snurportin 1 0.0301 0.3729 0.4083
Loa Loa (eye worm) ACC-1 protein 0.0095 0.0993 0.1292
Echinococcus multilocularis RUN 0.0022 0.0025 0.0018
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0101 0.1068 0.139
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.1068 0.1163
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0058 0.0755
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0598 0.0647
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0154 0.0251
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0666 0.0659
Mycobacterium ulcerans hypothetical protein 0.0071 0.067 0.3478
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.2467 0.3211
Schistosoma mansoni nAChR subunit 0.0095 0.0993 0.108
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0095 0.0993 0.1292
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0058 0.1166
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0039 0.0254 0.0269
Echinococcus multilocularis allatostatin A receptor 0.0101 0.1068 0.1163
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0095 0.0993 0.108
Leishmania major importin beta-1 subunit, putative 0.0023 0.0036 0.0077
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0068 0.0103
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Echinococcus granulosus intermediate filament protein 0.0055 0.0457 0.045
Brugia malayi Bromodomain containing protein 0.0057 0.0487 0.0633
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0095 0.0993 0.0985
Trypanosoma brucei heat shock protein, putative 0.0032 0.0154 0.0401
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0403 0.0433
Schistosoma mansoni alpha-1 adrenergic receptor 0.0101 0.1068 0.1163
Echinococcus granulosus heat shock protein 0.0032 0.0154 0.0146
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1068 0.1061
Onchocerca volvulus 0.0101 0.1068 0.1668
Brugia malayi Inositol-1 0.0038 0.0237 0.0309
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Brugia malayi hypothetical protein 0.0022 0.0025 0.0032
Schistosoma mansoni rab6-interacting 0.0022 0.0025 0.0018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.1215 0.1324
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0178 0.0186
Brugia malayi AKH receptor 0.0101 0.1068 0.139
Entamoeba histolytica hypothetical protein 0.0071 0.0673 0.5614
Loa Loa (eye worm) hypothetical protein 0.0055 0.0457 0.0595
Schistosoma mansoni nAChR subunit 0.0095 0.0993 0.108
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0471 0.0508
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Giardia lamblia Grp94/Hsp90 0.0025 0.0068 0.126
Brugia malayi Dopamine receptor protein 1 0.0101 0.1068 0.139
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0154 0.1235
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0101 0.1068 0.1163
Schistosoma mansoni growth hormone secretagogue receptor 0.0101 0.1068 0.1163
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0178 0.0466
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0101 0.1068 0.1163
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.1068 0.1163
Schistosoma mansoni nAChR subunit 0.0095 0.0993 0.108
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0154 0.0401
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0095 0.0993 0.1292
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Schistosoma mansoni tar DNA-binding protein 0.0381 0.4781 0.5237
Echinococcus multilocularis nAChR subunit 0.0056 0.0471 0.0508
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0403 0.1083
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0039 0.0254 0.033
Entamoeba histolytica hypothetical protein 0.0071 0.0673 0.5614
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0095 0.0993 0.0985
Echinococcus granulosus muscleblind protein 0.0167 0.1947 0.1941
Echinococcus granulosus fmrfamide receptor 0.0101 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Echinococcus granulosus glycine receptor subunit alpha 1 0.0095 0.0993 0.0985
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0101 0.1068 0.1163
Echinococcus granulosus G protein coupled receptor 139 0.0101 0.1068 0.1061
Schistosoma mansoni hypothetical protein 0.0101 0.1068 0.1163
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0101 0.1068 0.1061
Onchocerca volvulus 0.0101 0.1068 0.1668
Brugia malayi RE15519p 0.0101 0.1068 0.139
Loa Loa (eye worm) TAR-binding protein 0.0381 0.4781 0.6222
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0178 0.264
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Schistosoma mansoni opsin-like receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Plasmodium falciparum thioredoxin reductase 0.005 0.0391 0.8039
Loa Loa (eye worm) RNA binding protein 0.0381 0.4781 0.6222
Echinococcus multilocularis tar DNA binding protein 0.0381 0.4781 0.5237
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis G protein coupled receptor 139 0.0101 0.1068 0.1163
Brugia malayi sulfakinin receptor protein 0.0101 0.1068 0.139
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1403 0.2362
