Detailed information for compound 151462

Basic information

Technical information
  • TDR Targets ID: 151462
  • Name: 5-ethyl-3,5-dimethyl-1,3-oxazolidine-2,4-dion e
  • MW: 157.167 | Formula: C7H11NO3
  • H donors: 0 H acceptors: 2 LogP: 0.83 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1(C)OC(=O)N(C1=O)C
  • InChi: 1S/C7H11NO3/c1-4-7(2)5(9)8(3)6(10)11-7/h4H2,1-3H3
  • InChiKey: VQASKUSHBVDKGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Paramethadione
  • 5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione
  • 5-ethyl-3,5-dimethyloxazolidine-2,4-dione
  • 5-ethyl-3,5-dimethyl-oxazolidine-2,4-quinone
  • 115-67-3
  • 3,5-Dimethyl-5-ethyloxazolidine-2,4-dione
  • 4-27-00-03255 (Beilstein Handbook Reference)
  • 5-Ethyl-3,5-dimethyl-2,4-oxazolidinedione
  • A 348
  • BRN 0127715
  • EINECS 204-098-8
  • HSDB 3245
  • Isoethadione
  • Paradione
  • Parametadiona [INN-Spanish]
  • Parametadione
  • Parametadione [DCIT]
  • Paramethadione [BAN:INN]
  • Paramethadionum [INN-Latin]
  • C07411
  • D00495
  • Paradione (TN)
  • Paramethadione (INN)
  • 2,4-Oxazolidinedione, 5-ethyl-3,5-dimethyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphoglycerate kinase 0.0089 0.2125 0.4
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0095 0.2298 0.4334
Echinococcus multilocularis phosphoglycerate kinase 1 0.0089 0.2125 0.2083
Trypanosoma cruzi protein farnesyltransferase, putative 0.0131 0.3318 0.6303
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.257 0.8837
Schistosoma mansoni hypothetical protein 0.0148 0.3801 0.3767
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0131 0.3318 0.6303
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0199 0.5232 1
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0036 0.061 0.0444
Entamoeba histolytica hypothetical protein 0.0065 0.1457 0.1305
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0186 0.0134
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0175 0.0234
Echinococcus multilocularis musashi 0.0026 0.0344 0.0293
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0186 0.0183
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0246 0.0193
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0036 0.061 0.061
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0528 0.0917
Plasmodium vivax polyprenol reductase, putative 0.0065 0.1457 0.1411
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0903 0.0855
Brugia malayi Synaptic glycoprotein SC2 0.0065 0.1457 0.1457
Brugia malayi RNA binding protein 0.0123 0.3088 0.3088
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0367 1 1
Brugia malayi Phosphoglycerate kinase 0.0089 0.2125 0.2125
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Echinococcus multilocularis thyroid hormone receptor alpha 0.016 0.4138 0.4106
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3088 0.3051
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0175 0.0234
Onchocerca volvulus 0.0065 0.1457 0.5692
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0036 0.061 0.056
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0065 0.1457 0.1935
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0367 1 1
Schistosoma mansoni hypothetical protein 0.0165 0.4264 0.4233
Mycobacterium ulcerans phosphoglycerate kinase 0.0089 0.2125 0.4
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.1457 0.1411
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0186 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3088 0.3051
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0036 0.061 0.056
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0131 0.3318 0.3282
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2901 1
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0065 0.1457 0.1411
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0095 0.2298 0.4334
Brugia malayi follicle stimulating hormone receptor 0.0227 0.604 0.604
Echinococcus multilocularis lamin dm0 0.0026 0.0344 0.0293
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0065 0.1457 0.1411
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.1457 0.2709
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0089 0.2125 0.2857
Loa Loa (eye worm) hypothetical protein 0.0036 0.061 0.061
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0148 0.3801 0.3767
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0089 0.2125 0.4
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0131 0.3318 0.3282
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0199 0.5232 0.5232
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0089 0.2125 0.2083
Echinococcus multilocularis dna polymerase eta 0.0047 0.093 0.0881
Echinococcus multilocularis tar DNA binding protein 0.0123 0.3088 0.3051
Echinococcus granulosus lamin 0.0026 0.0344 0.0293
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0199 0.5232 0.7143
Echinococcus granulosus lamin dm0 0.0026 0.0344 0.0293
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0535 0.0665
Plasmodium falciparum geranylgeranyltransferase, putative 0.0036 0.061 0.056
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.257 0.8837
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0095 0.2298 0.2257
Loa Loa (eye worm) hypothetical protein 0.0089 0.2125 0.2125
Giardia lamblia Rab geranylgeranyltransferase 0.0095 0.2298 0.2257
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0036 0.061 0.0768
Trypanosoma brucei lanosterol synthase 0.0036 0.061 0.1076
