Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.0011 | 0.0008 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0004 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0008 | 0.0004 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0008 | 0.0008 |
Brugia malayi | thymidylate synthase | 0.0517 | 0.175 | 0.1746 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0198 | 0.0194 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0008 | 0.0004 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0089 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0011 | 0.0008 | 0.0004 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0041 | 0.0041 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1633 | 0.5584 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0004 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0089 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0041 | 0.0036 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0085 | 0.0085 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0198 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0517 | 0.175 | 0.175 |
Schistosoma mansoni | nuclear receptor | 0.0009 | 0.0004 | 0.0004 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.033 | 0.0326 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0041 | 0.0036 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1633 | 0.5584 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0517 | 0.175 | 0.175 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0217 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0036 |
Echinococcus multilocularis | geminin | 0.0168 | 0.055 | 0.055 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0085 | 0.0081 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.0085 | 0.0081 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0004 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.0033 | 0.0085 | 0.0462 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0.0041 | 0.0208 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.033 | 0.0326 |
Schistosoma mansoni | zinc finger protein | 0.0009 | 0.0004 | 0.0004 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0009 | 0.0004 | 0.0004 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.0004 | 0.0004 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0085 | 0.0081 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0041 | 0.0036 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0041 | 0.0036 |
Loa Loa (eye worm) | thymidylate synthase | 0.0517 | 0.175 | 0.1746 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.055 | 0.055 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | glutaminase | 0.0258 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | glutaminase | 0.0258 | 0.0859 | 0.0855 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0009 | 0.0004 | 0.0004 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0009 | 0.0004 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0085 | 0.0085 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1633 | 0.5584 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0089 | 0.0084 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0009 | 0.0004 | 0.0004 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0128 | 0.0128 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0198 | 0.0194 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0041 | 0.0036 |
Mycobacterium ulcerans | thymidylate synthase | 0.0517 | 0.175 | 0.0974 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0009 | 0.0004 | 0.0004 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0041 | 0.0036 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0041 | 0.0036 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0009 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0036 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0041 | 0.0036 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0469 | 0.1582 | 0.1582 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0217 | 0.0212 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1633 | 0.5584 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0041 | 0.0036 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0009 | 0.0004 | 0.0004 |
Echinococcus granulosus | dnaJ subfamily B | 0.0469 | 0.1582 | 0.1582 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0041 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.007 | 0.0212 | 0.0212 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0007 | 0.0007 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.055 | 0.055 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0009 | 0.0004 | 0.0004 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0041 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0004 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0041 | 0.0036 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.0091 | 0.0091 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0089 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0128 | 0.0124 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0007 | 0.0002 |
Onchocerca volvulus | 0.002 | 0.0041 | 0.0208 | |
Brugia malayi | hypothetical protein | 0.0246 | 0.0818 | 0.0814 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.0085 | 0.0081 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0004 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.033 | 0.0326 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0041 | 0.0036 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0517 | 0.175 | 0.1015 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0009 | 0.0004 | 0.0004 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0041 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0085 | 0.0085 |
Brugia malayi | glutaminase DH11.1 | 0.0258 | 0.0859 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0036 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0009 | 0.0004 | 0.0004 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0652 | 0.2211 | 0.2211 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0034 | 0.0089 | 0.0089 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0128 | 0.0128 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0217 | 0.0217 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0034 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | glutaminase 2 | 0.0258 | 0.0859 | 0.0855 |
Trichomonas vaginalis | glutaminase, putative | 0.0258 | 0.0859 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0008 | 0.0004 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0041 | 0.0036 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0198 | 0.0194 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0198 | 0.0194 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0041 | 0.0036 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0007 | 0.0007 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.0517 | 0.175 | 1 | |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0041 | 0.0041 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0089 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0198 | 0.0198 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0041 | 0.0036 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0009 | 0.0004 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0085 | 0.0085 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0085 | 0.0085 |
Echinococcus multilocularis | thymidylate synthase | 0.0517 | 0.175 | 0.175 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0008 | 0.0004 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1609 | 0.5502 | 0.5502 |
Schistosoma mansoni | hypothetical protein | 0.0469 | 0.1582 | 0.1582 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0128 | 0.0128 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0085 | 0.0085 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0198 | 0.0198 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0041 | 0.0041 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1633 | 0.5584 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0128 | 0.0128 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.033 | 0.0326 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0041 | 0.0036 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0198 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0128 | 0.0124 |
Schistosoma mansoni | nuclear receptor | 0.0009 | 0.0004 | 0.0004 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0011 | 0.0008 | 0.0008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0128 | 0.0128 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0041 | 0.0041 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0.0041 | 0.0208 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0085 | 0.0085 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0041 | 0.0036 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0041 | 0.0036 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0.0041 | 0.0208 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0085 | 0.0085 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0011 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0036 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.0091 | 0.0091 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0011 | 0.0008 | 0.0008 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0085 | 0.0085 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0009 | 0.0004 | 0.0004 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0198 | 0.0194 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0652 | 0.2211 | 0.2211 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0041 | 0.0036 |
Echinococcus granulosus | geminin | 0.0168 | 0.055 | 0.055 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0041 | 0.0036 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0009 | 0.0004 | 0.0004 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0041 | 0.0036 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0006 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0036 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0091 | 0.0091 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0198 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0085 | 0.0085 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0085 | 0.0081 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0198 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0034 | 0.0089 | 0.0089 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1633 | 0.5584 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0198 | 0.0194 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0652 | 0.2211 | 0.2211 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0085 | 0.0081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.