Onchocerca volvulus 0.0101 0.1068 0.1668
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus endoplasmin 0.0025 0.0068 0.006
Onchocerca volvulus 0.0071 0.067 0.1032
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0598 0.0778
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0039 0.0254 0.0246
Echinococcus multilocularis orexin receptor type 2 0.0101 0.1068 0.1163
Echinococcus multilocularis muscleblind protein 0.0167 0.1947 0.2128
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0178 0.0466
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0284 0.0757
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0237 0.1935
Echinococcus multilocularis serotonin receptor 0.0101 0.1068 0.1163
Brugia malayi Cation transporter family protein 0.0095 0.0993 0.1292
Schistosoma mansoni cpg binding protein 0.0029 0.0122 0.0125
Brugia malayi RNA, U transporter 1 0.008 0.0797 0.1037
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Echinococcus granulosus chromobox protein 1 0.0068 0.0634 0.0627
Echinococcus granulosus neuropeptide receptor 0.0101 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0178 0.2566
Brugia malayi neuropeptide F receptor 0.0101 0.1068 0.139
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.067 0.1064
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0673 0.0729
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1068 0.1061
Schistosoma mansoni hypothetical protein 0.0057 0.0487 0.0525
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0101 0.1068 0.139
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0178 0.3637
Onchocerca volvulus Putative nachr subunit 0.0095 0.0993 0.1548
Trichomonas vaginalis set domain proteins, putative 0.0461 0.5842 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0039 0.0254 0.033
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0403 0.8272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Entamoeba histolytica hypothetical protein 0.0071 0.0673 0.5614
Loa Loa (eye worm) melatonin receptor type 1A 0.0101 0.1068 0.139
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.067 0.1064
Schistosoma mansoni cpg binding protein 0.0028 0.0101 0.0101
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.067 0.1134
Onchocerca volvulus 0.0028 0.0101 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.0048
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0237 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Echinococcus multilocularis serotonin receptor 0.0101 0.1068 0.1163
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0237 0.3462
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0551 0.0596
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0673 0.0665
Giardia lamblia PHD finger protein 15 0.0057 0.0487 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Brugia malayi beta-lactamase family protein 0.0071 0.067 0.0872
Schistosoma mansoni nAChR subunit 0.0095 0.0993 0.108
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0782 0.0849
Schistosoma mansoni hypothetical protein 0.0046 0.0336 0.036
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0403 0.1083
Schistosoma mansoni hypothetical protein 0.0101 0.1068 0.1163
Onchocerca volvulus 0.0461 0.5842 0.9304
Onchocerca volvulus Alhambra homolog 0.0057 0.0487 0.0739
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0008 0.0099
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0095 0.0993 0.1292
Echinococcus granulosus 7tm_1 domain containing protein 0.0101 0.1068 0.1061
Echinococcus granulosus GPCR family 2 0.0065 0.0598 0.059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.0657 0.0712
Schistosoma mansoni loxhd1 0.0022 0.0025 0.0018
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0068 0.0103
Echinococcus granulosus 7TM GPCR rhodopsin 0.0101 0.1068 0.1061
Onchocerca volvulus 0.0095 0.0993 0.1548
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.1068 0.1163
Schistosoma mansoni heat shock protein 0.0032 0.0154 0.016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0457 0.0595
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1068 0.1163
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0178 0.0466
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0284 0.0757
Brugia malayi heat shock protein 90 0.0032 0.0154 0.0201
Brugia malayi Thioredoxin reductase 0.005 0.0391 0.051
Schistosoma mansoni intermediate filament proteins 0.0055 0.0457 0.0493
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0487 0.0525
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.3028 0.3022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0673 0.0729
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.067 0.0726
Loa Loa (eye worm) beta-lactamase 0.0071 0.067 0.0872
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.5721 1
Leishmania major hypothetical protein, conserved 0.0025 0.0058 0.0137
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.067 0.3478
Schistosoma mansoni hypothetical protein 0.0065 0.0598 0.0647
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0095 0.0993 0.108