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0095 0.2298 0.2257
Leishmania major farnesyltransferase beta subunit 0.0131 0.3318 0.6303
Loa Loa (eye worm) hypothetical protein 0.0047 0.093 0.093
Schistosoma mansoni lamin 0.0026 0.0344 0.0293
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0903 0.1641
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0036 0.061 0.0768
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.093 0.1692
Schistosoma mansoni phosphoglycerate kinase 0.0089 0.2125 0.2083
Brugia malayi glutathione reductase 0.0046 0.0903 0.0903
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0367 1 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0186 0.0134
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0131 0.3318 0.3282
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0033 0.0528 0.0917
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.257 0.8837
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0175 0.0234
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0033 0.0528 0.0917
Echinococcus granulosus importin subunit beta 1 0.0028 0.0396 0.0344
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0186 0.0134
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0903 0.2985
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.1457 0.1411
Leishmania major DNA polymerase kappa, putative 0.002 0.0175 0.0234
Loa Loa (eye worm) hypothetical protein 0.0026 0.0331 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0036 0.061 0.0444
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0095 0.2298 0.2257
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0199 0.5232 1
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.1457 0.1411
Loa Loa (eye worm) hypothetical protein 0.0028 0.0396 0.0396
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0175 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Echinococcus multilocularis synaptic glycoprotein sc2 0.0065 0.1457 0.1411
Loa Loa (eye worm) hypothetical protein 0.0065 0.1457 0.1457
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0131 0.3318 0.3282
Treponema pallidum phosphoglycerate kinase 0.0089 0.2125 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0095 0.2298 0.2257
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.1457 0.1411
Loa Loa (eye worm) hypothetical protein 0.0036 0.061 0.061
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0089 0.2125 1
Giardia lamblia Phosphoglycerate kinase 0.0089 0.2125 0.2083
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0272 0.7304 0.729
Toxoplasma gondii thioredoxin reductase 0.0046 0.0903 0.1172
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0036 0.061 0.061
Loa Loa (eye worm) TAR-binding protein 0.0123 0.3088 0.3088
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0036 0.061 0.1076
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0036 0.061 0.056
Loa Loa (eye worm) hypothetical protein 0.0026 0.0344 0.0344
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0175 0.0122
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0367 1 1
Plasmodium vivax geranylgeranyltransferase, putative 0.0036 0.061 0.056
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0036 0.061 0.056
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0036 0.061 0.061
Echinococcus granulosus synaptic glycoprotein sc2 0.0065 0.1457 0.1411
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0199 0.5232 0.5148
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.061 0.1076
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0367 1 1
Brugia malayi Thioredoxin reductase 0.0046 0.0903 0.0903
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0186 0.0257
Mycobacterium ulcerans hypothetical protein 0.0199 0.5232 1
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0095 0.2298 0.2257
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0095 0.2298 0.4334
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0367 1 1
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0095 0.2298 0.2161
Plasmodium falciparum phosphoglycerate kinase 0.0089 0.2125 0.2083
Trypanosoma cruzi lanosterol synthase, putative 0.0036 0.061 0.1076
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.061 0.1076
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0033 0.0528 0.0917
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0065 0.1457 0.1411
Leishmania major DNA polymerase eta, putative 0.0047 0.093 0.1692
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0095 0.2298 0.2257
Loa Loa (eye worm) hypothetical protein 0.0367 1 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0089 0.2125 0.2083
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0036 0.061 0.056
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0095 0.2298 0.2298
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0089 0.2125 0.4
Leishmania major phosphoglycerate kinase C, glycosomal 0.0089 0.2125 0.4
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0131 0.3318 0.3282
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0096 0.231 0.2269
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0246 0.0372
Giardia lamblia Rab geranylgeranyltransferase 0.0367 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.8071 0.8071
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0095 0.2298 0.4334
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0131 0.3318 0.3282
