Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.0647 | 0.1539 | 0.1172 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1872 | 0.5593 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1872 | 0.5593 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1872 | 0.5593 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0647 | 0.1539 | 0.1172 |
Echinococcus multilocularis | thymidylate synthase | 0.0647 | 0.1539 | 0.1313 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0647 | 0.1539 | 0.1539 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1872 | 0.5593 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0647 | 0.1539 | 0.1313 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1872 | 0.5593 | 0.5 |
Onchocerca volvulus | 0.0647 | 0.1539 | 0.5 | |
Schistosoma mansoni | lipoxygenase | 0.0261 | 0.026 | 0.026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0308 | 0.0416 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1872 | 0.5593 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 150 uM | Inhibitory activity against human thrombin | ChEMBL. | 12954052 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.