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.2202 0.2408
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0095 0.0993 0.108
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0025 0.0017
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0039 0.0254 0.0246
Brugia malayi follicle stimulating hormone receptor 0.0599 0.7683 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0039 0.0254 0.0269
Schistosoma mansoni inositol monophosphatase 0.0038 0.0237 0.0251
Echinococcus multilocularis fmrfamide receptor 0.0101 0.1068 0.1163
Echinococcus multilocularis glycine receptor subunit beta 0.0095 0.0993 0.108
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.067 0.1064
Brugia malayi hypothetical protein 0.0248 0.3028 0.3941
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Onchocerca volvulus 0.0056 0.0471 0.0714
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0237 0.0251
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0473 0.0465
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0254 0.033
Schistosoma mansoni chromobox protein 0.0068 0.0634 0.0687
Brugia malayi Heterochromatin protein 1 0.0068 0.0634 0.0826
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1068 0.1061
Onchocerca volvulus 0.0101 0.1068 0.1668
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0095 0.0993 0.108
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0284 0.0757
Echinococcus multilocularis protein patched 0.0047 0.0359 0.0385
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0403 0.0433
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0025 0.0017
Schistosoma mansoni chromobox protein 0.0068 0.0634 0.0687
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0095 0.0993 0.108
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0237 0.0393
Brugia malayi RNA binding protein 0.0381 0.4781 0.6222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1068 0.1163
Brugia malayi hypothetical protein 0.0039 0.0254 0.033
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.0254 0.0269
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.0872
Brugia malayi MH2 domain containing protein 0.0259 0.3166 0.4121
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.0578
Loa Loa (eye worm) acetylcholine receptor protein 0.0039 0.0254 0.033
Echinococcus granulosus geminin 0.0708 0.9121 0.912
Schistosoma mansoni hypothetical protein 0.0065 0.0598 0.0647
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0095 0.0993 0.108
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0666 0.0867
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0056 0.0471 0.0508
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0993 0.1292
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0101 0.1068 0.139
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0359 0.0467
Mycobacterium tuberculosis Conserved protein 0.0071 0.067 0.1064
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0095 0.0993 0.1292
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0141
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0101 0.1068 0.1163
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0178 0.2566
Mycobacterium leprae conserved hypothetical protein 0.0071 0.067 0.4506
Echinococcus granulosus snurportin 1 0.0301 0.3729 0.3724
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1068 0.1163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0095 0.0993 0.1292
Schistosoma mansoni tar DNA-binding protein 0.0381 0.4781 0.5237
Schistosoma mansoni histamine h1 receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.067 0.0872
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Schistosoma mansoni hypothetical protein 0.0046 0.0336 0.036
Loa Loa (eye worm) hypothetical protein 0.0047 0.0359 0.0467
Echinococcus multilocularis cpg binding protein 0.0029 0.0122 0.0125
Brugia malayi G-protein coupled receptor 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.0872
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0039 0.0254 0.033
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.067 0.1815
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1068 0.1061
Echinococcus granulosus g protein coupled receptor 0.0101 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Schistosoma mansoni hypothetical protein 0.0022 0.0025 0.0018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.067 0.0726
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0237 0.0628
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0391 0.051
Echinococcus multilocularis peregrin 0.0057 0.0487 0.0525
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0095 0.0993 0.1292
Echinococcus multilocularis chromobox protein 1 0.0068 0.0634 0.0687
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.1068 0.1163
Schistosoma mansoni acetylcholine receptor subunit beta 0.0039 0.0254 0.0269
Onchocerca volvulus 0.0101 0.1068 0.1668
Loa Loa (eye worm) hypothetical protein 0.0058 0.05 0.0651
Echinococcus granulosus glycine receptor subunit beta 0.0095 0.0993 0.0985
Onchocerca volvulus 0.0039 0.0254 0.0366
