TDR Targets

Basic information

Technical information

TDR Targets ID: 1514534
Name: 6-[2-[[2-methoxy-5-(trifluoromethyl)phenyl]ca rbamoylamino]ethyl]-N-methyl-1H-benzimidazole -2-carboxamide
MW: 435.4 | Formula: C20H20F3N5O3
H donors: 4 H acceptors: 3 LogP: 2.91 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)c1nc2c([nH]1)cc(cc2)CCNC(=O)Nc1cc(ccc1OC)C(F)(F)F
InChi: 1S/C20H20F3N5O3/c1-24-18(29)17-26-13-5-3-11(9-14(13)27-17)7-8-25-19(30)28-15-10-12(20(21,22)23)4-6-16(15)31-2/h3-6,9-10H,7-8H2,1-2H3,(H,24,29)(H,26,27)(H2,25,28,30)
InChiKey: BFCLSCZXIZAQPT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[2-[[[[2-methoxy-5-(trifluoromethyl)phenyl]amino]-oxomethyl]amino]ethyl]-N-methyl-1H-benzimidazole-2-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Raf-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	raf serine:threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Loa Loa (eye worm)	raf kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Schistosoma japonicum	ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative	Get druggable targets OG5_130459	All targets in OG5_130459
Echinococcus granulosus	raf serine:threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Brugia malayi	Raf kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.023	0.023
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.1004	0.1004
Trichomonas vaginalis	protein phosphatase 2C, putative	0.0121	0.2112	0.4708
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.023	0.023
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.023	0.023
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0379	0.0379
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0025	0.0025
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.023	0.0519
Schistosoma mansoni	hypothetical protein	0.0021	0.0187	0.0187
Trichomonas vaginalis	set domain proteins, putative	0.0242	0.4433	1
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.0046	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0025	0.0025
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0187	0.0187
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.006	0.0937	0.7748
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.023	0.023
Onchocerca volvulus		0.0023	0.023	0.0519
Brugia malayi	Carboxylesterase family protein	0.0282	0.5198	0.5198
Echinococcus granulosus	RUN	0.0021	0.0187	0.0187
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.023	0.023
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.1004	1
Onchocerca volvulus		0.0242	0.4433	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0025
Mycobacterium ulcerans	carboxylesterase, LipT	0.0048	0.0707	0.3975
Brugia malayi	hypothetical protein	0.0012	0.0025	0.0025
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0048	0.0707	0.1507
Echinococcus multilocularis	RUN	0.0021	0.0187	0.0187
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0148	0.2633	0.2633
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0025
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.023	0.023
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0063	0.1004	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0025	0.0025
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0358	0.0358
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.023	0.023
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.023	0.023
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.023	0.023
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0187	0.0187
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.023	0.023
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Loa Loa (eye worm)	carboxylesterase	0.0048	0.0707	0.0707
Schistosoma mansoni	acetylcholinesterase	0.0048	0.0707	0.0707
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.0707	0.0707
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0046	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0187	0.0187
Onchocerca volvulus		0.0013	0.0046	0.0105
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0379	0.0379
Schistosoma mansoni	rab6-interacting	0.0021	0.0187	0.0187
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.023	0.023
Echinococcus granulosus	carboxylesterase 5A	0.0282	0.5198	0.5198
Toxoplasma gondii	aldehyde dehydrogenase	0.0063	0.1004	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0063	0.1004	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.023	0.023
Brugia malayi	Raf kinase	0.0253	0.4626	0.4626
Loa Loa (eye worm)	hypothetical protein	0.0282	0.5198	0.5198
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0063	0.1004	0.1004
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0046	0.5
Echinococcus multilocularis	para nitrobenzyl esterase	0.0048	0.0707	0.0707
Brugia malayi	Carboxylesterase family protein	0.0048	0.0707	0.0707
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.0707	0.0707
Brugia malayi	Carboxylesterase family protein	0.0048	0.0707	0.0707
Trichomonas vaginalis	spcc417.12 protein, putative	0.0048	0.0707	0.1507
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.023	0.023
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.023	0.023
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.023	0.023
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.023	0.023
Trichomonas vaginalis	protein phosphatase 2C delta isoform, putative	0.0121	0.2112	0.4708
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.1004	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0187	0.0187
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.023	0.023
Echinococcus granulosus	raf serine:threonine protein kinase	0.0262	0.4801	0.4801
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.023	0.023
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.023	0.023
Schistosoma mansoni	aryl hydrocarbon receptor	0.0051	0.0764	0.0764
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0379	0.0379
Onchocerca volvulus		0.0048	0.0707	0.1596
Echinococcus granulosus	acetylcholinesterase	0.0282	0.5198	0.5198
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.023	0.023
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.023	0.023
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0048	0.0707	0.0707
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.023	0.023
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.023	0.023
Brugia malayi	nuclear hormone receptor	0.0023	0.023	0.023
Echinococcus granulosus	para nitrobenzyl esterase	0.0048	0.0707	0.0707
Brugia malayi	hypoxia-induced factor 1	0.0157	0.2794	0.2794
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0187	0.0187
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.023	0.023
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0025	0.0025
Brugia malayi	hypothetical protein	0.017	0.3046	0.3046
Echinococcus multilocularis	acetylcholinesterase	0.0282	0.5198	0.5198
Entamoeba histolytica	leucine rich repeat / protein phosphatase 2C domain containing protein	0.0121	0.2112	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0707	0.0707
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.023	0.023
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0379	0.0379
Schistosoma mansoni	loxhd1	0.0021	0.0187	0.0187
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.4801	0.4801
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.023	0.023
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.086	0.086
Schistosoma mansoni	rab6-interacting	0.0021	0.0187	0.0187
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0057	0.0894	0.0894
