Detailed information for compound 1515356

Basic information

Technical information
  • TDR Targets ID: 1515356
  • Name: N-[2-[(4-methoxyphenyl)methylamino]-2-oxoethy l]-3-oxo-2,4-dihydroquinoxaline-1-carboxamide
  • MW: 368.387 | Formula: C19H20N4O4
  • H donors: 3 H acceptors: 3 LogP: 0.9 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNC(=O)CNC(=O)N1CC(=O)Nc2c1cccc2
  • InChi: 1S/C19H20N4O4/c1-27-14-8-6-13(7-9-14)10-20-17(24)11-21-19(26)23-12-18(25)22-15-4-2-3-5-16(15)23/h2-9H,10-12H2,1H3,(H,20,24)(H,21,26)(H,22,25)
  • InChiKey: PRBKDBUDOLIYND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(4-methoxyphenyl)methylamino]-2-oxo-ethyl]-3-oxo-2,4-dihydroquinoxaline-1-carboxamide
  • 3-keto-N-[2-keto-2-[(4-methoxybenzyl)amino]ethyl]-2,4-dihydroquinoxaline-1-carboxamide
  • ZINC06662726

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.111 0.3742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Onchocerca volvulus Cathepsin L homolog 0.0101 0.2966 0.2591
Echinococcus granulosus cathepsin L cysteine protease 0.0052 0.111 0.3742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0506 0.1707
Leishmania major cathepsin L-like protease 0.0101 0.2966 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0067 0.1701 0.1959
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.111 0.3742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.1701 0.1701
Loa Loa (eye worm) ctsf protein 0.0101 0.2966 0.3417
Brugia malayi Cathepsin L-like precursor 0.0067 0.1701 0.1959
Loa Loa (eye worm) cysteine protease 0.0101 0.2966 0.3417
Leishmania major cysteine peptidase A (CPA) 0.0101 0.2966 1
Plasmodium vivax unspecified product 0.0033 0.0403 0.136
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0067 0.1701 0.5733
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Onchocerca volvulus 0.0101 0.2966 0.2591
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Echinococcus multilocularis cathepsin L cysteine protease 0.0101 0.2966 1
Leishmania major cathepsin L-like protease 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Loa Loa (eye worm) hypothetical protein 0.0033 0.0403 0.0465
Leishmania major cathepsin L-like protease 0.0101 0.2966 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0506 0.1707
Brugia malayi Cathepsin L-like precursor 0.0101 0.2966 0.3417
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0506 0.1707
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0506 0.1707
Onchocerca volvulus 0.0101 0.2966 0.2591
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.2966 1
Echinococcus multilocularis cysteine protease 0.0101 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0403 0.0465
Brugia malayi Cathepsin L-like precursor 0.0101 0.2966 0.3417
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0101 0.2966 0.2966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Brugia malayi cathepsin F-like cysteine proteinase 0.0033 0.0403 0.0465
Plasmodium vivax vivapain-3 0.0052 0.111 0.3742
Trypanosoma cruzi cruzipain precursor, putative 0.0101 0.2966 1
Onchocerca volvulus 0.0101 0.2966 0.2591
Plasmodium vivax vivapain-1 0.0052 0.111 0.3742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.2966 1
Echinococcus granulosus cathepsin l1 0.0067 0.1701 0.5733
Leishmania major cathepsin L-like protease 0.0101 0.2966 1
Onchocerca volvulus 0.0067 0.1701 0.1258
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.2966 1
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0403 0.136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.2966 0.3417
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0101 0.2966 0.3417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Trypanosoma cruzi cysteine protease, putative 0.0052 0.111 0.3742
Trypanosoma cruzi cysteine proteinase, putative 0.0052 0.111 0.3742
Schistosoma mansoni cathepsin s 0.0033 0.0403 0.136
Echinococcus multilocularis cathepsin L cysteine protease 0.0101 0.2966 1
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Brugia malayi Cathepsin L-like precursor 0.0101 0.2966 0.3417
Onchocerca volvulus Cathepsin F homolog 0.0101 0.2966 0.2591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.111 0.3742
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.111 0.1279
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0052 0.111 0.3742
Echinococcus multilocularis cysteine protease 0.0101 0.2966 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0033 0.0403 0.0465
Onchocerca volvulus Cathepsin L homolog 0.0101 0.2966 0.2591
Echinococcus multilocularis cathepsin L 0.0052 0.111 0.3742
Plasmodium falciparum cysteine proteinase falcipain 3 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0506 0.1707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0506 0.1707