Giardia lamblia DINP protein human, muc B family 0.002 0.0175 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3088 0.3051
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.257 0.5733
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.1457 0.2709
Leishmania major importin beta-1 subunit, putative 0.0023 0.0246 0.0372
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0199 0.5232 0.5207
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0175 0.0426
Trypanosoma brucei hypothetical protein, conserved 0.0095 0.2298 0.4334
Leishmania major phosphoglycerate kinase B, cytosolic 0.0089 0.2125 0.4
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0528 0.0917
Loa Loa (eye worm) RNA binding protein 0.0123 0.3088 0.3088
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0095 0.2298 0.4334
Plasmodium falciparum glutathione reductase 0.0046 0.0903 0.0855
Schistosoma mansoni ran 0.0021 0.0186 0.0134
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0903 0.0855
Toxoplasma gondii hypothetical protein 0.0095 0.2298 0.3096
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0246 0.0193
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0186 0.0186
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0036 0.061 0.056
Echinococcus multilocularis dna polymerase kappa 0.002 0.0175 0.0122
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0065 0.1457 0.1305
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0131 0.3318 0.3199
Schistosoma mansoni phosphoglycerate kinase 0.0089 0.2125 0.2083
Entamoeba histolytica hypothetical protein 0.0023 0.0246 0.0072
Echinococcus granulosus snurportin 1 0.0299 0.8071 0.806
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0065 0.1457 0.1411
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0367 1 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0903 0.0903
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3088 0.3051
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0199 0.5232 0.5207
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0199 0.5232 0.5207
Schistosoma mansoni DNA polymerase eta 0.0047 0.093 0.0881
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.3088 0.3088
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0903 0.0903
Echinococcus granulosus tar DNA binding protein 0.0123 0.3088 0.3051
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0053 0.0053
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0535 0.093
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0131 0.3318 0.4502
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0065 0.1457 0.1935
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0095 0.2298 0.2257
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0396 0.0472
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0131 0.3318 0.3318
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0186 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0175 0.0234
Schistosoma mansoni lamin 0.0026 0.0344 0.0293
Echinococcus granulosus dna polymerase kappa 0.002 0.0175 0.0122
Plasmodium vivax glutathione reductase, putative 0.0046 0.0903 0.0855
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0131 0.3318 0.3282
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0186 0.0186
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.257 0.8837
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.093 0.1692
Trichomonas vaginalis ran, putative 0.0021 0.0186 0.0134
Plasmodium falciparum importin beta, putative 0.0028 0.0396 0.0344
Schistosoma mansoni hypothetical protein 0.0165 0.4264 0.4233
Echinococcus multilocularis snurportin 1 0.0299 0.8071 0.806
Schistosoma mansoni importin beta-1 0.0028 0.0396 0.0344
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0367 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.2298 0.4334
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0036 0.061 0.1076
Loa Loa (eye worm) hypothetical protein 0.0199 0.5232 0.5232
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0095 0.2298 0.4334
Brugia malayi TAR-binding protein 0.0123 0.3088 0.3088
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0246 0.0193
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.1457 0.1411
Brugia malayi intermediate filament protein 0.0026 0.0344 0.0344
Leishmania major geranylgeranyltransferase, putative 0.0036 0.061 0.1076
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0367 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1457 0.1411
Schistosoma mansoni intermediate filament proteins 0.0026 0.0344 0.0293
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0186 0.0257
Echinococcus granulosus intermediate filament protein 0.0026 0.0344 0.0293
Giardia lamblia Prenyltransferase 0.0131 0.3318 0.3282
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0065 0.1457 0.1305
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0095 0.2298 0.2298
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0036 0.061 0.1956
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0089 0.2125 0.2857
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0175 0.0122
Schistosoma mansoni thyroid hormone receptor 0.016 0.4138 0.4106
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0344 0.0344
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0396 0.0661
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0175 0.0122
Plasmodium vivax importin-beta 2, putative 0.0028 0.0396 0.0344
Entamoeba histolytica phosphoglycerate kinase, putative 0.0089 0.2125 0.1985