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0013	0.0046	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.023	0.023
Schistosoma mansoni	lipoxygenase	0.0021	0.0187	0.0187
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0025	0.0025
Loa Loa (eye worm)	acetylcholinesterase 1	0.0282	0.5198	0.5198
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0048	0.0707	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0707	0.0707
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.023	0.023
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0048	0.0707	0.0707
Echinococcus multilocularis	transfer RNA-Lys	0.0037	0.0512	0.0512
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.023	0.023
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0187	0.0187
Brugia malayi	Doublecortin family protein	0.0021	0.0187	0.0187
Brugia malayi	steroid hormone receptor	0.0023	0.023	0.023
Brugia malayi	nuclear receptor NHR-88	0.0023	0.023	0.023
Trichomonas vaginalis	protein phosphatase type 2C, putative	0.0121	0.2112	0.4708
Plasmodium vivax	SET domain protein, putative	0.0031	0.0379	1
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0013	0.0046	0.0046
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0046	0.5
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0379	0.0379
Onchocerca volvulus		0.0048	0.0707	0.1596
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.023	0.023
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.023	0.0519
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.023	0.023
Brugia malayi	ecdysteroid receptor	0.0023	0.023	0.023
Brugia malayi	Carboxylesterase family protein	0.0048	0.0707	0.0707
Loa Loa (eye worm)	carboxylesterase	0.0048	0.0707	0.0707
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.0707	0.0707
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.023	0.023
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0025	0.0025
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.1004	1
Brugia malayi	bHLH-PAS transcription factor	0.0037	0.0512	0.0512
Onchocerca volvulus		0.0031	0.0379	0.0855
Echinococcus multilocularis	neuroligin	0.0048	0.0707	0.0707
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.023	0.023
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.023	0.023
Schistosoma mansoni	single-minded	0.0051	0.0764	0.0764
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0057	0.0894	0.0894
Schistosoma mansoni	polycystin 1-related	0.0021	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0707	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0025
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.006	0.0937	0.8643
Echinococcus granulosus	BC026374 protein S09 family	0.0048	0.0707	0.0707
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0048	0.0707	0.0707
Onchocerca volvulus		0.0037	0.0512	0.1154
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0707	0.0707
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.006	0.0937	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0025
Echinococcus granulosus	single minded 2	0.0037	0.0512	0.0512
Onchocerca volvulus		0.0048	0.0707	0.1596
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0025	0.0025
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.006	0.0937	0.0937
Echinococcus granulosus	acetylcholinesterase	0.0282	0.5198	0.5198
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.0046	0.5
Loa Loa (eye worm)	hypothetical protein	0.0282	0.5198	0.5198
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2109	0.2109
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.023	0.023
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.023	0.023
Brugia malayi	Carboxylesterase family protein	0.0282	0.5198	0.5198
Schistosoma mansoni	gliotactin	0.0048	0.0707	0.0707
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.006	0.0937	0.9302
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0187	0.5
Brugia malayi	hypothetical protein	0.0021	0.0187	0.0187
Brugia malayi	hypothetical protein	0.0021	0.0187	0.0187
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.017	0.3046	0.3046
Brugia malayi	hypothetical protein	0.0012	0.0025	0.0025
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0157	0.2794	0.2794
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0013	0.0046	0.0046
Brugia malayi	nuclear receptor RXR	0.0012	0.0025	0.0025
Schistosoma mansoni	lipoxygenase	0.0057	0.0894	0.0894
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.023	0.023
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0013	0.0046	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.023	0.023
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.006	0.0937	0.0937
Mycobacterium leprae	Possible regulatory protein	0.0013	0.0046	0.5
Brugia malayi	Pre-SET motif family protein	0.0031	0.0379	0.0379
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.023	0.0519
Brugia malayi	Carboxylesterase family protein	0.0048	0.0707	0.0707
Brugia malayi	Pre-SET motif family protein	0.0213	0.387	0.387
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.023	0.023
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.023	0.023
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0282	0.5198	0.5198
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0187	0.0187
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0013	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0707	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0707	0.0707
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0063	0.1004	0.1004
Echinococcus multilocularis	carboxylesterase 5A	0.0282	0.5198	0.5198
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0707	0.0707
Onchocerca volvulus		0.0021	0.0187	0.0422
Brugia malayi	PAS domain containing protein	0.0051	0.0764	0.0764
Echinococcus multilocularis	acetylcholinesterase	0.0282	0.5198	0.5198
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0213	0.387	0.387
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0046	0.5
Schistosoma mansoni	BC026374 protein (S09 family)	0.0048	0.0707	0.0707
Loa Loa (eye worm)	carboxylesterase	0.0282	0.5198	0.5198
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0025
Schistosoma mansoni	coup transcription factor	0.0023	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.023	0.023
Echinococcus granulosus	aryl hydrocarbon receptor	0.0013	0.0046	0.0046
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.006	0.0937	0.0937
Onchocerca volvulus		0.0048	0.0707	0.1596
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0187	0.0187
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.023	0.023
Onchocerca volvulus		0.0021	0.0187	0.0422
Echinococcus granulosus	neuroligin	0.0048	0.0707	0.0707
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.023	0.023
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.006	0.0937	0.8643
Loa Loa (eye worm)	hypothetical protein	0.0023	0.023	0.023
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.023	0.023
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0262	0.4801	0.4801
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0379	0.0379
Loa Loa (eye worm)	raf kinase	0.026	0.4776	0.4776
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0046	0.0046
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.023	0.023
Brugia malayi	hypothetical protein	0.0048	0.0707	0.0707
Onchocerca volvulus		0.0048	0.0707	0.1596

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.34 uM	Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting	ChEMBL.	21420298

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1760628

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1514534