Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor M1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | amine GPCR | Muscarinic acetylcholine receptor M1 | 460 aa | 463 aa | 27.0 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Muscarinic acetylcholine receptor M1 | 460 aa | 432 aa | 26.6 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Muscarinic acetylcholine receptor M1 | 460 aa | 462 aa | 23.4 % |
Loa Loa (eye worm) | hypothetical protein | Muscarinic acetylcholine receptor M1 | 460 aa | 425 aa | 22.1 % |
Echinococcus multilocularis | serotonin receptor | Muscarinic acetylcholine receptor M1 | 460 aa | 432 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.018 | 0.018 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0118 | 0.018 | 0.018 |
Brugia malayi | thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Echinococcus granulosus | thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 0.5 |
Onchocerca volvulus | 0.0184 | 0.0484 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1046 | 0.4446 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.0017 | 0.0017 |
Brugia malayi | hypothetical protein | 0.0088 | 0.004 | 0.004 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.004 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 0.018 | 0.018 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0184 | 0.0484 | 0.0446 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.73 mM | Tested for stimulating PI(phosphoinositol) hydrolysis in A9L-m1 cells, activity expressed as EC50 mM. | ChEMBL. | 7658434 |
IC50 (binding) | = 10.6 nM | Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand. | ChEMBL. | 7658434 |
IC50 (binding) | = 11.3 nM | Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-OXO-M as the radioligand. | ChEMBL. | 7658434 |
Max (functional) | = 46 % | Stimulating PI (phosphoinositol) hydrolysis in A9L-m1 cells. | ChEMBL. | 7658434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.