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0237 0.0628
Loa Loa (eye worm) TYRA-2 protein 0.0101 0.1068 0.139
Schistosoma mansoni inositol monophosphatase 0.0038 0.0237 0.0251
Mycobacterium tuberculosis Probable reductase 0.0113 0.1236 0.2065
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0391 0.0572
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1068 0.1163
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0404 0.1087
Echinococcus granulosus importin subunit beta 1 0.0028 0.0107 0.0099
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0068 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1068 0.1163
Brugia malayi G protein-coupled receptor 0.0101 0.1068 0.139
Schistosoma mansoni endoplasmin 0.0032 0.0154 0.016
Schistosoma mansoni hypothetical protein 0.0046 0.0336 0.036
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.067 0.0662
Echinococcus multilocularis heat shock protein 90 0.0032 0.0154 0.016
Schistosoma mansoni patched 1 0.0047 0.0359 0.0385
Schistosoma mansoni lipoxygenase 0.0022 0.0025 0.0018
Schistosoma mansoni amine GPCR 0.0101 0.1068 0.1163
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0095 0.0993 0.108
Echinococcus multilocularis lamin 0.0055 0.0457 0.0493
Schistosoma mansoni adenoreceptor 0.0101 0.1068 0.1163
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis protein dispatched 1 0.0054 0.0447 0.0482
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.1818 0.1987
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.0011
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0487 0.0525
Echinococcus granulosus glycine receptor subunit alpha 1 0.0095 0.0993 0.0985
Schistosoma mansoni hypothetical protein 0.0301 0.3729 0.4083
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0403 0.5964
Brugia malayi hypothetical protein 0.0493 0.6277 0.817
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0238 0.0394
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.1068 0.1061
Brugia malayi hypothetical protein 0.0039 0.0254 0.033
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0095 0.0993 0.0985
Schistosoma mansoni survival motor neuron protein 0.0051 0.0405 0.0435
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0551 0.0543
Onchocerca volvulus 0.0493 0.6277 1
Echinococcus multilocularis neuropeptide receptor A26 0.0584 0.7479 0.8198
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0993 0.1292
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0058 0.0137
Loa Loa (eye worm) ACC-1 protein 0.0095 0.0993 0.1292
Brugia malayi neuropeptide F receptor 0.0101 0.1068 0.139
Brugia malayi beta-lactamase family protein 0.0071 0.067 0.0872
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0154 0.0401
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0025 0.0032
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0101 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0057 0.0487 0.0633
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0359 0.0351
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0101 0.0131
Schistosoma mansoni lipoxygenase 0.0062 0.0551 0.0596
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.2202 0.2196
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0645 0.0699
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0101 0.1068 0.1061
Brugia malayi chromobox protein homolog 3 0.0038 0.0238 0.031
Brugia malayi Dopamine receptor 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.0872
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Brugia malayi hypothetical protein 0.0039 0.0254 0.033
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0101 0.1068 0.139
Mycobacterium ulcerans hypothetical protein 0.0156 0.1798 1
Echinococcus granulosus chromobox protein 1 0.0068 0.0634 0.0627
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1236 0.2065
Onchocerca volvulus 0.007 0.0657 0.1011
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Onchocerca volvulus 0.0095 0.0993 0.1548
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1335
Leishmania major hypothetical protein, conserved 0.0071 0.067 0.1815
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0381 0.4781 0.6222
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0487 0.7258
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Schistosoma mansoni biogenic amine receptor 0.0101 0.1068 0.1163
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0068 0.006
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Trypanosoma brucei heat shock protein, putative 0.0032 0.0154 0.0401
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Trypanosoma brucei heat shock protein, putative 0.0032 0.0154 0.0401
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus lamin 0.0055 0.0457 0.045
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.067 0.1134
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.067 0.1064
Schistosoma mansoni endoplasmin 0.0032 0.0154 0.016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0032
Echinococcus multilocularis dro:myosuppressin receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0025 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0381 0.4781 0.5237