Echinococcus granulosus phosphoglycerate kinase 1 0.0089 0.2125 0.2083
Trypanosoma brucei phosphoglycerate kinase 0.0033 0.0528 0.0917
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0131 0.3318 0.3282
Schistosoma mansoni hypothetical protein 0.0299 0.8071 0.806
Echinococcus granulosus dna polymerase eta 0.0047 0.093 0.0881
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2901 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0089 0.2125 0.7275
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0131 0.3318 0.3282
Trypanosoma brucei unspecified product 0.002 0.0175 0.0234
Echinococcus granulosus geminin 0.0165 0.4264 0.4233
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0175 0.0122
Brugia malayi Phosphoglycerate kinase 0.0033 0.0528 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Plasmodium falciparum thioredoxin reductase 0.0046 0.0903 0.0855
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0036 0.061 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Trypanosoma brucei phosphoglycerate kinase 0.0089 0.2125 0.4
Toxoplasma gondii hypothetical protein 0.0272 0.7304 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0903 0.0855
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2901 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0115 0.287 0.2832
Leishmania major GTP-binding protein, putative 0.0021 0.0186 0.0257
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2901 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0131 0.3318 0.3282
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.3088 0.3088
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3088 0.3051
Onchocerca volvulus 0.0095 0.2298 1
Echinococcus multilocularis geminin 0.0165 0.4264 0.4233
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0175 0.0122
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0344 0.0344
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0186 0.0134
Trypanosoma brucei phosphoglycerate kinase, putative 0.0033 0.0528 0.0917
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.093 0.093
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0036 0.061 0.056
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0131 0.3318 0.3318
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0199 0.5232 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0175 0.0234
Leishmania major trypanothione reductase 0.0046 0.0903 0.1641
Giardia lamblia Synaptic glycoprotein SC2 0.0065 0.1457 0.1411
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0148 0.3801 0.3767
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.2298 0.4334
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0175 0.0234
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0036 0.061 0.056
Schistosoma mansoni ran 0.0021 0.0186 0.0134
Loa Loa (eye worm) hypothetical protein 0.0065 0.1457 0.1457
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.257 0.8837
Giardia lamblia Rab geranylgeranyltransferase 0.0036 0.061 0.056
Trypanosoma cruzi protein farnesyltransferase, putative 0.0131 0.3318 0.6303
Echinococcus multilocularis lamin 0.0026 0.0344 0.0293
Trypanosoma brucei trypanothione reductase 0.0046 0.0903 0.1641
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0396 0.0661
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.1457 0.1411
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0199 0.5232 1
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0095 0.2298 0.4334
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0367 1 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0186 0.0012
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0344 0.0344
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0175 0.0175
Brugia malayi Importin beta-1 subunit 0.0028 0.0396 0.0396
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0089 0.2125 0.2083
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0131 0.3318 0.3282
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0175 0.0234
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0528 0.0917
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0175 0.0175
Brugia malayi RNA, U transporter 1 0.008 0.1858 0.1858
Trypanosoma cruzi lanosterol synthase, putative 0.0036 0.061 0.1076
Leishmania major DNA polymerase eta, putative 0.0033 0.0535 0.093
Mycobacterium tuberculosis Probable reductase 0.0105 0.257 0.8837
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1457 0.1411
Schistosoma mansoni thyroid hormone receptor 0.016 0.4138 0.4106
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0175 0.0426
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0175 0.0234
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.604 0.604
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0036 0.061 0.056
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0036 0.061 0.056
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0175 0.0234
Chlamydia trachomatis phosphoglycerate kinase 0.0089 0.2125 1
Plasmodium falciparum polyprenol reductase, putative 0.0065 0.1457 0.1411
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0175 0.0234
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0396 0.0344

Activities

Activity type Activity value Assay description Source Reference
Anticonvulsant activity (functional) 0 Virtual screen for compounds with anticonvulsant activity ChEMBL. 12873507

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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