Leishmania major cathepsin L-like protease 0.0101 0.2966 1
Onchocerca volvulus 0.0101 0.2966 0.2591
Brugia malayi Cathepsin L-like precursor 0.0033 0.0403 0.0465
Leishmania major cathepsin L-like protease 0.0101 0.2966 1
Plasmodium vivax unspecified product 0.0052 0.111 0.3742
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Schistosoma mansoni cathepsin F (C01 family) 0.0067 0.1701 0.5733
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0506 0.1707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Trypanosoma cruzi cruzipain precursor, putative 0.0033 0.0403 0.136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.111 0.111
Toxoplasma gondii cathepsin CPL 0.0101 0.2966 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.2966 0.3417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Trypanosoma cruzi cysteine proteinase, putative 0.0052 0.111 0.3742
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.111 0.3742
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0101 0.2966 1
Leishmania major cathepsin L-like protease 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.111 0.111
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0506 0.1707
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.111 0.3742
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0101 0.2966 0.2966
Brugia malayi Cathepsin L-like precursor 0.0101 0.2966 0.3417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Brugia malayi Pre-SET motif family protein 0.0036 0.0506 0.0583
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.2966 1
Brugia malayi Cathepsin L-like precursor 0.0101 0.2966 0.3417
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.2966 1
Echinococcus granulosus cathepsin L 0.0052 0.111 0.3742
Loa Loa (eye worm) hypothetical protein 0.0036 0.0506 0.0583
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1701 0.1959
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0052 0.111 0.3742
Brugia malayi Cathepsin L-like precursor 0.0101 0.2966 0.3417
Entamoeba histolytica cysteine proteinase, putative 0.0067 0.1701 0.5733
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8681 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0101 0.2966 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0101 0.2966 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.111 0.1279
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Loa Loa (eye worm) hypothetical protein 0.0067 0.1701 0.1959
Echinococcus granulosus cysteine protease 0.0052 0.111 0.3742
Echinococcus granulosus cathepsin l cysteine peptidase 0.0101 0.2966 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0456 0.1538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.1701 0.1701
Loa Loa (eye worm) fibroinase 0.0101 0.2966 0.3417
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0403 0.0465
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.111 0.3742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2966 0.2966
Brugia malayi Cathepsin L-like precursor 0.0067 0.1701 0.1959
Onchocerca volvulus 0.0101 0.2966 0.2591
Entamoeba histolytica cysteine proteinase 1, putative 0.0052 0.111 0.3742
Entamoeba histolytica cysteine protease, putative 0.0101 0.2966 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.2966 0.2966
Onchocerca volvulus 0.0101 0.2966 0.2591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.2966 1
Leishmania major cathepsin L-like protease 0.0101 0.2966 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0506 0.1707
Entamoeba histolytica cysteine proteinase 2 0.0052 0.111 0.3742
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Onchocerca volvulus 0.0101 0.2966 0.2591
Entamoeba histolytica cysteine protease, putative 0.0052 0.111 0.3742
Echinococcus granulosus cathepsin l1 0.0101 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1701 0.1959
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0052 0.111 0.3742
Brugia malayi cathepsin L-like precursor 0.0067 0.1701 0.1959
Loa Loa (eye worm) hypothetical protein 0.0033 0.0403 0.0465
Brugia malayi Pre-SET motif family protein 0.0251 0.8681 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0052 0.111 0.3742
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0052 0.111 0.3742
Plasmodium vivax vivapain-2 0.0101 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.2966 0.3417
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.111 0.3742
Plasmodium vivax vivapain-2 0.0101 0.2966 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0067 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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