Echinococcus granulosus serotonin receptor 0.0101 0.1068 0.1061
Brugia malayi Importin beta-1 subunit 0.0028 0.0107 0.0139
Onchocerca volvulus 0.0095 0.0993 0.1548
Loa Loa (eye worm) hypothetical protein 0.0493 0.6277 0.817
Plasmodium vivax glutathione reductase, putative 0.005 0.0391 0.5835
Echinococcus multilocularis glycine receptor subunit beta 0.0095 0.0993 0.108
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1588 0.4335
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3654 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0095 0.0993 0.0985
Loa Loa (eye worm) hypothetical protein 0.0167 0.1947 0.2534
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0121 0.0157
Onchocerca volvulus 0.003 0.0129 0.0166
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Plasmodium falciparum glutathione reductase 0.005 0.0391 0.8039
Schistosoma mansoni hypothetical protein 0.0708 0.9121 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1236 0.2065
Schistosoma mansoni opsin-like receptor 0.0101 0.1068 0.1163
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.067 0.3478
Entamoeba histolytica hypothetical protein 0.0071 0.0673 0.5614
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Schistosoma mansoni hypothetical protein 0.0065 0.0598 0.0647
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0095 0.0993 0.108
Loa Loa (eye worm) hypothetical protein 0.0065 0.0598 0.0778
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0458 0.6799
Brugia malayi Cation transporter family protein 0.0095 0.0993 0.1292
Brugia malayi Cation transporter family protein 0.0095 0.0993 0.1292
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.1818 0.1812
Schistosoma mansoni nAChR subunit 0.0095 0.0993 0.108
Brugia malayi putative neuropeptide receptor NPR1 0.0101 0.1068 0.139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0405 0.5101 0.664
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0276 0.046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0254 0.033
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0634 0.0826
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0154 0.2286
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0095 0.0993 0.108
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Echinococcus multilocularis neuropeptide receptor 0.0101 0.1068 0.1163
Plasmodium falciparum heat shock protein 90 0.0032 0.0154 0.3149
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Schistosoma mansoni hypothetical protein 0.0065 0.0598 0.0647
Schistosoma mansoni hypothetical protein 0.0046 0.0336 0.036
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0471 0.0508
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) endoplasmin 0.0032 0.0154 0.0201
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0121 0.0157
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.051 0.0502
Brugia malayi Augmenter of liver regeneration 0.0034 0.0178 0.0232
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0141
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Echinococcus granulosus peregrin 0.0057 0.0487 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0238 0.0394
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0095 0.0993 0.0985
Loa Loa (eye worm) hypothetical protein 0.0025 0.0058 0.0076
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0634 0.1074
Brugia malayi CHE-14 protein 0.0047 0.0359 0.0467
Brugia malayi hypothetical protein 0.0039 0.0254 0.033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0993 0.1292
Echinococcus multilocularis sex peptide receptor 0.0101 0.1068 0.1163
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.0136
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0082 0.0074
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0238 0.0341
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1068 0.1163
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1068 0.1061
Brugia malayi glutathione reductase 0.005 0.0391 0.051
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0101 0.1068 0.1163
Brugia malayi hypothetical protein 0.0071 0.0673 0.0876
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Trypanosoma brucei heat shock protein, putative 0.0032 0.0154 0.0401
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0599 0.7683 1
Plasmodium vivax SET domain protein, putative 0.0059 0.051 0.76
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0487 0.7231
Echinococcus granulosus cpg binding protein 0.0029 0.0122 0.0114
Echinococcus multilocularis muscleblind protein 1 0.0167 0.1947 0.2128
Onchocerca volvulus 0.0095 0.0993 0.1548
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0025 0.035
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0178 0.017
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Trypanosoma brucei trypanothione reductase 0.005 0.0391 0.1052
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.3028 0.3314
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis chromobox protein 1 0.0068 0.0634 0.0687
Echinococcus multilocularis g-protein coupled receptor 0.0101 0.1068 0.1163
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0666 0.0722
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1588 0.4335
Schistosoma mansoni nAChR subunit 0.0095 0.0993 0.108
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0039 0.0254 0.0269
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0025 0.0018
Echinococcus multilocularis neuropeptide FF receptor 2 0.0101 0.1068 0.1163
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0095 0.0993 0.1292
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0284 0.0757
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1236 0.8744
Loa Loa (eye worm) inositol-1 0.0038 0.0237 0.0309
Schistosoma mansoni myosin xvIII 0.0101 0.1068 0.1163
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0457 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1068 0.1061
Brugia malayi PHD-finger family protein 0.0057 0.0487 0.0633
Schistosoma mansoni amine GPCR 0.0101 0.1068 0.1163
Entamoeba histolytica hypothetical protein 0.0056 0.0471 0.3914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Brugia malayi Doublecortin family protein 0.0022 0.0025 0.0032
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0782 0.0775
Echinococcus granulosus allatostatin A receptor 0.0101 0.1068 0.1061
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0403 0.5964
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0237 0.0628
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.1192 0.1185
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0403 0.0395
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0154 0.0401
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0993 0.1292
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Echinococcus multilocularis neuropeptide s receptor 0.0584 0.7479 0.8198
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0039 0.0254 0.033
Schistosoma mansoni neuropeptide receptor 0.0101 0.1068 0.1163
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0154 0.0401
Schistosoma mansoni jumonji domain containing protein 0.0148 0.1695 0.1851
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.8576 0.9401
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0101 0.1068 0.1163
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0154 0.0401
Loa Loa (eye worm) transcription factor SMAD2 0.0259 0.3166 0.4121
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1068 0.1163
Mycobacterium tuberculosis Conserved protein 0.0071 0.067 0.1064
Brugia malayi Pre-SET motif family protein 0.0405 0.5101 0.664
Mycobacterium ulcerans lipase LipD 0.0071 0.067 0.3478
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Loa Loa (eye worm) hypothetical protein 0.0141 0.1602 0.2085
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.012 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.067 0.1815
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0154 0.2209
Echinococcus granulosus neuropeptide receptor A26 0.0584 0.7479 0.7477
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Brugia malayi intermediate filament protein 0.0055 0.0457 0.0595
Echinococcus multilocularis nAChR subunit 0.0095 0.0993 0.108
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.1192 0.1299
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.067 0.0726
Onchocerca volvulus 0.0071 0.067 0.1032
Echinococcus granulosus g-protein coupled receptor 0.0101 0.1068 0.1061
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.067 0.1064
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.1068 0.1061
Schistosoma mansoni hypothetical protein 0.0708 0.9121 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0101 0.1068 0.1061
Onchocerca volvulus Neuropeptide F receptor homolog 0.0101 0.1068 0.1668
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0598 0.0778
Echinococcus granulosus nAChR subunit 0.0095 0.0993 0.0985
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0058 0.0846
Schistosoma mansoni neuropeptide receptor 0.0101 0.1068 0.1163
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0039 0.0254 0.033
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1403 0.2362
Onchocerca volvulus 0.0101 0.1068 0.1668
Brugia malayi jmjC domain containing protein 0.0186 0.2202 0.2866
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1403 1
Schistosoma mansoni cpg binding protein 0.0029 0.0122 0.0125
Echinococcus multilocularis heat shock protein 90 0.0025 0.0068 0.0066
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.051 0.7577
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.1068 0.1163
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0095 0.0993 0.108
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0068 0.126
Echinococcus multilocularis musashi 0.0055 0.0457 0.0493
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0391 0.1052
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0095 0.0993 0.1292
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1798 0.306
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus nAChR subunit 0.0056 0.0471 0.0464
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0095 0.0993 0.1292
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0101 0.1068 0.139
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0541 0.0585
Leishmania major trypanothione reductase 0.005 0.0391 0.1052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0237 0.0393
Schistosoma mansoni tar DNA-binding protein 0.0381 0.4781 0.5237
Toxoplasma gondii ABC1 family protein 0.0071 0.067 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1068 0.1061
Brugia malayi G-protein coupled receptor 0.0101 0.1068 0.139
Schistosoma mansoni polycystin 1-related 0.0022 0.0025 0.0018
Onchocerca volvulus 0.0101 0.1068 0.1668
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1068 0.1061
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.067 0.1134
Trichomonas vaginalis esterase, putative 0.0071 0.067 0.1134
Brugia malayi ORL1-like opioid receptor 0.0101 0.1068 0.139
Brugia malayi RNA recognition motif domain containing protein 0.0381 0.4781 0.6222
Loa Loa (eye worm) LGC-31 protein 0.0095 0.0993 0.1292
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Brugia malayi putative neuropeptide receptor 0.0101 0.1068 0.139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.051 0.055
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis geminin 0.0708 0.9121 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Loa Loa (eye worm) GABA receptor subunit 0.0056 0.0471 0.0614
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0178 0.0466
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0237 0.0628
Echinococcus granulosus alpha 1A adrenergic receptor 0.0101 0.1068 0.1061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0101 0.1068 0.1163
Brugia malayi hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0154 0.0401
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0403 0.1083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1068 0.1163
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0036 0.0077
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0107 0.0108
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Leishmania major heat shock protein 83-1 0.0032 0.0154 0.0401
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0403 0.0433
Brugia malayi TAR-binding protein 0.0381 0.4781 0.6222
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0095 0.0993 0.1292
Brugia malayi Endoplasmin precursor 0.0032 0.0154 0.0201
Mycobacterium leprae Probable lipase LipE 0.0071 0.067 0.4506
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.1068 0.1163
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0403 0.0433
Plasmodium falciparum importin beta, putative 0.0028 0.0107 0.2173
Echinococcus granulosus orexin receptor type 2 0.0101 0.1068 0.1061
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1236 0.2065
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0095 0.0993 0.108
Onchocerca volvulus 0.0101 0.1068 0.1668
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0095 0.0993 0.1292
Loa Loa (eye worm) hypothetical protein 0.0095 0.0993 0.1292
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.067 0.1815
Echinococcus multilocularis expressed conserved protein 0.0103 0.1104 0.1202
Brugia malayi Serotonin receptor 0.055 0.7023 0.914
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.067 0.1134
Brugia malayi isocitrate dehydrogenase 0.0051 0.0403 0.0524
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0403 0.0524
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1068 0.1061
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0391 0.5835
Loa Loa (eye worm) MH2 domain-containing protein 0.0259 0.3166 0.4121
Echinococcus granulosus peptide allatostatin:somatostatin 0.0101 0.1068 0.1061
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1068 0.1061
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0101 0.1068 0.1163
Onchocerca volvulus 0.0101 0.1068 0.1668
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0403 0.1083
Trypanosoma brucei heat shock protein, putative 0.0032 0.0154 0.0401
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0403 0.0433
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.8576 0.9401
Brugia malayi excitatory GABA receptor EXP-1A 0.0095 0.0993 0.1292
Onchocerca volvulus 0.0056 0.0471 0.0714
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0095 0.0993 0.0985
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0154 0.0201
Echinococcus granulosus g protein coupled receptor 0.0101 0.1068 0.1061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.051 0.055
Echinococcus granulosus somatostatin receptor 0.0101 0.1068 0.1061
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0598 0.059
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.1602 0.2085
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0068 0.0165
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0403 0.0433
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1403 0.2362
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0487 0.0633
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.0048
Echinococcus granulosus dro:myosuppressin receptor 0.0101 0.1068 0.1061
Schistosoma mansoni amine GPCR 0.0101 0.1068 0.1163
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0056 0.0471 0.0614
Onchocerca volvulus 0.0101 0.1068 0.1668
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Trypanosoma brucei heat shock protein, putative 0.0032 0.0154 0.0401
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3654 1
Schistosoma mansoni neuropeptide receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.0872
Brugia malayi G protein-coupled receptor F59B2.13 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.4974 0.5449
Plasmodium vivax endoplasmin, putative 0.0032 0.0154 0.2286
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.033
Toxoplasma gondii hypothetical protein 0.0048 0.0365 0.5393
Brugia malayi hypothetical protein 0.0022 0.0025 0.0032
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0634 0.1074
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0095 0.0993 0.1292
Loa Loa (eye worm) hypothetical protein 0.0056 0.0471 0.0614
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0101 0.1068 0.1163
Echinococcus multilocularis heat shock protein 0.0032 0.0154 0.016
Brugia malayi larval opioid receptor 0.0101 0.1068 0.139
Onchocerca volvulus 0.0095 0.0993 0.1548
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Onchocerca volvulus 0.0055 0.0457 0.0692
Onchocerca volvulus 0.0051 0.0405 0.0608
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0095 0.0993 0.1292
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.1068 0.139
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0095 0.0993 0.1292
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0095 0.0993 0.1292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1068 0.1163
Trypanosoma brucei heat shock protein, putative 0.0032 0.0154 0.0401
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0403 0.1083
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1068 0.1163
Brugia malayi Dopamine receptor protein 2 0.0101 0.1068 0.139
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1236 0.2065
Echinococcus multilocularis G-protein coupled receptor, putative 0.0101 0.1068 0.1163
Plasmodium vivax importin-beta 2, putative 0.0028 0.0107 0.1578
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0237 0.0393
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.129 0.1678
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.0254 0.0269
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.1192 0.1552
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0058 0.0137
Onchocerca volvulus 0.0101 0.1068 0.1668
Schistosoma mansoni amine GPCR 0.0301 0.3721 0.4074
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0154 0.0401
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0095 0.0993 0.0985
Loa Loa (eye worm) hypothetical protein 0.0167 0.1947 0.2534
Schistosoma mansoni opsin-like receptor 0.0101 0.1068 0.1163
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1236 0.2065
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.1068 0.1163
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0036 0.0048
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0405 0.0527
Loa Loa (eye worm) hypothetical protein 0.011 0.1192 0.1552
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1068 0.1163
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.067 0.1064
Mycobacterium tuberculosis Conserved protein 0.0071 0.067 0.1064
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0095 0.0993 0.108
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0101 0.1068 0.139
Loa Loa (eye worm) hypothetical protein 0.0038 0.0238 0.031
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1068 0.1163
Loa Loa (eye worm) hypothetical protein 0.0101 0.1068 0.139
Brugia malayi Muscleblind-like protein 0.0167 0.1947 0.2534
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0025 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.067 0.1064
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0095 0.0993 0.108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.051 0.055
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0359 0.0601
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1588 0.4335
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0025 0.0482

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 6.9 Binding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblasts ChEMBL. 21381763
Ki (binding) = 7 Binding affinity to human adrenergic alpha1A receptor expressed in rat intact fibroblasts ChEMBL. 21381763
Ki (functional) = 7.3 Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay ChEMBL. 21381763
Ki (functional) = 9.3 Antagonist activity at human recombinant histamine H3 receptor expressed in CHO cells assessed as inhibition of histamine-induced GTP-gammaS binding ChEMBL. 21381763

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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